CN209048414U - A kind of experiment of nude mouse device for contactless thermotherapy research - Google Patents
A kind of experiment of nude mouse device for contactless thermotherapy research Download PDFInfo
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- CN209048414U CN209048414U CN201721613736.1U CN201721613736U CN209048414U CN 209048414 U CN209048414 U CN 209048414U CN 201721613736 U CN201721613736 U CN 201721613736U CN 209048414 U CN209048414 U CN 209048414U
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Abstract
The utility model patent discloses a kind of experiment of nude mouse device for contactless thermotherapy research, including the tubular container with interlayer and positioned on the narrow meshed screw type nut cap of tubular container one end: described tubular container one end with interlayer is tapered end, another end opening and port inner wall are equipped with internal screw thread, interlayer is constituted between the inner layer wall and outer wall of the tubular container with interlayer, it is connected between inner layer wall and outer wall by connecting plate, the mutually not opposite venthole that the inner layer wall and outer wall of the tubular container with interlayer are equipped with, the spareslots being mutually aligned；The screw type nut cap is equipped with aperture, and the screw type nut cap is equipped with external screw thread and the internal screw thread on this external screw thread and tubular container inner wall cooperates.The utility model structure is simple, vdiverse in function: the setting of interlayer, not only can guarantee that experimental animal was in the effective range of thermotherapy, but also experimental animal can be made to be not directly contacted with heat source to avoid scalding, moreover it is possible to simulate heat cure to the penetration of people.
Description
Technical field
The utility model relates generally to medical experiment apparatus field, and in particular to a kind of for contactless thermotherapy research
Experiment of nude mouse device.
Background technique
Thermotherapy is that a kind of important method in physiotherapy transfers heat to body using various heat sources as mediator, to reach
The therapy of therapeutic purposes.Studies have shown that therapeutic effect can be more in oncotherapy after thermotherapy and drug, radiotherapy, the combination of chemotherapy
It is good, caused by toxic side effect can also reduce, while thermotherapy can also activating immune system, improve immunity of organisms, and thermotherapy is complete
Body side effect is smaller.With people have to the deepen continuously research and thermotherapy itself of thermotherapy treatment pathogenic mechanism it is numerous
Advantage, the treatment method of thermotherapy are also more and more valued by people.
Thermotherapy is divided into contact thermotherapy and contactless two class of thermotherapy again, and contactless thermotherapy include high frequency transmission beam method and
Radiothermy etc., contactless thermotherapy can reduce patient's body and heat source directly contact and it is injured a possibility that, and by
There is certain penetrability in thermotherapies mode such as far infrared thermotherapy and magnetic induction thermotherapy itself, the heat effect that thermotherapy can be made to generate
The tissue of the subcutaneous certain depth of patient is reached, therefore the potential applicability in clinical practice of contactless thermotherapy is very considerable, however before this
A large amount of zoopery must be carried out, zoopery is the important support condition of life science.
Nude mice is a kind of common experimental animal model, is widely used in the relevant basic research of the diseases such as tumour,
But in current existing experimental study, the very rare appliance arrangement for combining contactless thermotherapy with zoopery, together
When due to experiment of nude mouse animal model itself particularity (such as nude mice nature are active, body surface hairless cover), appliance arrangement needs
It is (certain activity space, constant to guarantee to provide the good environment that can carry out normal physiological activity for nude mice in hyperthermia process
And temperature appropriate etc.), while needing to protect nude mice that it is made to avoid generating the bad damages such as scald, and meet the reality of above-mentioned requirements
Experiment device has not been reported.If the experiment of nude mouse device for contactless thermotherapy research for meeting requirements above can be constructed,
By the accuracy that zoopery can be improved to obtain reliable experimental data, solid base is provided for the clinical trial in later period
Plinth.
Summary of the invention
Demand and the problems of the above-mentioned prior art based on current era, the utility model provide can be directed to it is non-
The zoopery of contact thermotherapy research, but can according to the activity space in the difference in size regulating device container of experimental animal,
A kind of the multi-functional animal experiment for contactless thermotherapy research that other detection devices can also be inserted by spareslots fills
It sets.
The technical solution of the utility model is as follows:
A kind of experiment of nude mouse device for contactless thermotherapy research including the tubular container (1) with interlayer and is positioned on
The narrow meshed screw type nut cap (2) of tubular container (1) one end: described tubular container (1) one end with interlayer is tapered end
(11), another end opening and port inner wall are equipped with internal screw thread (12), the inner layer wall (13) of the tubular container (1) with interlayer
Interlayer (15) are constituted between outer wall (14), are connected between inner layer wall (13) and outer wall (14) by connecting plate (16), institute
State the mutually not opposite venthole being respectively equipped on the inner layer wall (13) and outer wall (14) of the tubular container (1) with interlayer
(17), it is also each provided with the spareslots (18) being mutually aligned respectively on inner layer wall (13) and outer wall (14)；The screw type lid
Cap (2) is equipped with aperture (21), and the screw type nut cap (2) is equipped with external screw thread (22) and this external screw thread (22) and tubular container
(1) internal screw thread on inner wall (12), which cooperates, connects.
The experiment of nude mouse device for contactless thermotherapy research further includes support construction (3), the support construction
It (3) include support plate (31) and support frame (32), (3 are used to support and the tubular container of fixing belt interlayer (1) and peace support construction
Narrow meshed screw type nut cap (2) in tubular container (1) one end.
Preferably, support frame as described above (32) quantity is 2-3, and support frame (32) is each other point-blank and spacing
It is fixed；
Preferably, the bottom of support frame as described above (32) is each attached on the support plate (31), the top of support frame (32)
It is round locking member (33), adjustable circumferential size makes for neatly fixing tubular container (1) and screw type nut cap (2)
It avoids being subjected to displacement because of the activity of nude mice；
Preferably, the tubular container (1) with interlayer is all made of transparent material (such as plastics, glass)；
Preferably, described tubular container (1) one end with interlayer is tapered end (11) for accommodating nude mice head, the other end
Opening and port inner wall are equipped with internal screw thread (12) and are used to cooperate with the external screw thread (22) of screw type nut cap (2)；
Preferably, the length of the tubular container (1) with interlayer is 200mm；
Preferably, the internal layer internal diameter of the tubular container (1) with interlayer is 35mm, this internal diameter enables nude mice to be limited
In the effective range of thermotherapy, while certain activity space is provided for nude mice, help to maintain the normal physiology of nude mice living
It is dynamic；
Preferably, the interlayer (15) is with a thickness of 5mm；
Preferably, the connecting plate (16) is long and narrow strip structure, and the quantity of the connecting plate (16) is 4, edge
Tubular container (1) circumferencial direction is arranged at equal intervals, for connecting inner layer wall (13) and outer wall (14)；
Preferably, the venthole (17) being located on inner layer wall (13) and the venthole (17) being located on outer wall (14)
Along the circumferential direction at equal intervals setting to form respective venthole circle, the venthole circle for being located at inner layer wall (13) with set
Venthole circle on outer wall (13) mutually staggers, and the venthole circle of ectonexine wall is not on straight line, to make to lead to
Stomata also maintains inside container while guaranteeing that gas normally circulates with nude mice eupnea in the tubular container with interlayer
Temperature it is constant；
Preferably, the inner layer wall (13) that is located at is aligned with each other with the spareslots (18) on outer wall (14)；
Preferably, depending on the size and shape of the spareslots (18) sensor selected by the standby functions；
Preferably, the quantity of the spareslots (18) is 1-2；
Preferably, the aperture (21) on the narrow meshed screw type nut cap (2) is in a circular table shape；
Preferably, on the external screw thread (22) and tubular container inner wall that the narrow meshed screw type nut cap (2) is equipped with
Internal screw thread (12) cooperates；
Preferably, the length for the external screw thread (22) that the narrow meshed screw type nut cap (2) is equipped with is 10mm；
Compared with prior art, the utility model has the following beneficial effects:
Experiment of nude mouse device provided by the utility model for contactless thermotherapy research, structure is simple, vdiverse in function:
The setting of interlayer not only can guarantee that experimental animal was in the effective range of thermotherapy, but also experimental animal can have been made to be not directly contacted with heat source
To avoid scalding, moreover it is possible to simulate heat cure to the penetration of people；Mutually not opposite venthole on interlayer is set simultaneously,
It can also be maintained inside container while guaranteeing that gas normally circulates with nude mice eupnea in the tubular container with interlayer
Temperature it is constant.
The spareslots being mutually aligned on interlayer is arranged in the utility model, can place detection environment and animal physiological situation
Sensor；And the nut cap of screw type enables devices to long according to the body of experimental animal, flexibly continuously adjusts tubular container
Interior activity space；And the internal layer internal diameter of the tubular container with interlayer is suitable for, and nude mice is made to be restricted to having for thermotherapy
There are also certain activity space while effect in range, help to maintain the normal physiological activity of nude mice.
Experiment of nude mouse device described in the utility model for contactless thermotherapy research further includes support construction, the branch
Tubular container and screw type nut cap can be flexibly firmly fixed in support structure, it is made to avoid being subjected to displacement because of the activity of nude mice；
The support construction of the utility model, the tubular container with interlayer and screw type nut cap are detachable, are readily cleaned disinfection, are suitable for
The long-term development of zoopery.
Detailed description of the invention
Fig. 1 is a kind of schematic perspective view of experiment of nude mouse device for contactless thermotherapy research；
Fig. 2 is a kind of three-dimensional knot of the tubular container with interlayer of experiment of nude mouse device for contactless thermotherapy research
Structure schematic diagram；
Fig. 3 is a kind of solid of the narrow meshed screw type nut cap of experiment of nude mouse device for contactless thermotherapy research
Schematic diagram；
Fig. 4 is a kind of stereoscopic schematic diagram of the support construction of experiment of nude mouse device for contactless thermotherapy research；
Wherein: tubular container of the 1- with interlayer, the tapered end 11-, 12- internal screw thread, 13- inner layer wall, 14- outer wall, 15- every
Layer, 16- connecting plate, 17- venthole, 18- spareslots, the narrow meshed screw type nut cap of 2-, 21- aperture, 22- external screw thread, 3- branch
Support structure, 31- support plate, 32- support frame, 33- circle locking member.
Specific embodiment
The utility model is described further with reference to the accompanying drawing.
Embodiment one:
As shown in Figure 1, Figure 2, Figure 3, Figure 4.A kind of experiment of nude mouse device for contactless thermotherapy research, including band every
The tubular container (1) of layer and the narrow meshed screw type nut cap (2) for being positioned on tubular container (1) one end: the tubulose with interlayer
Container (1) one end is tapered end (11), another end opening and port inner wall equipped with internal screw thread (12), the tubulose with interlayer
Between the inner layer wall (13) and outer wall (14) of container (1) constitute interlayer (15), between inner layer wall (13) and outer wall (14) according to
Be connected by connecting plate (16), the inner layer wall (13) of the tubular container (1) with interlayer and outer wall (14) be equipped with mutually not
Opposite venthole (17), the spareslots (18) being mutually aligned；The screw type nut cap (2) is equipped with aperture (21), the rotation
External screw thread (22) are equipped with into formula nut cap (2) and this external screw thread (22) and the internal screw thread (12) on tubular container (1) inner wall are mutual
Cooperation, in which:
The experiment of nude mouse device for contactless thermotherapy research further includes support construction (3), the support construction
It (3) include support plate (31) and support frame (32), the quantity of support frame as described above (32) is 2-3, and the bottom of support frame as described above is equal
It is fixed on the support plate (31), is round locking member (33) at the top of support frame (32)；The tubulose with interlayer holds
Transparent material (such as plastics, glass) pipe that device (1) length is 200mm, internal layer internal diameter is 35mm；Tubular container with interlayer
(1) interlayer (15) is with a thickness of 5mm；The venthole (17) being located on inner layer wall (13) be located at it is logical on outer wall (14)
Stomata (17) is along the circumferential direction arranged to form respective venthole circle at equal intervals, and is located at the venthole of inner layer wall (13)
It encloses and is located at the venthole circle on outer wall (14) to mutually stagger, the venthole circle of ectonexine wall is not on straight line；Institute
It states and is located at inner layer wall (13) and is aligned with each other with the spareslots (18) on outer wall (14), the quantity of spareslots (18) is 1-2, standby
Depending on the size and shape of slot (18) sensor selected by the standby functions；On the narrow meshed screw type nut cap (2)
Aperture (21) is in a circular table shape；The length for the external screw thread (22) that the narrow meshed screw type nut cap (2) is equipped with is 10mm, and institute
External screw thread (22) is stated to be threadedly coupled with internal screw thread (12) mutual cooperation on tubular container (1) inner wall.
When experimental implementation, narrow meshed screw type nut cap (2) is opened, nude mice is moved to the tubular container (1) with interlayer
The habit got into the cave is liked using it in open end, it is driven to pierce in the tubular container (1) with interlayer, while by the tail of nude mice
It is pulled out at the aperture (21) on screw type nut cap (2), immediately covers narrow meshed screw type nut cap (2), it is narrow meshed
External screw thread (22) in screw type nut cap (2) and the internal screw thread (12) of tubular container (1) one end with interlayer be combined with each other, turn
Narrow meshed screw type nut cap (2) determines the specific location that screw type nut cap (2) screw according to the size of nude mice, makes in tubulose
While the tapered end (11) of container (1) accommodates nude mice head, the scope of activities of limitation nude mice front and back in tubular container (1)；
By the round locking member at the top of the tubular container (1) with interlayer equipped with nude mice and screw type nut cap (2) insertion support frame (32)
(33) in, locking member (33) are locked, support construction (3) is made to fix the tubular container (1) with interlayer and rotation equipped with nude mice
Into formula nut cap (2)；By taking far infrared radiation thermotherapy as an example, the whole device (including support construction (3)) equipped with nude mice is put together
Enter within the scope of thermotherapy, the experiment of contactless thermotherapy research is carried out to nude mice；The non-contact of certain time is being carried out to nude mice
After the experiment of formula thermotherapy, close thermotherapeutic apparatus to stopping thermotherapy, will include support construction (3) the whole device equipped with nude mice from
It is taken out within the scope of thermotherapy, round locking member (33) is unclamped, to make the tubular container (1) with interlayer and precession equipped with nude mice
Formula nut cap (2) can be removed from support construction (3), screw out narrow meshed screw type nut cap (2) for nude mice from tubular container (1)
It takes out.
Embodiment two:
As shown in Figure 1, Figure 2, Figure 3, Figure 4, the difference of this example and embodiment 1 is only that: equipped with nude mice band every
The tubular container (1) and screw type nut cap (2) of layer are fixed on before support construction (3), by taking optical fiber temperature measuring sensor as an example, by light
Fine temperature transducer insertion spareslots (18) and then the deeply inside of the tubular container (1) with interlayer, to detect locating for nude mice
The temperature of experimental situation.Tubular container (1) with interlayer equipped with nude mice, to be inserted with sensor and screw type nut cap (2) is solid
Due on support construction (3), operating procedure same as Example 1 is carried out later, while observation optical fiber is surveyed during the experiment
The registration of temperature sensor, further, the result according to sensor are adjusted intensity, the range etc. of thermotherapy.
Examples detailed above only expresses the several embodiments of the utility model, and the description thereof is more specific and detailed, but not
It can be therefore understands that for a limitation on the scope of the patent of the present invention, there is no need and unable to give thoroughly all embodiments
It lifts.It should be pointed out that all any modifications within the design of the utility model, spirit and principle, made, equivalent replacement,
Improve etc., it should be included within the scope of protection of this utility model.
Claims (10)
1. a kind of experiment of nude mouse device for contactless thermotherapy research, which is characterized in that including the tubular container with interlayer
(1) and be positioned on tubular container (1) one end narrow meshed screw type nut cap (2): described tubular container (1) one end with interlayer is
Tapered end (11), another end opening and port inner wall are equipped with internal screw thread (12), the internal layer of the tubular container (1) with interlayer
Interlayer (15) are constituted between wall (13) and outer wall (14), connecting plate (16) phase is relied between inner layer wall (13) and outer wall (14)
Connect, the mutually not opposite ventilation being respectively equipped on the inner layer wall (13) of the tubular container (1) with interlayer and outer wall (14)
Hole (17) is also each provided with the spareslots (18) being mutually aligned on inner layer wall (13) and outer wall (14) respectively；The screw type
Nut cap (2) is equipped with aperture (21), and the screw type nut cap (2) is equipped with external screw thread (22) and this external screw thread (22) and tubulose hold
Internal screw thread (12) on device (1) inner wall, which cooperates, to be connected.
2. the experiment of nude mouse device according to claim 1 for contactless thermotherapy research, which is characterized in that the needle
Experiment of nude mouse device to contactless thermotherapy research further includes support construction (3), and the support construction (3) includes support plate
(31) it is used to support with support frame (32), support construction (3) with the tubular container of fixing belt interlayer (1) and positioned on tubular container
(1) the narrow meshed screw type nut cap (2) of one end.
3. the experiment of nude mouse device according to claim 2 for contactless thermotherapy research, which is characterized in that the branch
Support (32) quantity is 2-3, and support frame (32) is each other point-blank and spacing is fixed.
4. the experiment of nude mouse device according to claim 2 for contactless thermotherapy research, which is characterized in that the branch
The bottom of support (32) is each attached on the support plate (31), is round locking member (33) at the top of support frame (32), can
Regulating circumferential size avoids it due to the activity of nude mice for neatly fixing tubular container (1) and screw type nut cap (2)
It is subjected to displacement.
5. the experiment of nude mouse device according to claim 1 for contactless thermotherapy research, which is characterized in that the band
The tubular container (1) of interlayer is all made of transparent material.
6. the experiment of nude mouse device according to claim 1 for contactless thermotherapy research, which is characterized in that the band
The tapered end (11) of the tubular container (1) of interlayer is for accommodating nude mice head.
7. the experiment of nude mouse device according to claim 1 for contactless thermotherapy research, which is characterized in that the band
The length of the tubular container (1) of interlayer is 200mm；The internal layer internal diameter of the tubular container (1) with interlayer is 35mm；It is described every
Layer (15) is with a thickness of 5mm.
8. the experiment of nude mouse device according to claim 1 for contactless thermotherapy research, which is characterized in that the company
Fishplate bar (16) is long and narrow strip structure, and the quantity of the connecting plate (16) is 4, along tubular container (1) circumferencial direction etc.
Interval setting, for connecting inner layer wall (13) and outer wall (14).
9. the experiment of nude mouse device according to claim 1 for contactless thermotherapy research, which is characterized in that described to set
It is along the circumferential direction set at equal intervals in the venthole (17) on inner layer wall (13) with the venthole (17) being located on outer wall (14)
It sets to form respective venthole circle, the venthole circle for being located at inner layer wall (13) and the ventilation being located on outer wall (14)
Hole circle mutually staggers, and the venthole circle of ectonexine wall is not on straight line, so that venthole be made to guarantee the pipe with interlayer
While shape gas in container is normally circulated with nude mice eupnea, the temperature also maintained inside container is constant.
10. the experiment of nude mouse device according to claim 1 for contactless thermotherapy research, which is characterized in that described
Aperture (21) on narrow meshed screw type nut cap (2) is in a circular table shape；The narrow meshed screw type nut cap (2) is equipped with outer
The length of screw thread (22) is 10mm.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721613736.1U CN209048414U (en) | 2017-11-28 | 2017-11-28 | A kind of experiment of nude mouse device for contactless thermotherapy research |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201721613736.1U CN209048414U (en) | 2017-11-28 | 2017-11-28 | A kind of experiment of nude mouse device for contactless thermotherapy research |
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| CN209048414U true CN209048414U (en) | 2019-07-02 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107822765A (en) * | 2017-11-28 | 2018-03-23 | 南京医科大学 | A kind of experiment of nude mouse device for contactless thermotherapy research |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107822765A (en) * | 2017-11-28 | 2018-03-23 | 南京医科大学 | A kind of experiment of nude mouse device for contactless thermotherapy research |
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Effective date of registration: 20201124 Address after: 21-23 / F, east block, Mingjia science and technology building, 99 Shengli Road, Jiangning District, Nanjing City, Jiangsu Province (Jiangning Development Zone) Patentee after: Nanjing oncoli Biotechnology Co., Ltd Address before: No. 101 Jiangning longmian Road District of Nanjing City, Jiangsu province 211166 Patentee before: NANJING MEDICAL University |