CN208305807U - Lumen organization's construct printing equipment and 3D biometric print machine - Google Patents

Abstract

The utility model relates to a kind of lumen organization's construct printing equipments and 3D biometric print machine.Wherein, lumen organization's construct printing equipment includes nozzle component and biometric print platform, and biological construct is printed upon on the inner surface of lumen organization by nozzle component by biometric print platform.Lumen organization's construct printing equipment passes through setting nozzle component and biometric print platform, biological construct is printed upon on the inner surface of lumen organization by nozzle component by biometric print platform, appearance of the lumen organization after long-time is implanted into the problems such as the generation again and lumen restenosis of thrombus is avoided, the biological reliability of lumen organization is improved.

Description

Lumen organization's construct printing equipment and 3D biometric print machine

Technical field

The utility model relates to 3D biometric print technical field more particularly to a kind of lumen organization's construct printing equipment and 3D biometric print machine.

Background technique

In the prior art, common artificial blood vessel is by polymer fiber (such as nylon, terylene), silk or varicosity poly- four Made of vinyl fluoride.When carrying out vasotransplantation, lesion or impaired blood vessel are replaced using complete artificial blood vessel. Although being replaced using this artificial blood vessel to lesion or damaged blood vessels and clinically having obtained huge effect, its still face It faces danger or disaster to solve the problems, such as, the appearance occurred again with lumen restenosis including the thrombus after long-time is implanted into.Lead to these The basic reason of problem is, complete endothelial layer is lacked on the inner surface of this artificial blood vessel.

Further, since artificial blood vessel radially can hardly deformation occurs, the prior art can not be by outside to artificial Blood vessel, which carries out compression, makes biological brick substantially uniformity, complete and be entirely fitted on artificial blood vessel's inner wall.

Utility model content

To overcome the above technological deficiency, the technical issues of the utility model solves, is to provide a kind of lumen organization's construct and beats Printing equipment set with 3D biometric print machine, can be improved the biological reliability of lumen organization.

In order to solve the above technical problems, the utility model provides a kind of lumen organization's construct printing equipment comprising Biological construct is printed upon in lumen organization by nozzle component and biometric print platform, nozzle component by biometric print platform On surface.

Further, nozzle component includes medical adhesive spray head, and medical adhesive spray head includes medical adhesive container and medical adhesive nozzle, Medical adhesive container top is connect by gas circuit with air pump, and vacuum generator is equipped in gas circuit, for right under non-printing status Medical adhesive container generates negative pressure.

Further, nozzle component includes biological brick spray head, and biological brick spray head includes screw pump and biological brick nozzle.

Further, screw pump includes for squeezing out the biological brick for entering screw pump to the helical stator of biological brick nozzle And helical rotor, helical stator are made of silica gel material.

Further, the printing outlet end of biological brick nozzle has chamfering, the fillet surface of chamfering and beating for biological brick nozzle The angle for printing off the center line of mouth is 10 °~30 °.

Further, angle is 20 °.

Further, roughness Ra≤0.4 of the printing outlet end outer surface of biological brick nozzle.

Further, biometric print platform include platform base, rotating part and can the mobile docking section in relative rotation portion, rotation Transfer part includes swingle, and for carrying biological brick and medical adhesive to form biological construct, docking section includes hollow stem, hollow stem Outer wall for carrying lumen organization.

Further, the outer wall of swingle is covered with elastic membrane.

Further, the inner hollow of swingle is provided on the outer wall of swingle and is connected with inside venthole, for will The air of the inside of swingle is discharged to prop up elastic membrane.

Further, the inside of swingle is additionally provided with heating member.

Further, heating member includes spaced bringing-up section and spacer, and bringing-up section surface wrap has resistance wire, adds The diameter of hot arc is less than the diameter of spacer.

Further, heating member is equipped with temperature detection part close to one end of docking section, for detecting the temperature of heating member.

Further, biometric print platform further includes holding mechanism, for holding lumen organization so that it is de- from hollow stem From and be socketed biological construct.

Further, holding mechanism includes relatively-movable first holding block and second and holding block.

Further, holding mechanism further includes retaining part, for acting on the tail end of lumen organization so that it is from hollow stem It is detached from.

Further, retaining part cooperation is equipped with the Non-return ring for acting on the tail end of lumen organization.

Further, holding mechanism further includes being arranged in first and holding block and second to hold the limited block of block bottom, is used for To first hold block and second hold block relative movement limit so that first holds block and second and holds block and lumen group The outer wall knitted is tangent.

Further, holding mechanism further includes being arranged in first and holding block and second to hold the support platform of block bottom, is used In support lumen organization.

It further, further include the optic probe that can be moved inside swingle, for detecting biological construct inner wall Flatness, swingle are made of clear material.

Further, optic probe is movably disposed in swingle or hollow stem.

Further, optic probe is fixed in hollow stem.

Further, further include the liquid storage tank being arranged in below swingle, be detached from and fall from holding mechanism for accepting Biometric print construct.

The utility model additionally provides a kind of 3D biometric print machine comprising above-mentioned lumen organization's construct prints dress It sets.

As a result, based on the above-mentioned technical proposal, the utility model lumen organization construct printing equipment passes through setting nozzle group Biological construct is printed upon the inner surface of lumen organization by biometric print platform by part and biometric print platform, nozzle component On, appearance of the lumen organization after long-time is implanted into the problems such as the generation again and lumen restenosis of thrombus is avoided, pipe is improved The biological reliability of cavity tissue.3D biometric print machine provided by the utility model also correspondingly has above-mentioned advantageous effects.

Detailed description of the invention

Attached drawing described herein is used to provide a further understanding of the present invention, and is constituted part of this application, The illustrative embodiments and their description of the utility model are only used for explaining the utility model, do not constitute to the utility model not Work as restriction.In the accompanying drawings:

Fig. 1 is the overall structure diagram of the utility model lumen organization construct printing equipment embodiment；

Fig. 2 is the overall structure diagram of nozzle component in the utility model lumen organization construct printing equipment；

Fig. 3 is the schematic diagram of internal structure of nozzle component in the utility model lumen organization construct printing equipment；

Fig. 4 is the schematic diagram of the section structure of screw pump embodiment in the utility model lumen organization construct printing equipment；

Fig. 5 is the cross-section structure signal of biological brick nozzle embodiments in the utility model lumen organization construct printing equipment Figure；

Fig. 6 is the partial enlargement diagram of circled portion in Fig. 5；

Fig. 7 is the overall structure diagram of biometric print platform in the utility model lumen organization construct printing equipment；

Fig. 8 is the partial structural diagram of biometric print platform in the utility model lumen organization construct printing equipment；

Fig. 9 is the structural schematic diagram of swingle in the utility model lumen organization construct printing equipment；

Figure 10 is the structural schematic diagram of heating member in the utility model lumen organization construct printing equipment；

Figure 11 is that the structure inside swingle is arranged in heating member in the utility model lumen organization construct printing equipment Schematic diagram；

Figure 12 is the schematic diagram of internal structure of rotating part in the utility model lumen organization construct printing equipment；

Figure 13 is the structural representation that mechanism first embodiment is held in the utility model lumen organization construct printing equipment Figure；

Figure 14 is to hold mechanism first embodiment at another visual angle in the utility model lumen organization construct printing equipment Structural schematic diagram；

Figure 15 is the structural representation that mechanism second embodiment is held in the utility model lumen organization construct printing equipment Figure；

Figure 16 is to hold mechanism second embodiment in the utility model lumen organization construct printing equipment to hold lumen Structural schematic diagram when tissue.

Each appended drawing reference respectively represents:

1, nozzle component；11, medical adhesive spray head；111, medical adhesive container；112, medical adhesive nozzle；113, medical adhesive is living Plug；12, biological brick spray head；121, screw pump；1211, helical stator；1212, helical rotor；1213, inlet connecting；122, Biological brick nozzle；123, insulation cladding；124, biological brick piston；125, biological brick container；126, semiconductor coldplate；127, even Adapter tube；128, biological brick entrance；129, muff mouth；2, biometric print platform；21, rotating part；211, swingle；212, it heats Part；2121, bringing-up section；2122, link slot；2123, spacer；213, temperature detection part；214, sealing ring；22, mechanism is held； 221,221 ', first holds block；222,222 ', second holds block；223,223 ', retaining part；224, support platform；225, it limits Block；23, docking section；231, hollow stem；232, displacement mechanism.

Specific embodiment

Below by drawings and examples, the technical solution of the utility model is described in further detail.

Specific embodiment of the present utility model is asked for the ease of the design to the utility model, the technology that is solved Topic, the technical characteristic for constituting technical solution and bring technical effect have further description.It should be noted that for this The explanation of a little embodiments does not constitute the restriction to the utility model.In addition, the embodiment party of the utility model described below Technical characteristic involved in formula can be combined with each other as long as they do not conflict with each other.

In the utility model lumen organization construct printing equipment one schematical embodiment, as shown in Figure 1, lumen Tissue construct printing equipment includes nozzle component 1 and biometric print platform 2, and nozzle component 1 will be given birth to by biometric print platform 2 Object construct is printed upon on the inner surface of lumen organization.

In the schematical embodiment, life is passed through by setting nozzle component 1 and biometric print platform 2, nozzle component 1 Biological construct is printed upon on the inner surface of lumen organization by object print platform 2, avoids lumen organization's blood after long-time is implanted into Occur again and appearance the problems such as lumen restenosis of bolt, improve the biological reliability of lumen organization.Wherein, lumen organization In particular artificial blood vessel, such as commercially available Ge Er blood vessel, the inner surface that biological construct is printed upon artificial blood vessel can be to avoid people The generation of work blood vessel thrombus after long-time is implanted into.

In one improved embodiment of the utility model lumen organization construct printing equipment, as shown in Figures 2 and 3, Nozzle component 1 includes medical adhesive spray head 11, and medical adhesive spray head 11 includes medical adhesive container 111 and medical adhesive nozzle 112, medical adhesive For containing medical adhesive, medical adhesive nozzle 112 is directly connected to container 111 with medical adhesive container 111,111 top of medical adhesive container It is connect by gas circuit with air pump, vacuum generator is equipped in gas circuit, for being produced under non-printing status to medical adhesive container 111 Raw negative pressure.Since medical adhesive has fabulous mobility, in non-printing status, due to the effect of gravity, medical adhesive can also delay Slow drippage, therefore increase vacuum generator in gas circuit, in non-printing status, there are certain negative pressure, negative pressure in gas circuit It is offset with gravity, so that medical adhesive no longer freely drips.Specifically or further, as shown in figure 3, medical adhesive container 111 pushes up Portion is equipped with medical adhesive piston 113, and medical adhesive piston 113 is connect by gas circuit with air pump, and air pump pressurization is by medical adhesive from ink sac It squeezes out, vacuum generator is between air pump and medical adhesive piston 113.

In one improved embodiment of the utility model lumen organization construct printing equipment, as shown in Figure 2 to 4, Nozzle component 1 includes biological brick spray head 12, and biological brick spray head 12 includes that screw pump 121, biological brick nozzle 122 and biological brick hold Device 125, for biological brick container 125 for containing biological prepared Chinese ink (biological brick), the outlet of 125 bottom of biological brick container passes through connection Pipe 127 and inlet connecting 1213 are connected with the biological brick entrance 128 of screw pump 121, and life is equipped at the top of biological brick container 125 Object brick piston 124, biological brick piston 124 are connect by gas circuit with air pump, and air pump pressurizes biological prepared Chinese ink from biological brick container 125 It squeezes out to screw pump 121, screw pump 121 includes for squeezing out the biological brick for entering screw pump 121 to biological brick nozzle 122 helical stator 1211 and helical rotor 1212, helical stator 1211 are made of silica gel material.

Due to the physical property of biological brick, when the exit of biological brick container 125 is smaller, biological brick can not be extruded, It can be formed and be accumulated in exit, even if increasing pressure, biological brick is squeezed and broken can not all be extruded；Likewise, even if to biological brick 125 exit of container carries out the means such as angle design, can not all squeeze out biological brick.However, the demand of printing defines biology Brick cannot be largely extruded, and can only be extruded a small amount of several every time, therefore only send biological brick from biological brick container 125 It into screw pump 121, is squeezed out by screw pump 121, the outlet of screw pump 121 itself is larger, the biological brick quantity squeezed out every time Still it has been greater than use demand, thus has been provided with biological brick nozzle 122 in the exit of screw pump 121.

As shown in figure 4, helical stator 1211 can not rotate, helical rotor 1212 is rotated relative to helical stator 1211, spiral shell Groove type on gyrator 1212 can only load a small amount of biological brick in each chamber, biological brick is with helical rotor at chamber 1212 rotation is sent to biological brick nozzle 122.Due to the physical property of current biological prepared Chinese ink material, printing is needed in low temperature Under (4 DEG C) progress, the rubber material that the helical stator in existing screw pump is all made of, rubber material at low temperature can be old rapidly Change, black powder occurs in printing, the utility model changes helical stator 1211 to be made of silica gel, appearance when avoiding printing The problem of black powder.

In order to avoid when biological brick is in printing, " hanging pearl " occurs in 122 front end exit (Fig. 5 circled portion) of biological brick nozzle Phenomenon (that is: the viscosity of biological prepared Chinese ink is larger, after biological brick is extruded, will not directly drip, and hangs over nozzle exit, when after When the biological brick in face is extruded, the biological brick not dripped before drips at a big dropping liquid with subsequent stack up, hangs over spray Mouth exit can just drip down when the gravity that this big dropping liquid drips is greater than frictional force), in an improved embodiment, a side Face, as shown in Figure 5 and Figure 6, the printing outlet end of biological brick nozzle 122 have chamfering, the fillet surface and biological brick nozzle of chamfering The angle of the center line of 122 printing outlet is 10 °~30 °, and further, which is 20 °, and design can be effective in this way Avoid " hanging pearl " phenomenon.On the other hand, roughness Ra≤0.4, Ke Yitong of the printing outlet end outer surface of biological brick nozzle 122 It crosses in 122 outer surface plating coating of biological brick nozzle/polishing, to increase surface flatness, can preferably avoid " hanging pearl " existing As.

Since currently used biological prepared Chinese ink can tend to solidify the case where temperature is greater than 4 DEG C, it is therefore desirable to by biological brick Spray head maintains in 4 DEG C of environment temperature, in some improved embodiments, as shown in figure 3, biological brick spray head 12 further includes position Semiconductor coldplate 126 in 125 behind of screw pump 121 and biological brick container, semiconductor coldplate 126 can be passed by heat It leads and cools down to biological brick spray head 12.Further, as shown in figure 3, being equipped with muff mouth 129 outside biological brick nozzle 122, There is certain gap between 122 outside of muff mouth 129 and biological brick nozzle, be capable of forming air heat insulating layer.Further, As shown in Fig. 2, be equipped with insulation cladding 123 in screw pump 121 and 125 outer cover of biological brick container, insulation cladding 123 include box cover and It is covered on the heat-preservation cotton of lid outer surface, heat-preservation cotton can further increase heat insulation effect, the heat exchange of spray head and environment is reduced, Box cover is equipped with transparent window, for observing the splendid attire situation of biological prepared Chinese ink in biological brick container 125.

In some improved embodiments, lumen organization's construct printing equipment further includes displacement component, for mobile spray Head assembly 1, nozzle component 1 whole (biological brick spray head 12 and medical adhesive spray head 11) can be in the vertical direction and in horizontal direction It is displaced, medical adhesive spray head 11 can individually be gone up and down.Nozzle component 1 in the initial state, the exit of biological brick spray head 12 Horizontal position be located at the lower section of 11 exit horizontal position of medical adhesive spray head；In printing, displacement component will be under nozzle component 1 After being down to certain altitude, biological brick spray head 12 squeezes out biological brick, after completing lumen organization's printing, by rising overally after one section, Medical adhesive spray head 11 individually declines, and carries out medical adhesive printing.

In one improved embodiment of the utility model lumen organization construct printing equipment, as shown in Figure 7 and Figure 8, Biometric print platform 2 include platform base, rotating part 21 and can the mobile docking section 23 in relative rotation portion 21, rotating part 21 includes Swingle 211, for carrying biological brick and medical adhesive to form biological construct, docking section 23 includes hollow stem 231 and displacement Mechanism 232, the outer wall of hollow stem 231 is for carrying lumen organization, and inner cavity is for accommodating swingle 211 and biological construct.

After biological construct is made in swingle 211, hollow stem 231 passes through displacement mechanism 232 to 21 direction of rotating part Displacement, swingle 211 and biological construct enter the inner cavity of hollow stem 231, cover lumen organization outside hollow stem 231 with Hollow stem 231 is displaced to outside biological construct；Further, 231 surface of hollow stem is coated with teflon layer, can be avoided medical Glue is contacted with metal surface and is reacted.Hollow stem 231 is displaced to opposite direction again by displacement mechanism 232, and lumen organization is from sky Core bar 231 is removed, and biological construct outer surface is then set in, and is completed assembling and is obtained artificial organ precursor.Further, it rotates The outer wall of bar 211 is covered with elastic membrane, and when carrying out biological construct printing, elastic membrane is coated on swingle in nature 211 surfaces, biological brick are conducive to remove biological construct in this way in the surface composition biological construct of elastic membrane.Further, As shown in figure 9, the inner hollow of swingle 211, it is provided on the outer wall of swingle 211 and is connected with inside venthole, for will The air of the inside of swingle 211 is discharged to prop up elastic membrane, when biological construct and lumen organization are assembled, to rotation 211 internal ventilation of bar, gas expand outwardly from gas outlet and prop up and (be envisaged that into balloon by inflation) elastic membrane, elastomeric film surface Biological construct be displaced outwardly with the expansion of elastic membrane, finally contact and sticked in lumen organization with lumen organization inner wall On wall, artificial organ precursor is obtained.Practice have shown that the embodiment is easy to operate, it is easy to accomplish, it is with higher implementable Property.Specifically or further, as shown in figure 12, sealing ring 214, swingle 211 and sealing ring are equipped with inside rotating part 21 214 are detachably connected, and the effect of sealing ring 214 is to be sealed the inner cavity of swingle, so that elastic membrane is propped up in inflation Process is more controllable.

As the improvement to above-described embodiment, as shown in Figure 10 and Figure 11, the inside of swingle 211 is additionally provided with heating member 212.Heating member 212 can accelerate the setting rate of biological prepared Chinese ink, shorten biological construct preparation time, and heating member 212 needs Maintaining swingle surface temperature is 37~38 DEG C.Further, as shown in figure 11, the one end of heating member 212 close to docking section 23 Equipped with temperature detection part 213, for detecting the temperature of heating member 212, to maintain swingle surface temperature in real time.

In a specific or improved embodiment, as shown in Figure 10 and Figure 11, heating member 212 includes interval setting Bringing-up section 2121 and spacer 2123,2123 surface of spacer is provided with link slot 2122, and 2121 surface wrap of bringing-up section has electricity Silk is hindered, 2123 surface of spacer does not wind resistance wire, and the resistance wire between adjacent bringing-up section 2121 is worn from link slot 2122 It crosses, the diameter of bringing-up section 2121 is less than the diameter of spacer 2123.211 clearance fit of heating member 212 and swingle, spacer 2123 outer wall is in contact with 211 inner wall of swingle.The purpose that spacer is arranged is heating member 212 being inserted in swingle 211 When resistance wire is protected, avoid assembling when resistance wire is destroyed.

For how to remove lumen organization from hollow stem 231, in an improved embodiment, as shown in fig. 7, biological Print platform 2 further includes holding mechanism 22, for holding lumen organization so that it is from sky in the displacement of 231 opposite direction of hollow stem Core bar 231 is detached from and is socketed biological construct, and the embodiment is easy to implement, reliability with higher.

Specifically or further, Figure 13 and Figure 14 shows the structural schematic diagram for holding mechanism of first embodiment, Figure 15 The structural schematic diagram for holding mechanism that second embodiment is shown with Figure 16, below according to Figure 13 to Figure 16 to first embodiment and The structure for holding mechanism of two embodiments is described in detail.

As shown in Figure 13 and Figure 14, the mechanism 22 that holds of first embodiment holds block 221 including relatively-movable first Block 222 is held with second.First hold block 221 and second hold block 222 relative movement can preferably by setting guide rail To realize.Further, as shown in figure 14, holding mechanism 22 further includes that setting holds block 221 and second first and holds block The limited block 225 of 222 bottoms, for first hold block 221 and second hold block 222 relative movement limit so that First holds block 221 and second holds block 222 and the outer wall of lumen organization is tangent, can be in the process of assembling artificial organ precursor In, certain restriction effect is played to lumen organization.

In order to guarantee to remove lumen organization from hollow stem 231 as much as possible, in one further embodiment, such as scheme Shown in 13 and Figure 14, holding mechanism 22 further includes retaining part 223, for acting on lumen in the displacement of 231 opposite direction of hollow stem For the tail end of tissue so that it is detached from from hollow stem 231, prevention lumen organization follows hollow stem 231.Retaining part 223, can be set Block 221 is held first and/or second holds the tail end of block 222, can also hold block independently of first and second to hold block straight It connects and is arranged on holding mechanism.Further, the cooperation of retaining part 223 is equipped with the Non-return ring for acting on the tail end of lumen organization, So that lumen organization is easier to be detached from from hollow stem 231.Still further, as shown in figure 14, holding mechanism 22 further includes setting Block 221 and second is held first and holds the support platform 224 of 222 bottom of block, is used to support lumen organization.Lumen organization with During biological construct is docked, support platform 224 is just tangent with lumen organization bottom outer wall, is lumen organization Upward power is provided, lumen organization is avoided to drop.

As shown in Figure 15 and Figure 16, similar to the structure for holding mechanism of first embodiment, second embodiment holds machine Structure also includes relatively-movable first holding block 221 ' and second and holding block 222 ' and retaining part 223 '.With first embodiment Unlike, second embodiment hold the first of mechanism hold block 221 ' and second hold block 222 ' relative movement pass through set Leadscrew-nut mechanism is set to realize.

The connection relationship held between other unaccounted each components of mechanism and each component of second embodiment, function, Effect etc. can refer to first embodiment.

In one improved embodiment of the utility model lumen organization construct printing equipment, lumen organization's construct is beaten It further includes the liquid storage tank being arranged in below swingle 211 that printing equipment, which is set, for accepting from the biology for holding the disengaging of mechanism 22 and falling Print construct.After completing printing assembling, biometric print construct is embraced by holding mechanism 22, swingle 211 it is whole to Opposite direction exits, and biometric print construct is located at the surface of liquid storage tank, and provides support by holding mechanism 22；Machine is held at this time Structure 22, which removes, holds power, and biometric print construct is fallen in liquid storage tank vertically.In this way design can be avoided completion printing after by Manually, mechanical arm etc. is implemented to introduce new pollution during transfer operation, or in operation since misoperation is fought each other Print blood vessel causes damage etc., convenient for finished product packing etc..

Illustrate the utility model lumen organization construct printing equipment for embodiment shown in Fig. 1~Figure 14 below Artificial organ precursor building process it is as follows:

Biological prepared Chinese ink is constructed into biological construct in elastomeric film surface by biological brick spray head 12, then passes through medical adhesive spray head 11 uniformly squeeze out one layer of medical glue-line for adhesion biological brick and lumen organization on biological construct surface；

After biological construct is made, hollow stem 231 is moved towards swingle 211, until hollow stem 231 covers completely It is located at outside swingle 211, lumen organization is fully located at outside biological construct at this time, and hollow stem 231 is directed away from swingle 211 direction is moved, and is held mechanism 22 at this time and is prevented lumen organization that hollow stem 231 is followed to move, finally, hollow stem 231 It is completely separable with swingle 211, but lumen organization still stays in outside biological construct.Due to the limitation of mechanical structure, at this time Between lumen organization and biological construct necessarily have gap, at this time by support platform 224 to lumen organization provide one to On power, avoid lumen organization from leading to being bonded not between biological construct and artificial blood vessel since the effect of gravity moves downward Uniformly.Then it ventilates into swingle 211, elastic membrane is propped up, so that biological construct is fitted in lumen organization's inner wall completely On, heating member 212 heats, and accelerates biological prepared Chinese ink solidification, finally obtains artificial organ precursor, by artificial organ precursor from swingle It is removed on 211.

Since the artificial organ precursor after printed needs to detect the flatness of its inner wall, in the utility model lumen organization In one improved embodiment of construct printing equipment, lumen organization's construct printing equipment further includes can be in swingle 211 The mobile optic probe in portion, for detecting the flatness of biological construct inner wall, swingle 211 is made of clear material.By light Probe designs are learned into the form that can be moved inside swingle 211, artificial organ precursor is being removed it from swingle 211 Before, mobile optic probe takes pictures to biological construct inner wall by image capture software, judges the biological brick coating of printing It is whether complete and smooth, the structure of 211 inner hollow of swingle is made full use of, Fabric utilization is improved, it is with higher Exploitativeness.

For how to realize that optic probe can move inside swingle 211, in some improved embodiments, optics is visited Head is fixed in hollow stem 231, such as hollow stem 231 is designed as double-layer nested structure, and first layer is artificial for being arranged Optic probe is arranged in blood vessel, second layer front end；Swingle 211 is also double-layer structure, and ventilation in the interlayer in double-layer structure is used for Elastic membrane is propped up, elastic membrane is placed only in 211 surface of swingle without covering front end, is to be able to that optic probe is allowed to stretch in this way Enter in swingle 211.In an assembling process, lumen organization is set in biological construct surface, and optic probe is also with hollow stem 231 It is moved to the distalmost end of biological construct, when taking off lumen organization, optic probe is also moved to artificial premise with hollow stem 231 The front end of tissue, to complete flatness detection during assembling.Certainly, in some other improved embodiment, Optic probe is movably disposed in hollow stem 231, i.e., optic probe equally can relative to 231 self-movement of hollow stem Complete flatness detection.In some other improved embodiment, optic probe is movably disposed in swingle 211, light It learns probe and is moved to the other end from one end in swingle 211, complete flatness detection.

The utility model additionally provides a kind of 3D biometric print machine comprising above-mentioned lumen organization's construct prints dress It sets.Since the utility model lumen organization construct printing equipment can be improved the biological reliability of lumen organization, correspondingly, this Utility model 3D biometric print machine also has above-mentioned advantageous effects, and details are not described herein.

The embodiment combined above is described in detail the embodiments of the present invention, but the utility model not office It is limited to described embodiment.For a person skilled in the art, the principles of the present invention and essence are not being departed from A variety of variations, modification, equivalence replacement and modification is carried out to these embodiments in the case where spirit to still fall in the utility model Protection scope within.

Claims (24)

1. a kind of lumen organization's construct printing equipment, which is characterized in that including nozzle component (1) and biometric print platform (2), The nozzle component (1) includes the biological brick spray head for spraying biological brick to form biological construct, and the biometric print is flat Biological construct is printed upon described by platform for carrying lumen organization, the nozzle component by the biometric print platform (2) On the inner surface of lumen organization.

2. lumen organization's construct printing equipment according to claim 1, which is characterized in that nozzle component (1) packet It includes medical adhesive spray head (11), the medical adhesive spray head (11) includes medical adhesive container (111) and medical adhesive nozzle (112), described It is connect by gas circuit with air pump at the top of medical adhesive container (111), vacuum generator is equipped in the gas circuit, for non-print Negative pressure is generated to the medical adhesive container (111) under state.

3. lumen organization's construct printing equipment according to claim 1, which is characterized in that nozzle component (1) packet It includes biological brick spray head (12), the biological brick spray head (12) includes screw pump (121) and biological brick nozzle (122).

4. lumen organization's construct printing equipment according to claim 3, which is characterized in that screw pump (121) packet It includes for squeezing out the biological brick for entering the screw pump (121) to the helical stator (1211) of the biological brick nozzle (122) With helical rotor (1212), the helical stator (1211) is made of silica gel material.

5. lumen organization's construct printing equipment according to claim 3, which is characterized in that the biological brick nozzle (122) printing outlet end has chamfering, during the printing of the fillet surface of the chamfering and the biological brick nozzle (122) exports The angle of heart line is 10 °~30 °.

6. lumen organization's construct printing equipment according to claim 5, which is characterized in that the angle is 20 °.

7. lumen organization's construct printing equipment according to claim 3, which is characterized in that the biological brick nozzle (122) roughness Ra≤0.4 of printing outlet end outer surface.

8. lumen organization's construct printing equipment according to claim 1, which is characterized in that the biometric print platform It (2) include platform base, rotating part (21) and the docking section (23) that can be moved relative to the rotating part (21), the rotating part It (21) include swingle (211), for carrying biological brick and medical adhesive to form biological construct, the docking section (23) includes Hollow stem (231), the outer wall of the hollow stem (231) is for carrying lumen organization.

9. lumen organization's construct printing equipment according to claim 8, which is characterized in that the swingle (211) Outer wall is covered with elastic membrane.

10. lumen organization's construct printing equipment according to claim 9, which is characterized in that the swingle (211) Inner hollow, be provided on the outer wall of the swingle (211) with internal venthole be connected to, be used for the swingle (211) air of inside is discharged to prop up the elastic membrane.

11. lumen organization's construct printing equipment according to claim 8, which is characterized in that the swingle (211) Inside is additionally provided with heating member (212).

12. lumen organization's construct printing equipment according to claim 11, which is characterized in that the heating member (212) Including spaced bringing-up section (2121) and spacer (2123), bringing-up section (2121) surface wrap has resistance wire, institute The diameter for stating bringing-up section (2121) is less than the diameter of the spacer (2123).

13. lumen organization's construct printing equipment according to claim 11, which is characterized in that the heating member (212) One end close to the docking section (23) is equipped with temperature detection part (213), for detecting the temperature of the heating member (212).

14. lumen organization's construct printing equipment according to claim 8, which is characterized in that the biometric print platform It (2) further include holding mechanism (22), for holding the lumen organization so that it is detached from from the hollow stem (231) and is socketed institute State biological construct.

15. lumen organization's construct printing equipment according to claim 14, which is characterized in that described to hold mechanism (22) Block and second, which is held, including relatively-movable first holds block.

16. lumen organization's construct printing equipment according to claim 15, which is characterized in that described to hold mechanism (22) It further include retaining part, for acting on the tail end of the lumen organization so that it is detached from from the hollow stem (231).

17. lumen organization's construct printing equipment according to claim 16, which is characterized in that the retaining part cooperation is set There is the Non-return ring for the tail end for acting on the lumen organization.

18. lumen organization's construct printing equipment according to claim 15, which is characterized in that described to hold mechanism (22) It further include being arranged in described first and holding block and described second to hold the limited block (225) of block bottom, for first folder Holding block and described second hold block relative movement limited so that described first holds block and described second and holds block and institute The outer wall for stating lumen organization is tangent.

19. lumen organization's construct printing equipment according to claim 15, which is characterized in that described to hold mechanism (22) Further include being arranged in described first and holding block and described second to hold the support platform (224) of block bottom, is used to support the pipe Cavity tissue.

20. lumen organization's construct printing equipment according to claim 8, which is characterized in that further including can be in the rotation Mobile optic probe inside bull stick (211), for detecting the flatness of the biological construct inner wall, the swingle (211) it is made of clear material.

21. lumen organization's construct printing equipment according to claim 20, which is characterized in that the optic probe is removable It is arranged in the swingle (211) or the hollow stem (231) dynamicly.

22. lumen organization's construct printing equipment according to claim 20, which is characterized in that the optic probe is fixed Setting is in the hollow stem (231).

23. lumen organization's construct printing equipment according to claim 14, which is characterized in that further include being arranged described Liquid storage tank below swingle (211), for accepting from the biometric print construct for holding mechanism (22) and being detached from and falling.

24. a kind of 3D biometric print machine, which is characterized in that including the described in any item lumen organization's buildings of claim 1~23 Body printing equipment.