CN208511518U - The production line of the dry total mix linkage of whole grain of pelletizing - Google Patents
The production line of the dry total mix linkage of whole grain of pelletizing Download PDFInfo
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- CN208511518U CN208511518U CN201820303121.7U CN201820303121U CN208511518U CN 208511518 U CN208511518 U CN 208511518U CN 201820303121 U CN201820303121 U CN 201820303121U CN 208511518 U CN208511518 U CN 208511518U
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Abstract
The utility model discloses a kind of production lines of the dry total mix linkage of granulation whole grain, are used for the production of oral solid formulation drug formative stage, the production line of the dry total mix linkage of granulation whole grain includes granulator, pelletizing machine drying machine and total mix machine.Granulator is used for pelletizing forming;Pelletizing machine receives the shaped article that the granulator generates, and is subject to shaping to the shaped article, and the pelletizing machine is rotating vibrating type wet process pelletizing machine;Drying machine receives the shaped article after the pelletizing machine shaping, and the shaped article after shaping is dried;Total mix machine receives the shaped article after the drying machine is dry, and the shaped article is sufficiently mixed.The utility model can be realized consecutive production, also eliminates terminal sieving link and intermediate all swivel links, reduces equipment and cost of labor and labor intensity, substantially increase production efficiency.
Description
Technical field
The utility model relates to biological medicine and field of pharmaceutical machinery, in particular to a kind of to be used for oral solid formulation drug
The production line of the dry total mix linkage of the granulation whole grain of formative stage production.
Background technique
Oral solid formulation drug is required to pelletize in the preparations shaping stage, and existing granulation technique usually requires four works
Sequence, process are as follows: granulation → drying → whole grain or sieving → total mix, it is oscillating granulator or rotation that granulation process, which generally selects equipment,
Rotatable granulator;It is hot air circular drying machine or boiling drier or fluid bed dryer or vibration that drying process, which generally selects equipment,
Fluid bed dryer;Whole grain process generally selects swing pelletizing machine or Fastgranulatemachine, and sieving process generally selects equipment for vibration
Dynamic sieving machine;Total mix process generally selects Multidirectional motion pelletizing machine or two-dimentional total mix machine.This four processes are respectively in four rooms
Interior progress, each process at least need two people to operate.
There are main problems to be for the prior art: in granulating stage, regardless of which kind of granulator, principle is all to pass through moist wood
Roller bearing squeezes screen mesh shape into particle, this can inevitably produce some fine powders and strip coarse granule, quick with formula is smashed again after dry
Pelletizing machine is made into suitable little particle, or is selected fine powder and coarse granule with shaking screen, recycling reprocessing.Granulation technique institute in this way
It is lower (about 90~95%) to obtain conforming particle yield, and needs four processes, five machines, 4 rooms, at least 8 people
Operation, not only equipment and high labor cost, large labor intensity are unable to consecutive production, can only produce to discontinuous, production efficiency
It is low, moreover, dry granulation dust-producing amount is big, very big influence is caused to the control of workshop cleanliness, intermediate week swivel link is more, medicine
Object is exposed to that the aerial time is longer, and the probability polluted by air-borne bacterium, settling bacteria is larger, causes the underproof wind of particle
Danger.The dry particl made, which needs manually to be transferred in total mix device, carries out total mix, and labor intensity is very big, and dust-producing amount is also very big, right
Cleanliness control in workshop brings very big pressure.
The information disclosed in the background technology section is intended only to increase the understanding to the general background of the utility model, and
It is not construed as recognizing or implying in any form that information composition is already known to those of ordinary skill in the art existing
Technology.
Utility model content
The purpose of this utility model is to provide a kind of production lines of the dry total mix linkage of granulation whole grain, to overcome existing
Technical equipment and high labor cost, large labor intensity are unable to consecutive production, can only produce to discontinuous, production efficiency is low
Defect.
To achieve the above object, the utility model provides a kind of production line of dry total mix linkage of granulation whole grain, uses
In the production of oral solid formulation drug formative stage, the production line that the dry total mix of whole grain of pelletizing links includes granulator, whole grain
Machine drying machine and total mix machine.Granulator is used for pelletizing forming;Pelletizing machine receives the shaped article that the granulator generates, and right
The shaped article is subject to shaping, and the pelletizing machine is rotating vibrating type wet process pelletizing machine;Drying machine is received through the pelletizing machine shaping
The shaped article afterwards, and the shaped article after shaping is dried;Total mix machine is received through the drying machine
The shaped article after drying, and the shaped article is sufficiently mixed.
Preferably, in above-mentioned technical proposal, pelletizing machine is suitable for tablet, capsule or granule.
Preferably, in above-mentioned technical proposal, drying machine is vibration fluid bed dryer.
Preferably, in above-mentioned technical proposal, granulator is oscillating granulator or rotary granulator.
Preferably, in above-mentioned technical proposal, total mix machine is Multidirectional motion pelletizing machine or two-dimentional total mix machine.
Compared with prior art, the production line of the dry total mix linkage of the granulation whole grain of the utility model has following beneficial to effect
Fruit: the fine powder of granulation production can be recombined into particle by the production line, meanwhile, it is shaken by intergranular active force and sieve
The coarse granule of strip is interrupted adjustment into the particle of suitable size by power, the dry particl qualification rate of granulation up to 100%, without after
Sieve eliminates and needs terminal sieving link originally, greatly reduces the dust pollution of environment in workshop.At the same time, the production
Line also creatively integrates granulator, wet process pelletizing machine, vibration fluid bed dryer, two-dimentional total mix machine, changes original
The discontinuity for carrying out granulation technique realizes the consecutive production of granulation, and entire pelletization by needing at least 8 people to reduce to 3 originally
People, four rooms are reduced to a room and are operated, and are not only reduced equipment and cost of labor and labor intensity, are greatly improved
Production efficiency reduces in three needed originally moreover, entire pelletization material flows in a closed system
Between all swivel links so that drug is exposed to the aerial time and greatly shortens, avoiding drug may be polluted by air-borne bacteria
And underproof risk.
Detailed description of the invention
Fig. 1 is the plane figure of the production line of the dry total mix linkage of granulation whole grain according to the present utility model.
Fig. 2 is the cross-sectional layout figure of the production line of the dry total mix linkage of granulation whole grain according to the present utility model.
Main appended drawing reference explanation:
1- granulator, 2- pelletizing machine, 3- drying machine, 4- total mix machine.
Specific embodiment
With reference to the accompanying drawing, specific embodiment of the present utility model is described in detail, it is to be understood that this is practical
Novel protection scope is not limited by the specific implementation.
Unless otherwise explicitly stated, otherwise in entire disclosure and claims, term " includes " or its change
Changing such as "comprising" or " including " etc. will be understood to comprise stated element or component, and not exclude other members
Part or other component parts.
As shown in Figure 1 to Figure 2, Fig. 1, Fig. 2 are the production lines of the dry total mix linkage of granulation whole grain according to the present utility model
Plane figure and cross-sectional layout figure.According to a kind of dry total mix linkage of granulation whole grain of specific embodiment of the present invention
Production line, be used for the production of oral solid formulation drug formative stage, the production line packet of the dry total mix linkage of granulation whole grain
Include granulator 1, pelletizing machine 2 and drying machine 3 and total mix machine 4.
In some embodiments, granulator 1 can be oscillating granulator 1 or rotary granulator 1 (but this be practical new
Type is not limited thereto), granulator 1 is used for pelletizing forming.Pelletizing machine 2 receives the shaped article that granulator 1 generates, and to molding
Product is subject to shaping.Pelletizing machine 2 is rotating vibrating type wet process pelletizing machine 2, and dry method whole grain after traditional drying is changed to drying by the present embodiment
Preceding wet process whole grain, whole grain equipment also by it is existing smash formula whole grain and be changed to rotating vibrating type wet process pelletizing machine 2 (shaken by Rotary Round
Dynamic sieve is realized).Drying machine 3 receives the shaped article after 2 shaping of pelletizing machine, and place is dried in the shaped article after shaping
Reason, the drying machine 3 of the present embodiment are vibration fluid bed dryer 3.The molding that total mix machine 4 receives after the drying machine 3 is dry produces
Product, and shaped article is sufficiently mixed.Total mix machine 4 is generally Multidirectional motion pelletizing machine or two-dimentional total mix machine, and (but this is practical
It is novel to be not limited thereto).
In some embodiments, the granulation process of the utility model is that granulation → wet process whole grain (is suitable for tablet, capsule
Agent, granule etc.) → drying → total mix, while granulator 1, wet process pelletizing machine 2, vibration fluid bed dryer 3, two-dimentional total mix machine
4 integrate.The advantage of doing so is that consecutive production may be implemented, terminal sieving link and intermediate all changes are also eliminated
Section.
In conclusion compared with prior art, the granulation whole grain of the utility model dries the excellent of the production line of total mix linkage
Point is: the fine powder of granulation production can be recombined into particle by the production line, meanwhile, it is shaken by intergranular active force and sieve
Swing power and the coarse granule of strip interrupted adjustment into the particle of suitable size, the dry particl qualification rate of granulation up to 100%, without after
Sieve eliminates and needs terminal sieving link originally, greatly reduces the dust pollution of environment in workshop.At the same time, the production
Line also creatively integrates granulator, wet process pelletizing machine, vibration fluid bed dryer, two-dimentional total mix machine, changes original
The discontinuity for carrying out granulation technique realizes the consecutive production of granulation, and entire pelletization by needing at least 8 people to reduce to 3 originally
People, four rooms are reduced to a room and are operated, and are not only reduced equipment and cost of labor and labor intensity, are greatly improved
Production efficiency reduces in three needed originally moreover, entire pelletization material flows in a closed system
Between all swivel links so that drug is exposed to the aerial time and greatly shortens, avoiding drug may be polluted by air-borne bacteria
And underproof risk.
The description of the aforementioned specific exemplary embodiment to the utility model is in order to illustrate and illustration purpose.These
Description is not wishing to for the utility model to be limited to disclosed precise forms, and it will be apparent that according to the above instruction, can carry out
It is many to change and change.The purpose of selecting and describing the exemplary embodiment is that explaining the specific principle of the utility model
And its practical application, so that those skilled in the art can be realized and utilize a variety of different examples of the utility model
Property embodiment and various chooses and changes.The scope of the utility model is intended to by claims and its waits similar shapes
Formula is limited.
Claims (5)
1. a kind of production line of the dry total mix linkage of granulation whole grain, is used for the production of oral solid formulation drug formative stage,
It is characterized in that, the production line of the dry total mix linkage of granulation whole grain includes:
Granulator is used for pelletizing forming;
Pelletizing machine receives the shaped article that the granulator generates, and is subject to shaping, the pelletizing machine to the shaped article
For rotating vibrating type wet process pelletizing machine;
Drying machine, receives the shaped article after the pelletizing machine shaping, and by the shaped article after shaping into
Row is dried;And
Total mix machine receives the shaped article after the drying machine is dry, and the shaped article sufficiently mix
It closes.
2. the production line of the dry total mix linkage of granulation whole grain according to claim 1, which is characterized in that the pelletizing machine is suitable
For tablet, capsule or granule.
3. the production line of the dry total mix linkage of granulation whole grain according to claim 1, which is characterized in that the drying machine is
Vibrate fluid bed dryer.
4. the production line of the dry total mix linkage of granulation whole grain according to claim 1, which is characterized in that the granulator is
Oscillating granulator or rotary granulator.
5. the production line of the dry total mix linkage of granulation whole grain according to claim 1, which is characterized in that the total mix machine is
Multidirectional motion pelletizing machine or two-dimentional total mix machine.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201820303121.7U CN208511518U (en) | 2018-03-05 | 2018-03-05 | The production line of the dry total mix linkage of whole grain of pelletizing |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201820303121.7U CN208511518U (en) | 2018-03-05 | 2018-03-05 | The production line of the dry total mix linkage of whole grain of pelletizing |
Publications (1)
Publication Number | Publication Date |
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CN208511518U true CN208511518U (en) | 2019-02-19 |
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CN201820303121.7U Active CN208511518U (en) | 2018-03-05 | 2018-03-05 | The production line of the dry total mix linkage of whole grain of pelletizing |
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CN (1) | CN208511518U (en) |
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2018
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CP03 | Change of name, title or address |
Address after: No.38, Chengnan Road, Quanzhou Town, Quanzhou County, Guilin, Guangxi 541500 Patentee after: GUANGXI CHANFANG PHARMACY Co.,Ltd. Address before: 541599 No.38, Chengnan Road, Quanzhou Town, Quanzhou County, Guilin City, Guangxi Zhuang Autonomous Region Patentee before: GUANGXI CHANFANG PHARMACEUTICAL Co.,Ltd. |