CN208980612U - 3- chlorpromazine chloride process units - Google Patents
3- chlorpromazine chloride process units Download PDFInfo
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- CN208980612U CN208980612U CN201821811234.4U CN201821811234U CN208980612U CN 208980612 U CN208980612 U CN 208980612U CN 201821811234 U CN201821811234 U CN 201821811234U CN 208980612 U CN208980612 U CN 208980612U
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Abstract
The utility model relates to a kind of 3- chlorpromazine chloride process units, the gas-liquid reactor being connected in series including propylene acid storage tank, at least two, thionyl chloride storage tank, at least two flow reactors being connected in series and 3- chlorpromazine chloride storage tank；The discharge port of propylene acid storage tank is connected by pipeline with the feed inlet for the gas-liquid reactor for being located at front end；Discharge port positioned at the gas-liquid reactor of rearmost end is connected by pipeline with the feed inlet for the flow reactor for being located at front end, and the discharge port of thionyl chloride storage tank is connected by pipeline with the feed inlet for the flow reactor for being located at front end；Discharge port positioned at the flow reactor of rearmost end is connected by pipeline with the feed inlet of 3- chlorpromazine chloride storage tank；The gas outlet of flow reactor is connected by being equipped with the pipeline of condenser with the air inlet for the gas-liquid reactor for being located at rearmost end.The 3- chlorpromazine chloride process units of the utility model realizes serialization circulation production, product yield high.
Description
Technical field
The utility model relates to a kind of equipment of successive reaction production 3- chlorpromazine chloride, belong to chemosynthesis technical field.
Background technique
3- chlorpromazine chloride is a kind of widely used compound intermediate.Common 3- chlorpromazine chloride production technology is by anti-
The reaction of kettle gap is answered to complete.Currently, mainly following two method: (one) acrylic acid aqueous solution and hydrochloric acid reaction generate aqueous
After 3- chloropropionic acid, then concentrated dehydration, 3- chloropropionic acid again with thionyl chloride react generate 3- chlorpromazine chloride, by-product be hydrochloric acid and
Sulfur dioxide mixture gas.There are many this method three wastes, and scene is difficult to arrange, equipment seriously corroded, and three-protection design and auxiliary are set
It is standby very much, it invests very big.(2) 3- chlorpromazine chloride reacts with phosphorus trichloride and then is added a small amount of Methanol Decomposition dichloro phosphorous acid life
At 3- chlorpromazine chloride and phosphite ester.The separation of this method products obtained therefrom is relatively difficult, needs rectifying to can be only achieved 97% or more and contains
Amount.And by-product phosphite ester is also more intractable, and production cost is higher.
Summary of the invention
The technical problems to be solved in the utility model is to provide a kind of product yield high, the 3- chlorine of serialization circulation production
Propionyl chloride process units.
A kind of technical solution that the utility model proposes to solve above-mentioned technical problem is: a kind of 3- chlorpromazine chloride production dress
It sets, gas-liquid reactor, the thionyl chloride storage tank, at least two companies being connected in series being connected in series including propylene acid storage tank, at least two
Continuous reactor and 3- chlorpromazine chloride storage tank；Before the discharge port of the propylene acid storage tank is by being equipped with the pipeline of metering pump and being located at most
The feed inlet of the gas-liquid reactor at end is connected；Discharge port positioned at the gas-liquid reactor of rearmost end passes through the pipeline equipped with metering pump
It is connected with the feed inlet for the flow reactor for being located at front end, the discharge port of the thionyl chloride storage tank is by being equipped with metering pump
Pipeline is connected with the feed inlet for the flow reactor for being located at front end；Discharge port positioned at the flow reactor of rearmost end passes through pipe
Road is connected with the feed inlet of 3- chlorpromazine chloride storage tank；The gas outlet of each flow reactor by be equipped with condenser pipeline with
Air inlet positioned at the gas-liquid reactor of rearmost end is connected；The gas outlet of the adjacent gas-liquid reactor positioned at rear end and before being located at
The air inlet of the gas-liquid reactor at end is connected.
Apparatus for absorbing SO 2 is equipped at the gas outlet of the gas-liquid reactor of front end.Apparatus for absorbing SO 2 can
To be the container for filling sodium hydroxide solution, tail portion can connect activated carbon adsorption device.
The discharge port of the adjacent gas-liquid reactor positioned at front end is by being equipped with the pipeline of metering pump and being located at rear end
Gas-liquid reactor feed inlet be connected.
The gas-liquid reactor has two to five, and the flow reactor has two to seven.
The flow reactor is provided with the reaction kettle of agitating device.
The gas-liquid reactor is packed tower, bubbling reactor, plate-type reactor, venturi reactor or falling liquid film reaction
Device.
The utility model has the effect of positive: the 3- chlorpromazine chloride process units of the utility model using thionyl chloride with
The reaction of 3- chloropropionic acid generates 3- chlorpromazine chloride, and generated hydrogen chloride gas is back to gas-liquid reactor and carries out successive reaction, chlorine
Change hydrogen and react generation 3- chloropropionic acid with acrylic acid, the sulfur dioxide gas that last gas-liquid reactor generates passes through sulfur dioxide and absorbs
Device absorbs.Whole device is a closed continuous reaction system, and overall process can realize automatic operation, improve reaction and set
Standby utilization rate improves the utilization rate of resource, water, electricity and gas cost decline 50%, and three wastes decline 80% improves the yield of product,
The value of byproduct is improved, and is a kind of effective environmentally protective production technology.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the 3- chlorpromazine chloride process units of embodiment 1；
Fig. 2 is the gas chromatogram of 3- chloropropionic acid made from the production method of application examples 1；
Fig. 3 is the gas chromatogram of 3- chlorpromazine chloride made from the production method of application examples 1.
Specific embodiment
Embodiment 1
As shown in Figure 1, the 3- chlorpromazine chloride process units of the present embodiment includes 1, two gas being connected in series of propylene acid storage tank
Liquid reactor 2,3, three flow reactors being connected in series 4 of thionyl chloride storage tank and 3- chlorpromazine chloride storage tank 5.Propylene acid storage tank 1
Discharge port be connected by being equipped with the pipeline of metering pump with the feed inlet of the first gas-liquid reactor 2 positioned at front end.Positioned at rear end
The discharge port of the second gas-liquid reactor 2 pass through the pipeline for being equipped with metering pump and first flow reactor 4 for being located at front end
Feed inlet is connected, the discharge port of thionyl chloride storage tank 3 by be equipped with the pipeline of metering pump be located at front end it is first continuous anti-
The feed inlet of device 4 is answered to be connected.Discharge port positioned at the third flow reactor 4 of rearmost end passes through pipeline and 3- chlorpromazine chloride storage tank
5 feed inlet is connected.The gas outlet of each flow reactor 4 is by the pipeline equipped with condenser 6 and positioned at the second of rear end
The air inlet of gas-liquid reactor 2 is connected.The gas outlet of second gas-liquid reactor 2 is connected with the air inlet of the first gas-liquid reactor 2.
Apparatus for absorbing SO 27 is equipped at the gas outlet of first gas-liquid reactor 2.The discharge port of first gas-liquid reactor 2 is by setting
There are the pipeline of metering pump and the feed inlet of the second gas-liquid reactor 2 to be connected.Flow reactor 4 is provided with the reaction of agitating device
Kettle, gas-liquid reactor 2 are packed towers.
Application examples 1
The production method for preparing 3- chlorpromazine chloride of the application example, using the 3- chlorpromazine chloride process units of embodiment 1.Instead
Before should starting, in the flow reactor 4(reaction kettle that each volume is 1L) in the qualified 3- chlorpromazine chloride of 600ml is added,
Each have the gas-liquid reactor 2(packed tower of filler 1000mm) in the 3- chloropropionic acid for taking liquid level 70% is added.When reaction starting,
3- chloropropionic acid solution in thionyl chloride and gas-liquid reactor 2 in thionyl chloride storage tank 3, which enters, reacts life in flow reactor 4
At 3- chlorpromazine chloride and hydrogen chloride, reaction equation is as follows:
。
If you need to add the catalyst such as N dinethylformamide during the reaction, need in the first flow reactor 4
The device for individually quantitatively adding catalyst is set at feed inlet.
3- chlorpromazine chloride therein enters 3- chlorpromazine chloride storage tank 5, after hydrogen chloride reflux therein and in propylene acid storage tank 1
Acrylic acid enter in gas-liquid reactor 2 reaction to generate 3- chloropropionic acid reaction equation as follows:
。
The temperature for controlling flow reactor 4 is 50 DEG C to 55 DEG C, and the temperature of gas-liquid reactor 2 is 30 DEG C to 40 DEG C, is passed through
Metering pump, respectively control acrylic acid with the flow velocity of 5.60ml/min enter the first gas-liquid reactor 2 in, thionyl chloride with
The flow velocity of 5.40ml/min enters in the first flow reactor 4, and continuous feed samples after 5 hours, and the second gas-liquid reactor 2 goes out
The gas chromatogram of 3- chloropropionic acid at material mouth is as shown in Fig. 2, data are as shown in table 1.
1 3- chloropropionic acid data from gas chromatography table of table
| Serial number | Ingredient names | Retention time | Peak area | Area percentage |
| 1 | Acrylic acid | 10.17min | 79.1460 | 22.2794% |
| 2 | 3- chloropropionic acid | 15.35min | 276.0966 | 77.7206% |
| It is total | 355.2426 | 100% |
The gas chromatogram of the 3- chlorpromazine chloride of the discharge outlet of third flow reactor 4 is as shown in figure 3, data such as table 2
It is shown.Obtained crude product 3- chlorpromazine chloride is collected through simple distillation, obtains product.GC purity 99%, yield 80%.
2 3- chlorpromazine chloride data from gas chromatography table of table
| Peak number | Retention time | Peak height | Peak area | Content | Ingredient names |
| 1 | 2.522min | 26696.424 | 70141.898 | 0.9955 | |
| 2 | 6.895 min | 344180.594 | 6944417.500 | 98.5628 | 3- chlorpromazine chloride |
| 3 | 6.978 min | 5347.754 | 19882.068 | 0.2822 | |
| 4 | 9.997 min | 110.787 | 4544.651 | 0.0645 | |
| 5 | 11.782 min | 97.302 | 1262.778 | 0.0179 | |
| 6 | 14.487 min | 2414.898 | 5429.500 | 0.0771 |
Obviously, above-described embodiment is merely examples for clearly illustrating the present invention, and is not to this reality
With the restriction of novel embodiment.For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways.There is no necessity and possibility to exhaust all the enbodiments.And these
Belong to obvious changes or variations that the spirit of the utility model is extended out still in the protection scope of the utility model
Among.
Claims (6)
1. a kind of 3- chlorpromazine chloride process units, it is characterised in that: including propylene acid storage tank (1), at least two gas being connected in series
The flow reactor (4) and 3- chlorpromazine chloride storage tank (5) that liquid reactor (2), thionyl chloride storage tank (3), at least two are connected in series；
The discharge port of the propylene acid storage tank (1) by be equipped with metering pump pipeline be located at front end gas-liquid reactor (2) into
Material mouth is connected；Discharge port positioned at the gas-liquid reactor (2) of rearmost end by the pipeline equipped with metering pump and is located at front end
The feed inlet of flow reactor (4) is connected, and the discharge port of the thionyl chloride storage tank (3) is by being equipped with pipeline and the position of metering pump
It is connected in the feed inlet of the flow reactor (4) of front end；Discharge port positioned at the flow reactor (4) of rearmost end passes through pipeline
It is connected with the feed inlet of 3- chlorpromazine chloride storage tank (5)；The gas outlet of each flow reactor (4) is by being equipped with condenser (6)
Pipeline be connected with the air inlet of gas-liquid reactor (2) for being located at rearmost end；The adjacent gas-liquid reactor (2) positioned at rear end
Gas outlet is connected with the air inlet for the gas-liquid reactor (2) for being located at front end.
2. 3- chlorpromazine chloride process units according to claim 1, it is characterised in that: the gas-liquid reactor positioned at front end
(2) apparatus for absorbing SO 2 (7) are equipped at gas outlet.
3. 3- chlorpromazine chloride process units according to claim 2, it is characterised in that: the adjacent gas positioned at front end
The discharge port of liquid reactor (2) is connected by being equipped with the pipeline of metering pump with the feed inlet for the gas-liquid reactor (2) for being located at rear end.
4. 3- chlorpromazine chloride process units according to claim 1, it is characterised in that: the gas-liquid reactor (2) has two
To five, the flow reactor (4) has two to seven.
5. 3- chlorpromazine chloride process units according to claim 1, it is characterised in that: the flow reactor (4) is to set
There is the reaction kettle of agitating device.
6. 3- chlorpromazine chloride process units according to claim 1, it is characterised in that: the gas-liquid reactor (2) is to fill out
Expect tower, bubbling reactor, plate-type reactor, venturi reactor or falling film reactor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821811234.4U CN208980612U (en) | 2018-11-05 | 2018-11-05 | 3- chlorpromazine chloride process units |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821811234.4U CN208980612U (en) | 2018-11-05 | 2018-11-05 | 3- chlorpromazine chloride process units |
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| CN201821811234.4U Active CN208980612U (en) | 2018-11-05 | 2018-11-05 | 3- chlorpromazine chloride process units |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110124590A (en) * | 2019-06-22 | 2019-08-16 | 栎安化学(上海)有限公司 | A kind of production equipment and its technique of 3- chlorpromazine chloride |
| CN110845351A (en) * | 2019-10-08 | 2020-02-28 | 安徽生源化工有限公司 | Production process of chloropropylglutamine |
-
2018
- 2018-11-05 CN CN201821811234.4U patent/CN208980612U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110124590A (en) * | 2019-06-22 | 2019-08-16 | 栎安化学(上海)有限公司 | A kind of production equipment and its technique of 3- chlorpromazine chloride |
| CN110845351A (en) * | 2019-10-08 | 2020-02-28 | 安徽生源化工有限公司 | Production process of chloropropylglutamine |
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Address after: 223800 Jiangsu Suqian Suyu ecological Chemical Technology Industrial Park Zhongxing Road North End Patentee after: Kelaibo (Jiangsu) Technology Co.,Ltd. Address before: 223800 North end of Zhongxing Road, Ecological Chemical Technology Industrial Park, Suyu District, Changzhou City, Jiangsu Province Patentee before: SUQIAN KEYLAB BIOCHEMICAL CO.,LTD. |