CN208462122U - Cold-plasma jet system based on piezoelectric ceramic transformer - Google Patents
Cold-plasma jet system based on piezoelectric ceramic transformer Download PDFInfo
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Abstract
The utility model discloses the cold-plasma jet system based on piezoelectric ceramic transformer, system mainly includes high voltagehigh frequency power supply device, cold plasma generator, noble gas source, pressure reducing valve, power supply adaptor.The oscillator of high voltagehigh frequency power supply device generates oscillator signal and is transmitted to modulator, the modulator, which is adjusted oscillator signal according to the feedback signal of gear control signal and cold plasma generator working condition and exports to power amplification unit, carries out power amplification processing, and power amplification unit is transmitted to piezoelectric ceramic transformer after carrying out power amplification processing；When modulator adjusts out the resonance frequency identical frequency with piezoelectric ceramic transformer, the piezoelectric ceramic transformer output power to cold plasma generator.The utility model can produce safe and stable cold-plasma jet, the Propiobacterium processing on adolescent skin.
Description
Technical field
The utility model relates to technical field of medical equipment, more particularly to the cold plasma based on piezoelectric ceramic transformer
Body fluidic system.
Background technique
Acne is commonly called as " whelk ", is the common chronic inflammatory skin disease for being apt to occur in puberty hair follicle sebum glandular tissue
Disease, incidence of acne reaches 80% in teenager, and it is excessively active that people are usually mistaken for internal hormone secretion, causes grease
Secretion is excessive, blocked pore.However, it is teen-age patent that acne, which is not, internal propionibacterium acnes under covering are only
Arch-criminal.
It is generally existing to take effect although there is the treatment method of the various whelks such as oral, external application, photodynamic therapy at present
Slowly, the disadvantages of effect is not significant, prolonged application side effect is big, the treatment of acne, which becomes, perplexs teen-age a great problem.Acne
Occur mainly with androgen secretion exception, the mass propagation of propionibacterium acnes, Inflammatory Lesions, not normal and hair follicle sebum is immunized
Gland conduit dyskeratosis etc. is related, and wherein propionibacterium acnes are main pathogenics.Propionibacterium acnes are a kind of grams
Positive bacteria.The propionibacterium acnes for invading sebaceous glands discharge multiple biological activities enzyme, these enzymes can decompose the trigalloyl in sebum
Glycerol generates free fatty acid and low molecular polypeptide.Wherein, free fatty acid can hair follicle stimulating wall cause inflammation, while stimulating hair
Capsule sebaceous gland duct hyperplasia and hyperkeratosis, cause sebum secretion to be obstructed, drainage difficulty, to increase acne incidence；Low point
The releasable hydrolase of sub- polypeptide and inflammation medium, induce local inflammation reaction, and sebaceous glands is destroyed, and form acne.
Atmosphere cold plasma is the recent studies on field that academia rises in recent years, since it is generated under atmospheric pressure,
Gas temperature is low, the active height of particle, arouses widespread concern in the application of various fields especially biomedical aspect.
Research in recent years discovery, cold plasma is close or slightly above room temperature, will not cause apparent heat injury to human body and biological tissue,
Ambient enviroment is not polluted, and can effectively inactivate the pathogenic microorganisms such as various bacteriums, fungi and virus；In mouth infection disease
Disease, facial anti-wrinkle remove scar, blood coagulation hemostasis, wound healing, oncotherapy etc. are promoted to also show good application prospect.
Existing literature report, cold plasma active constituent H2O2Stubbornness is broken through etc. the channel that can be opened by aquaporin
Propionibacterium acnes membranes barriers, kill propionibacterium acnes.Document " Dayun Yan.The Application of
the Cold Plasma-Stimulated Medium in Cancer Treatment.Ph.D.dissertation of
The School of Engineering and Applied Science of the George Washington
University.2016 " proves that when selecting suitable dose, under tissue is acted on by cold plasma, normal cell can
With survival, and cancer cell due to special oxidation mechanism apoptosis, show the bright prospects that cold plasma application has.Document
“Ihor Korolov.The effect of the plasma needle on the human keratinocytes
related to the wound healing process.Journal of PhysicsD:Applied Physics, 49
(2016) 035401 " tissues of the discovery containing propionibacterium acnes can be killed bacillus, while cutin by under cold plasma effect
Cell mobilization degree is unaffected, is conducive to skin repair.In terms for the treatment of for skin disease, cold plasma has been reported for skin
Scorching, wet tinea, psoriasis etc., but to the research of the device in terms of acne treatment, there is not been reported.
Atmosphere cold plasma mainly uses dielectric barrier discharge mode to generate at present, but there are various discharge types
The shortcomings that, such as region of discharge is narrow, electric discharge is uneven, and gas temperature is excessively high, largely limit atmospheric pressure etc.
The application range of gas ions, especially in the medical-therapeutic treatment of human body field for needing low gas temperature, high chemical characteristic.How in atmospheric pressure
Stable cold plasma is generated in open space outside lower electrode gap always to be the hot spot of research.Recent study people
The innovative method for applying strong electrical field using air-flow and on narrow electrode gap of member, can make the plasma generated from
In stomata spray and the open space of non-electrical clearance between poles generate cold plasma so that many novel plasma applications at
It is possible.
Utility model content
In order to solve the deficiencies in the prior art, the utility model provides the cold plasma based on piezoelectric ceramic transformer
Fluidic system applies the method for strong electrical field using inert gas and on narrow electrode gap, make the plasma generated from
It is sprayed in stomata and generates cold-plasma jet in the open space of non-electrical clearance between poles, had the characteristics that portable, easy-operating.
Cold-plasma jet system based on piezoelectric ceramic transformer, including cold plasma generator and be described cold etc.
The high voltagehigh frequency power supply device of ion generator offer voltage source；
The high voltagehigh frequency power supply device includes the oscillator being sequentially connected, modulator, power amplifier and piezoelectric ceramics
Transformer；
The oscillator generates oscillator signal and is simultaneously transmitted to modulator, and the modulator is according to gear control signal and cold etc.
The feedback signal of ion generator working condition is adjusted oscillator signal and exports to power amplification unit progress power and puts
Big processing, power amplification unit are transmitted to piezoelectric ceramic transformer after carrying out power amplification processing；
It is described when the oscillator and the frequency of oscillation of modulator output consistent with the resonance frequency of piezoelectric ceramic transformer
Piezoelectric ceramic transformer output power to cold plasma generator so that cold plasma generator generate stablize, long range etc.
Gas ions jet stream.
Further preferred technical solution, the high voltagehigh frequency power supply device further include that working condition feedback is detected with protection
Device, the working condition feedback and Protective Detector are connected between modulator and plasma generator, plasma are sent out
The working condition of raw device feeds back to the protection that modulator realizes plasma generator.
Further preferred technical solution, oscillator, modulator, the power amplifier of the high voltagehigh frequency power supply device are equal
DC power supply is accessed, the DC power supply is the voltage adapter of 12V.
Further preferred technical solution, the oscillator, modulator, the control list for controlling oscillator and modulator
Member uses monolithic integrated optical circuit.
Further preferred technical solution, the power amplification unit include recommend framework MOSFET power module and with
Connected protection detection circuit constitute.
Further preferred technical solution, the cold plasma generator are fixed cold etc. based on dielectric barrier discharge
Ion generator, including power supply, two electrodes and dielectric, two electrodes are interior electrode and external electrode；
The interior electrode passes through quartz ampoule, and the external electrode and quartz ampoule are concatenated into tubbiness, forms annular electrode；
Connection only has AC power source between the interior electrode and external electrode, interior by adjusting AC supply voltage and frequency
The electric discharge that external electrode generates is the jet model of plasma medium barrier discharge.
Further preferred technical solution, the cold plasma generator are that the hand-held based on cold-plasma jet is cold
Plasma generator, including gun-type shell are provided with outer layer quartz ampoule in the gun-type shell, internal high pressure electrode, outside connect
Ground electrode and gas diversion tube；
The gas diversion tube is arranged in the lower part of gun-type shell and is passed through inert gas, the internal high pressure electrode and height
High intensity light source is pressed to be connected, high voltagehigh frequency power supply device applies high pressure to internal high pressure electrode, and the outer layer quartz ampoule is interior will
Plasma is generated, and sprays to form plasma jet from the jet hole of gun-type shell with air-flow.
Further preferred technical solution, the inert gas are provided by the noble gas source in air accumulator, the storage
Gas tank port is also connected with pressure reducing valve and snorkel, and the snorkel is connected to gas diversion tube.
Disclosed herein as well is a kind of application, the cold-plasma jet system based on piezoelectric ceramic transformer is used for
Adolescent acne treatment.
Disclosed herein as well is the working methods of the cold-plasma jet system based on piezoelectric ceramic transformer, comprising:
Control oscillator generates oscillator signal and is transmitted to modulator；
Modulator according to the feedback signal of gear control signal and cold plasma generator working condition to oscillator signal into
Row, which is adjusted and exported to power amplification unit, carries out power amplification processing, and power amplification unit transmits after carrying out power amplification processing
To piezoelectric ceramic transformer；
Piezoelectric ceramic transformer output power is stablized so that cold plasma generator generates to cold plasma generator, is long
The plasma jet of distance.
Compared with prior art, the utility model has the beneficial effects that
1, the utility model can produce safe and stable cold-plasma jet, the acne bar on adolescent skin
Bacterium processing.
2, the high frequency based on piezoelectric ceramic transformer of the utility model, High Level AC Voltage source module, can be used for it is cold it is equal from
Electronic generator provide power supply so that cold plasma generator occur cold plasma, with miniaturization, safety, low cost it is excellent
Point.
3, the utility model pistol type plasma generator is applied using inert gas and on narrow electrode gap
The method of strong electrical field sprays the plasma generated from stomata and generates cold plasma in the open space of non-electrical clearance between poles
Body jet stream has the characteristics that portable, easy-operating.
4, abundant verifying of the utility model by laboratory sample under a variety of control mode groups, different bacterium amounts, Yi Jizhi
Hope person's human experimentation control verifying, designed cold-plasma jet device have specific therapeutic effect to Propiobacterium,
Popularization and application foreground is wide.
Detailed description of the invention
The accompanying drawings constituting a part of this application is used to provide further understanding of the present application, and the application's shows
Meaning property embodiment and its explanation are not constituted an undue limitation on the present application for explaining the application.
Fig. 1 is existing electromagnetic transformers schematic illustration；
Fig. 2 is piezoelectric ceramic transformer schematic illustration involved in the embodiment of the present application；
Fig. 3 is the embodiment of the present application subbase in the high voltagehigh frequency power supply device schematic illustration of piezoelectric ceramic transformer；
Fig. 4 is application fixed cold plasma generator schematic diagram of the examples of implementation based on dielectric barrier discharge；
Fig. 5 is the embodiment of the present application subbase in the cold plasma generator structure chart of hand-held of fluidics；
Fig. 6 is the embodiment of the present application subbase in the adolescent acne therapeutic device structural representation of cold-plasma jet technology
Figure；
Fig. 7 is the spectrum analysis schematic diagram of the sub- cold-plasma jet of the embodiment of the present application；
In figure, 1, oscillator, 2, modulator, 3, power amplifier, 4, piezoelectric ceramic transformer, 5, plasma generation
Device, 6, control unit, 7, working condition feedback and Protective Detector；
5-1, interior electrode, 5-2, quartz ampoule, 5-3, external electrode, 5-4, AC power source；
5-5, gun-type shell, 5-6, gas diversion tube, 5-7, internal high pressure copper rod, 5-8, outer layer quartz ampoule, 5-9,
External copper pipe grounding electrode, 5-10, high voltagehigh frequency power supply device, 5-11, argon bottle, 5-12, commercial power socket, 5-13, direct current
12v power supply adaptor.
Specific embodiment
It is noted that following detailed description is all illustrative, it is intended to provide further instruction to the application.Unless another
It indicates, all technical and scientific terms used herein has usual with the application person of an ordinary skill in the technical field
The identical meanings of understanding.
It should be noted that term used herein above is merely to describe specific embodiment, and be not intended to restricted root
According to the illustrative embodiments of the application.As used herein, unless the context clearly indicates otherwise, otherwise singular
Also it is intended to include plural form, additionally, it should be understood that, when in the present specification using term "comprising" and/or " packet
Include " when, indicate existing characteristics, step, operation, device, component and/or their combination.
Acne is commonly called as " whelk ", is common to be apt to occur in hebetic pilosebaceous unit chronic inflammatory skin
Disease is easily examined and refractory.Cold plasma sterilization, in terms of application cause everybody concern, utilize cold plasma pair
The device of the treatment of acne is there is not yet report.There are device complexity, volume is big in cold plasma source at present, and expensive wait lacks
Point.The cold plasma source design scheme that cost is low present applicant proposes a kind of light, has made the doctor of a set of man-machine close friend
With device, stable cold plasma can be generated in the open space outside electrode gap under atmospheric pressure, reaching quickly to kill
The design object of propionibacterium acnes in acne.
Mechanical energy can be converted the characteristic of electric energy using piezoelectric ceramics by the application, be made based on the micro- of piezoelectric ceramic transformer
Type high-frequency and high-voltage power supply and plasma generator apply strong electrical field using inert gas and on narrow electrode gap
Method sprays the plasma generated from stomata and generates cold-plasma jet in the open space of non-electrical clearance between poles.
Propionibacterium acnes are handled with this new gas discharge source similar to airflow pattern.
As a result: it is verified by multiple groups, the laboratory sample of different modes and human volunteer's experiment contrast, it is designed
Cold-plasma jet device has specific therapeutic effect to Propiobacterium.
The principle generated about cold plasma: plasma is the 4th state of substance, and gas is heated under normal conditions
To after excessive temperature, when gas molecule is ionized as the mixture of atom, electronics and free radical, referred to as plasma.Deng from
Daughter technology can be used for material surface modifying, plasma scope, ozone generator etc., cut in a organized way in medical application
It removes, sterilize and blood coagulation etc..But due to temperature height, the application in thermally sensitive field is restricted.
According to gas discharge theory, the mean kinetic energy of electronics is proportional to E/p, and wherein E is electric field strength, and p is air pressure.Air pressure
Lower, electron energy is higher, and the collision between gas particle and energy transmission are weaker, may make air themperature under certain condition
Maintain room temperature.Therefore, the device for generating low temperature plasma generally requires vacuum warehouse, but such device is complicated, expensive, volume
Greatly, its application in biomedicine is limited.
If not using vacuum warehouse, problem to be solved has: 1) in open air, should make gas electric with high voltage
From avoiding generating electric arc again, because electric arc is current path, once there is electric current, then can consume electric energy to generating heat；2) energy
Enough continual and steady generation cold plasmas.
According to gas discharge theory, if the air in electric field between electrode is formed electric arc, then can be produced by after high pressure ionization
Raw strong light radiation, discharge current is big, and gas temperature is high.To avoid that arc discharge occurs, it should block electricity between positive and negative electrode
Circulation road stops the electric field between positive and negative electrode using dielectric, and which is referred to as dielectric barrier discharge, can be in atmospheric pressure
Lower generation cold plasma.But the discharge mode is filament-like discharges mode, discharge channel is by filament shape micro discharge channels group
At, discharge space and on the time in irregular distribution, cause its application effect limited.
The research discovery of American scholar 2005 uses pure inert gas, is easy to get to stable cold plasma, while generating
Plasma is rich in chemically reactive substance.But have higher requirement to power parameter, need control voltage 1kV~5kV,
Frequency 1kHz~27MHz, 15~250W of power, in the range of 1~10 liter/min of gas flow rate.
Several kilovolts of high pressures are generated in power output end, it is necessary to utilize step-up transformer.And traditional electromagnetic transformers by
Iron core and its winding composition, boosting no-load voltage ratio is higher, and iron core is bigger, and secondary winding turns are more, and principle is as shown in Figure 1, electromagnetism
Transformer is widely used in electric system, can accomplish the power of thousands of kW or even MW, the advantage for having capacity big, but apparatus body
Product is difficult to light and handy portable.
In view of bio-medical plasma source only needs the power of tens W, therefore small and exquisite electronic device can be sought.?
Field of electronic devices has a kind of acoustics electronic device for being called piezoelectric ceramic transformer, by motorola inc of the U.S.
C.A.Rosen utility model, the alternating voltage of several volts can be raised to several kilovolts or more by it.It utilizes piezoceramic material
Low-voltage electric energy is first converted to mechanical energy by piezoelectric effect, and resonance principle is recycled to be converted to high voltage electric energy.Chinese Enterprises system at present
The piezoelectric ceramic transformer thickness of detector made only has about 3mm, this is the size that electromagnetic transformers are difficult to.For this purpose, choosing
The multilayer piezoelectric ceramic transformer of model MPT3307B70 as plasma electrical source step-up transformer component, having a size of
33 × 8 × 3mm, 12 ± 0.1V of input voltage, rated power 70W, resonance frequency 58.0KHZ, as shown in Figure 2.
It, could the exchange of output amplitude maximum when the input voltage frequency of piezoelectric ceramic transformer is only equal to its resonance frequency
The working efficiency of voltage, piezoelectric ceramic transformer is just in optimum state.For this purpose, devising the height based on piezoelectric ceramic transformer
High intensity light source is pressed, principle is as shown in Figure 3.Including oscillator 1, modulator 2, power amplifier 3, piezoelectric ceramic transformer
4, control unit 6, working condition feedback and protection detection 7.Two terminal outputs of piezoelectric ceramic transformer are connected to plasma
Generator 5 needs to access the voltage of 12V in input terminal in the case of the conventional 50Hz of input voltage selection, 220V electric main
The general power supply adaptor of laptop can be used in adapter, i.e., usually said DC power supply.Oscillator, modulator
And control section is completed using the monolithic integrated optical circuit BA9785A of one piece of ROHM (rom) company, power output is used and is recommended
The MOSFET power module TPC8206 of framework is protected to detect and be completed by integrated circuit 10393, output circuit has piezoelectricity to complete
Ceramic transformer and plasma generator are constituted.Other than plasma generator, this above several part are mounted on one block of electricity
On the plate of road.
High voltagehigh frequency power supply can provide voltage source for plasma generator, however the design of plasma generator is still
In the presence of harsh requirement, it is contemplated that the cold-plasma jet device of temperature can be received in order to generate human skin, needed
Meet easily operated, room temperature, steadily lasting requirement, the factors such as electrode structure, air-flow selection and man-machine close friend are particularly important.
For this purpose, devising fixed and two kinds of cold plasma generator arrangements of hand-held, and comparative analysis is carried out.
The fixed cold plasma generator based on dielectric barrier discharge, medium are disclosed in a kind of examples of implementation of the application
Barrier discharge is the typical way that thermal nonequilibrium cold plasma is generated under atmospheric pressure, and electrode structure mainly has parallel-plate and coaxial
Two kinds of forms of stick cylinder, while at least one electrode is covered by dielectric or dielectric is fixed between electrode.Due to
The effect of dielectric, charge accumulated form reversed space electric field on the surface of dielectric and weaken external application electric field, limit
The growth of discharge current is made, thus the conversion for efficiently avoiding discharging to electric arc or spark discharge.Accordingly, figure is devised
Fixed cold plasma device shown in 4 based on dielectric barrier discharge.The plasma device is by three major part groups
At, respectively AC power source 5-4, two copper electrodes (interior electrode 5-1 and external electrode 5-3) and dielectric.Plasma generator packet
Containing two electrodes.Interior electrode is located in quartz ampoule 5-4, and 2 millimeters of diameter, 300 millimeters of length.External electrode and quartz ampoule are concatenated into bucket
Shape forms 15 millimeters of diameter, the annular electrode of 1.2 millimeters thicks.2 milli of the distance between internal electrode and external electrode bottom
Rice.Porous aluminas is filled between internal and external electrode does dielectric.The device is run in the environment of atmospheric pressure and air, passes through adjusting
Voltage and frequency, the electric discharge of generation are filament-like discharges modes.Filament-like discharges mode is experimentally observed usually by a large amount of thin
Filamentous micro discharge channels composition in discharge space and is in random distribution on the time.Due under atmospheric pressure, the breakdown potential of gas
Very high (such as air is 30k V/cm) is pressed, leads to the gap of dielectric barrier discharge usually relatively narrow (millimeter to centimetres).Such as
The constantly improve applied voltage of fruit is put since discharging gap non-uniform electric may result in electric discharge and be rapidly converted into spark
Electricity, while excessively high voltage will lead to security risk.Therefore for this test, dielectric impedance glow discharge still has one
Fixed limitation.
The cold plasma generator of hand-held based on cold-plasma jet is disclosed in the application another kind examples of implementation,
In order to solve the problems such as narrow based on region of discharge existing for dielectric barrier discharge, electric discharge is uneven, and gas temperature is excessively high, obtain
Stable cold plasma, by consulting pertinent literature, discovery uses pure inert gas, such as helium/argon gas, is easy to get to stable
Glow discharge plasma.Glow discharge mode can effectively fill up the deficiency of filament-like discharges, while the plasma generated
It is generally in cold nonequilibrium condition, is rich in high chemically reactive substance, therefore apply suitable for biomedicine.For this purpose, upper one
On the basis of a experimental rig, a kind of cold plasma generator of hand-held is devised, as shown in figure 5, using air-flow and narrow
The method for applying strong electrical field on small electrode gap, sprays the plasma generated from stomata, in the opening of non-electrical clearance between poles
Space generates cold plasma, obtains the gas discharge power similar to airflow pattern, cold-plasma jet is formed, in order to grasp
Make and uses.The device is connect by a gun-type shell 5-5, outer layer quartz ampoule 5-8, internal high pressure copper rod 5-7, external copper pipe
Ground electrode 5-9, gas diversion tube 5-6 composition, cost of manufacture is lower, and the position and connection relationship between each component are as shown in Figure 6.
In the cold plasma generator of hand-held, gas diversion tube is provided in gun-type shell, the gas diversion tube is used for
By inert gas, the gas diversion tube is vertically connected with outer layer quartz ampoule, and internal high pressure electricity is placed in outer layer quartz ampoule
Pole, the outside of the outer layer quartz ampoule are provided with external grounding electrode, the external grounding electrode and internal high pressure electrode difference
It is connected to high voltagehigh frequency power supply device.
In use, being passed through this kind of inert gas of helium/argon gas (He/Ar), internal high pressure copper rod electricity by the diversion pipe of lower part
Pole applies high pressure, will generate plasma in quartz ampoule, and spray to form plasma jet from jet hole with air-flow.Plasma
Body jet stream can be realized the separation of interelectrode region of discharge and working region spatially, while can be by active material and band
Charged particle is directly transported to the surface of object to be treated and achievees the effect that processing, is suitable for the practical application of this test.
The assembling and test of adolescent acne therapeutic device based on cold-plasma jet technology: in high-frequency and high-voltage power supply
Module occurs, on the basis of cold plasma generator, device also need to increase noble gas source (being provided by argon bottle 5-11),
Pressure reducing valve, direct current 12v power supply adaptor 5-13, snorkel, work are that direct current 12v power supply adaptor 5-13 is inserted in commercial power socket
On, it by mains-supplied, is then assembled, then constitutes the adolescent acne based on cold-plasma jet technology of complete set
Therapeutic device, as shown in Figure 6.
Voltage and frequency test when device works: in order to test the homemade high voltagehigh frequency electricity based on piezoelectric ceramic transformer
Source can reach excitation cold plasma required for voltage and frequency, by oscillograph to device run when working condition into
Measurement is gone.It can be seen that voltage effective value is 2.94kV, frequency 58.14kHz, frequency and voltage value meet excitation plasma
Peak value needed for body.
When carrying out plasma temperature test, high voltagehigh frequency power supply is not only opened, inert gas is also led to.By argon gas
Bottle is opened, and pressure reducing valve is adjusted, and makes argon gas, by quartz ampoule, the mains plug of power supply adaptor to be inserted in 5 liters/min of flow velocity
Enter in the socket on wall, after several seconds, it can be seen that the gas in quartz ampoule gradually starts aura occur, and device produces
Plasma jet, finger, which touches jet stream only, can feel that slight gas is blown, without senses of discomfort such as any heat or electric shocks.
It is tested using infrared radiation thermometer, jet plasma generating device uses the sample after maximum corona treatment
Product temperature degree is able to maintain at 40 DEG C, is truly realized the degree that human skin can be born.
In order to measure the effective component for the cold-plasma jet that the device issues, the light of high voltage laboratory is borrowed
Spectrometer, the jet stream issued when running to device carry out spectrum analysis, and obtained result is as shown in Figure 7, it can be seen that spectral component
With the relative intensity highest of the spectrum in 307 nanometers, 690 nanometers~840 nanometer ranges.Relevant information is consulted[10], it is confirmed as
O、O2*、N、 N2 +, OH isoreactivity particle emission spectrum.
In short, tested after device assembling by supply voltage, frequency, temperature and effective component, learn designed
Cold jet plasma device, the plasma temperature of generation is low, without the senses of discomfort such as any heat or electric shock, effective active composition
It is high.Again due to being using mode of jet, human body is maintained a certain distance with plasma generator, can be in the feelings for ensureing safety
Carry out the test of acne under condition.
Cold-plasma jet antibacterial experiment in vitro: the portable adolescent acne therapeutic device developed is moved to biology
Cold-plasma jet antibacterial experiment in vitro is carried out in laboratory.On superclean bench, 115 DEG C of height of GAM agar medium are improved
It is cooling that 5% sheep blood is added after pressure sterilizing 20min, it is poured in diameter 9cm plate culture dish, propionibacterium acnes is used as with this
The recovery plate of bacterial strain is lyophilized.It is inoculated in plate culture dish using plate streak by bacterial strain is lyophilized, 37 DEG C of Anaerobic culturels
72h.The bacterium colony that picking is individually grown is to sterile saline, and Maxwell turbidimetry for Determination propionibacterium acnes concentration, adjustment bacterium is most
Big concentration is 1.5 × 108CFU/mL (0.5 Maxwell is than turbid unit), and successively it is diluted to 1.5 × 107CFU/mL(5×10-2
A Maxwell is than turbid unit), 1.5 × 106CFU/mL(5×10-3A Maxwell is than turbid unit), 1.5 × 105CFU/mL(5×10-4It is a
Maxwell is than turbid unit), 1.5 × 104CFU/mL(5×10-5A Maxwell is than turbid unit).Using loop-carrier by various concentration bacterium
Liquid is equably coated in different sterile agar cultures, 3 culture mediums of each concentration.With self-control cold-plasma jet dress
Set irradiation culture medium, 2.9kV, 58kHz, argon gas, irradiation spacing is 5cm, and irradiation position is positive middle part 1cm2Position, irradiation
Time 2 minutes, this group was used as experimental group (2. group).Set up 2 groups of controls simultaneously, one group be no irradiation group, i.e. blank control group (1.
Group)；Another group is without ionization argon gas group, argon gas flow velocity, processing spacing and processing time same experimental group (3. group).After having handled,
Sample is placed in 37 DEG C of constant incubator after Anaerobic culturel 24 hours, observes bacterium colony situation in each group culture dish and clapped
According to.The above experiment repeats 3 times.
Cold-plasma jet treats acne human experimentation: 15 being suffered from the patient of bilateral face acnes, with refrigeration certainly
Plasma jet device, which is given, treats, and each irradiation time is 60s, and 1 time a day, continuous 5 days are 1 course for the treatment of, and rest is given after 2 days
Give the 2nd course for the treatment of.This research randomly chooses unilateral face and gives irradiation treatment, and non-irradiated another half of face is then as control.2
Curative effect is assessed after a course for the treatment of.It is assessed with the acne standards of grading reported in document.Before treatment and each treatment is until controlling
The severity for treating end acne can all be scored assessment.
After carrying out cold plasma his jet stream processing propionibacterium acnes culture dish for 24 hours, experimental group is taken out from incubator
With control group sample, by 1. group, 2. group, the 3. sequence organized marshalling from top to bottom.It can be observed that the experiment of middle row
The intermediate 1cm of group (2. group)2Bacterial number significantly reduces at irradiation, and a piece of " blank zone, " range corresponding to blank zone is presented
For low temperature plasma range of exposures；And blank control group (1. group) and without ionization argon gas group (3. group) illuminated place bacterium and week
It encloses compared to no reduction.Illustrate this experimental provision effectively and targeted therapy works well.In the plasma treatment procedure of 2min,
Plasma reactor is in room temperature always, and the temperature of culture dish is substantially not detectable variation, and whole process is complete cold sterilization.
Cold-plasma jet treats Inflammatory Acne: 15 patients with acne treat 2 treatments through cold-plasma jet
Cheng Hou fully recovers 8, effective 5, improves 2, total effective rate 93.3%.All patient's finished chemoradiotherapies, irradiation part is without bright
Aobvious discomfort, some patientss have slight furfur and pigmentation after 3 days, 2 weeks or so can complete incidence graph.Do not occur skin lesion, exudation,
The serious adverse reactions such as ulcer, scar.
Above-described embodiment of the application is applied to for the cold-plasma jet system based on piezoelectric ceramic transformer and controls
Cuo is treated, but be not limited to that above-mentioned application implementation example.
The foregoing is merely preferred embodiment of the present application, are not intended to limit this application, for the skill of this field
For art personnel, various changes and changes are possible in this application.Within the spirit and principles of this application, made any to repair
Change, equivalent replacement, improvement etc., should be included within the scope of protection of this application.
Claims (8)
1. the cold-plasma jet system based on piezoelectric ceramic transformer, characterized in that including cold plasma generator and be
The cold plasma generator provides the high voltagehigh frequency power supply device of voltage source；
The high voltagehigh frequency power supply device includes the oscillator being sequentially connected, modulator, power amplifier and piezoelectric ceramics transformation
Device；
The oscillator generates oscillator signal and is transmitted to modulator, and the modulator is according to gear control signal and cold plasma
The feedback signal of generator working condition is adjusted and exports to power amplification unit to oscillator signal and carries out at power amplification
Reason, power amplification unit are transmitted to piezoelectric ceramic transformer after carrying out power amplification processing；
When the oscillator and the frequency of oscillation of modulator output consistent with the resonance frequency of piezoelectric ceramic transformer, the piezoelectricity
Ceramic transformer output power is to cold plasma generator, so that cold plasma generator generates stable, long range plasma
Body jet stream.
2. the cold-plasma jet system based on piezoelectric ceramic transformer as described in claim 1, characterized in that the height
Pressure high intensity light source further includes working condition feedback and Protective Detector, and the working condition feedback is connect with Protective Detector
Between modulator and plasma generator, by the working condition of plasma generator feed back to modulator realize equity from
The protection of daughter generator.
3. the cold-plasma jet system based on piezoelectric ceramic transformer as described in claim 1, characterized in that the height
Oscillator, modulator, the power amplifier of pressure high intensity light source access DC power supply, and the DC power supply is the electricity of 12V
Press adapter.
4. the cold-plasma jet system based on piezoelectric ceramic transformer as described in claim 1, characterized in that the vibration
Device, modulator, the control unit for controlling oscillator and modulator are swung using monolithic integrated optical circuit.
5. the cold-plasma jet system based on piezoelectric ceramic transformer as described in claim 1, characterized in that the function
Rate amplifying unit includes that the protection detection circuit recommending the MOSFET power module of framework and being attached thereto is constituted.
6. the cold-plasma jet system based on piezoelectric ceramic transformer as described in claim 1, characterized in that described cold
Plasma generator is the fixed cold plasma generator based on dielectric barrier discharge, including power supply, two electrodes and electricity are situated between
Matter, two electrodes are interior electrode and external electrode；
The interior electrode passes through quartz ampoule, and the external electrode and quartz ampoule are concatenated into tubbiness, forms annular electrode；
Connection only has AC power source between the interior electrode and external electrode, by adjusting AC supply voltage and frequency, interior dispatch from foreign news agency
The electric discharge that pole generates is the jet model of plasma medium barrier discharge.
7. the cold-plasma jet system based on piezoelectric ceramic transformer as described in claim 1, characterized in that described cold
Plasma generator is the cold plasma generator of hand-held based on cold-plasma jet, including gun-type shell, the gun-type
Outer layer quartz ampoule, internal high pressure electrode, external grounding electrode and gas diversion tube are provided in shell；
The gas diversion tube is arranged in the lower part of gun-type shell and is passed through inert gas, and the internal high pressure electrode and high pressure are high
Frequency power device is connected, and high voltagehigh frequency power supply device applies high pressure to internal high pressure electrode, and the outer layer quartz ampoule will be interior to be generated
Plasma, and spray to form plasma jet from the jet hole of gun-type shell with air-flow.
8. the cold-plasma jet system based on piezoelectric ceramic transformer as claimed in claim 7, characterized in that described lazy
Property gas by air accumulator noble gas source provide, the air accumulator port is also connected with pressure reducing valve and snorkel, described
Snorkel is connected to gas diversion tube.
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| CN201821241862.3U CN208462122U (en) | 2018-08-02 | 2018-08-02 | Cold-plasma jet system based on piezoelectric ceramic transformer |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108684129A (en) * | 2018-08-02 | 2018-10-19 | 王诗君 | Cold-plasma jet system and method based on piezoelectric ceramic transformer |
| CN110392478A (en) * | 2019-06-28 | 2019-10-29 | 西安交通大学 | A kind of safe fluidic device of double high pressure tricyclic structures of reverse phase |
| CN113141699A (en) * | 2020-01-17 | 2021-07-20 | 飞秒科技有限公司 | Plasma device with replaceable handpiece |
| CN116909203A (en) * | 2023-09-14 | 2023-10-20 | 中国人民解放军海军工程大学 | Interelectrode constant voltage and constant current control device and control method for plasma reactor |
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2018
- 2018-08-02 CN CN201821241862.3U patent/CN208462122U/en active Active
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108684129A (en) * | 2018-08-02 | 2018-10-19 | 王诗君 | Cold-plasma jet system and method based on piezoelectric ceramic transformer |
| CN108684129B (en) * | 2018-08-02 | 2024-05-14 | 王诗君 | Cold plasma jet system and method based on piezoelectric ceramic transformer |
| CN110392478A (en) * | 2019-06-28 | 2019-10-29 | 西安交通大学 | A kind of safe fluidic device of double high pressure tricyclic structures of reverse phase |
| WO2020258606A1 (en) * | 2019-06-28 | 2020-12-30 | 西安交通大学 | Reverse-phase double-high-voltage three-ring-structure safety jet device |
| CN113141699A (en) * | 2020-01-17 | 2021-07-20 | 飞秒科技有限公司 | Plasma device with replaceable handpiece |
| CN116909203A (en) * | 2023-09-14 | 2023-10-20 | 中国人民解放军海军工程大学 | Interelectrode constant voltage and constant current control device and control method for plasma reactor |
| CN116909203B (en) * | 2023-09-14 | 2023-12-26 | 中国人民解放军海军工程大学 | Interelectrode constant voltage and constant current control device and control method for plasma reactor |
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