CN208596112U - A kind of ketosis detection device based on incoherent cavity enhanced spectroscopy - Google Patents
A kind of ketosis detection device based on incoherent cavity enhanced spectroscopy Download PDFInfo
- Publication number
- CN208596112U CN208596112U CN201820717030.8U CN201820717030U CN208596112U CN 208596112 U CN208596112 U CN 208596112U CN 201820717030 U CN201820717030 U CN 201820717030U CN 208596112 U CN208596112 U CN 208596112U
- Authority
- CN
- China
- Prior art keywords
- ketosis
- incoherent
- gas
- cavity
- enhanced spectroscopy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The utility model relates to a kind of ketosis detection device based on incoherent cavity enhanced spectroscopy, which includes LED light source, lens, optical filter, diaphragm, optics cavity, gas sampling mouth, exhaust outlet, N2Input port, achromatic lens, optical fiber, spectrometer, signal processing system.Acetone gas concentration is bigger much than the acetone gas concentration in general normal person's exhaled gas in the gas of ketosis patient exhalation, the high detection sensitivity having using incoherent cavity enhanced spectroscopy, the size that can highly precisely detect acetone gas concentration in patient's exhaled gas is diagnosed to be whether patient suffers from ketosis according to the acetone gas concentration in exhaled gas.The utility model high sensitivity, stability are good, easy to use, can not be limited by place, noninvasive, rapidly and accurately detect whether patient suffers from ketosis.
Description
Technical field
The utility model relates to the detection of ketosis, especially a kind of ketosis detection based on incoherent cavity enhanced spectroscopy
Device.
Background technique
Ketoboidies is the metabolite that fatty acid beta oxidation decomposes, including acetoacetate, beta-hydroxy-butanoic acid and acetone.Normal person
There are micro ketoboidies in serum, and ketoboidies is that the energy of many tissues including central nervous system comes during human body is hungry
Source, therefore there is important physiological significance.In the generating process of ketoboidies, insulin and its antagonist hormonal (such as glucagon,
Catecholamine etc.) it adjusts its generation and utilizes, keep its concentration in the normal range.
When insufficient insulin in human body, obstacle occurs for carbohydate metabolism, and glucose in blood cannot make full use of, and fat can quilt
A large amount of decompose generates ketoboidies to provide energy to body, and ketoplasia is caused to increase.In addition, diabetic's (especially 1 type sugar
Urine disease) infection, stress or when deactivated insulin, ketoplasia increases.When the ketoboidies of generation is more than extrahepatic tissue institute
When can utilize, ketosis is generated.
The diagnostic method of ketosis is to carry out laboratory examination to blood and urine at present, by detection blood glucose, blood ketone, glucose in urine,
The indexs such as urine ketone bodies, blood electrolyte and urea nitrogen (BUN), serum pH are made a definite diagnosis.So ketosis inspection needs to acquire patient's
Blood, urine are then sent through inspection center's chemical examination detection, and patient checks, the time of waiting report result is long.
Utility model content
The utility model provides a kind of device based on incoherent cavity enhanced spectroscopy detection ketosis.Using incoherent
Cavity enhanced spectroscopy detects the acetone gas concentration in exhaled gas, can not be limited by place, is noninvasive, quick and precisely
Ground is diagnosed to be whether patient suffers from ketosis.
Technical solution used by the utility model is according to as follows:
Ketosis patient's body ketoplasia increases, and excessive ketoboidies is mainly discharged from kidney, and acetone, can because there is volatility
It is freely discharged from respiratory tract.The acetone gas concentration of ketosis patient exhalation is bigger than normal person, therefore passes through the third of detection exhalation
The concentration of ketone gas can quickly detect whether patient suffers from ketosis.
Through optics cavity, whether there is or not the light intensity variations for absorbing gas and chamber by measurement light source for incoherent cavity enhanced spectroscopy
The reflectivity of mirror determines the concentration of under test gas.Assuming that the effective cavity length of optics cavity is L, the reflectivity of hysteroscope is R, I0With I points
Not Wei intracavitary no under test gas and output intensity when having a under test gas, CiFor the concentration of under test gas, σiFor the suction of under test gas
Receive section.The absorption coefficient of intracavity gas can indicate are as follows:
The concentration C of under test gasiIt is obtained by the method for least square fitting.
The utility model be based on incoherent cavity enhanced spectroscopy detect ketosis, detection device include: LED light source, lens,
Optical filter, diaphragm, optics cavity, gas sampling mouth, exhaust outlet, N2Input port, achromatic lens, optical fiber, spectrometer, signal processing
System.N is first passed through when use2Clean optics cavity；LED light source issues detection light after collimated, filters through optical filter, diaphragm
Stray light is incident to optics cavity.Patient is blown by gas sampling mouth into optics cavity, and detection light is incident to full of sample gas
Optics cavity, the emergent light of optics cavity focuses by achromatic lens, and coupled into optical fibres is transmitted to spectrometer, then connects to spectrometer
The signal arrived after receipts carries out Data Management Analysis, obtains the concentration data of acetone in patient exhalation air.What last basis obtained
Data judge whether patient suffers from ketosis.
Further, above-mentioned LED light source, emits specific central wavelength, and wave-length coverage is [400-460nm].
Further, above-mentioned optics cavity, plano-concave lens of the hysteroscope by two pieces of reflectivity greater than 99.9% form, LED
The light of the 400-460nm wavelength of sending is in the high-reflection region of hysteroscope.
Further, above-mentioned sample gas, the gas breathed out after avoiding movement 2 hours for patient, detection gas are to suffer from
The acetone gas of person's exhalation.
Relative to traditional ketosis detection method, the utility model is detected based on the ketosis of incoherent cavity enhanced spectroscopy
Device, high sensitivity, stability are good, can not be limited by place, is noninvasive, quickly and accurately whether detection patient suffers from ketosis.
In addition, do not need to draw blood for type-1 diabetes mellitus patient, can accomplish in advance, rapid screening.
Detailed description of the invention
Attached drawing 1 is the apparatus structure schematic diagram of the utility model.
Specific embodiment
The present invention will be further described with reference to the accompanying drawings and examples.
Fig. 1 is the apparatus structure schematic diagram of the utility model.It include: LED light source (1), lens (2), optical filter (3), light
Late (4), optics cavity (5), gas sampling mouth (6), exhaust outlet (7), the input port N2 (8), achromatic lens (9), optical fiber (10), light
Spectrometer (11), data processing system (12).
It is as follows to test implementation process:
1, N is opened2Input port (8) inputs N2It cleans optics cavity (5), intracavity gas is discharged from exhaust outlet (7).
2, LED light source (1) emits the detection light of specific central wavelength, after lens (2) collimation, then through optical filter (3) and
After diaphragm (4) eliminates stray light, it is incident to optics cavity (5).
3, patient is blown by gas sampling mouth (6) into optics cavity (5), and detection light is incident to the sample gas of patient
Optics cavity (5).
4, the emergent light of optics cavity (5) focuses through achromatic lens (9) and is coupled into optical fiber (10).
5, optical signal is transmitted to spectrometer (11) through optical fiber (10).
6, the optical signal data received is transmitted to data processing system (12) and handled by spectrometer (11).
Claims (2)
1. a kind of ketosis detection device based on incoherent cavity enhanced spectroscopy, comprising: LED light source (1), filters at lens (2)
Piece (3), diaphragm (4), optics cavity (5), gas sampling mouth (6), exhaust outlet (7), N2Input port (8), achromatic lens (9), light
Fine (10), spectrometer (11), data processing system (12), it is characterised in that: LED light source (1) launches specific central wavelength
Light is detected, patient is continuously blown by gas sampling mouth (6) to optics cavity (5), and the light that optics cavity transmits is through achromatic lens
(9) it is coupled into optical fiber (10), then spectrometer (11) is transmitted to by optical fiber, the signal that spectrometer receives is through data processing system
(12) after analyzing, determine whether patient suffers from ketosis.
2. a kind of ketosis detection device based on incoherent cavity enhanced spectroscopy according to claim 1, feature exist
In: the LED light source (1) emits specific central wavelength, and wave-length coverage is [400-460nm].
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820717030.8U CN208596112U (en) | 2018-05-07 | 2018-05-07 | A kind of ketosis detection device based on incoherent cavity enhanced spectroscopy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820717030.8U CN208596112U (en) | 2018-05-07 | 2018-05-07 | A kind of ketosis detection device based on incoherent cavity enhanced spectroscopy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208596112U true CN208596112U (en) | 2019-03-12 |
Family
ID=65600486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820717030.8U Expired - Fee Related CN208596112U (en) | 2018-05-07 | 2018-05-07 | A kind of ketosis detection device based on incoherent cavity enhanced spectroscopy |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208596112U (en) |
-
2018
- 2018-05-07 CN CN201820717030.8U patent/CN208596112U/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR950014941B1 (en) | Multi-channel molecular gas analysis by laser-activated raman light scattering | |
| US6186958B1 (en) | Breath test analyzer | |
| US20060167348A1 (en) | Method for generating a net analyte signal calibration model and uses thereof | |
| US20090082642A1 (en) | System and method for measurement of biological parameters of a subject | |
| CN101553160A (en) | Non-invasive glucose sensor | |
| EP1460413B1 (en) | Method and apparatus for in vitro or in vivo measurement of a concentration of a component | |
| JP3093871B2 (en) | Optical blood glucose non-destructive measuring device | |
| GB2540982A (en) | Gas phase fluorescence analysis | |
| EP1018938B1 (en) | Breath test analyser | |
| US20150185207A1 (en) | Quantifying Neutrophil Concentration in Blood | |
| JP2005253478A (en) | Hemoglobin analyzer | |
| Oda et al. | Near-infrared time-resolved spectroscopy system for tissue oxygenation monitor | |
| KR20070083854A (en) | Ir spectrographic apparatus and method for diagnosis of disease | |
| CN208596112U (en) | A kind of ketosis detection device based on incoherent cavity enhanced spectroscopy | |
| CN105241828A (en) | CRDS acetone breath analyzer for noninvasively measuring blood ketone body level | |
| Wang et al. | Breath acetone analysis of diabetic dogs using a cavity ringdown breath analyzer | |
| RU2633494C2 (en) | Biosensor for non-invasive optical monitoring of biological tissues pathology | |
| Uystepruyst et al. | Evaluation of accuracy of pulse oximetry in newborn calves | |
| Hampel et al. | Optical measurement of nasal swellings | |
| Gupta et al. | Jaundice prediction through non-invasive techniques: Issues and challenges | |
| US20050154268A1 (en) | Body component concentration measuring apparatus and method | |
| US9173965B2 (en) | Device and method for measuring an analyte under the nail | |
| Namjou et al. | Breath-analysis using mid-infrared tunable laser spectroscopy | |
| CN205759073U (en) | Piercing needle based on Infrared spectra adsorption analytical technology and type blood vessel navigation system | |
| Abbas et al. | Haemoglobin detection in blood by signal to image scanning using Photo-Plethysmo-Graphic-Technique (PPG) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190312 Termination date: 20200507 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |