CN208988913U - A kind of plate PET not finite angle molecular image positioning system under rotation situation - Google Patents

Abstract

The utility model discloses the finite angle molecular image positioning systems under a kind of plate PET not rotation situation.The utility model will be imaged sample and be placed in a pair of centre without the mechanical plate PET rotated；A pair of of visible light generator issues two beam visible lights, and by the angle of two beam visible light of motor synchronously control, so that the crosspoint of two beam visible lights is located at the surface of imaging sample, computer calculates the position in crosspoint and storage；The position a pair of plates PET remains unchanged acquisition PET data, and is transmitted to computer；Computer minimizes algorithm TV combinational algorithm by expectation-maximization algorithm EM and full variation, overcome the difficulty bigger than normal of anamorphose, picture noise as caused by missing angle, obtain PET reconstruction image, then the crosspoint of two beam visible lights is fused in PET reconstruction image, and it is shown in a manner of pseudo- bright spot, realization is merged with optical information, as a reference point with crosspoint, to directly display the target point in imaging sample and intuitively position target point.

Description

A kind of plate PET not finite angle molecular image positioning system under rotation situation

Technical field

The utility model relates to field of medical technology, and in particular to a kind of plate PET not finite angle point under rotation situation Sub-image positioning system.

Background technique

It is a kind of non-intruding that (Positron Emission Tomography, PET), which is imaged, in positron emission computerized tomography Property molecular medicine image technology, can noninvasive, quantitative, dynamically reflect that intravital metabolism, biochemical reaction, function are living Degree is horizontal with perfusion.Since the glucose metabolism of malignant cell can be much higher than normal tissue cell, PET is clinically It is widely used in the imaging diagnosis of malignant tumour.With the development of science and technology, tumour increasingly becomes the maximum prestige of human life The side of body.Surgical operation is to treat one of the most ancient most efficient method of tumour.Tumour is normally in body, therefore before surgery Tumor-localizing is made great sense in operation.

With PET deepening continuously in the application, clinic diagnosis and basic research to the understanding of PET instrument and acceptance by It gradually improves, while also the performance to PET instrument and function propose new demand, promotes the researcher of PET instrument to develop new Methods and techniques, the update of instruments is pushed from multiple links such as system design, hardware device and image reconstruction.From system The angle of design is set out, and researcher proposes various new structural PET imaging systems.Wherein, it is detected using a pair of plates The PET imaging system of device is easy to high sexual valence since its is simple for structure, in engineering and realizes, has open and controllability concurrently, always Concern by researcher.It is different from the ring-shaped P ET for traditionally using multiple detectors, plate PET is only with a pair of flat Partitioned detector constitutes whole system.Open adjustable plate PET can be used for guiding in real time stereotaxis biopsy, mention The accuracy of high biopsy sampling；In the surgical resection of tumour or guiding in real time radiotherapy, open PET construction be may make Treatment and imaging synchronous can carry out, can real-time detection and positioning residual lesions, treatment is guided, the radical cure of operation is improved Effect.

For plate PET, two plate rotations, the complete data that can collect 180 degree carries out image reconstruction.Patient at present PET tumor imaging imaging inspection can only be carried out in PET machine before surgery, in operating bed on patient, and operation carries out In, patient posture, tissue internal organs, the presence of tumour and position (tumors remaining) have big change, how to carry out during surgery The quick PET imaging and positioning of tumour (tumors remaining), at present still without solution and technology.

Utility model content

In order to solve the problems, such as that positioning inaccurate and aiming spot in existing art in PET position fixing process changes, this Utility model proposes a kind of plate PET finite angle molecular image positioning system, and plate PET is not required to rotate, can be realized to point The fast image imaging of target point in sub-image and positioning in real time.

Finite angle molecular image positioning system of the plate PET of the utility model not under rotation situation include: imaging bed, at As bracket, a pair of plates PET, visible light source, motor and computer；Wherein, imaging sample is located on imaging bed；A pair of plates PET is opposite, and without mechanical rotation, is mounted on imaging bracket, and imaging sample is located at the centre of a pair of plates PET, and Acquisition angles >=90 ° of plate PET；A pair of plates PET is connected to computer；Visible light source includes a pair of of visible light generator, It is connected to motor；A pair of of visible light generator and motor are respectively connected to computer；Two beams that a pair of of visible light generator issues The crosspoint of visible light is located at the surface of imaging sample.

It includes movable stand and linking arm that bracket, which is imaged,；Wherein, movable stand can move, the linking arm on movable stand, A pair of opposite plate PET is fixedly mounted respectively at the both ends of linking arm.Linking arm uses C-arm.

Visible light generator uses laser pen.

The advantages of the utility model:

The utility model will be imaged sample and be placed in a pair of centre without the mechanical plate PET rotated, and plate PET Acquisition angles >=90 °；A pair of of visible light generator issues two beam visible lights, passes through the angle of two beam visible light of motor synchronously control Degree, so that the crosspoint of two beam visible lights is located at the surface of imaging sample, computer calculates the position in crosspoint and storage；It is a pair of The position plate PET remains unchanged acquisition PET data, and is transmitted to computer；Computer is by expectation-maximization algorithm EM and entirely Variation minimizes algorithm TV combinational algorithm, obtains PET reconstruction image, and the crosspoint of two beam visible lights is then fused to PET weight It builds in image, and is shown in a manner of pseudo- bright spot, realization is merged with optical information, and it is as a reference point with crosspoint, thus directly aobvious The target point that is shown as in decent simultaneously intuitively positions target point.

Detailed description of the invention

Fig. 1 is the schematic diagram of one embodiment of the plate PET finite angle molecular image positioning system of the utility model；

Fig. 2 is the imaging schematic diagram of the plate PET finite angle molecular image positioning system of the utility model；

Fig. 3 is a pair of plates of one embodiment of the plate PET finite angle molecular image positioning system of the utility model The schematic diagram of PET.

Specific embodiment

With reference to the accompanying drawing, by specific embodiment, the utility model is further described.

As shown in Figure 1, the plate PET finite angle molecular image positioning system of the present embodiment includes: imaging bed 1, imaging branch Frame, a pair of plates PET (5 and 6), visible light source, motor and computer；Wherein, imaging sample is located on imaging bed 1；A pair is flat Plate PET (5 and 6) relatively, and without mechanical rotation, is mounted on imaging bracket, and imaging bracket includes movable stand 2 and linking arm 3, linking arm 3 uses C-arm, and imaging sample is located at the centre of a pair of plates PET, and acquisition angles >=90 ° of plate PET, It is that coordinate origin establishes xyz coordinate system with the rotation center 4 of a pair of plates PET；A pair of plates PET is connected to computer.

As shown in Fig. 2, visible light source includes a pair of of visible light generator 7, it is connected to motor；A pair of of visible light generator 7 Computer is respectively connected to motor；A pair of of visible light generator 7 issues two beam visible lights, can by two beam of motor synchronously control Light-exposed angle, so that the crosspoint 10 of two beam visible lights is located at the surface of imaging sample, a pair of of visible light generator at this time Tilt angle is transmitted to computer, and computer calculates the position in crosspoint and storage；A pair of plates PET acquisition PET data, and pass Transport to computer；After computer pretreatment, algorithm TV combinational algorithm is minimized by expectation-maximization algorithm EM and full variation, is obtained To PET reconstruction image；The crosspoint of two beam visible lights is fused in PET reconstruction image by computer, and is shown in a manner of pseudo- bright spot To show, realization is merged with optical information, and it is as a reference point with crosspoint 10, to directly display the target point 8 being imaged in sample simultaneously Intuitive positioning target point 8.

In the present embodiment, it is seen that optical generator uses laser pen.As shown in figure 3, the thickness H=15cm of plate PET, long Spend L=30cm, width W=40cm, distance D≤40cm.

The plate PET of the present embodiment not finite angle molecular image localization method under rotation situation, comprising the following steps:

1) imaging sample is placed on imaging bed, a pair of plates PET is opposite, and without mechanical rotation, is located at Above and below the vertical direction of imaging sample, the distance between a pair of plates PET, distance D≤40cm are adjusted, so that plate PET The rotation center coordinate of a pair of plates PET is calculated in acquisition angles >=90 °, computer.

2) computer calculates the position in crosspoint:

A) a pair of of visible light generator issues two beam visible lights, by the angle of two beam visible light of motor synchronously control, two The crosspoint of beam visible light is vertically that y-axis is mobile always, so that the crosspoint of two beam visible lights is located at imaging sample Surface；

B) confirm a pair of of visible light generator at this time, and the tilt angle of a pair of of visible light generator is transmitted to calculating Machine；

C) computer calculates the position in crosspoint, and the position of storage crosspoint according to the tilt angle of visible light generator It sets.

3) position a pair of plates PETT remains unchanged acquisition PET data, and is transmitted to computer.

4) computer pre-processes PET data.

5) computer is iterated expectation-maximization algorithm EM twice to pretreated PET data, obtains reconstruction figure Picture.

6) computer carries out full variation to reconstruction image and minimizes algorithm TV, to image smoothing and denoising.

7) step 5) is repeated with 6), and picture quality constantly improves, until meeting scheduled image condition or reaching scheduled Until iterative step, PET reconstruction image is obtained.

8) crosspoint of two beam visible lights is fused in PET reconstruction image by computer, and is shown in a manner of pseudo- bright spot, real Now merged with optical information.

9) as a reference point with crosspoint, thus directly display the target point in imaging sample and intuitively position target point, And determine absolute coordinate position of the target point about the rotation center coordinate of plate PET.

In step 5), when EM carries out image reconstruction to complete data for projection or small missing angle, iterative approximation Effect it is relatively good, but when EM is used to lack greatly in the case of angle, if the number of iterations is more, reconstruction image has serious high frequency to make an uproar Sound artifact, the number of iterations is few, and reconstruction image then has serious deformation, and such image cannot be used for practical application.

In step 6), TV is applied to image denoising, and can be effectively maintained marginal information while denoising.

TV is used for the quick reconstruction of plate PET serious loss angle target point by the utility model in conjunction with EM, and is used A kind of TV of optimization and EM built-up sequence guarantee that lesser noise generates increasing the number of iterations simultaneously, overcome well by In lacking anamorphose caused by angle, picture noise difficulty bigger than normal, it can preferably obtain the maximum of plate PET and rebuild the visual field The imaging of the remaining target point of subrange in the region FOV.

It is finally noted that the purpose for publicizing and implementing example is to help to further understand the utility model, but originally The technical staff in field is understood that in the spirit and scope for not departing from the utility model and the attached claims, various Substitutions and modifications are all possible.Therefore, the utility model should not be limited to embodiment disclosure of that, and the utility model is wanted Seek the range of protection subject to the scope defined in the claims.

Claims (4)

1. a kind of plate PET not finite angle molecular image positioning system under rotation situation, which is characterized in that the positioning system It include: imaging bed, imaging bracket, a pair of plates PET, visible light source, motor and computer；Wherein, imaging sample is located at imaging On bed；The pair of plate PET is opposite, and without mechanical rotation, is mounted on imaging bracket, imaging sample is located at a pair of flat The centre of plate PET, and acquisition angles >=90 ° of plate PET；The pair of plate PET is connected to computer；The visible light Source includes a pair of of visible light generator, is connected to motor；The pair of visible light generator and motor are respectively connected to computer； The crosspoint for the two beam visible lights that a pair of of visible light generator issues is located at the surface of imaging sample.

2. positioning system as described in claim 1, which is characterized in that the imaging bracket includes movable stand and linking arm；` its In, the movable stand can move, the linking arm on movable stand, be fixedly mounted respectively at the both ends of linking arm a pair of opposite Plate PET.

3. positioning system as claimed in claim 2, which is characterized in that the linking arm uses C-arm.

4. positioning system as described in claim 1, which is characterized in that the visible light generator uses laser pen.