CN208741541U - A kind of extraction element of GINKGO BILOBA EXTRACT and ginkgo lactones - Google Patents
A kind of extraction element of GINKGO BILOBA EXTRACT and ginkgo lactones Download PDFInfo
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- CN208741541U CN208741541U CN201820156190.XU CN201820156190U CN208741541U CN 208741541 U CN208741541 U CN 208741541U CN 201820156190 U CN201820156190 U CN 201820156190U CN 208741541 U CN208741541 U CN 208741541U
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Abstract
The utility model discloses the extraction elements of a kind of GINKGO BILOBA EXTRACT and ginkgo lactones, including ultrasonic extraction tank, the first reduced pressure kettle, adsorbing separation tank, the second reduced pressure kettle and collecting tank；The liquid outlet opening of ultrasonic extraction tank is connected by filter with the feeding inlet of the first reduced pressure kettle, the concentrate discharge port of first reduced pressure kettle is connected with the feeding inlet of adsorbing separation tank, adsorbing separation tank is exported equipped with eluent, eluent outlet is connected with the feeding inlet of the second reduced pressure kettle, and the concentrate discharge port of the second reduced pressure kettle is connected with the feeding inlet of collecting tank.The content of GINKGO BILOBA EXTRACT and ginkgo lactones is high in its ginkgo biloba p.e obtained, high production efficiency.
Description
Technical field
The utility model belongs to the extractive technique field of GINKGO BILOBA EXTRACT and ginkgo lactones, and in particular to a kind of GINKGO BILOBA EXTRACT and
The extraction element of ginkgo lactones.
Background technique
Ginkgo is a kind of perennial woody plant also known as maidenhair tree, Gong Sunshu.Ginkgo is current naked sub- plant rare in the world
One of object, existence history can be traced to before 200,000,000 years, and the age of tree reaches over thousands of year, is known as the title of " living fossil ".Ginkgo leaf chemistry at
Dividing mainly has flavonoids, terpene, phenols, 25 kinds of effective elements and 17 kinds of amino acid etc..
Flavonoid compounds in ginkgo leaf by Quercetin, Kaempferol, Isorhamnetin, bayberry bark element, luteolin and
The single, double, triple glycoside of apiolin forms, wherein rear three kinds of substance proportion very littles, determine first three main component
Content can reflect substantially flavone compound content height.Ginko leaves flavone has expansion blood vessel, inhibits blood platelet
Activation factor, anti-oxidant, Adjust-blood lipid and the pharmacological actions such as antitumor have special efficacy to treatment angina pectoris, myocardial infarction etc., yellow
Keto-alcohol glucoside or a kind of scavenger of peroxylradicals, can eliminate the freedom to the toxic effect of cardiovascular and cerebrovascular endothelial cell
Base has the health-care effects such as anti-aging and anti-cancer.
Ginkgolides mainly includes diterpenoid-lactone and sesquiterpene lactone.Diterpenoid-lactone has 5 kinds, i.e. ginkgolides
(Ginkgolides) A, B, C, M and J, abbreviation GA, GB, GC, GM, GJ；Sesquiterpene lactone has a kind, i.e. Bilobalide
(Bilobalide), abbreviation BB.Ginkgolides has the anti-platelet activating factor (Platelet-activating of specificity
Factor, PAF) activity, be natural PAF antagonist, the diseases such as asthma, lung allergy and heart failure can be treated, wherein especially with
The active highest of GB, Bilobalide are psychoneural medicine, are resistant to the aging of nerve endings, are real anti-aging substance.
There are many patent document isolated for GINKGO BILOBA EXTRACT and ginkgolides extraction, and method is variant.Most of selection
Water extract-alcohol precipitation or alcohol extracting-water precipitating then carry out column chromatography using macroreticular resin layer, and the method products obtained therefrom content is relatively low, production efficiency
It is low.
Utility model content
Based on this, in view of the above-mentioned problems, the utility model proposes the extraction element of a kind of GINKGO BILOBA EXTRACT and ginkgo lactones,
The content of GINKGO BILOBA EXTRACT and ginkgo lactones is high in ginkgo biloba p.e obtained, high production efficiency.
The technical solution of the utility model is: a kind of extraction element of GINKGO BILOBA EXTRACT and ginkgo lactones, including ultrasonic wave mention
Take tank, first that kettle, adsorbing separation tank, the second reduced pressure kettle and collecting tank is concentrated under reduced pressure；The liquid of ultrasonic extraction tank discharges
Mouthful by filter with first reduced pressure kettle feeding inlet be connected, first be concentrated under reduced pressure kettle concentrate discharge port with adsorb divide
Feeding inlet from tank is connected, and adsorbing separation tank is exported equipped with eluent, and eluent outlet enters with the second reduced pressure kettle
Material mouth is connected, and the concentrate discharge port of the second reduced pressure kettle is connected with the feeding inlet of collecting tank.
Preferably, further include tunnel oven and crush box, be equipped with conveyer belt in tunnel oven, one end of conveyer belt extends to
In the feeding inlet of crush box, the discharge port of crush box is connected with the feeding inlet of the ultrasonic extraction tank.
Preferably, the bottom of the filter is equipped with discharge of filter residues mouth, and the side wall of the ultrasonic extraction tank is equipped with filter residue
Feeding inlet, the discharge of filter residues mouth of filter are connected with the filter residue feeding inlet of ultrasonic extraction tank by circulating pump.
Further, the first reduced pressure kettle includes concentration tank, the first condenser, vapour liquid separator, the second condensation
Device and submerged soil；The distillation vapor outlet of concentration tank is connected with the steam ports that enters of the first condenser, the venthole and vapour of the first condenser
The steam ports that enters of liquid/gas separator is connected, and the liquid outlet of vapour liquid separator is connected with concentration tank, the venthole of vapour liquid separator and second
The steam ports that enters of condenser is connected, and the liquid outlet of the second condenser is connected with submerged soil.
Further, the concentration tank includes concentration tank shell and the alembic in concentration tank shell, alembic
Conduction oil is equipped between concentration tank shell and heats the electric heater of conduction oil；The top of alembic is equipped with exhaust valve, safety
Valve and distillation vapor outlet, the distillation vapor outlet are connected with the steam ports that enters of the first condenser；The bottom of alembic goes out equipped with concentrate
Material mouth.
Preferably, barometer is additionally provided on the alembic.
Further, the second reduced pressure kettle is identical as the first reduced pressure structure of kettle.
Preferably, the adsorbing separation tank includes tank body and is set to the intracorporal macroreticular resin layer of tank, and the bottom of tank body is equipped with
Waste liquid outlet and the eluent export, and waste collection tank is connected at waste liquid outlet, and eluent outlet subtracts with described second
The feeding inlet of concentration kettle is pressed to be connected.
The beneficial effects of the utility model are: issuing ultrasonic wave by ultrasonic extraction tank carries out solvent extraction, ultrasonic wave
Leaf Cells In Ginkgo Biloba L wall is crushed, so that extracting the effective component Rapid contact in solvent and ginkgo leaf, accelerates GINKGO BILOBA EXTRACT and silver
The leaching of apricot lactones is extracted；After filter filters, filtrate is passed through the first reduced pressure kettle and is subtracted liquid after ultrasonic extraction
Pressure concentration, reduced pressure can carry out at a lower temperature, avoid damage to Ingredients Active；Concentrate after concentration is passed through adsorbing separation
In tank, adsorbing separation is carried out, the separating liquid of argentiferous flavone and ginkgo lactones enters the second reduced pressure kettle and depressurized again
Concentration, the concentrate after being concentrated under reduced pressure again, which enters in collecting tank, to be saved；First reduced pressure kettle and the second reduced pressure kettle are equal
Using heat-conducting oil heating alembic, it is heated evenly alembic, avoids directly heating alembic using heat source and causing uneven heating
It is even cause localized hyperthermia to influence extract is active happens；The ginkgo biloba p.e prepared using the present apparatus, GINKGO BILOBA EXTRACT
It is high with the content of ginkgo lactones, and preparation efficiency is high.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the extraction element of GINKGO BILOBA EXTRACT and ginkgo lactones；
Fig. 2 is the structural schematic diagram of the first reduced pressure kettle.
Kettle, 41- is concentrated under reduced pressure in 10- tunnel oven, 11- conveyer belt, 20- crush box, 30- ultrasonic extraction tank, 40- first
First condenser, 42- vapour liquid separator, the second condenser of 43-, 44- submerged soil, 45- conduction oil, 46- electric heater, 47- steam
Evaporate tank, 48- concentration tank shell, 49- barometer, 410- exhaust valve, 411- safety valve, 412- concentrate discharge port, 50- absorption point
From tank, 51- macroreticular resin layer, 52- waste collection tank, 53- eluent entrance, 60- second is concentrated under reduced pressure kettle, 70- collecting tank,
80- filter, 91- circulating pump, 92- booster pump, 93- valve.
Specific embodiment
The embodiments of the present invention are described in detail with reference to the accompanying drawing.
Embodiment 1
As depicted in figs. 1 and 2, the extraction element of a kind of GINKGO BILOBA EXTRACT and ginkgo lactones, including ultrasonic extraction tank 30,
One is concentrated under reduced pressure kettle 40, kettle 60 and collecting tank 70 is concentrated under reduced pressure in adsorbing separation tank 50, second；The liquid discharge of ultrasonic extraction tank 30
Material mouth is connected by filter 80 with the feeding inlet of the first reduced pressure kettle 40, and first is concentrated under reduced pressure the concentrate discharge port of kettle 40
It is connected with the feeding inlet of adsorbing separation tank 50, adsorbing separation tank 50 is exported equipped with eluent, and eluent outlet subtracts with second
The feeding inlet of concentration kettle 60 is pressed to be connected, the concentrate discharge port of the second reduced pressure kettle 60 is connected with the feeding inlet of collecting tank 70.
Wherein, filter 80 and first reduced pressure kettle 40 between, first reduced pressure kettle 40 and adsorbing separation tank 50 between and inhale
Booster pump 92 is equipped between attached knockout drum 50 and the second reduced pressure kettle 60.
When work, dry powdered ginkgo leaf raw material is mixed with water and is added in ultrasonic extraction tank 30, ultrasonic wave is passed through
Extractor 30 issues ultrasonic wave and carries out solvent extraction, and Leaf Cells In Ginkgo Biloba L wall is crushed by ultrasonic wave, so that extracting solvent and ginkgo leaf
In effective component Rapid contact, accelerate the leaching of GINKGO BILOBA EXTRACT and ginkgo lactones to extract；Liquid is by filtering after ultrasonic extraction
After device 80 filters, filtrate is passed through the first reduced pressure kettle 40 and is concentrated under reduced pressure, and reduced pressure can carry out at a lower temperature, keeps away
Exempt to destroy Ingredients Active；Concentrate after concentration is passed through in adsorbing separation tank 50, carries out adsorbing separation, argentiferous flavone and ginkgo
The separating liquid of lactones enters the second reduced pressure kettle 60 and is concentrated under reduced pressure again, and the concentrate after being concentrated under reduced pressure again enters receipts
It is saved in collection tank 70.
In another embodiment, further include tunnel oven 10 and crush box 20, be equipped with conveyer belt 11 in tunnel oven 10,
One end of conveyer belt 11 extends in the feeding inlet of crush box 20, the discharge port of crush box 20 and the ultrasonic extraction tank 30
Feeding inlet is connected.
Ginkgo leaf is automatically fed into crush box 20 by conveyer belt 11, and is dried ginkgo leaf by tunnel oven 10,
Ginkgo leaf after drying, which enters in crush box 20, to be crushed, and is sent directly into ultrasonic extraction tank 30 after crushing, realizes drying
The automatic preparation and feeding of powdered ginkgo leaf raw material.
In another embodiment, the bottom of the filter 80 is equipped with discharge of filter residues mouth, the ultrasonic extraction tank 30
Side wall be equipped with filter residue feeding inlet, the discharge of filter residues mouth of filter 80 and the filter residue feeding inlet of ultrasonic extraction tank 30 pass through circulation
Pump 91 is connected.
The filter residue liquid that filter 80 is separated is sent into ultrasonic extraction tank 30 by circulating pump 91 and carries out ultrasound again
It extracts, increases the recovery rate of GINKGO BILOBA EXTRACT and ginkgo lactones.
In another embodiment, the first reduced pressure kettle 40 includes concentration tank, the first condenser 41, vapor-liquid separation
Device 42, the second condenser 43 and submerged soil 44；The distillation vapor outlet of concentration tank is connected with the steam ports that enters of the first condenser 41, and first
The venthole of condenser 41 is connected with the steam ports that enters of vapour liquid separator 42, and the liquid outlet of vapour liquid separator 42 is connected with concentration tank,
The venthole of vapour liquid separator 42 is connected with the steam ports that enters of the second condenser 43, the liquid outlet and submerged soil 44 of the second condenser 43
It is connected.
Specifically, the concentration tank includes concentration tank shell 48 and the alembic 47 in concentration tank shell 48, distillation
Conduction oil 45 is equipped between tank 47 and concentration tank shell 48 and heats the electric heater 46 of conduction oil；The top of alembic 47 is equipped with
Exhaust valve 410, safety valve 411 and distillation vapor outlet, the distillation vapor outlet are connected with the steam ports that enters of the first condenser 41；Alembic
47 bottom is equipped with concentrate discharge port 412.
In another embodiment, barometer 49 is additionally provided on the alembic 47.
In another embodiment, the second reduced pressure kettle 60 is identical as the first reduced pressure structure of kettle 40.
First reduced pressure kettle 40 is identical with principle with the structure of the second reduced pressure kettle 60, is all made of the heating of conduction oil 45
Alembic 47 is heated evenly alembic 47, avoids being directly heated alembic 47 using heat source and being caused uneven heating is even to lead to office
Portion's high temperature influences that extract is active happens.
In another embodiment, the adsorbing separation tank 50 including tank body and is set to the intracorporal macroreticular resin layer 51 of tank,
The bottom of tank body is equipped with waste liquid outlet and the eluent outlet, is connected with waste collection tank 52, eluent at waste liquid outlet
It exports and is connected with the feeding inlet of the second reduced pressure kettle 60.
Macroreticular resin layer 51 can adsorb the effective components such as GINKGO BILOBA EXTRACT and ginkgo lactones, and waste liquid then enters waste collection tank
52, at regular intervals, eluent is added to adsorbing separation tank 50 by eluent entrance 53, eluent is by macroreticular resin layer 51
The GINKGO BILOBA EXTRACT and ginkgo lactones of absorption elute, and the eluent containing GINKGO BILOBA EXTRACT and ginkgo lactones enters second and kettle is concentrated under reduced pressure
60 are concentrated under reduced pressure again；In elution process, the first valve 93 that 40 lower section of kettle is concentrated under reduced pressure is closed, 52 feeding inlet of waste collection tank
The valve 93 at place is closed.
Specific embodiment of the present utility model above described embodiment only expresses, the description thereof is more specific and detailed,
But it should not be understood as limiting the scope of the patent of the utility model.It should be pointed out that for the common of this field
For technical staff, without departing from the concept of the premise utility, various modifications and improvements can be made, these all belong to
In the protection scope of the utility model.
Claims (8)
1. the extraction element of a kind of GINKGO BILOBA EXTRACT and ginkgo lactones, it is characterised in that: dense including ultrasonic extraction tank, the first decompression
Kettle and collecting tank is concentrated under reduced pressure in contracting kettle, adsorbing separation tank, second；The liquid outlet opening of ultrasonic extraction tank passes through filter and the
One feeding inlet that kettle is concentrated under reduced pressure is connected, and first is concentrated under reduced pressure the feeding inlet phase of the concentrate discharge port and adsorbing separation tank of kettle
Even, adsorbing separation tank is exported equipped with eluent, and eluent outlet is connected with the feeding inlet of the second reduced pressure kettle, and second subtracts
The concentrate discharge port of pressure concentration kettle is connected with the feeding inlet of collecting tank.
2. the extraction element of GINKGO BILOBA EXTRACT according to claim 1 and ginkgo lactones, it is characterised in that: further include that tunnel dries
Case and crush box, tunnel oven is interior to be equipped with conveyer belt, and one end of conveyer belt extends in the feeding inlet of crush box, and crush box goes out
Material mouth is connected with the feeding inlet of the ultrasonic extraction tank.
3. the extraction element of GINKGO BILOBA EXTRACT according to claim 1 and ginkgo lactones, it is characterised in that: the filter
Bottom is equipped with discharge of filter residues mouth, and the side wall of the ultrasonic extraction tank is equipped with filter residue feeding inlet, the discharge of filter residues mouth of filter with
The filter residue feeding inlet of ultrasonic extraction tank is connected by circulating pump.
4. the extraction element of GINKGO BILOBA EXTRACT according to claim 1 and ginkgo lactones, it is characterised in that: first decompression
Concentration kettle includes concentration tank, the first condenser, vapour liquid separator, the second condenser and submerged soil；The distillation vapor outlet of concentration tank
It is connected with the steam ports that enters of the first condenser, the venthole of the first condenser is connected with the steam ports that enters of vapour liquid separator, vapor-liquid separation
The liquid outlet of device is connected with concentration tank, and the venthole of vapour liquid separator is connected with the steam ports that enters of the second condenser, the second condenser
Liquid outlet be connected with submerged soil.
5. according to the extraction element of GINKGO BILOBA EXTRACT as claimed in claim 4 and ginkgo lactones, it is characterised in that: the concentration tank includes
Concentration tank shell and the alembic in concentration tank shell are equipped with conduction oil between alembic and concentration tank shell and heating are led
The electric heater of hot oil；The top of alembic is equipped with exhaust valve, safety valve and distillation vapor outlet, the distillation vapor outlet and first cold
The steam ports that enters of condenser is connected；The bottom of alembic is equipped with concentrate discharge port.
6. according to the extraction element of GINKGO BILOBA EXTRACT and ginkgo lactones described in claim 5, it is characterised in that: on the alembic also
Equipped with barometer.
7. the extraction element of GINKGO BILOBA EXTRACT according to claim 6 and ginkgo lactones, it is characterised in that: second decompression
Concentration kettle is identical as the first reduced pressure structure of kettle.
8. the extraction element of GINKGO BILOBA EXTRACT according to claim 1 and ginkgo lactones, it is characterised in that: the adsorbing separation
Tank includes tank body and is set to the intracorporal macroreticular resin layer of tank, and the bottom of tank body is equipped with waste liquid outlet and the eluent outlet,
Waste collection tank is connected at waste liquid outlet, eluent outlet is connected with the feeding inlet of the second reduced pressure kettle.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201820156190.XU CN208741541U (en) | 2018-01-30 | 2018-01-30 | A kind of extraction element of GINKGO BILOBA EXTRACT and ginkgo lactones |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201820156190.XU CN208741541U (en) | 2018-01-30 | 2018-01-30 | A kind of extraction element of GINKGO BILOBA EXTRACT and ginkgo lactones |
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| CN208741541U true CN208741541U (en) | 2019-04-16 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114159832A (en) * | 2021-12-23 | 2022-03-11 | 上海信谊百路达药业有限公司 | Bilobalide B extraction element |
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2018
- 2018-01-30 CN CN201820156190.XU patent/CN208741541U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114159832A (en) * | 2021-12-23 | 2022-03-11 | 上海信谊百路达药业有限公司 | Bilobalide B extraction element |
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