CN208517317U - A kind of preparation facilities of huperzine - Google Patents
A kind of preparation facilities of huperzine Download PDFInfo
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- CN208517317U CN208517317U CN201820832759.XU CN201820832759U CN208517317U CN 208517317 U CN208517317 U CN 208517317U CN 201820832759 U CN201820832759 U CN 201820832759U CN 208517317 U CN208517317 U CN 208517317U
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- huperzine
- preparation facilities
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Abstract
The utility model provides a kind of huperzine preparation facilities, including shredder assemblies, extraction assembly, extraction module and crystallization component, several Disintegrating knifes are equipped in shredder assemblies, extraction assembly includes sequentially connected extract equipment, centrifuge and first filter, extraction module includes sequentially connected macroreticular resin chromatographic column, vacuum concentration pot and extractor, crystallization component includes sequentially connected dissolving tank, the second filter, crystallization kettle and elution equipment.The utility model is using crushing, extracting, extracting and crystallizing integrated design, and intelligent control, operation is simple, and extraction time is short, at low cost, and the recovery rate of huperzine can be improved.
Description
Technical field
The utility model relates to active components of plants extract equipments, and in particular to a kind of preparation facilities of huperzine.
Background technique
So far, huperzine (Huperzine-A) is extracted in unique pure plant in the world for pre-
Drug that is anti-and treating all kinds of brain memory dysfunctions.As a kind of invertibity acetylcholinesterase (AChE) inhibitor, stone
To severe muscle, powerless, failure of memory and senile dementia have preferable therapeutic effect, and duration of efficacy to China fir alkali
Longer, no serious adverse reaction is the most effective drug of current above-mentioned illness.The main source of huperzine is feet added to a snake by an ignorant artist at present
Shi Shan (serrate clubmoss herb), but content of the huperzine in serrate clubmoss herb is very low, produces the great economic benefit of huperzine of high-purity.
The device that the huperzine preparation process of the prior art uses is expensive, needs manual control, the degree of automation
Low, control is complicated, and operation requirement property is high, and recovery rate is lower, is not suitable for large-scale industrial production.
Summary of the invention
The utility model provides a kind of preparation facilities of huperzine, and its object is to be directed to existing for existing equipment not
Foot, using crushing, extraction, extraction and crystallization integrated design, intelligent control, operation is simple, and extraction time is short, at low cost, and
And the recovery rate of huperzine is improved, realize high-purity.
To achieve the above object, technical solutions of the utility model are as follows:
A kind of huperzine preparation facilities, including shredder assemblies, extraction assembly, extraction module and the crystallization group set gradually
Part, the shredder assemblies are interior to be equipped with several Disintegrating knifes being spirally distributed, and Disintegrating knife is connected with first motor, crushing knife
Fine powder accommodating cavity is equipped with below piece, the extraction assembly includes sequentially connected extract equipment, centrifuge and first filter；Institute
Stating extract equipment includes extractor, ultrasonic generator and the first vacuum pump, and bottom is equipped with primary heater, extractor in extractor
Interior side is equipped with mixing drum, and mixing drum is connected with the second motor, and the other side is equipped with ultrasonator, ultrasonator in extractor
It is connect by energy conduit with ultrasonic generator, extractor is connect with the first vacuum pump；The extraction module includes being sequentially connected
Macroreticular resin chromatographic column, vacuum concentration pot and extractor, vacuum concentration pot includes concentration tank and the second vacuum pump, concentration tank and
The connection of second vacuum pump；The crystallization component includes sequentially connected dissolving tank, the second filter, crystallization kettle and elution equipment,
Eluting equipment includes elution pond.
Preferably, the sieve that mesh number is 20 ~ 40 is equipped between the Disintegrating knife and fine powder accommodating cavity.
Preferably, the centrifuge is disk centrifugal separator.
Preferably, the filter membrane of the first filter is the ceramic membrane that molecule aperture is 50 ~ 100 nm.
Preferably, the filler of the macroreticular resin chromatographic column is LX-20B type macroporous absorbent resin.
Preferably, agitating plate is equipped in the concentration tank, agitating plate is connected with third motor.
Preferably, the concentration tank lower part is equipped with steam jacket.
Preferably, agitating paddle is equipped in the dissolving tank, agitating paddle is connected with the 4th motor.
Preferably, the dissolution bottom of pond portion is equipped with secondary heater.
Preferably, the crystallization kettle lower part is equipped with cooling jacket.
Preferably, the elution equipment is additionally provided with elution liquid storage tank and peristaltic pump, and the leacheate eluted in liquid storage tank passes through
Peristaltic pump is pumped into elution pond.
Above-mentioned technical proposal has the beneficial effect that
1, the device is using crushing, extraction, extraction and crystallization integrated design, intelligent control.
2, operation is simple, and extraction time is short, at low cost, can industrial expanded production.
3, the recovery rate of huperzine is improved, realizes high-purity.
Detailed description of the invention
Fig. 1 is the utility model structure diagram.
Fig. 2 is the shredder assemblies structural schematic diagram of the utility model.
Fig. 3 is the extraction assembly structural schematic diagram of the utility model.
Fig. 4 is the extraction module structural schematic diagram of the utility model.
Fig. 5 is the crystallization component structure diagram of the utility model.
Detailed description of the invention: 1 is shredder assemblies, and 2 be extraction assembly, and 3 be extraction module, and 4 be crystallization component, and 11 be crushing knife
Piece, 12 be first motor, and 13 be sieve, and 14 be fine powder accommodating cavity, and 21 be ultrasonic generator, and 22 be extractor, and 23 is true for first
Sky pump, 24 be centrifuge, and 25 be first filter, and 221 be primary heater, and 222 be mixing drum, and 223 be the second motor, 224
It is energy conduit for ultrasonator, 225,31 be macroreticular resin chromatographic column, and 32 be concentration tank, and 33 be the second vacuum pump, and 34 are
Extractor, 321 be agitating plate, and 322 be steam jacket, and 41 be dissolving tank, and 42 be the second filter, and 43 be crystallization kettle, and 44 be leaching
Wash pool, 45 be peristaltic pump, and 46 be elution liquid storage tank, and 411 be agitating paddle, and 412 be secondary heater, and 431 be cooling jacket.
Specific embodiment
Illustrate the utility model now in conjunction with drawings and examples.
As shown in Figure 1, the utility model discloses a kind of preparation facilities of total curcumin, including shredder assemblies 1, extraction group
Part 2, extraction module 3 and crystallization component 4.
As shown in connection with fig. 2, several Disintegrating knifes 11 being spirally distributed, Disintegrating knife 11 are provided in shredder assemblies 1
It is connected with first motor 12, sieve 13 is equipped with below Disintegrating knife 11, is equipped with fine powder accommodating cavity 14 below sieve 13.The present embodiment
Middle Disintegrating knife 11 is arranged 6 groups, and the mesh number of sieve 13 is 20 mesh.
As shown in connection with fig. 3, extraction assembly 2 includes extract equipment, disk centrifugal separator 24 and first filter 25, the extraction
Equipment includes ultrasonic generator 21, extractor 22 and the first vacuum pump 23, and 22 bottom of extractor is equipped with primary heater 221, mentions
Side in tank 22 is taken to be provided with mixing drum 222, mixing drum 222 is connected with the second motor 223, and the other side is provided in extractor 22
Ultrasonator 224, ultrasonator 224 are connect by energy conduit 225 with ultrasonic generator 21, and extractor 22 and first is very
23 connection of sky pump.In the present embodiment, the ultrafiltration membrane of first filter 25 is the ceramic membrane that molecule aperture is 50 nm.
As shown in connection with fig. 4, extraction module includes macroreticular resin chromatographic column 31, vacuum concentration pot and extractor 34, and vacuum is dense
Contracting tank includes concentration tank 32 and the second vacuum pump 33, and agitating plate 321 is equipped in concentration tank 32, and agitating plate 321 is connected with third electricity
Machine, 32 lower part of concentration tank are equipped with steam jacket 322, and concentration tank 32 and the second vacuum pump 33 connect, in the present embodiment, macroreticular resin
The filler of chromatographic column 31 is LX-20B type macroporous absorbent resin.
As shown in connection with fig. 5, crystallization component include include dissolving tank 41, the second filter 42, crystallization kettle 43 and elution equipment,
Agitating paddle 411 is equipped in dissolving tank 41, agitating paddle 411 is connected with the 4th motor, and 41 bottom of dissolving tank is equipped with secondary heater
412,43 lower part of crystallization kettle is equipped with cooling jacket 431, and elution equipment includes elution pond 44, peristaltic pump 45 and elution liquid storage tank 46.
The Principle of Process of the utility model are as follows:
A. the serrate clubmoss herb dry feedstock of whole strain crushes through Disintegrating knife 11, is sieved through sieve 13, obtains fine powder.
B1. raw material fine powder and pure water are added in extractor, 221 heating temperature of primary heater is to stir at 50 ~ 60 DEG C
It extracts, then 23 vacuum drawing liquid of the first vacuum pump, discards aqueous, retain the raw material after water mentions in extractor.
B2. be added aqueous sulfuric acid in extractor and water mention after raw material stir evenly, pure methanol is then added, first
2 ~ 3 h are stirred, 3 ~ 4 h of ultrasonic extraction is then carried out, last vacuum drawing liquid repeats said extracted step several times, will mention
It takes liquid to merge, obtains combined extract.
B3. combined extract adjusts pH with ammonia spirit, and it is miscellaneous then to remove fine particle therein with disk centrifugal separator 24
Matter obtains centrifugate, and centrifugate is filtered with first filter 25, obtains filtrate.Filtrate asks for a clarification bright.
C1. filtrate is adsorbed to saturation with macroporous adsorption resin chromatography column 31, then first uses pure water rinsing, then elute, received
Collect mixed solvent eluent.
C2. it is concentrated in vacuo mixed solvent eluent in vacuum concentration pot to the 10 ~ 15% of original volume, then uses ammonium hydroxide molten
Liquid adjusts pH, the hybrid extraction solvent extraction of chloroform and normal propyl alcohol is used in extractor 34 several times, by extractant layer
Merge, obtains combining extraction liquid.
C3. vacuum concentration combining extraction liquid obtains crude product to solvent-free.
D1. it wants to dissolve crude product with pure methanol in dissolving tank 41, filters, be then slowly added dropwise pure while hot in the second filter 42
The volumetric concentration of water to methanol is 50 ~ 60 %, stands crystallization in crystallization kettle 43.
D2. crystal is eluted several times with methanol solution in elution pond 44, obtain huperzine finished product.
The purity of the huperzine finished product extracted by utility model device is up to 98 % or more, and extraction efficiency
Height is suitable for industrialized production, practical.
The preferable specific embodiment of the above, only the utility model, any technology people for being familiar with the art
Within the technical scope disclosed by the utility model, any changes or substitutions that can be easily thought of, should all cover in the utility model by member
Within protection scope.
Claims (10)
1. a kind of huperzine preparation facilities, which is characterized in that including shredder assemblies, extraction assembly, the extraction group set gradually
Part and crystallization component, the shredder assemblies are interior to be equipped with several Disintegrating knifes being spirally distributed, and Disintegrating knife is connected with first
Motor, is equipped with fine powder accommodating cavity below Disintegrating knife, and the extraction assembly includes sequentially connected extract equipment, centrifuge and the
One filter；The extract equipment includes extractor, ultrasonic generator and the first vacuum pump, and bottom is equipped with first and adds in extractor
Hot device, side is equipped with mixing drum in extractor, and mixing drum is connected with the second motor, and the other side is equipped with sonic oscillation in extractor
Device, ultrasonator are connect by energy conduit with ultrasonic generator, and extractor is connect with the first vacuum pump；The extraction module
Including sequentially connected macroreticular resin chromatographic column, vacuum concentration pot and extractor, vacuum concentration pot includes that concentration tank and second are true
Sky pump, concentration tank and the connection of the second vacuum pump；The crystallization component includes sequentially connected dissolving tank, the second filter, crystallization
Kettle and elution equipment, elution equipment include elution pond.
2. a kind of huperzine preparation facilities according to claim 1, which is characterized in that the Disintegrating knife and fine powder hold
Set the sieve for being equipped with that mesh number is 20 ~ 40 between chamber.
3. a kind of huperzine preparation facilities according to claim 1, which is characterized in that the filter membrane of the first filter
The ceramic membrane for being 50 ~ 100 nm for molecule aperture.
4. a kind of huperzine preparation facilities according to claim 1, which is characterized in that the centrifuge is disk centrifugal
Machine.
5. a kind of huperzine preparation facilities according to claim 1, which is characterized in that the macroreticular resin chromatographic column
Filler is LX-20B type macroporous absorbent resin.
6. a kind of huperzine preparation facilities according to claim 1, which is characterized in that be equipped with stirring in the concentration tank
Plate, agitating plate are connected with third motor.
7. a kind of huperzine preparation facilities according to claim 1, which is characterized in that the concentration tank lower part, which is equipped with, steams
Vapour collet.
8. a kind of huperzine preparation facilities according to claim 1, which is characterized in that be equipped with stirring in the dissolving tank
Paddle, agitating paddle are connected with the 4th motor；The dissolution bottom of pond portion is equipped with secondary heater.
9. a kind of huperzine preparation facilities according to claim 1, which is characterized in that the crystallization kettle lower part is equipped with cold
But collet.
10. a kind of huperzine preparation facilities according to claim 1, which is characterized in that the elution equipment is additionally provided with
Liquid storage tank and peristaltic pump are eluted, the leacheate eluted in liquid storage tank is pumped into elution pond by peristaltic pump.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820832759.XU CN208517317U (en) | 2018-05-31 | 2018-05-31 | A kind of preparation facilities of huperzine |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820832759.XU CN208517317U (en) | 2018-05-31 | 2018-05-31 | A kind of preparation facilities of huperzine |
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| Publication Number | Publication Date |
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| CN208517317U true CN208517317U (en) | 2019-02-19 |
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| CN201820832759.XU Active CN208517317U (en) | 2018-05-31 | 2018-05-31 | A kind of preparation facilities of huperzine |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110115858A (en) * | 2019-06-26 | 2019-08-13 | 湖南正清制药集团股份有限公司 | Extract the circulation second level cross-flow Centrifugical extraction control system and method for cucoline |
-
2018
- 2018-05-31 CN CN201820832759.XU patent/CN208517317U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110115858A (en) * | 2019-06-26 | 2019-08-13 | 湖南正清制药集团股份有限公司 | Extract the circulation second level cross-flow Centrifugical extraction control system and method for cucoline |
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