CN208444493U - A kind of Molecular Simulation Technique drug target and small molecule cooperate dynamic model - Google Patents
A kind of Molecular Simulation Technique drug target and small molecule cooperate dynamic model Download PDFInfo
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- CN208444493U CN208444493U CN201820347517.1U CN201820347517U CN208444493U CN 208444493 U CN208444493 U CN 208444493U CN 201820347517 U CN201820347517 U CN 201820347517U CN 208444493 U CN208444493 U CN 208444493U
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- cabinet
- small molecule
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- wall
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Abstract
The utility model discloses a kind of Molecular Simulation Technique drug targets of field of biotechnology and small molecule to cooperate dynamic model, including cabinet, it is opened up at the top of cabinet fluted, glass plate is placed at the top of groove, the side wall of cabinet is fixedly installed air blower, cabinets cavity side wall offers air inlet, air blower is connected to air inlet, the inner cavity of cabinet is fixedly connected with multiple groups cell model by support column, the outer wall of multiple groups cell model is respectively arranged with protrusion of different shapes, the bottom of cabinet is fixedly installed support base, the utility model drives drug molecule model by wind-force, drug molecule model and cell model are specifically bound by magnet absorption, the mistake specifically bound between Molecular Simulation Technique drug target and small molecule objective can be understood convenient for learning molecule analogue technique drug target and small molecule cooperation convenient for people Journey, be convenient for it is appreciated that, learning knowledge.
Description
Technical field
The utility model relates to field of biotechnology, specially a kind of Molecular Simulation Technique drug target and small molecule cooperate
Dynamic model.
Background technique
Molecular docking, drug screening, the optimization of primer, quantitative structure activity relationship and medicine are carried out by computer simulation means
The drug design methods such as effect group model, can reveal that the mechanism of action of drug and receptor targets, explore the space knot of drug target
Structure, final goal are to design the molecule with can selectively in conjunction with a certain target；It constructed, shown using Molecular Simulation Technique
Show, analyze and store complicated molecular model, observe the structure feature of Medicine small molecule in three dimensions, changes small molecule shape
Shape and orientation, and small molecule and the mechanism of action by macromolecular target spot are detected, judge Medicine small molecule in conjunction with receptor macromolecular
Possibility active site, moreover it is possible to the structure of Medicine small molecule is modified, propose improve drug pharmacodynamics and kinetics
The scheme of matter realizes intuitive, visual drug molecule design in " three-dimensional space ".Artificial intelligence utilizes big data and machine
Learning method goes out up to a million kinds of small molecule chemical combination relevant to particular target according to existing medicament research and development data Automated Design
Object, and compound is screened according to other conditions such as drug effect, selectivity, ADME.The compound then screened can quilt
It synthesizes and carries out experiment detection, then experimental data can be fed back in AI system for improving the choosing of next round compound
It selects.
And during learning molecule analogue technique drug target and small molecule cooperate, it can not find a kind of people on the market
The dynamic model for Molecular Simulation Technique drug target and the small molecule cooperation directly observed, objective can understand molecule convenient for people
The process specifically bound between analogue technique drug target and small molecule, be convenient for it is appreciated that, learning knowledge.
Based on this, the utility model devises a kind of Molecular Simulation Technique drug target and small molecule cooperates dynamic model,
To solve the above problems.
Utility model content
The purpose of this utility model is to provide a kind of Molecular Simulation Technique drug targets and small molecule to cooperate dynamic model,
With solve it is mentioned above in the background art and during learning molecule analogue technique drug target and small molecule cooperate, city
The dynamic model that can not find a kind of the Molecular Simulation Technique drug target that people directly observe and small molecule cooperation on face, is convenient for people
Objective can understand the process specifically bound between Molecular Simulation Technique drug target and small molecule, be convenient for it is appreciated that,
The problem of learning knowledge.
To achieve the above object, the utility model provides the following technical solutions: a kind of Molecular Simulation Technique drug target with
Small molecule cooperates dynamic model, including cabinet, opens up fluted at the top of the cabinet, is placed with glass at the top of the groove
Plate, the side wall of the cabinet are fixedly installed air blower, and the cabinets cavity side wall offers air inlet, the air blower with into
Air port connection, the inner cavity of the cabinet are fixedly connected with multiple groups cell model by support column, the multiple groups cell model outside
Wall is respectively arranged with protrusion of different shapes, and the bottom of the cabinet is fixedly installed support base, and the side wall of the cabinet is fixed
It is connected with fixes sleeve, the fixes sleeve inner cavity is arranged with motion bar, and one end of the motion bar is fixedly installed pushing plate,
The other end of the motion bar is provided with handle, is fixedly installed feeding opening at the top of the fixes sleeve, wherein described in one group
The outer wall of cell model is fixedly installed triangular hill, the outer wall of the triangular hill be fixedly uniformly arranged with two groups it is permanent
Magnet, the cabinets cavity activity are placed with multiple groups drug molecule model, and the drug molecule model includes mounting base, the peace
One end of dress seat is fixedly installed V type link block, and the inner wall fixation of the V-type link block offers two groups of rectangular channels, the square
Shape slot is identical as permanent magnet size, and is cooperated by magnetic.
Preferably, the upper lower wall of the mounting base is fixedly installed rotation axis, and the outer wall of the rotation axis is arranged with wing plate,
The side wall of the wing plate is provided with air blast slot.
Preferably, the cell model is at least provided with nine groups.
Preferably, the outer wall of the handle is evenly arranged with anti-skid chequer.
Preferably, cover board is rotatably connected at the top of the feeding opening.
Compared with prior art, the utility model has the beneficial effects that setting of the utility model by feeding opening, it will be more
Group drug molecule model pours into feeding opening, by pushing handle manually, interior drug molecule model is promoted cabinets cavity, is led to
It crosses air blower and generates wind, entered in cabinet by air inlet, drug molecule model is rolled by wind-force, is rotated in cabinet,
By the magnetism cooperation between permanent magnet and V-type link block, drug molecule model is enable to be combined with protrusion, without tying with protrusion
It closes, realizes specific binding, wind-force is received convenient for rousing wind into air blast slot convenient for wing plate, by medicine by the setting of air blast slot
Object molecular model is rolled with the wind, is watched by the setting of groove convenient for putting at the top of the box body glass plate convenient for people, this
Drug molecule model is driven by wind-force using novel, drug molecule model and cell model specificity knot are made by magnet absorption
It closes, objective can understand Molecular Simulation Technique medicine convenient for learning molecule analogue technique drug target and small molecule cooperation convenient for people
The process specifically bound between object target spot and small molecule, be convenient for it is appreciated that, learning knowledge.
Detailed description of the invention
In order to illustrate more clearly of the technical solution of the utility model embodiment, make required for being described below to embodiment
Attached drawing is briefly described, it should be apparent that, the drawings in the following description are merely some embodiments of the present invention,
For those of ordinary skill in the art, without creative efforts, it can also be obtained according to these attached drawings
Other attached drawings.
Fig. 1 is the utility model main perspective structural schematic diagram；
Fig. 2 is the utility model side view corner structure schematic diagram；
Fig. 3 is the utility model drug molecule model depression angle structural schematic diagram；
Fig. 4 is the utility model drug molecule model side view corner structure schematic diagram.
In attached drawing, parts list represented by the reference numerals are as follows:
1- cabinet, 2- groove, 3- air blower, 4- air inlet, 5- cell model, 6- protrusion, 7- support base, 8- fixing sleeve
Cylinder, 9- motion bar, 10- handle, 11- feeding opening, 12- triangular hill, 13- permanent magnet, 14- mounting base, the connection of 15-V type
Block, 16- rotation axis, 17- wing plate, 18- air blast slot, 19- cover board.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without creative efforts
All other embodiment obtained, fall within the protection scope of the utility model.
Please refer to Fig. 1-3, the utility model provides a kind of technical solution: a kind of Molecular Simulation Technique drug target with small point
Son cooperation dynamic model, including cabinet 1, the top of cabinet 1 open up fluted 2, and the top of groove 2 is placed with glass plate, cabinet
1 side wall is fixedly installed air blower 3, and 1 intracavity sidewall of cabinet offers air inlet 4, and air blower 3 is connected to air inlet 4, cabinet
1 inner cavity is fixedly connected with multiple groups cell model 5 by support column, and the outer wall of multiple groups cell model 5 is respectively arranged with not similar shape
The protrusion 6 of shape, the bottom of cabinet 1 are fixedly installed support base 7, and the side wall of cabinet 1 is fixedly connected with fixes sleeve 8, fixing sleeve
8 inner cavities of cylinder are arranged with motion bar 9, and one end of motion bar 9 is fixedly installed pushing plate, and the other end of motion bar 9 is provided with handle
10, the top of fixes sleeve 8 is fixedly installed feeding opening 11, wherein the outer wall of one group of cell model 5 is fixedly installed triangle
Protrusion 12, the outer wall of triangular hill 12 is fixedly uniformly arranged with two group permanent-magnets 13, and 1 inner cavity activity of cabinet is placed with multiple groups
Drug molecule model, drug molecule model include mounting base 14, and one end of mounting base 14 is fixedly installed V-type link block 15, V-type
The inner wall fixation of link block 15 offers two groups of rectangular channels, and rectangular channel is identical as 13 size of permanent magnet, and by magnetic mutual
Cooperation.
Wherein, the upper lower wall of mounting base 14 is fixedly installed rotation axis 16, and the outer wall of rotation axis 16 is arranged with wing plate 17, the wing
The side wall of plate 17 is provided with air blast slot 18, and at least provided with nine groups, the outer wall of handle 10 is evenly arranged with anti-skidding cell model 5
Line, the top of feeding opening 11 are rotatably connected to cover board 19.
One concrete application of the present embodiment are as follows: the utility model passes through the setting of feeding opening 11, by multiple groups drug molecule
Model pours into feeding opening 11, by pushing handle 10 manually, the drug molecule model in 9 is promoted 1 inner cavity of cabinet, passes through drum
Blower 3 generates wind, is entered in cabinet 1 by air inlet 4, rolls drug molecule model by wind-force, rotate in cabinet 1,
By the magnetism cooperation between permanent magnet 13 and V-type link block 15, drug molecule model is enable to be combined with triangular hill 12,
Without being combined with protrusion 6, specific binding is realized, be convenient for by the setting of air blast slot 18 convenient for rousing wind into air blast slot 18
Wing plate 17 receives wind-force, and drug molecule model is rolled with the wind, by the setting of groove 2, convenient for glass plate is placed on cabinet 1
Top is watched convenient for people, and the use of the new type drives drug molecule model by wind-force, makes drug molecule mould by magnet absorption
Type and cell model 5 are specifically bound, can convenient for people convenient for learning molecule analogue technique drug target and small molecule cooperation
It is objective to understand the process specifically bound between Molecular Simulation Technique drug target and small molecule, be convenient for it is appreciated that, study is known
Know.
In the description of this specification, the description of reference term " one embodiment ", " example ", " specific example " etc. means
Particular features, structures, materials, or characteristics described in conjunction with this embodiment or example are contained at least one of the utility model
In embodiment or example.In the present specification, schematic expression of the above terms be not necessarily referring to identical embodiment or
Example.Moreover, particular features, structures, materials, or characteristics described can be in any one or more embodiment or examples
In can be combined in any suitable manner.
The preferred embodiment in the utility model disclosed above is only intended to help to illustrate the utility model.Preferred embodiment is simultaneously
There is no the details that detailed descriptionthe is all, also not limiting the utility model is only the specific embodiment.Obviously, according to this theory
The content of bright book can make many modifications and variations.These embodiments are chosen and specifically described to this specification, is in order to preferably
The principles of the present invention and practical application are explained, so that skilled artisan be enable to better understand and utilize this
Utility model.The utility model is limited only by the claims and their full scope and equivalents.
Claims (5)
1. a kind of Molecular Simulation Technique drug target and small molecule cooperate dynamic model, including cabinet (1), it is characterised in that: institute
It states and is opened up at the top of cabinet (1) fluted (2), glass plate, the side wall of the cabinet (1) are placed at the top of the groove (2)
It is fixedly installed air blower (3), cabinet (1) intracavity sidewall offers air inlet (4), the air blower (3) and air inlet
(4) it is connected to, the inner cavity of the cabinet (1) is fixedly connected with multiple groups cell model (5) by support column, the multiple groups cell model
(5) outer wall is respectively arranged with raised (6) of different shapes, and the bottom of the cabinet (1) is fixedly installed support base (7), institute
The side wall for stating cabinet (1) is fixedly connected with fixes sleeve (8), and fixes sleeve (8) inner cavity is arranged with motion bar (9), described
One end of motion bar (9) is fixedly installed pushing plate, and the other end of the motion bar (9) is provided with handle (10), the fixation
Feeding opening (11) are fixedly installed at the top of sleeve (8), wherein the outer wall of cell model described in one group (5) is fixedly installed triangle
Shape protrusion (12), the outer wall of the triangular hill (12) are fixedly uniformly arranged with two group permanent-magnets (13), the cabinet (1)
Inner cavity activity is placed with multiple groups drug molecule model, and the drug molecule model includes mounting base (14), the mounting base (14)
One end be fixedly installed V-type link block (15), the fixation of the inner wall of the V-type link block (15) offers two groups of rectangular channels, institute
It is identical as permanent magnet (13) size to state rectangular channel, and is cooperated by magnetic.
2. a kind of Molecular Simulation Technique drug target according to claim 1 and small molecule cooperate dynamic model, feature
Be: the upper lower wall of the mounting base (14) is fixedly installed rotation axis (16), and the outer wall of the rotation axis (16) is arranged with the wing
The side wall of plate (17), the wing plate (17) is provided with air blast slot (18).
3. a kind of Molecular Simulation Technique drug target according to claim 1 and small molecule cooperate dynamic model, feature
Be: the cell model (5) is at least provided with nine groups.
4. a kind of Molecular Simulation Technique drug target according to claim 1 and small molecule cooperate dynamic model, feature
Be: the outer wall of the handle (10) is evenly arranged with anti-skid chequer.
5. a kind of Molecular Simulation Technique drug target according to claim 1 and small molecule cooperate dynamic model, feature
It is: is rotatably connected to cover board (19) at the top of the feeding opening (11).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820347517.1U CN208444493U (en) | 2018-03-14 | 2018-03-14 | A kind of Molecular Simulation Technique drug target and small molecule cooperate dynamic model |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820347517.1U CN208444493U (en) | 2018-03-14 | 2018-03-14 | A kind of Molecular Simulation Technique drug target and small molecule cooperate dynamic model |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208444493U true CN208444493U (en) | 2019-01-29 |
Family
ID=65092895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820347517.1U Expired - Fee Related CN208444493U (en) | 2018-03-14 | 2018-03-14 | A kind of Molecular Simulation Technique drug target and small molecule cooperate dynamic model |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208444493U (en) |
-
2018
- 2018-03-14 CN CN201820347517.1U patent/CN208444493U/en not_active Expired - Fee Related
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190129 Termination date: 20200314 |
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| CF01 | Termination of patent right due to non-payment of annual fee |