CN208302606U - A kind of bio-pharmaceuticals stock stirring device - Google Patents
A kind of bio-pharmaceuticals stock stirring device Download PDFInfo
- Publication number
- CN208302606U CN208302606U CN201721765045.3U CN201721765045U CN208302606U CN 208302606 U CN208302606 U CN 208302606U CN 201721765045 U CN201721765045 U CN 201721765045U CN 208302606 U CN208302606 U CN 208302606U
- Authority
- CN
- China
- Prior art keywords
- fixedly connected
- transverse slat
- bio
- pharmaceuticals
- shell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The utility model discloses a kind of bio-pharmaceuticals stock stirring devices, including shell, stirred tank is fixedly connected between the two sides of the inner walls, transverse slat is fixedly connected between the two sides of the inner walls and at the top of stirred tank, telecontrol equipment is fixedly connected at the top of the transverse slat, the bottom of the telecontrol equipment runs through transverse slat and extends to the bottom of transverse slat, one end that telecontrol equipment is located at transverse slat bottom is fixedly connected with ratch, the side of the ratch is engaged with first gear, agitating shaft is fixedly connected at the axle center of the first gear, the utility model relates to bio-pharmaceuticals correlative technology fields.The bio-pharmaceuticals stock stirring device, control the frequency of charging, avoiding disposably feeding excessively causes raw material to heap the effect for influencing to be stirred, be conducive to improve the uniformity of raw material, thoroughly stirring is carried out repeatedly to raw material, avoiding unidirectionally stirring causes raw material bonding to influence mixed effect, and mechanical mechanism is reasonable, and using effect is good.
Description
Technical field
The utility model relates to bio-pharmaceuticals correlative technology field, specially a kind of bio-pharmaceuticals stock stirring device.
Background technique
Bio-pharmaceutical refers to the research achievement with microbiology, biology, medicine, biochemistry etc., from organism, life
Object tissue, cell, organ, body fluid etc., the science such as comprehensive utilization microbiology, chemistry, biochemistry, biotechnology, pharmacy
The product that principle and one kind of method manufacture are used to prevent, treat and diagnose, bio-pharmaceutical raw material are with natural biomaterial
It is main, including microorganism, human body, animal, plant, marine organisms etc., it is purposeful artificial obtained raw with the development of biotechnology
Raw material becomes the main source of current biological pharmaceutical raw material, and such as the animal material made from immunization changes gene structure system
The characteristics of microorganism obtained or other cell materials etc., bio-pharmaceutical is that pharmacological activity is high, toxic side effect is small, and nutritive value is high.
Bio-pharmaceutical mainly has protein, nucleic acid, carbohydrate, lipid etc., the component units of these substances be amino acid, nucleotide, monosaccharide,
Fatty acid etc., not only harmless to human body but also be important nutriment, bio-pharmaceuticals is to produce medicine using biological living
The method of object, such as people's antitrypsin, bio-pharmaceuticals are expressed using transgenic corns production human antibody, transgenic cow mammary gland
Industry has a extensive future, global pharmaceuticals have half be biosynthesis, it will be widely used in treating cancer, AIDS,
A variety of diseases such as coronary heart disease, anaemia, depauperation, diabetes.
In the process of bio-pharmaceuticals, it is often necessary to be stirred mixing to raw material, existing agitating device is general
It is to be stirred using blender fixation to raw material, material directly pours into, and easy heap is in heaps, and mixing effect is bad, is easy shadow
The uniformity for ringing material leads to material following process and inconvenient to use, and using effect is bad.
Utility model content
In view of the deficiencies of the prior art, the utility model provides a kind of bio-pharmaceuticals stock stirring device, solves
Material directly pours into the process of bio-pharmaceuticals, and easy heap is in heaps, and mixing effect is bad, is easy to influence the uniform of material
Degree, leads to material following process and inconvenient to use, the bad problem of using effect.
In order to achieve the above object, the utility model is achieved by the following technical programs: a kind of bio-pharmaceuticals raw material
Agitating device, including shell, are fixedly connected with stirred tank between the two sides of the inner walls, the two sides of the inner walls it
Between and be located at stirred tank at the top of be fixedly connected with transverse slat, telecontrol equipment, the movement are fixedly connected at the top of the transverse slat
The bottom of device runs through transverse slat and extends to the bottom of transverse slat, and one end that the telecontrol equipment is located at transverse slat bottom is fixedly connected with
Ratch, the side of the ratch are engaged with first gear, and agitating shaft is fixedly connected at the axle center of the first gear, described to stir
The bottom end for mixing axis runs through the top of stirred tank and extends to the inside of stirred tank, and the bottom of the inner walls is fixedly connected with out
Expect device, the top movable of the discharging device is connected with feed box.
Preferably, the telecontrol equipment includes motion motor, the fixed company in the bottom of the motion motor and the top of transverse slat
It connects, the output shaft of the motion motor is fixedly connected with bull stick, and the bull stick is rotatably connected to work far from one end of motion motor
Motion block, the surface activity of the movable block are connected with loose slot, and the bottom of the loose slot is fixedly connected with vertical bar, the vertical bar
One end of separate loose slot through transverse slat and extend to the bottom of transverse slat.
Preferably, the discharging device includes movable plate, and the two sides of the movable plate bottom are fixedly connected to support rod,
The bottom end of the support rod and the basal sliding of inner walls connect, and the surface of the movable plate is fixedly connected with discharging machine,
The first belt pulley is fixedly connected on the output shaft of the discharging machine, the surface of first belt pulley is driven by belt to be connected
It is connected to the second belt pulley, the side of second belt pulley is fixedly connected with second gear, the second gear and movable plate
Side is fixedly connected, and the bottom of the second gear is engaged with tooth plate, and the tooth plate is fixedly connected with the bottom of inner walls.
Preferably, the left side of the case top is fixedly connected with motor, institute through there is feed hopper at the top of the transverse slat
The output shaft for stating motor is fixedly connected with rotating plate, and the side on the rotating plate surface is fixedly connected with push rod, the surface of the push rod
It is connected with sheave, the top of the sheave is flexibly connected with the bottom of feed hopper, and the inside of the transverse slat, which is run through, charging
The bottom end of pipe, the feed pipe runs through the top of stirred tank and extends to the inside of stirred tank.
Preferably, support column, the bottom end of the support column and the top of transverse slat are fixedly connected at the axle center of the sheave
Rotation connection.
Preferably, the two sides of the inner walls and be located at stirred tank bottom be fixedly connected to telescopic rod, it is described to stretch
Contracting bar is fixedly connected with baffle far from one end of inner walls.
Beneficial effect
The utility model provides a kind of bio-pharmaceuticals stock stirring device.Have it is following the utility model has the advantages that
(1), the bio-pharmaceuticals stock stirring device, by being fixedly connected with stirred tank between the two sides of inner walls,
It is fixedly connected with transverse slat between the two sides of inner walls and at the top of stirred tank, is fixedly connected with sportswear at the top of transverse slat
It sets, the bottom of telecontrol equipment runs through transverse slat and extends to the bottom of transverse slat, and telecontrol equipment is located at the fixed company in one end of transverse slat bottom
It is connected to ratch, the side of ratch is engaged with first gear, and agitating shaft, the bottom of agitating shaft are fixedly connected at the axle center of first gear
End runs through the top of stirred tank and extends to the inside of stirred tank, is stirred to raw material, improves the mixed effect of raw material, convenient
To the following process of raw material.
(2), the bio-pharmaceuticals stock stirring device, being run through by the left side of case top has feed hopper, the top of transverse slat
Portion is fixedly connected with motor, and the output shaft of motor is fixedly connected with rotating plate, and the side on rotating plate surface is fixedly connected with push rod, push rod
Surface activity be connected with sheave, the top of sheave is flexibly connected with the bottom of feed hopper, the inside of transverse slat through there is feed pipe,
The bottom end of feed pipe runs through the top of stirred tank and extends to the inside of stirred tank, passes through motor work and drives sheave rotation, control
The frequency for making charging, avoiding disposably feeding excessively causes raw material to heap the effect for influencing to be stirred, and is conducive to improve raw material
The uniformity.
(3), the bio-pharmaceuticals stock stirring device, by being fixedly connected at the top of the bottom of motion motor and transverse slat,
The output shaft of motion motor is fixedly connected with bull stick, and bull stick is rotatably connected to movable block, movable block far from one end of motion motor
Surface activity be connected with loose slot, the bottom of loose slot is fixedly connected with vertical bar, and one end of the separate loose slot of vertical bar is run through
Transverse slat and the bottom for extending to transverse slat are worked by motion motor and agitating shaft are driven to carry out positive and negative rotation, are carried out to raw material repeatedly thorough
The stirring at bottom, avoiding unidirectionally stirring causes raw material bonding to influence mixed effect, and mechanical mechanism is reasonable, and using effect is good.
(4), the bio-pharmaceuticals stock stirring device is fixedly connected to support rod by the two sides of movable plate bottom,
The bottom end of support rod and the basal sliding of inner walls connect, and the surface of movable plate is fixedly connected with discharging machine, discharging machine
Output shaft on be fixedly connected with the first belt pulley, the surface of the first belt pulley is sequentially connected with the second belt pulley by belt,
The side of second belt pulley is fixedly connected with second gear, and second gear is fixedly connected with the side of movable plate, second gear
Bottom is engaged with tooth plate, and tooth plate is fixedly connected with the bottom of inner walls, facilitates the raw material after being stirred to send out, does not need
Artificial discharging, alleviates labor workload, improves work efficiency.
Detailed description of the invention
FIG. 1 is a schematic structural view of the utility model;
Fig. 2 is the structural schematic diagram of the utility model rotating plate and sheave;
Fig. 3 is the structural schematic diagram of the utility model telecontrol equipment;
Fig. 4 is the structural schematic diagram of the utility model discharging device.
In figure: 1 shell, 2 stirred tanks, 3 transverse slats, 4 telecontrol equipments, 41 motion motors, 42 bull sticks, 43 movable blocks, 44 activities
Slot, 45 vertical bars, 5 ratch, 6 first gears, 7 agitating shafts, 8 telescopic rods, 9 baffles, 10 discharging devices, 101 movable plates, 102 supports
Bar, 103 discharging machines, 104 first belt pulleys, 105 belts, 106 second belt pulleys, 107 second gears, 108 tooth plates, 11 dischargings
Case, 12 feed hoppers, 13 motors, 14 rotating plates, 15 sheaves, 16 push rods, 17 feed pipes, 18 support columns.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work
Every other embodiment obtained, fall within the protection scope of the utility model.
Fig. 1-4 is please referred to, the utility model provides a kind of technical solution: a kind of bio-pharmaceuticals stock stirring device, packet
Shell 1 is included, stirred tank 2 is fixedly connected between the two sides of 1 inner wall of shell, the bottom of stirred tank 2 offers feed opening, shell 1
The two sides of inner wall and the bottom for being located at stirred tank 2 are fixedly connected to telescopic rod 8, and the one end of telescopic rod 8 far from 1 inner wall of shell is solid
Surely it is connected with baffle 9, baffle 9 is adapted with feed opening, feed opening can be blocked, and between the two sides of 1 inner wall of shell and is located at
The top of stirred tank 2 is fixedly connected with transverse slat 3, and through there is feed hopper 12, the top of transverse slat 3 is fixed to be connected in the left side at 1 top of shell
It is connected to motor 13, the output shaft of motor 13 is fixedly connected with rotating plate 14, and the side on 14 surface of rotating plate is fixedly connected with push rod 16, pushes away
The surface activity of bar 16 is connected with sheave 15, and push rod 16 drives sheave 15 to carry out intermittent rotary, controls the speed of blanking, avoid
Disposable charging excessively causes raw material to heap the effect for influencing to be stirred, and is conducive to the uniformity for improving raw material, sheave 15
Be fixedly connected with support column 18 at axle center, the bottom end of support column 18 and the top of transverse slat 3 are rotatablely connected, the top of sheave 15 with into
The bottom of hopper 12 is flexibly connected, and through there is feed pipe 17, the top of stirred tank 2 is run through in the bottom end of feed pipe 17 for the inside of transverse slat 3
Portion and the inside for extending to stirred tank 2, the top of feed pipe 17 are provided with the feed opening of inverted conical shape, and the top of transverse slat 3 is fixed
It is connected with telecontrol equipment 4, the bottom of telecontrol equipment 4 runs through transverse slat 3 and extends to the bottom of transverse slat 3, and telecontrol equipment 4 is located at cross
One end of 3 bottom of plate is fixedly connected with ratch 5, and the side of ratch 5 is engaged with first gear 6, and the movement of ratch 5 drives the first tooth
6 rotation of wheel, avoiding unidirectionally stirring causes raw material bonding to influence mixed effect, and mechanical mechanism is reasonable, and using effect is good, first gear
Agitating shaft 7 is fixedly connected at 6 axle center, the bottom end of agitating shaft 7 runs through the top of stirred tank 2 and extends to the interior of stirred tank 2
The top in portion, agitating shaft 7 is connect with the lower rotation of transverse slat 3, and the bottom of 1 inner wall of shell is fixedly connected with discharging device 10, out
The top movable of material device 10 is connected with feed box 11, and the right side opening of shell 1 is equipped with opening compatible with feed box 11, movement
Device 4 includes motion motor 41, and the bottom of motion motor 41 is fixedly connected with the top of transverse slat 3, the output shaft of motion motor 41
It is fixedly connected with bull stick 42, bull stick 42 is rotatably connected to movable block 43, the surface of movable block 43 far from one end of motion motor 41
It is connected with loose slot 44, the bottom of loose slot 44 is fixedly connected with vertical bar 45, one end of the separate loose slot 44 of vertical bar 45
Through transverse slat 3 and the bottom of transverse slat 3 is extended to, one end that vertical bar 45 is located at 3 bottom of transverse slat is fixedly connected with the right end of ratch 5,
Discharging device 10 includes movable plate 101, and the two sides of 101 bottom of movable plate are fixedly connected to support rod 102, support rod 102
Bottom end is connect with the basal sliding of 1 inner wall of shell, and the bottom of 1 inner wall of shell offers sliding slot, and the internal slide of the sliding slot connects
It is connected to sliding block, the top of sliding block is fixedly connected with the bottom end of support rod 102, and the surface of movable plate 101 is fixedly connected with discharging electricity
Machine 103 is fixedly connected with the first belt pulley 104 on the output shaft of discharging machine 103, and the surface of the first belt pulley 104 passes through skin
Band 105 is sequentially connected with the second belt pulley 106, and the side of the second belt pulley 106 is fixedly connected with second gear 107, the second tooth
Wheel 107 is fixedly connected with the side of movable plate 101, and the bottom of second gear 107 is engaged with tooth plate 108, tooth plate 108 and shell 1
The bottom of inner wall is fixedly connected, and the raw material after being stirred is facilitated to send out, and is not needed manually to discharge, is alleviated manual working
Amount, improves work efficiency.
When work, raw material is poured into through feed hopper 12, motor 13 works, and drives rotating plate 14 to rotate, to pass through push rod 16
Sheave 15 is driven to rotate, control raw material interval drops downward into feed pipe 17, drops downward into inside stirred tank 2,41 work of motion motor
Make, bull stick 42 is driven to rotate, drive loose slot 44 to move back and forth by movable block 43, to drive ratch by vertical bar 45
5 move back and forth, so that first gear 6 be driven to carry out positive and negative rotation, drive agitating shaft 7 to carry out positive and negative rotation, stir raw material
It mixes, after the completion of stirring, telescopic rod 8 is shunk, and baffle 9 is driven to move to two sides, is detached from stirred tank 2, and material drops downward into discharging
Inside case 11, discharging machine 103 works, and the first belt pulley 104 is driven to be rotated clockwise, and drives second by belt 105
Belt pulley 106 rotates, so that second gear 107 be driven to be rotated clockwise, is intermeshed with tooth plate 108, drives movable plate
101 move right, and feed box 11 is sent out, easy to use.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.In the absence of more restrictions.By sentence " element limited including one ..., it is not excluded that
There is also other identical elements in the process, method, article or apparatus that includes the element ".
While there has been shown and described that the embodiments of the present invention, for the ordinary skill in the art,
It is understood that these embodiments can be carried out with a variety of variations in the case where not departing from the principles of the present invention and spirit, repaired
Change, replacement and variant, the scope of the utility model is defined by the appended claims and the equivalents thereof.
Claims (6)
1. a kind of bio-pharmaceuticals stock stirring device, including shell (1), it is characterised in that: the two sides of shell (1) inner wall
Between be fixedly connected with stirred tank (2), between the two sides of shell (1) inner wall and be located at the top of stirred tank (2) and fixed connect
It is connected to transverse slat (3), is fixedly connected with telecontrol equipment (4) at the top of the transverse slat (3), the bottom of the telecontrol equipment (4) is run through
Transverse slat (3) and the bottom for extending to transverse slat (3), one end that the telecontrol equipment (4) is located at transverse slat (3) bottom are fixedly connected with teeth
The side of bar (5), the ratch (5) is engaged with first gear (6), is fixedly connected with and is stirred at the axle center of the first gear (6)
It mixes axis (7), the bottom end of the agitating shaft (7) runs through the top of stirred tank (2) and extends to the inside of stirred tank (2), the shell
The bottom of body (1) inner wall is fixedly connected with discharging device (10), and the top movable of the discharging device (10) is connected with feed box
(11)。
2. a kind of bio-pharmaceuticals stock stirring device according to claim 1, it is characterised in that: the telecontrol equipment
(4) include motion motor (41), be fixedly connected at the top of the bottom and transverse slat (3) of the motion motor (41), the movement electricity
The output shaft of machine (41) is fixedly connected with bull stick (42), and the bull stick (42) is rotatably connected to far from the one end of motion motor (41)
The surface activity of movable block (43), the movable block (43) is connected with loose slot (44), and the bottom of the loose slot (44) is fixed
It is connected with vertical bar (45), one end of the separate loose slot (44) of the vertical bar (45) through transverse slat (3) and extends to transverse slat (3)
Bottom.
3. a kind of bio-pharmaceuticals stock stirring device according to claim 1, it is characterised in that: the discharging device
It (10) include movable plate (101), the two sides of movable plate (101) bottom are fixedly connected to support rod (102), the support
The bottom end of bar (102) is connect with the basal sliding of shell (1) inner wall, and the surface of the movable plate (101) is fixedly connected with discharging
Motor (103) is fixedly connected with the first belt pulley (104) on the output shaft of the discharging machine (103), first belt pulley
(104) surface is sequentially connected with the second belt pulley (106) by belt (105), and the side of second belt pulley (106) is solid
Surely it is connected with second gear (107), the second gear (107) is fixedly connected with the side of movable plate (101), second tooth
The bottom of wheel (107) is engaged with tooth plate (108), and the tooth plate (108) is fixedly connected with the bottom of shell (1) inner wall.
4. a kind of bio-pharmaceuticals stock stirring device according to claim 1, it is characterised in that: shell (1) top
The left side in portion is fixedly connected with motor (13) through having feed hopper (12) at the top of the transverse slat (3), the motor (13) it is defeated
Shaft is fixedly connected with rotating plate (14), and the side on rotating plate (14) surface is fixedly connected with push rod (16), the push rod (16)
Surface activity be connected with sheave (15), the top of the sheave (15) is flexibly connected with the bottom of feed hopper (12), the cross
Through having feed pipe (17), the bottom end of the feed pipe (17), which is run through the top of stirred tank (2) and extended to, to be stirred for the inside of plate (3)
Mix the inside of slot (2).
5. a kind of bio-pharmaceuticals stock stirring device according to claim 4, it is characterised in that: the sheave (15)
It is fixedly connected at axle center support column (18), the bottom end of the support column (18) and the top of transverse slat (3) are rotatablely connected.
6. a kind of bio-pharmaceuticals stock stirring device according to claim 1, it is characterised in that: in the shell (1)
Two sides of the wall and bottom for being located at stirred tank (2) is fixedly connected to telescopic rod (8), the telescopic rod (8) is far from shell (1)
One end of wall is fixedly connected with baffle (9).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201721765045.3U CN208302606U (en) | 2017-12-16 | 2017-12-16 | A kind of bio-pharmaceuticals stock stirring device |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201721765045.3U CN208302606U (en) | 2017-12-16 | 2017-12-16 | A kind of bio-pharmaceuticals stock stirring device |
Publications (1)
Publication Number | Publication Date |
---|---|
CN208302606U true CN208302606U (en) | 2019-01-01 |
Family
ID=64731042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201721765045.3U Expired - Fee Related CN208302606U (en) | 2017-12-16 | 2017-12-16 | A kind of bio-pharmaceuticals stock stirring device |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN208302606U (en) |
-
2017
- 2017-12-16 CN CN201721765045.3U patent/CN208302606U/en not_active Expired - Fee Related
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108211893A (en) | A kind of bio-pharmaceuticals stock stirring device | |
CN106955614A (en) | A kind of modern agriculture depth material stirring processing equipment | |
CN112237881B (en) | Multifunctional stirring device for bio-pharmaceuticals | |
CN207187543U (en) | A kind of agitating device for bio-pharmaceuticals | |
CN110302689A (en) | A kind of mixing plant for bio-pharmaceuticals | |
CN208104390U (en) | A kind of bio-pharmaceuticals stirring edging device | |
CN210840943U (en) | Culture medium mixing arrangement | |
CN202766518U (en) | Uniform inoculation apparatus of solid fermentation tank | |
CN207270814U (en) | A kind of bio-pharmaceuticals extracting solution filtration apparatus | |
CN208302606U (en) | A kind of bio-pharmaceuticals stock stirring device | |
CN205412724U (en) | Agitating unit for bio -pharmaceuticals | |
CN205517771U (en) | Chemical industry stirring reaction device | |
CN206715762U (en) | A kind of modern agriculture depth material stirring processing equipment | |
CN204746191U (en) | Agitating unit for bio -pharmaceuticals | |
CN210009918U (en) | Compounding equipment is used in fertilizer production | |
CN211886474U (en) | Compounding device is used in fertilizer production | |
CN201123346Y (en) | Continuous vacuum flour-mixing machine | |
CN208944003U (en) | A kind of pharmacy dispensation apparatus | |
CN209287148U (en) | Deployment device is used in a kind of production of ferment | |
CN208701038U (en) | A kind of agitating device for feed fermentation | |
CN212167247U (en) | A agitating unit for bio-pharmaceuticals | |
CN221085636U (en) | Constant-temperature preparation box for production of cytarabine and daunorubicin compound liposome | |
CN215027813U (en) | A agitating unit for pharmaceutical raw materials compounding | |
CN205517363U (en) | A agitator for antiseptic solution production | |
CN215540563U (en) | Production polycarboxylate water reducing agent's agitating unit |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20190717 Address after: Room 1211, 781 Cailun Road, Pudong New Area, Shanghai, 201203 Patentee after: Shanghai Ruiwa Technology Co., Ltd. Address before: 311800 Zhaojiacun 700, Jiyang Street, Zhuji City, Shaoxing City, Zhejiang Province Patentee before: Zhao Xiaoli |
|
TR01 | Transfer of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190101 Termination date: 20191216 |
|
CF01 | Termination of patent right due to non-payment of annual fee |