CN208910237U - Measure the device of biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism - Google Patents
Measure the device of biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism Download PDFInfo
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- CN208910237U CN208910237U CN201820928320.7U CN201820928320U CN208910237U CN 208910237 U CN208910237 U CN 208910237U CN 201820928320 U CN201820928320 U CN 201820928320U CN 208910237 U CN208910237 U CN 208910237U
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Abstract
The utility model provides a kind of device for measuring biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism, belongs to field of biomedicine technology.Described device includes: high coherent laser and laser diode, it is connected by launching fiber with transmitting probe, photodetector, it is connected on transmitting probe by reception optical fiber, the photodetector is also connected with counter and personal computer in turn, and the transmitting probe and receiving transducer are connected to biological tissue.Utility model device only needs for fibre-optical probe to be placed in biological tissue, obtains blood volume, the blood oxygen saturation of biological tissue by measuring the light intensity decays of different wave length；Blood flow is obtained by measuring the light intensity normalized autocorrelation curve of high coherent laser；The variation of biological tissue's oxygen metabolism rate can be measured by the change of blood oxygen saturation and blood flow.
Description
Technical field
The utility model belongs to field of biomedicine technology, specially measurement biological tissue's blood volume, blood oxygen, blood flow and oxygen
The device of metabolism.
Background technique
Blood volume, blood oxygen saturation, blood flow and the oxygen metabolism rate of biological tissue are very heavy for measuring biological tissue
It wants.Near infrared light (650nm-950nm) has very high penetrability in biological tissues, can be realized deep layer biological tissue
The non-invasive measurement of (depth reaches 1-3cm).It include oxygen and hemoglobin to the main molecules of near-infrared absorption in biological tissue
(HbO2), deoxyhemoglobin (HHb), water and fat etc., therefore the scattered light intensity by detecting multiple near-infrared wavelengths can be with
Oxygen and hemoglobin (HbO in inverting biological tissue2), deoxyhemoglobin (HHb), blood volume (tHb=HbO2+ HHb), blood hold
Amount, blood oxygen saturation (StO2=HbO2/ tHb), the concentration of water and fat, referred to as near-infrared spectrum technique.Near-infrared spreads phase
Spectrum (Diffuse Correlation Spectroscopy, DCS) and near infrared spectrum advantage having the same are closed, such as similar
Detection method and identical smooth penetration depth.
Utility model content
The purpose of this utility model is to provide infrared spectrum technology and near-infrared diffusion Correlated Spectroscopy is blended, one is provided
Kind measures the device of biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism, can be realized simultaneously life using utility model device
The measurement of object tissue blood volume, blood oxygen saturation, blood flow and oxygen metabolism rate.The utility model aim passes through following technical side
Case is realized:
A kind of device measuring biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism characterized by comprising
High coherent laser and laser diode are connected by launching fiber with transmitting probe,
Photodetector is connected on transmitting probe by reception optical fiber,
The photodetector is also connected with counter and personal computer in turn,
The transmitting probe and receiving transducer are connected to biological tissue.
As a kind of measurement biological tissue's blood volume described in the utility model, blood oxygen, blood flow and oxygen metabolism device one
A specific embodiment is additionally provided with photoswitch between the high coherent laser and laser diode and launching fiber.
As a kind of measurement biological tissue's blood volume described in the utility model, blood oxygen, blood flow and oxygen metabolism device one
A specific embodiment, the photodetector are single-photon detector.
As a kind of measurement biological tissue's blood volume described in the utility model, blood oxygen, blood flow and oxygen metabolism device one
A specific embodiment, the wavelength of the high coherent laser are 600~950nm, line width 10-5~10-4Nm, power are greater than
50mW。
As a kind of measurement biological tissue's blood volume described in the utility model, blood oxygen, blood flow and oxygen metabolism device one
A specific embodiment, the laser diode use and the different wavelength of high coherent laser, wave-length coverage be 600~
950nm, breadth of spectrum line are 1~2nm, and power is greater than 50mW.
As a kind of measurement biological tissue's blood volume described in the utility model, blood oxygen, blood flow and oxygen metabolism device one
A specific embodiment, the launching fiber are multimode fibre, and core diameter is 50 μm, 62.5 μm, 100 μm or more.
As a kind of measurement biological tissue's blood volume described in the utility model, blood oxygen, blood flow and oxygen metabolism device one
A specific embodiment, the transmitting probe are one of multimode fibre or self-focusing lens.
As a kind of measurement biological tissue's blood volume described in the utility model, blood oxygen, blood flow and oxygen metabolism device one
A specific embodiment, the reception optical fiber are single mode optical fiber, and core diameter is 5 μm.
As a kind of measurement biological tissue's blood volume described in the utility model, blood oxygen, blood flow and oxygen metabolism device one
A specific embodiment, the receiving transducer are one of single mode optical fiber or self-focusing lens.
Using device described in the utility model to the blood volume of biological tissue, blood oxygen saturation, blood flow and oxo
The method that the rate of thanking measures are as follows: use high-coherence light source and laser diode mixed type light source, pass through photoswitch, launching fiber
It is incident in biological tissue with transmitting probe；Single-photon detector is received by receiving transducer, reception optical fiber and comes from biological tissue
Scattering light, and light intensity signal is converted into electric pulse, counter is realized electric pulse and counted, and computer realizes light intensity and light intensity
The calculating of normalized autocorrelation obtains blood volume, blood oxygen saturation, blood flow and the oxygen of biological tissue finally by theory analysis
The variation of metabolic rate.
Further, the blood volume of the biological tissue, blood oxygen saturation by measure different wave length light intensity decays come
It obtains；The blood flow of the biological tissue is obtained by measuring the light intensity normalized autocorrelation curve of high coherent laser；It is described
The variation of biological tissue's oxygen metabolism rate can be obtained by blood oxygen saturation and blood flow.
Further, the calculation formula of the blood volume tHb are as follows:
In above formula, CHHb,Respectively indicate the concentration of oxygen and hemoglobin and deoxyhemoglobin；
The blood oxygen saturation StO2Calculation formula are as follows:
In above formula, CHHb,Respectively indicate the concentration of oxygen and hemoglobin and deoxyhemoglobin.
Further, the light intensity normalized autocorrelation g2The calculation formula of (τ) are as follows:
In above formula, < > indicates average to the time, and I (t) indicates the light intensity of t moment, and I (t+ τ) indicates the light intensity at t+ τ moment, τ
Indicate delay time.
Further, the oxygen metabolism rate rCMRO2Calculation formula are as follows:
In above formula, Δ CHHb/CHHbIndicate the opposite variation of oxyhemoglobin concentration；ΔtHb/tHb0Indicate blood volume
Opposite variation；Indicate the opposite variation of blood flow.
Compared with prior art, the utility model has the following beneficial effects:
The utility model provides a kind of device for measuring biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism, using high phase
Dry laser and laser diode provide mixed type light source, and the time division multiplexing of two kinds of light sources is realized using photoswitch；By hybrid optical
After being incident on biological tissue, the light source received is detected by photodetector, finally by counter and personal meter
Calculation machine realizes that the record of light intensity and normalized autocorrelation light intensity calculate.Utility model device is a kind of by near-infrared spectrum technique
With near-infrared diffusion Correlated Spectroscopy effective integration solution, can measure simultaneously blood volume, blood oxygen saturation, blood flow and
The variation of oxygen metabolism rate.
Detailed description of the invention
Fig. 1 is the connection signal for the device that the utility model measures biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism
Figure.
Fig. 2 is blood flow and the relationship for normalizing light intensity autocorrelator trace.
Appended drawing reference: 1- high coherent laser, 2- laser diode, 3- photoswitch, 4- launching fiber, 5- transmitting probe,
6- biological tissue, 7- receiving transducer, 8- reception optical fiber, 9- single-photon detector, 10- counter, 11- personal computer.
Specific embodiment
With reference to the accompanying drawing, the utility model is described in detail.
In order to make the purpose of the utility model, technical solutions and advantages more clearly understood, below in conjunction with attached drawing and implementation
Example, the present invention will be further described in detail.It should be appreciated that specific embodiment described herein is only used to explain
The utility model is not used to limit the utility model.
Below with reference to specific structure and principle to a kind of optics for measuring biological tissue's multiple performance simultaneously of the utility model
Device is described in detail.
A kind of device measuring biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism, as shown in Figure 1.Described device packet
It includes:
High coherent laser and laser diode are connected by launching fiber with transmitting probe,
Photodetector is connected on transmitting probe by reception optical fiber,
The photodetector is also connected with counter and personal computer in turn,
The transmitting probe and receiving transducer are connected to biological tissue.
In the utility model Optical devices, the effect of high coherent laser, laser diode is to provide light source.Launching fiber
And transmitting probe is incident on light source is mixed in biological tissue, receiving transducer, reception optical fiber are used to connect from biological tissue
The light of receipts passes to photodetector, and photodetector receives the scattering from biological tissue by receiving transducer, reception optical fiber
Light, and light intensity signal is converted into electric pulse, the effect of counter is to realize the acquisition of light intensity, and counter is in the unit time
Electric pulse is sampled, and unit pulse number and light intensity are directly proportional；The record of light intensity and the normalization of light intensity are realized using computer
It calculates.
High coherent laser in the utility model Optical devices is that near-infrared spreads Correlated Spectroscopy (Diffuse
Correlation Spectroscopy, DCS), laser diode is near infrared spectrum, using high coherent laser and laser two
The mixed type light source of pole pipe offer different wave length light intensity.Scattering particles is moved due to existing in biological tissue, such as red blood cell etc.,
It can result in the Strength Changes of laser speckle, this is only just able to achieve using high coherent laser, therefore simultaneously using high coherent laser
It can be realized blood flow measurement in conjunction with coherent states field diffusion theory；Oxyhemoglobin and reduced hemoglobin pair in biological tissue
The absorption of infrared light is different, and is changed by the light intensity of multiple wavelength and is combined light intensity diffusion theory that can obtain biological tissue
Blood volume and blood oxygen saturation since blood oxygen saturation and blood flow information can be obtained simultaneously while being also able to achieve oxygen
The measure of the change of metabolic rate.Therefore, it can be realized using be concerned with light laser, laser diode mixed type light source of the utility model
Near-infrared spectrum technique and near-infrared spread Correlated Spectroscopy effective integration, and the light intensity of multiple wavelength is combined to change, realization blood volume,
It is measured while blood oxygen saturation, blood flow and oxygen metabolism rate.
Photoswitch is additionally provided between the high coherent laser and laser diode and launching fiber；The photodetection
Device is single-photon detector.Photoswitch is used to control the mixing light source that high coherent laser, laser diode provide, benefit
The time division multiplexing of two kinds of light sources is realized with photoswitch, photoswitch can be such that two light sources are emitted simultaneously from a light source port, protect
The same position that two kinds of light sources are capable of precise measurement biological tissue is demonstrate,proved.The preferred single-photon detector of the utility model is as photoelectricity
Detector, this is because the received scattered light intensity of single mode optical fiber is extremely faint, therefore photodetector will have single photon detection
Ability, and photon pulse is converted into electric pulse, effectively two kinds of light sources can not be merged using other types detector.
Further, the wavelength of the high coherent laser is 600~950nm, line width 10-5~10-4Nm, power are greater than
50mW.Laser has high coherence, and wave-length coverage is in 600~950nm, and line width is 10-5~10-4Nm, to guarantee from life
The optical signal scattered in object tissue can interfere, and obtain blood flow by measuring the normalized autocorrelation of light intensity.
Further, the laser diode use and the different wavelength of high coherent laser, wave-length coverage be 600~
950nm, breadth of spectrum line are 1~2nm, and power is greater than 50mW.Laser diode uses and the different wavelength of high coherent laser,
Wave-length coverage is 600~950nm, and breadth of spectrum line is 1~2nm, can be with by measurement two or the scattered light intensity of above wavelength
Inverting blood volume, blood oxygen saturation and blood flow.
Further, the launching fiber is multimode fibre, and core diameter is 50 μm, 62.5 μm, 100 μm or more.Light will be emitted
Fibre is preferably that multimode fibre is because the coupling ratio single mode optical fiber of multimode fibre and laser is more easy.
Further, the transmitting probe is one of multimode fibre or self-focusing lens.
Further, the receiving transducer is one of single mode optical fiber or self-focusing lens.
Further, the reception optical fiber is single mode optical fiber, and core diameter is 5 μm.
The method method that biological tissue's blood appearance, blood oxygen, blood flow and oxygen metabolism are measured using utility model device,
Using high-coherence light source and laser diode mixed type light source, biology is incident on by photoswitch, launching fiber and transmitting probe
In tissue；Single-photon detector receives the scattering light from biological tissue by receiving transducer, reception optical fiber, and light intensity signal
It is converted into electric pulse, counter is realized electric pulse and counted, and computer realizes the calculating of light intensity and light intensity normalized autocorrelation, most
The variation of the blood volume, blood oxygen saturation, blood flow and oxygen metabolism rate of biological tissue is obtained by theory analysis afterwards.
Further, the blood volume of the biological tissue, blood oxygen saturation by measure different wave length light intensity decays come
It obtains；The blood flow of the biological tissue is obtained by measuring the light intensity normalized autocorrelation curve of high coherent laser；It is described
The variation of biological tissue's oxygen metabolism rate can be obtained by blood oxygen saturation and blood flow.
Using utility model device to the blood volume of biological tissue, blood oxygen saturation, blood flow and oxygen metabolism rate into
The specific calculating process of row measurement is as follows:
If the wavelength of high coherent laser is λ1, light probe transmitting optical power beReceived corresponding optical power isThe wavelength of laser diode is λ2, light probe transmitting optical power beReceived corresponding optical power is
Absorption in biological tissue is mainly oxygen and hemoglobin and deoxidation blood oxygen protein, is determined according to Modified Beer-Lambert
Rule:
Wherein CHHb,Respectively indicate the concentration of oxygen and hemoglobin and deoxyhemoglobin；With
Hemoglobin and deoxyhemoglobin are respectively indicated in wavelength X1The extinction coefficient at place is known quantity；With
Hemoglobin and deoxyhemoglobin are respectively indicated in wavelength X2The extinction coefficient at place；DPF(λ1) and DPF (λ2) respectively indicate wave
Long λ1And wavelength X2The differential path coefficient that transmits in biological tissues of light, with the specific structure of biological tissue and optical
Matter is related；D indicates the spacing of transmitting probe and receiving transducer, can obtain
Therefore, total blood volume tHb is
Blood oxygen saturation StO2For
It is relevant to will cause near-infrared for generally existing movement scattering particles (such as red blood cell, microorganism etc.) in the biological sample
The phase change of scattered optical field describes the phase change of scattered optical field using the cross-correlation of scattered optical field.Scattered optical field it is mutual
Correlation follows the Correlated Spectroscopy diffusion equation (1,2) similar with near-infrared diffusion equation.In unlimited diffusing model, light intensity auto-correlation letter
Number is
Wherein G1(ρ, τ)=< E*(ρ, t) E (ρ, t+ τ) > expression light field auto-correlation；When E (ρ, t+ τ) indicates to be located at t+ τ at ρ
The distribution of light intensity at quarter, E*(ρ, t) indicates the distribution of light intensity complex conjugate for being located at t moment at ρ；Total hair of S expression isotropism light source
Penetrate power；μaIndicate absorption coefficient；μs' indicate reduced scattering coefficient；k0Indicate wave vector；DBIndicate Cluster Brownian diffusion coefficient, Neng Goubiao
Levy the dynamic characteristic of strong scattering medium；τ indicates time delay, and time delay is bigger, and correlation intensity is smaller；ρ indicates source and detection
The spacing of device.
Actual measurement is normalized light intensity auto-correlation, i.e.,
g2(τ)=<I (t) I (t+ τ)>/<I (t)>2 (2)
Here I (t) indicates luminous intensity, can be normalization light intensity auto-correlation and normalization light using Siegert relationship
Field auto-correlation connects, i.e.,
g2(τ)=1+ β | g1(τ)|2 (3)
In above formula, β is a constant, depends on optical collection device and light source characteristic；
g1(τ)=G1(τ)/G1It (0) is normalization light field auto-correlation；
Blood flow is bigger, and normalization light intensity autocorrelator trace decline is faster, as shown in Figure 2.Light intensity is normalized by fitting
Autocorrelator trace can obtain β and DB, wherein DBIt is exactly blood flow.
By blood volume, oxyhemoglobin and blood flow as a result, being obtained with oxygen metabolism rate rCMRO2Variation:
In above formula, Δ CHHb/CHHbIndicate the opposite variation of oxyhemoglobin concentration；ΔtHb/tHb0Indicate blood volume
Opposite variation；Indicate the opposite variation of blood flow.The variation of blood flow can be obtained from Fig. 2 according to blood flow
It arrives.
The utility model provides a kind of device for measuring biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism, using high phase
Dry laser and laser diode provide mixed type light source, and the time division multiplexing of two kinds of light sources is realized using photoswitch；By hybrid optical
After being incident on biological tissue, the light source received is detected by photodetector, finally by counter and personal meter
Calculation machine realizes that the record of light intensity and normalized autocorrelation light intensity calculate.The utility model is a kind of by near-infrared spectrum technique and close
The solution of infrared diffusion Correlated Spectroscopy effective integration can measure blood volume, blood oxygen saturation, blood flow and oxo simultaneously
Thank to the variation of rate.
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this
Made any modifications, equivalent replacements, and improvements etc., should be included in the utility model within the spirit and principle of utility model
Protection scope within.
Claims (9)
1. a kind of device for measuring biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism characterized by comprising
High coherent laser and laser diode are connected by launching fiber with transmitting probe,
Photodetector is connected on transmitting probe by reception optical fiber,
The photodetector is also connected with counter and personal computer in turn,
The transmitting probe and receiving transducer are connected to biological tissue.
2. the device of a kind of measurement biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism, feature exist as described in claim 1
In being additionally provided with photoswitch between the high coherent laser and laser diode and launching fiber.
3. the device of a kind of measurement biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism, feature exist as described in claim 1
In the photodetector is single-photon detector.
4. the device of a kind of measurement biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism, feature exist as described in claim 1
In the wavelength of the high coherent laser is 600~950nm, line width 10-5~10-4Nm, power are greater than 50mW.
5. the device of a kind of measurement biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism, feature exist as described in claim 1
In the laser diode uses and the different wavelength of high coherent laser, and wave-length coverage is 600~950nm, breadth of spectrum line
For 1~2nm, power is greater than 50mW.
6. the device of a kind of measurement biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism, feature exist as described in claim 1
In the launching fiber is multimode fibre, and core diameter is 50 μm, 62.5 μm, 100 μm or more.
7. the device of a kind of measurement biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism, feature exist as described in claim 1
In the transmitting probe is one of multimode fibre or self-focusing lens.
8. the device of a kind of measurement biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism, feature exist as described in claim 1
In the reception optical fiber is single mode optical fiber, and core diameter is 5 μm.
9. the device of a kind of measurement biological tissue's blood volume, blood oxygen, blood flow and oxygen metabolism, feature exist as described in claim 1
In the receiving transducer is one of single mode optical fiber or self-focusing lens.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108670240A (en) * | 2018-06-15 | 2018-10-19 | 中国工程物理研究院流体物理研究所 | The device and method of measurement biological tissue blood volume, blood oxygen, blood flow and oxygen metabolism |
| CN114469043A (en) * | 2022-01-26 | 2022-05-13 | 北京工业大学 | Tissue blood flow detection device and method based on FPGA |
-
2018
- 2018-06-15 CN CN201820928320.7U patent/CN208910237U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108670240A (en) * | 2018-06-15 | 2018-10-19 | 中国工程物理研究院流体物理研究所 | The device and method of measurement biological tissue blood volume, blood oxygen, blood flow and oxygen metabolism |
| CN108670240B (en) * | 2018-06-15 | 2023-11-28 | 中国工程物理研究院流体物理研究所 | Device and method for measuring blood volume, blood oxygen, blood flow and oxygen metabolism of biological tissue |
| CN114469043A (en) * | 2022-01-26 | 2022-05-13 | 北京工业大学 | Tissue blood flow detection device and method based on FPGA |
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