CN208883754U - A kind of semi-automatic multi-channel solid phase peptide synthesizer - Google Patents
A kind of semi-automatic multi-channel solid phase peptide synthesizer Download PDFInfo
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- CN208883754U CN208883754U CN201821177367.0U CN201821177367U CN208883754U CN 208883754 U CN208883754 U CN 208883754U CN 201821177367 U CN201821177367 U CN 201821177367U CN 208883754 U CN208883754 U CN 208883754U
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Abstract
The utility model discloses a kind of semi-automatic multi-channel solid phase peptide synthesizers, including multi-channel solid phase peptide synthesizer, the upper end of multi-channel solid phase peptide synthesizer offers through-hole, upper through-hole runs through the internal-response channel that multi-channel solid phase peptide synthesizer is arranged in, channel is fixedly connected on upper through-hole, the lower end in channel and upper through-hole are fixedly connected with the first sealing ring, drain cap is connected on the inside of channel, the lower end of drain cap is movably set with micromotor, the upper end in channel is opened up there are two slot, it is plugged with the first Reagent Tube and the second Reagent Tube respectively in two slots；Two Reagent Tubes by being connected to the upper end of multi-channel solid phase peptide synthesizer by the device, two Reagent Tubes are first poured into corresponding reaction solution, control operation is carried out by two different valves respectively, after operation terminates, the collecting pipe that extra reagent flows into lower end is subjected to unified collection, the apparatus structure is simple, and it is convenient to operate.
Description
Technical field
The utility model relates to the correlative technology field of solid phase peptide synthesizer, specially a kind of semi-automatic multi-channel solid phase
Peptide synthesizer.
Background technique
The chemical synthesising technology of polypeptide either liquid phase method or solid phase method are all mature, and in recent decades, solid phase method is more
Method of peptide synthesis is time saving with its, laborsaving, material-saving, convenient for automatically controlling, outstanding advantage easy to popularize and become Peptide systhesis
Conventional method, and expand to nucleic acid synthesis etc. other fields, developed successfully solid-phase polypeptide conjunction from Merrifield in 1963
Since at method, by continuous improve and perfect, one had become in peptide and protein synthesis to solid phase method today is normal
With technology, and the Fully automated synthesis of polypeptide is promoted, automates Peptide systhesis for having had certain polypeptide of mature technology
Synthesis has its superiority really, but automatic synthesizer is expensive, therefore is difficult to popularize in China, for no mature technology
For Peptide systhesis, synthesis have many advantages, such as that easy to detect, result is reliable and yield stable by hand, however synthesize has it by hand
Limitation especially shows that its combined coefficient is low, is difficult to meet the parallel projects of a fairly large number of polypeptide；
In the prior art, in Solid-phase synthesis peptides reaction, need to be used alternatingly activator and deprotection agent as reaction solution
Reaction is participated in, needs repeatedly alternately to add both reaction solutions, since reaction needs to carry out in the state of sealing, and is difficult to control
Pouring volume processed also can inevitably enter air in operation, influence the purity of reaction；For this purpose, the utility model proposes a kind of half
Automated multi-channel solid phase peptide synthesizer is for solving the above problems.
Utility model content
The purpose of this utility model is to provide a kind of semi-automatic multi-channel solid phase peptide synthesizers, to solve above-mentioned background
The problem of being proposed in technology.
To achieve the above object, the utility model provides the following technical solutions: a kind of semi-automatic multi-channel solid phase peptide conjunction
Cheng Yi, including multi-channel solid phase peptide synthesizer, the upper end of the multi-channel solid phase peptide synthesizer offers through-hole, described
Upper through-hole runs through the internal-response channel that multi-channel solid phase peptide synthesizer is arranged in, and is fixedly connected on the upper through-hole logical
Road, the lower end in the channel and upper through-hole are fixedly connected with the first sealing ring, are connected with drain cap on the inside of the channel, described
The lower end of drain cap is movably set with micromotor, and the upper end in the channel is opened up there are two slot, and two slots are interior to distinguish grafting
There are the first Reagent Tube and the second Reagent Tube, the lower end of first Reagent Tube is fixedly connected with the first valve, first reagent
The upper end of pipe is connected with the first sealing cover, and the lower end of second Reagent Tube is fixedly connected with the second valve, second reagent
The upper end of pipe is connected with the second sealing cover, is fixedly connected with collecting pipe in the lower sidewalls in the channel, the collecting pipe it is upper
Side is fixedly connected with third valve close to the position in channel.
Preferably, the section of first sealing ring is ring structure, the inner wall of the first sealing ring and channel lower end it is outer
Wall fixed bonding, and the inner wall fixed bonding of the outer wall of the first sealing ring and upper through-hole, the outer circular size of the first sealing ring
Equal to the inner circular size of upper through-hole.
Preferably, the channel is circular cylinder structure, and the lower end in channel is provided with multiple preformed holes, is plugged on respectively
In multi-channel reaction pipe in through-hole, upper cover and the channel in channel are an integral molding structure, and are provided with two on the upper lid in channel
Reserved through hole slot, the notch of through-hole groove are provided with the second sealing ring.
Preferably, the drain cap is circular plate structure, and the area of section of drain cap is equal to the inner section area in channel, drain cap
The micromotor of bottom end connection is fixedly connected on the inner wall in channel by connecting rod.
Preferably, first sealing cover is circular cylinder structure, and the bottom end of the first sealing cover is round slot structure, round
Fixed bonding has rubber ring on the inner wall of slot, and the upper end of the first sealing cover is fixedly connected with handle.
Compared with prior art, the utility model has the beneficial effects that
Two Reagent Tubes by being connected to the upper end of multi-channel solid phase peptide synthesizer by the device, first by two Reagent Tubes
It pours into corresponding reaction solution to be sealed, in the synthesis process, carries out alternately controlling operation respectively by two different valves,
Time saving and energy saving and more accurate, raising reactant purity, after operation terminates, by extra reagent is gradually poured into compared to existing
The collecting pipe for flowing into lower end carries out unified collection, and the apparatus structure is simple, and it is convenient to operate.
Detailed description of the invention
Fig. 1 is the structural blast schematic diagram of the utility model；
Fig. 2 is the channel design cross-sectional view of the utility model.
In figure: 1 multi-channel solid phase peptide synthesizer, through-hole, 3 first sealing rings, 4 channels, 5 drain caps, 6 micro electrics on 2
Machine, 7 first Reagent Tubes, 8 second Reagent Tubes, 9 first valves, 10 second valves, 11 first sealing covers, 12 second sealing covers, 13
Collecting pipe, 14 third valves, 15 second sealing rings.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work
Every other embodiment obtained, fall within the protection scope of the utility model.
The utility model provides a kind of technical solution referring to FIG. 1-2: a kind of semi-automatic multi-channel solid phase peptide synthesis
Instrument, including multi-channel solid phase peptide synthesizer 1, the upper end of multi-channel solid phase peptide synthesizer 1 offer through-hole 2, upper through-hole 2
Through the internal-response channel that multi-channel solid phase peptide synthesizer 1 is arranged in, channel 4, channel 4 are fixedly connected on upper through-hole 2
Lower end and upper through-hole 2 be fixedly connected with the first sealing ring 3, be connected with drain cap 5 on the inside of channel 4, the lower end activity of drain cap 5
It is provided with micromotor 6, the upper end in channel 4 is opened up there are two slot, is plugged with the first Reagent Tube 7 and the in two slots respectively
Two Reagent Tubes 8, the lower end of the first Reagent Tube 7 are fixedly connected with the first valve 9, and it is close that the upper end of the first Reagent Tube 7 is connected with first
Capping 11, the lower end of the second Reagent Tube 8 is fixedly connected with the second valve 10, and the upper end of the second Reagent Tube 8 is connected with the second sealing
Lid 12, is fixedly connected with collecting pipe 13 in the lower sidewalls in channel 4, and the top of collecting pipe 13 fixed connects close to the position in channel 4
It is connected to third valve 14.
Further, the section of the first sealing ring 3 is ring structure, inner wall and 4 lower end of channel of the first sealing ring 3
Outer wall fixed bonding, and the inner wall fixed bonding of the outer wall of the first sealing ring 3 and upper through-hole 2, the outer circular of the first sealing ring 3
Size is equal to the inner circular size of upper through-hole 2, and the first sealing ring 3 plays sealing function to channel 4 and upper through-hole 2.
Further, channel 4 is circular cylinder structure, and the lower end in channel 4 is provided with multiple preformed holes, is plugged on respectively
In multi-channel reaction pipe in through-hole 2, upper cover and the channel 4 in channel 4 are an integral molding structure, and are provided on the upper lid in channel 4
Two reserved through hole slots, the notch of through-hole groove are provided with the second sealing ring 15, the second sealing ring 15 to the through-hole groove in channel 4 and
Play the role of sealing in junction.
Further, drain cap 5 is circular plate structure, and the area of section of drain cap 5 is equal to the inner section area in channel 4, leakage
The micromotor 6 of 5 bottom end of disk connection is fixedly connected on the inner wall in channel 4 by connecting rod, the inner wall in channel 4 and the placement of drain cap 5
Place is provided with a circle groove, and the correspondence of drain cap 5 rotates in a groove.
Further, the first sealing cover 11 is circular cylinder structure, and the bottom end of the first sealing cover 11 is round slot structure, circle
Fixed bonding has rubber ring on the inner wall of shape slot, and the upper end of the first sealing cover 11 is fixedly connected with handle, the first sealing cover 11
Structure it is identical with the structure of the second sealing cover 12, the first sealing cover 11 and the second sealing cover 12 play sealing function.
Working principle: in actual work, channel 4 is connected to the upper end of multi-channel solid phase peptide synthesizer 1, and will collect
Third valve 14 on pipe 13 is closed, and the upper end through-hole groove in channel 4 is separately connected the first Reagent Tube 7 and the second Reagent Tube 8, will
The reagent needed in reaction is poured into respectively in the first Reagent Tube 7 and the second Reagent Tube 8, according to the demand in reaction process, respectively
The first valve 9 and the second valve 10 are alternately opened, in reaction solution progress channel 4, the rotation of drain cap 5 is driven by micromotor 6,
Reaction solution, in the lower end in channel 4, is further flowed into through-hole 2 by the through-hole uniformly penetrating on drain cap 5, if reaction terminates
Afterwards, there is extra reaction solution, then by opening third valve 14, reaction solution is allowed to respectively enter in collecting pipe 13 at unified collection
Reason, the apparatus structure is simple, and it is convenient to operate, and has very high practical value.
While there has been shown and described that the embodiments of the present invention, for the ordinary skill in the art,
It is understood that these embodiments can be carried out with a variety of variations in the case where not departing from the principles of the present invention and spirit, repaired
Change, replacement and variant, the scope of the utility model is defined by the appended claims and the equivalents thereof.
Claims (5)
1. a kind of semi-automatic multi-channel solid phase peptide synthesizer, including multi-channel solid phase peptide synthesizer (1), the multichannel is solid
The upper end of phase Peptide synthesizer (1) offers through-hole (2), it is characterised in that: the upper through-hole (2) is through setting in multichannel
The internal-response channel of solid phase peptide synthesizer (1) is fixedly connected with channel (4) on the upper through-hole (2), the channel (4)
Lower end and upper through-hole (2) be fixedly connected with the first sealing ring (3), be connected with drain cap (5), institute on the inside of the channel (4)
The lower end for stating drain cap (5) is movably set with micromotor (6), and the upper end of the channel (4) is opened up there are two slot, two slots
It is inside plugged with the first Reagent Tube (7) and the second Reagent Tube (8) respectively, the lower end of first Reagent Tube (7) is fixedly connected with
The upper end of one valve (9), first Reagent Tube (7) is connected with the first sealing cover (11), the lower end of second Reagent Tube (8)
It is fixedly connected with the second valve (10), the upper end of second Reagent Tube (8) is connected with the second sealing cover (12), the channel
(4) it is fixedly connected in lower sidewalls collecting pipe (13), the top of the collecting pipe (13) is fixed close to the position of channel (4)
It is connected with third valve (14).
2. a kind of semi-automatic multi-channel solid phase peptide synthesizer according to claim 1, it is characterised in that: described first is close
The section of seal (3) is ring structure, the outer wall fixed bonding of the inner wall of the first sealing ring (3) and channel (4) lower end, and first
The outer wall of sealing ring (3) and the inner wall fixed bonding of upper through-hole (2), the outer circular size of the first sealing ring (3) are equal to upper logical
The inner circular size in hole (2).
3. a kind of semi-automatic multi-channel solid phase peptide synthesizer according to claim 1, it is characterised in that: the channel
It (4) is circular cylinder structure, the lower end of channel (4) is provided with multiple preformed holes, the multichannel being plugged in through-hole (2) respectively
In reaction tube, upper cover and channel (4) of channel (4) are an integral molding structure, and two are provided on the upper lid of channel (4) and is reserved and is led to
Hole slot, the notch of through-hole groove are provided with the second sealing ring (15).
4. a kind of semi-automatic multi-channel solid phase peptide synthesizer according to claim 1, it is characterised in that: the drain cap
It (5) is circular plate structure, the area of section of drain cap (5) is equal to the inner section area of channel (4), the connection of drain cap (5) bottom end
Micromotor (6) is fixedly connected on the inner wall of channel (4) by connecting rod.
5. a kind of semi-automatic multi-channel solid phase peptide synthesizer according to claim 1, it is characterised in that: described first is close
Covering (11) is circular cylinder structure, and the bottom end of the first sealing cover (11) is round slot structure, is fixed on the inner wall of circular trough viscous
It is connected to rubber ring, and the upper end of the first sealing cover (11) is fixedly connected with handle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821177367.0U CN208883754U (en) | 2018-07-24 | 2018-07-24 | A kind of semi-automatic multi-channel solid phase peptide synthesizer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821177367.0U CN208883754U (en) | 2018-07-24 | 2018-07-24 | A kind of semi-automatic multi-channel solid phase peptide synthesizer |
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| CN208883754U true CN208883754U (en) | 2019-05-21 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110283229A (en) * | 2019-07-24 | 2019-09-27 | 上海友尹化工科技有限公司 | A kind of production system for polypeptide drugs |
| CN113813903A (en) * | 2021-09-14 | 2021-12-21 | 韩青芬 | Multichannel polypeptide reaction synthesizer |
-
2018
- 2018-07-24 CN CN201821177367.0U patent/CN208883754U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110283229A (en) * | 2019-07-24 | 2019-09-27 | 上海友尹化工科技有限公司 | A kind of production system for polypeptide drugs |
| CN113813903A (en) * | 2021-09-14 | 2021-12-21 | 韩青芬 | Multichannel polypeptide reaction synthesizer |
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