CN208892856U - A kind of tack dura mater sticking patch - Google Patents
A kind of tack dura mater sticking patch Download PDFInfo
- Publication number
- CN208892856U CN208892856U CN201820149605.0U CN201820149605U CN208892856U CN 208892856 U CN208892856 U CN 208892856U CN 201820149605 U CN201820149605 U CN 201820149605U CN 208892856 U CN208892856 U CN 208892856U
- Authority
- CN
- China
- Prior art keywords
- dura mater
- sticking patch
- tack
- glue
- sensitive adhesive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
The utility model discloses a kind of tack dura mater sticking patch, and the glue-line including substrate and coating on the surface of the substrate, substrate is artificial dura mater.The utility model has the beneficial effects that the application combines artificial dura mater with pressure sensitive adhesive, tack dura mater sticking patch is produced.The dura mater simplified in operation repairs process, the requirement for Doctors' skill is reduced, the watertightness of dura mater repairing is improved, while can be applied to the position for being difficult to operation stitching, also it can be applied to dura defect position, solve the problems, such as that bond site hardness is excessive when a-cyanoacrylate bonding.This product can also be applied to the bonding of skull and dura mater, substitute traditional dura mater suture suspention, avoid a possibility that sewing needle potentially damages brain tissue during suspending in midair, shorten operating time.
Description
Technical field
The utility model relates to a kind of neurosurgery technical field, specially a kind of tack dura mater sticking patch.
Background technique
Neurosurgery generally requires suture anatomical reduction for the hard brain (ridge) membrane of incision, in no hard brain (ridge) membrane
It is generally sutured at present with sutures in the case where defect, if there is dura defect, then needs to use self fascia or artificial
Material is repaired.
It (is exactly after suturing dura mater, with certain pressure water flooding, it is desirable that suture that the suture repair of dura mater, which requires watertight suture,
Anhydrous leakage), artificial dura mater whether or not using, suture dura mater is higher for the technical requirements of operative doctor, time-consuming to take
Power, skilled practitioner complete dura mater suture in the time that the position for being easy suture is generally also required to 20 minutes or more, some operations
30-40 minutes time is even needed to complete dura mater suture.When can be by the suture for shortening dura mater if there is a kind of artificial material
Between, or substitution dura mater suture in some cases, it is not only able to save the time of doctor, Doctors' skill is wanted in reduction
It asks, accelerates the cultivation cycle of doctor, can more shorten the operating time of patient, reduce the surgery anesthesia time, it will be able to reduce fiber crops
The application of liquor-saturated drug reduces corresponding medical expense to reduce damage of the surgery anesthesia for patient.
Watertight suture dura mater is all difficult to accomplish in many cases,.The diameter of section of sewing needle is greater than suture simultaneously
The diameter of section of line causes cerebrospinal fluid from the pinhole leak of dura mater suture site.So being needed in many cases using medical
Adhesive is as the supplement patching material after dura mater suture.The most common medical adhesive of neurosurgery is a-cyanoacrylate.This
Class medical adhesive dressing resultant force is stronger, but elasticity and toughness are insufficient, simultaneously because must apply simultaneously with patching material, and work as liquid
In the slightly more environment of body, excessive velocities of the a-cyanoacrylate since polymerization reaction occurs will form hardened block, instead
Bonding well cannot occur with the purpose object (dura mater) of bonding, cured film is formed by after bonding due to elastic deficiency, is also held
It is easily broken, in turn results in leakage.When in addition using a-cyanoacrylate as adhesive in operation, doctor is also difficult to slap
The amount used is held, excessively will cause that be partially glued object really up to the mark with glue, is easy to fall off, it is very few with glue and to will cause bonding force excessively weak,
It is difficult to accomplish suitable glue consumption every time experienced doctor.A-cyanoacrylate generally requires when bonding dura mater
The tissues such as self muscle, fascia, fat using patient have aggravated the damage of patient with the use of that could complete to bond reluctantly.
Fibrin Glue is another typical binders.By main gel (main component is fibrinogen), catalysis
Agent (main component is fibrin ferment), main gel lysate (for the sodium chloride solution that sterilizes), catalyst lysate are (for the calcium chloride that sterilizes
Solution) composition.Since this product is blood product, so theoretically there is pathophorous danger, while the effect of this product is main
Surface of a wound exudation and veinlet bleeding are prevented suitable for surgical procedure, prevent tissue adhesion, when being used as adhesive, bonding force is weak,
Medical protein glue price is more expensive simultaneously, also limits medical protein glue and is used to repair bonding dura mater.
Ideal medical adhesive should have certain adhesive strength, and this intensity needs to be maintained at certain within a certain period of time
Level, the elasticity and toughness that stick portion needs to have certain；It needs to apply under conditions of having blood and tissue fluid；It needs
It is used under normal temperature and pressure；It needs safe and non-toxic.Up to the present the adhesive of medical for complying fully with requirement is not present.
Artificial dura mater has certain elasticity, toughness and intensity, but existing artificial dura mater is in the mistake of design and producing
Non- organizational coherence is pursued in journey merely.Existing adhesive of medical often perhaps adhesive strength is inadequate or elastic and toughness not
It is enough.
Lack a kind of simple and convenient artificial dura mater of tack at present, to shorten the time when repairing dura mater, simplifies journey
Sequence, while at the position for being inconvenient to suture, it can convenient and fast agglutinating repair dura defect.
Utility model content
The purpose of this utility model is that solve the above-mentioned problems and provides a kind of by artificial dura mater and pressure sensitive adhesive phase
In conjunction with producing a kind of not only flexible, toughness, intensity, but also there is relatively strong bond intensity；It can use at normal temperature simultaneously, it is only necessary to
Want certain pressure that can bond with autologous tissue；And it can be answered in the environment for having blood, cerebrospinal fluid, tissue exudates more
Tack dura mater sticking patch and preparation method thereof.
The utility model is achieved through the following technical solutions above-mentioned purpose, a kind of tack dura mater sticking patch, including substrate
And the glue-line of coating on the surface of the substrate, the substrate are artificial dura mater.
Preferably, the glue-line is pressure sensitive adhesive.
It preferably, further include the barrier paper being covered on glue-line.
It preferably, further include the dura mater disk for placing artificial dura mater, the artificial dura mater is laid in dura mater disk.
Preferably, there is arc notch, part tack dura mater sticking patch is covered on the arc and lacks on the dura mater plate edge
On mouth.
Preferably, the barrier paper have it is corresponding with arc notch position to outside the dura mater sticking patch stretch out after again back bending simultaneously
Pad is located at the extension below artificial dura mater, and the extension is greater than arc notch, and intermediate portion is covered on arc notch,
Marginal portion pad is located between dura mater disk and artificial dura mater.
Preferably, edge corresponding with extension is embedded with and just takes off item on the glue-line, and an one end of just taking off is embedded
In glue-line, the other end it is exposed outside the tack dura mater sticking patch and be extended portion package.
The beneficial effects of the utility model are:
(1) the application combines artificial dura mater with pressure sensitive adhesive, produces tack dura mater sticking patch.Simplify the dura mater in operation
Process is repaired, the requirement for Doctors' skill is reduced, improves the watertightness of dura mater repairing,
It can be applied to the position for being difficult to operation stitching simultaneously, also can be applied to dura defect position.There to be elasticity
Artificial dura mater in conjunction with pressure sensitive adhesive, also solve the problems, such as that bond site hardness is excessive when a-cyanoacrylate bonding.This
Product can also be applied to the bonding of skull and dura mater, substitute traditional dura mater suture suspention, avoid sewing needle during suspention
A possibility that potential damage brain tissue, shorten operating time；
(2) part pressure sensitive adhesive has been applied to medical field, uses by many years, is proved to nontoxic to organizing；It protects
The organization security of tack dura mater is demonstrate,proved；
(3) tack dura mater sticking patch has both the advantages of artificial dura mater and pressure sensitive adhesive, with certain toughness and elasticity and
It can be with self-adhesion；Avoiding artificial dura mater simultaneously cannot voluntarily and tissue adhesion, and common biogum institute's shape after organizations
At film lack flexibility toughness, one layer of watertight film cannot be formed the shortcomings that；
(4) barrier paper is covered on glue-line, prevents glue-line from polluting；Artificial dura mater is contained in dura mater disk, each artificial dura mater
It can independently save；There is extension, the arc notch on extension and dura mater disk is corresponding, convenient to clamp the benefit on barrier paper
The two sides of piece, to take out the sticking patch out of dura mater disk, extension can also will be exposed at the artificial dura mater at arc notch and wrap up
Get up, prevents from polluting；
(5) item is just taken off since glue-line is embedded with, after extension starts, just takes off item exposing, just take off item and extension is mutual
Cooperation, can easily tear barrier paper, avoid and look for the trouble for opening position, reduce and therefore make to dura mater sticking patch
At damage.
Detailed description of the invention
Fig. 1 is the schematic cross-section of the utility model；
Fig. 2 is the perspective representation of the utility model；
Fig. 3 is the extension schematic diagram of the utility model；
Fig. 4 is that the utility model removes the schematic diagram after barrier paper and dura mater disk.
In figure: 1, artificial dura mater, 2, pressure sensitive adhesive, 21, just take off item, 3, barrier paper, 31, extension, 311, branch, 4, dura mater
Disk, 41, arc notch.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work
Every other embodiment obtained, fall within the protection scope of the utility model.
Embodiment one
It please refers to shown in Fig. 1-4, a kind of tack dura mater sticking patch, the glue-line including substrate and coating on the surface of the substrate,
Substrate is artificial dura mater 1, which directly passes through glue-line and pasted.Glue-line is pressure sensitive adhesive 2, and pressure sensitive adhesive 2 can
To select acrylate pressure-sensitive adhesive non-toxic to humans, polyurethane contact adhesive, organic pressure-sensitive gel, thermoplastic elastomer (TPE) pressure
Quick glue, rubber pressure-sensitive adhesive or other pressure sensitive adhesives.Due to the bonding force formed between 2 tissue of pressure sensitive adhesive and artificial dura mater 1
Mainly Van der Waals force influences very tissue so the structure of gluing of surfaces is not destroyed after bonding plane is formed
It is small.
The component of the application is mainly artificial dura mater 1 and pressure sensitive adhesive 2.Artificial dura mater 1 is in clinical application many years, safety
Property is very high.Part pressure sensitive adhesive 2 including organic pressure-sensitive gel, has equally been applied to medical field, uses by many years,
It is proved to nontoxic to organizing.It ensure that the organization security of tack dura mater.Tack dura mater, which has both artificial dura mater 1, to be had
The advantages of certain toughness and elasticity and pressure sensitive adhesive 2 can be with self-adhesions.Avoiding artificial dura mater 1 simultaneously cannot be voluntarily viscous with tissue
It closes, and common biogum is formed by film after organizations and lacks flexibility toughness, cannot form one layer of watertight film
Disadvantage.Such as ethylene methacrylic type Silica hydrogel of part pressure sensitive adhesive 2, can be applied in the environment of water, ensure that in the tissue for having water
On bonding force.Pressure sensitive adhesive 2 can be applied repeatedly, be conducive to making repeated attempts for bond site and mode in operation.This production
Product can be applied to the hemostasis of the suspention between dura mater and skull bone edge, substitution dura mater suture, or as the supplement of dura mater suture repair,
It can be applied to the repairing of leakage of cerebrospinal, the closure of skull sinus cavities in operation can be used for repairing and be difficult to the dura mater that sutures lacking
Damage.Simplify dura mater and repair sewing process, will be saved the plenty of time for operative doctor, and provide better guarantee for patient.Simultaneously originally
Product will avoid reducing the damage of patient using autologous fat or fasciai patch dura mater in some patients' operation.
It further include the barrier paper 3 being covered on glue-line and the dura mater disk for placing artificial dura mater 1 on the dura mater sticking patch of the application
4, artificial dura mater 1 is laid in dura mater disk 4.There is arc notch 41, the covering of part tack dura mater sticking patch on 4 edge of dura mater disk
On the arc notch 41, convenient for picking up artificial dura mater 1 from two sides, taken out from dura mater disk 4.
Barrier paper 3 have it is corresponding with 41 position of arc notch to outside the dura mater sticking patch stretch out after again back bending and pad be located at people
The extension 31 of 1 lower section of work dura mater, extension 31 are greater than arc notch 41, and intermediate portion is covered on arc notch 41, side
Edge point pad is located between dura mater disk 4 and artificial dura mater 1,1 portion envelops of artificial dura mater that will be exposed on arc notch 41,
To prevent pollution.
Have the branch 311 for stretching out arc notch 41 can be with branch 311 after taking out dura mater sticking patch on extension 31
For handgrip, extension 31 is raised；Branch 311 is a part for cutting and bending from extension 31, and production is simple；It can be with this
Branch 311 is handgrip, and extension 31 and artificial dura mater 1 are removed.
Edge corresponding with extension 31, which is embedded with, on glue-line just takes off item 21, just takes off 21 one end of item and is embedded in glue-line,
The other end it is exposed outside the tack dura mater sticking patch and be extended portion 31 wrap up, can be with the extension after extension 31 is opened
Portion 31 and just to take off item 21 be handgrip, barrier paper 3 is removed from glue-line, and the subsequent dura mater sticking patch can be attached to required position,
Just taking off item 21 is made of material absorbed by the body, and after which pastes, longer part can be cut, shorter portion
Dividing can retain, and can finally be absorbed by the body.
Tack dura mater sticking patch the production method is as follows: glue is applied to artificial dural surface first, forms glue-line；Secondly, to
After glue-line is dry, barrier paper is sticked on glue-line；Finally, preservation after disinfection to reserve.
Embodiment two
Artificial dura mater 1 selects absorbable collagen protein sponge, and pressure sensitive adhesive 2 selects ethylene methacrylic type Silica hydrogel pressure sensitive adhesive, every
Polytetrafluoroethylene film is selected from paper 3.Two kinds of component 1:1 of two-component ethylene methacrylic type Silica hydrogel pressure sensitive adhesive AB are mixed, vacuum defoamation,
In on 5mm thickness collagen sponge, bondline thickness 0.02-0.03mm, 120 ° of bakings cooling in 10 minutes is pasted on brush coating after cooling
It is after disinfection to reserve on the polytetrafluoroethylene film of 0.1mm thickness.
Silicon rubber have biggish biologically inert, in tissue have stronger compatibility, with tissue and divide
Bleeding Long Term Contact is not degradable, is resistant to the significantly temperature difference.
180 ° of sur-face peeling power for measuring sample are 60 ± 1g/25mm, meet operation and require.
Tack dura mater sticking patch prepared by the above method is applied to rabbit, specific experiment is as follows:
10 rabbit, every 1.5-2.5kg of weight, the windowing of bilateral calvarium portion, every side dura mater incision is about 5mm, and wipes out
Dura mater causes the dura defect of an about 5 × 2mm, randomly chooses left and right sides (being marked with gentian violet, to distinguish), brain surface
The gelfoam (preventing artificial dura mater and brain tissue adhesion) that conventional low cost is placed between dura mater, by the tack of 10 × 10mm
Dura mater sticking patch is pasted on rabbit dural surface.As control, same dura mater incision is about 5mm, and wipes out for opposite side with rabbit
Dura mater causes the dura defect of an about 5X2mm, and the gelfoam of conventional low cost is placed between brain surface and dura mater, by 10 ×
The common collagen dura mater sticking patch of 10mm is pasted on rabbit dural surface.Whether observation dura defect mend has after five minutes
Cerebrospinal fluid leakage, and record.Rabbit scalp is sutured, and is raised.Rabbit head suture skin is opened after 1 week, observation bilateral is hard
Film mend whether there is leakage of cerebrospinal, and record.
As a result:
The repairing same day observes result: the common collagen film of tack applys side 1 (10%) and cerebrospinal fluid leakage occurs, and 9
Example (90%) anencephaly cerebrospinal fluid leakage；Common collagen film applys side 8 (80%) and cerebrospinal fluid leakage, 2 (20%) nothings occurs
Cerebrospinal fluid leakage
| There are cerebrospinal fluid to leak (example) | There is no cerebrospinal fluid to leak (example) | |
| Tack dura mater | 1 (10%) | 9 (90%) |
| Common collagen film | 8 (80%) | 2 (20%) |
P < 0.01
After 1 week, because feeding reason, 1 rabbit death is survived 9.Rabbit skin of head notch heals well.It opens
Rabbit skin of head suture, observation dura defect mend are leaked with the presence or absence of cerebrospinal fluid.
Observe result: tack dura mater sticking patch sticks the equal anencephaly cerebrospinal fluid leakage in side；Common collagen film applys side 6
(66.7%) there are cerebrospinal fluid leakage, 3 (33.3%) anencephaly cerebrospinal fluid leakages.
| There are cerebrospinal fluid to leak (example) | There is no cerebrospinal fluid to leak (example) | |
| Tack dura mater | 0 | 9 (100%) |
| Common collagen film | 6 (66.7%) | 3 (33.3%) |
P < 0.01
Repair rabbit dura mater using tack dura mater sticking patch, operation at that time and after a week, relative to common collagen film,
Leakage of cerebrospinal can be significantly prevented, and statistically significant.
It is obvious to a person skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and
And without departing substantially from the spirit or essential attributes of the utility model, it can realize that this is practical new in other specific forms
Type.Therefore, in all respects, the present embodiments are to be considered as illustrative and not restrictive, this is practical new
The range of type is indicated by the appended claims rather than the foregoing description, it is intended that containing for the equivalent requirements of the claims will be fallen in
All changes in justice and range are embraced therein.It should not treat any reference in the claims as limiting
Related claim.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (6)
1. a kind of tack dura mater sticking patch, which is characterized in that including the glue-line of substrate and coating on the surface of the substrate, the substrate
For artificial dura mater (1), the glue-line is pressure sensitive adhesive (2), the pressure sensitive adhesive (2) be acrylic acid rouge pressure sensitive adhesive, polyurethane contact adhesive,
Organic pressure-sensitive gel, thermoplastic elastomer (TPE) pressure sensitive adhesive, rubber pressure-sensitive adhesive, one in ethylene methacrylic type Silica hydrogel pressure sensitive adhesive
Kind.
2. a kind of tack dura mater sticking patch according to claim 1, it is characterised in that: further include be covered on glue-line every
From paper (3).
3. a kind of tack dura mater sticking patch according to claim 2, it is characterised in that: further include place artificial dura mater hard
Membranous disc (4), the artificial dura mater (1) are laid in dura mater disk (4).
4. a kind of tack dura mater sticking patch according to claim 3, it is characterised in that: have on dura mater disk (4) edge
Have arc notch (41), part tack dura mater sticking patch is covered on the arc notch (41).
5. a kind of tack dura mater sticking patch according to claim 4, it is characterised in that: the barrier paper (3) has and arc
V notch v (41) position is corresponding stretched out to outside the dura mater sticking patch after back bending and pad again and be located at extension below artificial dura mater (1)
(31), the extension (31) is greater than arc notch (41), and intermediate portion is covered on arc notch (41), marginal portion pad
It is located between dura mater disk (4) and artificial dura mater (1).
6. a kind of tack dura mater sticking patch according to claim 5, it is characterised in that: on the glue-line with extension (31)
Corresponding edge, which is embedded with, just takes off item (21), and described item (21) one end of just taking off is embedded in glue-line, the other end it is exposed this from
Sticky dura mater sticking patch is outer and is extended portion (31) package.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820149605.0U CN208892856U (en) | 2018-01-29 | 2018-01-29 | A kind of tack dura mater sticking patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820149605.0U CN208892856U (en) | 2018-01-29 | 2018-01-29 | A kind of tack dura mater sticking patch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208892856U true CN208892856U (en) | 2019-05-24 |
Family
ID=66565145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820149605.0U Active CN208892856U (en) | 2018-01-29 | 2018-01-29 | A kind of tack dura mater sticking patch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208892856U (en) |
-
2018
- 2018-01-29 CN CN201820149605.0U patent/CN208892856U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108272529A (en) | A kind of tack dura mater sticking patch and preparation method thereof | |
| US5780048A (en) | First aid bandage dressing system and method of application thereof | |
| Singer et al. | The cyanoacrylate topical skin adhesives | |
| Halsted | Ligature and suture material: the employment of fine silk in preference to catgut and the advantages of transfixion of tissues and vessels in control of hemorrhage also an account of the introduction of gloves, gutta-percha tissue and silver foil | |
| Bhende et al. | In vitro assessment of microbial barrier properties of Dermabond® topical skin adhesive | |
| US6386203B1 (en) | Controlled viscosity dermal adhesive | |
| JP5101110B2 (en) | Wound closure device and method with adhesive | |
| RU2203095C2 (en) | Biologically compatible glue | |
| US20100297218A1 (en) | Tissue adhesive compositions and methods thereof | |
| Azadani et al. | Mechanical properties of surgical glues used in aortic root replacement | |
| CN106574022A (en) | Low cytotoxicity switchable adhesive compositions, medical dressings and skin coverings, and methods of treatment using same | |
| US20110152924A1 (en) | Oxidized regenerated cellulose adhesive tape | |
| Han et al. | Fixation of split-thickness skin graft using fast-clotting fibrin glue containing undiluted high-concentration thrombin or sutures: a comparison study | |
| JP2019198697A (en) | Positioning agent and method of using the same | |
| Samuel et al. | The use of Indermil (n-butyl cyanoacrylate) in otorhinolaryngology and head and neck surgery. A preliminary report on the first 33 patients | |
| CN109620327A (en) | Button Skin stretching device and skin drawing and stretching method | |
| CN208892856U (en) | A kind of tack dura mater sticking patch | |
| Schneppendahl et al. | Initial stability of two different adhesives compared to suture repair for acute Achilles tendon rupture—a biomechanical evaluation | |
| Avery et al. | The use of butyl cyanoacrylate as a tissue adhesive in maxillo-facial and cranio-facial surgery | |
| CN112386741A (en) | Self-adhesive hemostatic artificial dura mater repairing tablet and preparation method thereof | |
| JP2003126235A (en) | Patch material for medical care | |
| SALASCHE et al. | Skin grafting: perioperative technique and management | |
| CN101985049A (en) | Chitosan bandage | |
| Ebnesajjad | Adhesives for medical and dental applications | |
| US10806492B2 (en) | Nail plate growth guide surgical implantation kit |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20211022 Address after: 310023 room 201-2, building 1, No. 181, Wuchang Avenue, Wuchang Street, Hangzhou, Zhejiang Patentee after: Pengtuo Biotechnology (Hangzhou) Co.,Ltd. Address before: 100032 No.11, gate 17, 6th floor, No.45, Chenggen South Street, Xihuang, Xicheng District, Beijing Patentee before: Meng Guolu |