CN208677647U - Artificial endothelium ophthalmic implant - Google Patents
Artificial endothelium ophthalmic implant Download PDFInfo
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- CN208677647U CN208677647U CN201721211594.6U CN201721211594U CN208677647U CN 208677647 U CN208677647 U CN 208677647U CN 201721211594 U CN201721211594 U CN 201721211594U CN 208677647 U CN208677647 U CN 208677647U
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- endothelium
- ophthalmic implant
- cornea
- implantation material
- temperature
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Abstract
The utility model relates to artificial endothelium ophthalmic implants.Endothelium ophthalmic implant is made of clear, transparent, biocompatible material, and forms overlay film on the side of the implantation material.The overlay film is temperature-responsive polymer, and when temperature of the temperature-responsive polymer being bonded in higher than 32 DEG C is activated.
Description
Technical field
The utility model relates generally to the endothelium ophthalmic implant for the treatment of excess moisture, edemous cornea.
Background technique
The quality of eyes sensory function is heavily dependent on across cornea and passes through lenticular smooth conductive performance, with
And there are also the optical property of these organs and the transparencies and other factors of cornea and eye lens.
The expert of field of ophthalmology understands that Corneal transparency generally depends on the ability that cornea is maintained at dewatering state.Cornea
Dewatering state is influenced by multiple complementary factors, and most important one factor is most deep cellular layer, the endothelium in cornea
Effectively pump is inhaled present in cell.Due to surgical operation, wound, infection or congenital times for easily catching an illness constitution and making endothelial function
What, which is destroyed, leads to all layers that cornea is flow in water beyond certain level, therefore destroys its transparency.The symptom of this situation
It is not only the significant decrease of eyesight, and late symptom will lead to obvious pain and scar, this is a kind of known as bullous
The situation of keratopathy.
Moisture when eyes are opened during another important physiological mechanism for making corneal dehydration is awakening from tear film steams
Hair.Dehydration is operated by moisture from tear film evaporation, this leaves the solution being more concentrated at ocular surface, and tear film is caused to become
More hypertonicity.Hypertonicity tear film drains out more water by the osmosis from cornea itself；It is exactly the opposite in nighttime conditions.
There are some hypertonic solution eye drops to enhance the mechanism in the market, Unfortunately, due to blinking for eyelid, their work
With being of short duration.
Currently, there is no conservative treatment for unsound edematous state.Gradually development comes many surgical operations
It solves the problems, such as this: being known as furrow pits removing corneal transplantation (DLEK) from classical full-thickness corneal transplantation to what is developed recently
With the surgical operation of descemet's membrane removing esoderma cornea transplantation (DSEK).In the latter, base is removed from the cornea of diseased eye
The thin rear portion of matter tissue or lentil (together with descemet's membrane film and attached endothelial cell).It is executed on the eyes of donor
Similar operation is to obtain donor tissue.When donor tissue is placed in recipient eye, suture is not needed by graft
It keeps to host cornea.All these operations have the shortcomings that donor dependence.
Utility model content
The utility model relates to be implanted into artificial endothelium ophthalmic implant to the rear surface of cornea, to treat edemous eye
Eyeball, this will be described in greater detail hereinafter.
Embodiment according to the present utility model provides a kind of endothelium being made of clear, transparent, biocompatible material
Ophthalmic implant.Overlay film is formed on the side of the implantation material.The overlay film is temperature-responsive polymer, and the temperature-responsive is poly-
It is activated when closing the temperature of object being bonded in higher than 32 DEG C.
Before the implantation material is bonded to the rear portion of cornea, a part at cornea rear portion can be removed (although not must
Must remove), such as example, and descemet's membrane film remove together matrix organization thin rear portion and and its endothelium for being attached it is thin
Born of the same parents, or only remove thin rear portion and and its endothelial cell for being attached of descemet's membrane film.
Detailed description of the invention
It makes in conjunction with the accompanying drawings and described in detail below the utility model will be understood and appreciated more fully from, in which:
Fig. 1 and Fig. 2 is forward sight and the side of the artificial endothelium implantation material of embodiment construction according to the present utility model and operation
Depending on rough schematic view.
Specific embodiment
Referring now to fig. 1 and Fig. 2, which illustrate the artificial endothelium eyes of embodiment according to the present utility model construction and operation
With implantation material 100.The implantation material 100 is able to use to substitute the graft from donor in DSEK operation.Implantation material 100 be by
Clearly, the Permanent implantation object of transparent, foldable, biocompatible silicon elastomeric material construction.Implantation material 100 be used as stop water from
The waterproof layer flowed in anterior chamber.Together, cornea aquation and transparent is maintained with from the evaporation of the front surface of cornea.
Implantation material 100 can be constructed by clear, transparent, biocompatible material, such as, but not limited to silicone resin.Implantation material
100 can be therefore e.g. rigid, semi-rigid or folding.
The production of implantation material 100 includes that the parameter provided according to material manufacturer shapes silicone resin raw material using mold,
And overlay film 104 (Fig. 2) then is formed on the side of implantation material 100.Overlay film 104 is preferably pNIPAM (poly- (N- isopropyl third
Acrylamide)) it a kind of-temperature-responsive polymer one and is applied using plasma enhanced chemical vapor deposition (PECVD) technology
It covers over the implant.PECVD be in matrix by film from gaseous deposit to solid process.Chemistry involved in the process
Reaction, the chemical reaction occur after the plasma of reaction gas generates.The temperature sensitive 104 of the pNIPAM is polymerization
Implantation material 100 can be bonded to the rear portion of cornea 102 by binder, the polymer-binder.After being implanted into implantation material 100, glue
Conjunction process is activated when being higher than 32 DEG C of temperature (this is lowest critical solution temperature).The adhesion process is reversible: if
If needing, when being lower than 32 DEG C of temperature, can implantation material be removed and be replaced.
It can take into account the refractive status of patient when designing implantation material 100, so that can be together with alleviating edemas state
Carry out include astigmatic correction refractive correction.
Implantation material 100 can be designed as sizes, such as whole surface from the radius of 1-2mm cornea after covering
6mm or bigger radius, or intermediate arbitrary dimension.
The thickness of implantation material 100 can be from several microns to more than 100 microns.Thickness can be diametrically in entire implantation material
It is identical, or can be different such that at the different piece of entire implantation material diameter with diopter, such as compared to center
For it is relatively thin or opposite at periphery.
It is contemplated that the curvature of the rear surface of cornea 102, better to provide especially in the situation of rigid implants
Bonding.
It, can be from the cornea of patient's eye such as in PLK or DSEL before implantation material 100 is bonded to the rear portion of cornea
Remove thin rear portion or the lentil of matrix organization (together with descemet's membrane film and attached endothelial cell).Alternatively, with
In descemet's membrane removing esoderma cornea transplantation, descemet's membrane film and endothelial cell are only removed.Alternatively, can not have
Implantation material is attached to the endothelium of cornea in the case where removing any rear surface.
In order to prevent due to preventing completely cornea atrophy caused by nutrient material glucose etc., implantation material 100 can shape
It at there is one or more through-holes 106, is flowed in and out with controlling a small amount of fluid from cornea, this will be enough for nutritional support
But not cause corneal edema.
In another embodiment of the utility model, the outer surface of (in face of cornea) implantation material 100 can have hydrophilic
Property, to further enhance the bonding to cornea, therefore produce hydrophobe-hydrophile implantation material.It can consider when designing implantation material
To the refractive status of patient, so that refractive correction can be carried out together with alleviating edemas state.
Claims (5)
1. a kind of ophthalmic implant, characterized by comprising:
Endothelium ophthalmic implant, the endothelium ophthalmic implant are made of clear, transparent, biocompatible material；And it is formed
Overlay film on the side of the implantation material, the overlay film include temperature-responsive polymer, the temperature-responsive polymer
The temperature being bonded in higher than 32 DEG C when be activated.
2. ophthalmic implant according to claim 1, which is characterized in that the temperature-responsive polymer includes pNIPAM
(poly(N-isopropylacrylamide)).
3. ophthalmic implant according to claim 1, which is characterized in that the endothelium ophthalmic implant is rigid.
4. ophthalmic implant according to claim 1, which is characterized in that the endothelium ophthalmic implant is folding.
5. ophthalmic implant according to claim 1, which is characterized in that the endothelium ophthalmic implant be formed with one or
Multiple through-holes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721211594.6U CN208677647U (en) | 2017-09-21 | 2017-09-21 | Artificial endothelium ophthalmic implant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721211594.6U CN208677647U (en) | 2017-09-21 | 2017-09-21 | Artificial endothelium ophthalmic implant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208677647U true CN208677647U (en) | 2019-04-02 |
Family
ID=65874399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721211594.6U Active CN208677647U (en) | 2017-09-21 | 2017-09-21 | Artificial endothelium ophthalmic implant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208677647U (en) |
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2017
- 2017-09-21 CN CN201721211594.6U patent/CN208677647U/en active Active
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