CN208672428U - A kind of circulating tumor cell enriching apparatus - Google Patents
A kind of circulating tumor cell enriching apparatus Download PDFInfo
- Publication number
- CN208672428U CN208672428U CN201821238748.5U CN201821238748U CN208672428U CN 208672428 U CN208672428 U CN 208672428U CN 201821238748 U CN201821238748 U CN 201821238748U CN 208672428 U CN208672428 U CN 208672428U
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- Prior art keywords
- plate
- tumor cell
- circulating tumor
- enriching apparatus
- slot
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Abstract
The utility model relates to lesion detection equipment technical fields, in particular a kind of circulating tumor cell enriching apparatus, including placement plate, it is mounted on the runner plate for placing plate surface and the clamping device that placement plate two sides are set, the inside of placing groove is equipped with magnet, runner plate is internally provided with micro flow channel, clamping device includes fixed cylinder and the retracting cylinder that is arranged in inside fixed cylinder, clamping plate is installed at the top of retracting cylinder, clamping plate is internally provided with clip slot, clip slot is internally provided with several tube seats, the circulating tumor cell enriching apparatus, change the flow of pipeline internal liquid transmission using the tube seat clamping pipeline of different-diameter, retracting cylinder height change is utilized simultaneously, change the flow velocity of pipeline internal liquid transmission；Circulating tumor cell is enriched with by magnet, improves the capture rate of circulating tumor cell.
Description
Technical field
The utility model relates to lesion detection equipment technical field, specially a kind of circulating tumor cell enriching apparatus.
Background technique
With the development of semiconductor microactuator processing technology, micro-fluidic chip has been subjected to the extensive concern miniflow of scientists
Control technology is a kind of systematic science technology manipulated for indivisible (10-9~10-18L) fluid, and micro-fluidic chip is micro-
Fluidics realize main platform and technique device, be mainly characterized by accommodate fluid resulting structure (channel, reaction chamber and
Other certain functional components) it is in one dimension at least micron order scale, minimal amount of CTC in tumour patient blood (is followed
Ring tumour cell) detection when, often using micro-fluidic chip for CTC enrichment.
But existing circulating tumor cell enriching apparatus, flow and flow velocity to blood are difficult to control, and cause circulation swollen
The capture rate of oncocyte is lower.In consideration of it, it is proposed that a kind of circulating tumor cell enriching apparatus.
Utility model content
The purpose of this utility model is to provide a kind of circulating tumor cell enriching apparatus, to solve in above-mentioned background technique
The flow and flow velocity to blood proposed is difficult to control, the problem for causing the capture rate of circulating tumor cell lower.
To achieve the above object, the utility model provides the following technical solutions:
A kind of circulating tumor cell enriching apparatus, including placement plate, be mounted on it is described place plate surface runner plate and
The clamping device of the placement plate two sides is set, and the placement plate is provided with placing groove close to the runner plate side, described
The inside of placing groove is equipped with magnet, and the placing groove side is provided with push rod, and the bottom of the magnet is provided with supporting plate, institute
The one end for stating supporting plate is equipped with pulley, and the placing groove inner wall is provided with inclined plate, the supporting plate close to described pulley one end
The other side be provided with crushing block, the runner plate is internally provided with micro flow channel.
Preferably, the pulley and the inclined plate are slidably connected.
Preferably, the crushing block is trapezoidal.
Preferably, the clamping device includes fixed cylinder and the retracting cylinder that is arranged in inside the fixed cylinder, described solid
Safety barrel surface is provided with regulating tank, and the regulating tank side is provided with several card slots, and the surface of the card slot is provided with limit
Column, the outer wall bottom end of the retracting cylinder are equipped with adjusting rod, and one end of the adjusting rod is equipped with push-and-pull head.
Preferably, the adjusting rod and the regulating tank are slidably connected.
Preferably, clamping plate is installed, the clamping plate is internally provided with clip slot, the clip slot at the top of the retracting cylinder
Several tube seats are internally provided with, one end of the clip slot is provided with outlet slot.
Preferably, the clip slot and the outlet slot are an integral molding structure.
Compared with prior art, the utility model has the beneficial effects that the circulating tumor cell enriching apparatus, straight using difference
The tube seat clamping pipeline of diameter changes the flow of pipeline internal liquid transmission, while utilizing retracting cylinder height change, changes in pipeline
The flow velocity of portion's liquid transmission；Circulating tumor cell is enriched with by magnet, improves the capture rate of circulating tumor cell.
Detailed description of the invention
Fig. 1 is the overall structure diagram of the utility model；
Fig. 2 is the placement plate schematic diagram of internal structure of the utility model；
Fig. 3 is the clamping device Structure explosion diagram of the utility model.
In figure: 1, placement plate；11, placing groove；12, magnet；13, push rod；14, supporting plate；15, pulley；16, inclined plate；17,
Crushing block；2, runner plate；21, micro flow channel；22, pipe joint；3, clamping device；31, fixed cylinder；32, retracting cylinder；33, it adjusts
Save slot；34, card slot；35, limited post；36, adjusting rod；37, head is pushed and pulled；38, clamping plate；39, clip slot；310, tube seat；311, it exports
Slot.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work
Every other embodiment obtained, fall within the protection scope of the utility model.
In the description of the present invention, it should be understood that term " center ", " longitudinal direction ", " transverse direction ", " length ", " width
Degree ", " thickness ", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outside",
The orientation or positional relationship of the instructions such as " clockwise ", " counterclockwise " be based on the orientation or positional relationship shown in the drawings, be only for
Convenient for description the utility model and simplify description, rather than the equipment of indication or suggestion meaning or element must have specifically
Orientation is constructed and operated in a specific orientation, therefore should not be understood as limiting the present invention.
Fig. 1-3 is please referred to, the utility model provides a kind of technical solution:
A kind of circulating tumor cell enriching apparatus as depicted in figs. 1 and 2, including placement plate 1, is mounted on 1 surface of placement plate
Runner plate 2 and the clamping devices 3 of 1 two sides of placement plate is set, placement plate 1 is provided with placing groove close to 2 side of runner plate
11, the inside of placing groove 11 is equipped with magnet 12, and 11 side of placing groove is provided with push rod 13, and the bottom of magnet 12 is provided with support
Plate 14, one end of supporting plate 14 are equipped with pulley 15, and 11 inner wall of placing groove is provided with inclined plate 16, supporting plate close to 15 one end of pulley
14 other side is provided with crushing block 17, and runner plate 2 is internally provided with micro flow channel 21, and pulley 15 and the sliding of inclined plate 16 connect
It connects, crushing block 17 is trapezoidal.
In the present embodiment, the size of placing groove 11 is greater than the size of magnet 12, so that magnet 12 has foot in placing groove 11
Enough space carry out activities.
Further, micro flow channel 21 is in " fish-bone " shape, is returned using " fish-bone " shape ditch in micro flow channel 21, can cause blood
One of liquid is slight to mediate, to enhance the contact of itself and antibody modification surface.
Specifically, push rod 13 is connected with the top slide of crushing block 17, and 11 bottom of the bottom of crushing block 17 and placing groove
It is slidably connected, pushes crushing block 17 that crushing block 17 is slided in placing groove 11 using push rod 13.
In addition, the both ends of micro flow channel 21 are provided with the pipe nozzle 22 for pipeline connection, it is convenient that pipeline is connected
It connects.
Be worth explanation when, runner plate 2 be Wen Hao limited liability company production model WH-Chip micro-fluidic chip,
Its matched circuit and power supply can also be provided by this producer, in addition, being related to runner plate 2 in the utility model is the prior art,
Those skilled in the art may be implemented completely, be not necessarily to superfluous words, and the content of the utility model protection is not related to the knot to runner plate 2 yet
Structure and working principle are improved.
As shown in figure 3, clamping device 3 includes fixed cylinder 31 and the retracting cylinder 32 being arranged in inside fixed cylinder 31, it is fixed
31 surfaces of cylinder are provided with regulating tank 33, and 33 side of regulating tank is provided with several card slots 34, and the surface of card slot 34 is provided with limit
Column 35, the outer wall bottom end of retracting cylinder 32 are equipped with adjusting rod 36, and one end of adjusting rod 36 is equipped with push-and-pull head 37,36 He of adjusting rod
Regulating tank 33 is slidably connected.
In the present embodiment, retracting cylinder 32 and fixed cylinder 31 are slidably connected, convenient to adjust to the height and position of retracting cylinder 32
Section.
Specifically, adjusting rod 36 and card slot 34 are engaged by clamping, facilitate and snap onto adjusting rod 36 in card slot 34 to adjusting rod
36 are limited.
Further, limited post 35 is made of rubber material, using the elasticity of rubber, adjusting rod 36 is facilitated to snap onto card
In slot 34.
As shown in figure 3, the top of retracting cylinder 32 is equipped with clamping plate 38, clamping plate 38 is internally provided with clip slot 39, clip slot 39
Be internally provided with several tube seats 310, one end of clip slot 39 is provided with outlet slot 311, and clip slot 39 and outlet slot 311 are integrated
Molding structure.
In the present embodiment, the use of clamping plate 38 PVC plastic material is made, so that clamping plate 38 has certain elasticity, convenience pair
Liquid pipe is clamped.
Specifically, the diameter of each tube seat 310 is all different, it is stuck in using pipeline in different tube seats 310 and changes pipeline
Diameter, to control the flow rate of liquid inside pipeline.
Inlet tube and outlet tube when in use, are respectively connected to adapter tube by the circulating tumor cell enriching apparatus of the present embodiment
On mouth 22, and the pipeline near pipe nozzle 22 is snapped onto from outlet slot 311 in clamping plate 38, and pipeline is caught in
Into different tube seats 310, change the flow of pipeline internal liquid transmission using the diameter clamping pipeline of different tube seats 310, together
Shi Liyong adjusting rod 36 slides the whole height of adjustment retracting cylinder 32 in regulating tank 33, only needs when being limited by adjusting rod
36 are snapped onto card slot 34 and are supported using limited post 35 to adjusting rod 36 is fixed to 36 side of adjusting rod, are facilitated and are utilized pipeline
The different flow velocitys for changing the transmission of pipeline internal liquid of height；
When work, push rod 13 is pressed downwards, so that push rod 13 is supported to on the bevel edge of crushing block 17, and pushes crushing block 17
It is moved to 12 side of magnet, pulley 15 slides rising on inclined plate 16 at this time, and magnet 12 is stretched out placing groove 11, and blood passes through
Pipe nozzle 22 flows into micro flow channel 21, and the resilience of fishbone ditch enough causes a slight mediation of blood in micro flow channel 21, thus
The contact of itself and antibody modification surface is enhanced, and using there is magnet 12, circulating tumor cell is enriched with, immune magnetic is received
The circulating tumor cell of rice grain capture under the action of a gradient strength, can be dispersed in 2 surface of runner plate of certain area,
Aggregation is avoided, the circulating tumor cell for being dispersed in 2 surface of runner plate can also directly be further analyzed, and raising follows
The capture rate of ring tumour cell.
In above embodiments, the flow that pipeline changes the transmission of pipeline internal liquid is clamped using the tube seat 310 of different-diameter,
32 height change of retracting cylinder is utilized simultaneously, changes the flow velocity of pipeline internal liquid transmission；By magnet 12 to circulating tumor cell
It is enriched with, improves the capture rate of circulating tumor cell.
Basic principles, main features, and advantages of the present invention has been shown and described above.Current row
The technical staff of industry is described in above embodiments and description it should be appreciated that the present utility model is not limited to the above embodiments
Be only the utility model preference, be not intended to limit the utility model, do not departing from the spirit and scope of the utility model
Under the premise of, the utility model also has various changes and improvements, these changes and improvements both fall within claimed it is practical
In novel range.The protection scope of the present invention is defined by the appended claims and their equivalents.
Claims (7)
1. a kind of circulating tumor cell enriching apparatus, including placement plate (1), it is mounted on the runner plate on the placement plate (1) surface
(2) and setting the placement plate (1) two sides clamping device (3), it is characterised in that: the placement plate (1) is close to described
Runner plate (2) side is provided with placing groove (11), and the inside of the placing groove (11) is equipped with magnet (12), the placing groove
(11) side is provided with push rod (13), and the bottom of the magnet (12) is provided with supporting plate (14), and the one of the supporting plate (14)
End is equipped with pulley (15), and placing groove (11) inner wall is provided with inclined plate (16) close to the pulley (15) one end, described to hold
The other side of supporting plate (14) is provided with crushing block (17), and the runner plate (2) is internally provided with micro flow channel (21).
2. circulating tumor cell enriching apparatus according to claim 1, it is characterised in that: the pulley (15) and it is described tiltedly
Plate (16) is slidably connected.
3. circulating tumor cell enriching apparatus according to claim 1, it is characterised in that: the crushing block (17) is in ladder
Shape.
4. circulating tumor cell enriching apparatus according to claim 1, it is characterised in that: the clamping device (3) includes
In the retracting cylinder (32) of the fixed cylinder (31) inside, fixed cylinder (31) surface is provided with tune for fixed cylinder (31) and setting
It saves slot (33), regulating tank (33) side is provided with several card slots (34), and the surface of the card slot (34) is provided with limit
The outer wall bottom end of column (35), the retracting cylinder (32) is equipped with adjusting rod (36), and one end of the adjusting rod (36), which is equipped with, to push away
Pull head (37).
5. circulating tumor cell enriching apparatus according to claim 4, it is characterised in that: the adjusting rod (36) and described
Regulating tank (33) is slidably connected.
6. circulating tumor cell enriching apparatus according to claim 4, it is characterised in that: the top of the retracting cylinder (32)
It is equipped with clamping plate (38), the clamping plate (38) is internally provided with clip slot (39), and being internally provided with for the clip slot (39) is several
One end of a tube seat (310), the clip slot (39) is provided with outlet slot (311).
7. circulating tumor cell enriching apparatus according to claim 6, it is characterised in that: the clip slot (39) and it is described go out
Mouth slot (311) is an integral molding structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821238748.5U CN208672428U (en) | 2018-08-02 | 2018-08-02 | A kind of circulating tumor cell enriching apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821238748.5U CN208672428U (en) | 2018-08-02 | 2018-08-02 | A kind of circulating tumor cell enriching apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208672428U true CN208672428U (en) | 2019-03-29 |
Family
ID=65833128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821238748.5U Expired - Fee Related CN208672428U (en) | 2018-08-02 | 2018-08-02 | A kind of circulating tumor cell enriching apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208672428U (en) |
-
2018
- 2018-08-02 CN CN201821238748.5U patent/CN208672428U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190329 Termination date: 20190802 |
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| CF01 | Termination of patent right due to non-payment of annual fee |