CN208206768U - A kind of optical system - Google Patents
A kind of optical system Download PDFInfo
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- CN208206768U CN208206768U CN201820574258.6U CN201820574258U CN208206768U CN 208206768 U CN208206768 U CN 208206768U CN 201820574258 U CN201820574258 U CN 201820574258U CN 208206768 U CN208206768 U CN 208206768U
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Abstract
The utility model relates to a kind of optical systems, for in blood cell analysis device, the optical system includes laser light source, light beam shaping module, sample flow chamber and scattering optical detecting unit, the light beam shaping module makes to generate irradiation hot spot in the tested sample on sample flow chamber for the light beam that laser light source issues to be collimated and assembled, and the scattering optical detecting unit is used to receive the scattering light that flow chamber issues, photoelectric conversion and processing.Forward direction astigmatism collection assembly is using diaphragm and scattering light collector to preceding being collected and detecting to astigmatism, avoid in conventional design using focus lamp first to it is preceding assembled to astigmatism after collect, it avoids using focus lamp in forward direction astigmatism collection system, the stability of system is improved to a certain extent, the complexity and size for reducing system have the characteristics that small in size and structure is simple to astigmatism collection assembly before making.
Description
Technical field
The invention belongs to medical diagnosis technical fields, more particularly to for the optical system in blood cell analysis device
System.
Background technique
Blood cell analysis device generally comprises light source for the various cell parameters in blood to be counted and classified
The optical system of unit, flow chamber and photodetector unit, wherein flow chamber provides an optical detection area, makes cell sample
Pass sequentially through the detection zone of flow chamber.Light source provides an illumination beam and is irradiated in the detection zone of flow chamber, works as cell
When passing through detection zone, illumination beam is irradiated on cell and scatters, and the scattering light that photodetector unit will test is received
Collect and be converted to electric signal, to these conversion after electric signals carry out processing and analysis can be obtained by it is various present in blood
The parameter of cell, with the processing such as counted and classified.
The cell for passing through flow chamber detection zone in order to facilitate detection needs light beam to be irradiated to detection zone and forms a light
Spot.Common spherical lens convergent beam is used in the prior art, and this condenser lens is focused at the light of flow chamber detection zone
Energy distribution is more dispersed and hot spot is relatively narrow, causes cell stream that may deviate the center of energy of focal beam spot, is unfavorable for detecting
The stability of signal and the cell detection of high speed influence to measure cell in the distribution of scatter plot.
Utility model content
The utility model provide it is a kind of it is small in size, structure is simple, spot size is suitable, optical quality optimizes is used for blood
The optical system of liquid cell analysis apparatus and the blood cell analysis device for capableing of real reacting cells distributed intelligence.
Specifically, optical system provided by the utility model is used in blood cell analysis device, including laser light
Source, light beam shaping module, sample flow chamber and scattering optical detecting unit, the light beam shaping module are used to issue laser light source
Light beam collimated and assembled make generate irradiation hot spot in the tested sample on sample flow chamber, the scattering optical detecting unit
Scattering light for issuing to flow chamber received, photoelectric conversion and processing.
As an implementation, the light beam that laser light source issues includes slow axis and fast axle is mutually perpendicular two planes
The light beam in direction.
As an implementation, light beam shaping module includes the collimating mirror being sequentially distributed, for the slow of laser light source
The cylindrical mirror that axis direction light beam is dissipated and the focus lamp for convergent beam.
As an implementation, collimating mirror is aspherical mirror, and the numerical aperture of collimating mirror is greater than fast axis direction light beam
The angle of divergence.
As an implementation, the cylindrical mirror is negative the group of cylindrical mirror or a negative cylindrical mirror and a positive cylindrical mirror
It closes.
As an implementation, focus lamp is plano-convex spherical mirror or a plano-concave spherical mirror and a plano-convex spherical mirror
Combination.
As an implementation, scattering optical detecting unit includes forward scattering light collection assembly；Forward scattering light is collected
Component includes the diaphragm being sequentially distributed and scattering light collector.
As an implementation, the scattering light collector includes the low-angle photoelectricity for collecting low-angle scattering light
Diode and middle angle photodiode for angle scattering light in collecting.
As an implementation, the low-angle photodiode and middle angle photodiode are separately installed respective
Supporting element on or integrated installation on supporting element.
As an implementation, the scattering optical detecting unit further includes side scattered light collection assembly, lateral scattering
Light collection assembly and forward scattering light collection assembly right angle setting.
As an implementation, side scattered light collection assembly includes collecting lens and lateral photodiode.
As an implementation, collecting lens are aspherical mirror, and numerical aperture is greater than 0.4, collecting lens to sample
The distance between flow chamber is greater than 2mm.
As an implementation, sample flow chamber is rectangular parallelepiped structure, and cuboid center has through-hole.
Beneficial effect
The beneficial effects of the utility model are:
Shaping is carried out to the hot spot that laser light source generates by the light beam shaping module in optical system to obtain being suitble to detection
Hot spot, that is, generate that a size is suitable, and beam quality optimizes, be capable of the hot spot of really reacting cells distributed intelligence, and make
Hot spot is just fallen on the tested sample on sample flow chamber.Be conducive to be evenly distributed on the energy of hot spot in sample flow chamber
On tested sample on, avoid cell stream in this sample from deviateing the center of energy of focal beam spot, be conducive to improve detection letter
Number stability, optimization measurement cell scatter plot distribution performance.
Forward direction astigmatism collection assembly, to preceding being collected and detecting to astigmatism, is avoided using diaphragm and scattering light collector
In conventional design using focus lamp first to it is preceding assembled to astigmatism after collect, avoid using in forward direction astigmatism collection system
Focus lamp improves the stability of system to a certain extent, reduces the complexity and size of system, collects before making to astigmatism
Component has the characteristics that small in size and structure is simple.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of the utility model optical system；
Fig. 2 is another structural schematic diagram of the utility model optical system；
Fig. 3 is another structural schematic diagram of the utility model optical system；
Fig. 4 is the structural schematic diagram of the utility model blood cell analysis device；
Fig. 5 is the other direction structural schematic diagram of the utility model blood cell analysis device；
Fig. 6 is the other direction structural schematic diagram of the utility model blood cell analysis device.
Specific embodiment
In the following detailed description, the subsidiary reference word of legend is a part here, it is to illustrate this
The utility model can the mode of actable specific concrete scheme illustrate.This utility model is not precluded in we can also be real
Row others concrete scheme and the knot for changing this utility model without prejudice to the use scope of this utility model
Structure.
As depicted in figs. 1 and 2, the optical system for blood cell analysis device includes laser light source 2, beam shaping mould
Block, sample flow chamber 10 and scattering optical detecting unit.The light beam that light beam shaping module is used to issue laser light source 2 collimates
Make to generate irradiation hot spot in the tested sample 11 on sample flow chamber 10 with assembling, scatters optical detecting unit and be used for flow chamber 10
The scattering light of sending received, photoelectric conversion and processing.
In the utility model, laser light source 2 is semiconductor laser diode, and the output wavelength of laser diode is 600nm-
700nm (nanometer).The light beam that laser diode issues includes slow axis and fast axle is the light beam of mutually perpendicular two in-planes,
And light beam is different in slow axis and fast axis divergence angle, and general fast axis divergence angle is 2-4 times of slow axis divergence.It is false in Fig. 1
If X-axis is slow axis, Y-axis is fast axle, then beam cross section ovalisation shape.In order to enable hot spot of the irradiation in cell stream direction is most
Measure it is small, so fast axis divergence angle should be consistent with cell stream direction.Assuming that cell stream direction is Y-axis, laser diode
Fast axis direction is also Y-axis.In some embodiments, the output wavelength of laser diode is 670nm.In other embodiments, laser
Diode output wavelength is 635nm, and fast axle and slow axis divergence are respectively 31 ° and 8 °.More specifically in embodiment, laser two
The rated power 10mw (megawatt) of pole pipe, operating power 5mw.
The light beam shaping module of the utility model includes the collimating mirror 4 being sequentially distributed, for carrying out to slow-axis direction light beam
The cylindrical mirror of diverging and focus lamp for convergent beam.Collimating mirror 4 is used for both direction, that is, fast axis direction to laser light source 2
It is collimated to obtain collimated output beam with the light beam of slow-axis direction, the hot spot after cylindrical mirror and focus lamp collimation carries out shaping
The hot spot for being suitble to detection is obtained, and on the tested sample 11 for falling in hot spot just on sample flow chamber 10.
In some embodiments, collimating mirror 4 is aspherical mirror, and the numerical aperture (NA) of collimating mirror 4 is greater than the hair of fast axle light beam
Angle is dissipated, the light beam whole collimation lens for issuing laser light source 2 is collected.In some embodiments, the numerical aperture of the collimating mirror
It is 0.52.It is dissipated by the light beam of collimating mirror 4 by cylindrical mirror, the small light spot for generating laser light source 2 becomes suitable for detecting
Hot spot.
As shown in Figure 1 to Figure 3, in some embodiments, cylindrical mirror is being negative cylindrical mirror 6 or a negative cylindrical mirror 6 and one just
The combination of cylindrical mirror 602 is dissipated for the light beam to slow-axis direction.As shown in Fig. 2, slow axis beam enters negative cylindrical mirror 6
Or the combination of above-mentioned cylindrical mirror carries out diverging and forms divergent beams 5, and simultaneously, fast axle light beam then passes through column in a manner of directional light
Face mirror.According to the law of refraction, light beam passes through the combination of negative cylindrical mirror 6 or above-mentioned cylindrical mirror, i.e., negative cylindrical mirror 6 with same path
Or the combination of above-mentioned cylindrical mirror does not generate additional effect to fast axle light beam, can drop to most on the influence of fast axle beam quality
It is low, it is therefore, optimal by the optical quality after the combination of negative cylindrical mirror 6 or above-mentioned cylindrical mirror.
As shown in Figure 1 to Figure 3, in some embodiments, focus lamp is plano-convex spherical mirror 8 or 802 He of plano-concave spherical mirror
The combination of one plano-convex spherical mirror 8.Focus lamp is used to carry out converging action, the i.e. light to slow axis and fast axis direction to entire light beam
Shu Jinhang is assembled.
In order to make the beam irradiation of the sending of laser diode 2 on cell, and hot spot can only act on individual cells, quilt
The hot spot and cell size in Y-axis (fast axle) direction match at detection cell, are 10-20um (micron), X-axis (slow axis) direction light
Spot size is appropriate, and one side hot spot is sufficiently large can to ensure that cell has shaking to cause to scatter in flow process in X-direction
Light intensity does not have significant change, and another aspect hot spot will lead to greatly very much the energy dropoff irradiated on cell, therefore, X-direction light
Spot size is 200-400um (micron).As an implementation, the sample flow chamber 10 is made of quartz glass, outside
Diameter is the cuboid of 4*4mm side length, and center bore is the through-hole of 200um*200um, and cell flows through hot spot spoke by this through-hole
According to region.
The scattering optical detecting unit of the utility model include it is preceding to astigmatism collection assembly, forward direction astigmatism collection assembly include according to
The diaphragm 12 and scattering light collector of secondary distribution.In specific embodiment, scattering light collector includes dissipating for collecting low-angle
The low-angle photodiode 14 of coloured light and middle angle photodiode 16 for angle scattering light in collecting, wherein small angle
Degree refers to the angular range of scattering light in 1 ° -6 °, and middle angle refers to the angular range of scattering light in 8 °~25 °；Diaphragm 12
Low-angle and middle angle scattering light is allowed to pass through, other optical signals are blocked.Small angle photodiode in some embodiments
14 and middle angle photodiode 16 it is separately installed on respective supporting element or integrated installation is on supporting element.That is low-angle light
Electric diode 14 and its supporting element and middle angle photodiode 16 and its supporting element are two independent devices or low-angle
Photodiode 14 and middle angle photodiode 16 are commonly mounted on a supporting element.
Scattering optical detecting unit further includes lateral astigmatism collection assembly, lateral astigmatism collection assembly and forward direction astigmatism collection group
Part right angle setting, i.e., before be mounted on Z-direction from Fig. 1 to astigmatism collection assembly on, lateral astigmatism collection assembly is mounted on Fig. 1's
In X-direction.Lateral astigmatism collection assembly includes collecting lens 18 and lateral photodiode 20.Collecting lens are aspherical
Mirror, numerical aperture are greater than 0.4, and the effective focal length of collecting lens is greater than 2mm, and wherein effective focal length refers to collecting lens to sample
The distance between flow chamber.More scattered light signals can be collected as far as possible, be conducive to improve signal-to-noise ratio.Collecting lens have
2mm need to be greater than by imitating focal length, that is, collecting lens and sample flow chamber when installation is avoided to interfere；Lateral photodiode 20 is used to receive
The scattered light signal being collected into.
It is as Figure 4-Figure 6 blood cell analysis device, Fig. 4 is the right inward portion structural schematic diagram of device, and Fig. 5 is dress
Internally structural schematic diagram, Fig. 6 are rear interior structural schematic diagram in the left side set, including device housing, optical system 34 are located at
In the shell.It is fixed with sampling needle 36 on the outer wall of shell front, which is used to collect the finger tip blood sample of subject.This
Outside, power module 31, sampling module 32, counting module 33 and fluid path control system 35 and circuit module are equipped in shell
37.Wherein, optical system 34, power module 31, sampling module 32, counting module 33 and fluid path control system 35 are all by circuit
Module 31 be connected to simultaneously transmit signal, thus realize blood cell analysis device to the various cell parameters in blood carry out count and
The function of classification.
Claims (13)
1. a kind of optical system, in blood cell analysis device, which is characterized in that the optical system includes laser light
Source, light beam shaping module, sample flow chamber and scattering optical detecting unit, the light beam shaping module are used to issue laser light source
Light beam collimated and assembled make generate irradiation hot spot in the tested sample on sample flow chamber, the scattering optical detecting unit
Scattering light for issuing to flow chamber received, photoelectric conversion and processing.
2. optical system according to claim 1, which is characterized in that the light beam that laser light source issues includes slow axis and fast axle
For the light beam of mutually perpendicular two in-planes.
3. optical system according to claim 2, which is characterized in that light beam shaping module includes the collimation being sequentially distributed
Mirror, the cylindrical mirror dissipated for the slow-axis direction light beam to laser light source and for the focus lamp of convergent beam.
4. optical system according to claim 3, which is characterized in that collimating mirror is aspherical mirror, the numerical aperture of collimating mirror
Diameter is greater than the angle of divergence of fast axis direction light beam.
5. optical system according to claim 3, which is characterized in that the cylindrical mirror is negative cylindrical mirror or a negative cylinder
The combination of mirror and a positive cylindrical mirror.
6. optical system according to claim 3, which is characterized in that focus lamp is plano-convex spherical mirror or a plano-concave spherical surface
The combination of mirror and a plano-convex spherical mirror.
7. optical system according to claim 1, which is characterized in that scattering optical detecting unit includes that forward scattering light is collected
Component；Forward scattering light collection assembly includes the diaphragm being sequentially distributed and scattering light collector.
8. optical system according to claim 7, which is characterized in that the scattering light collector includes for collecting small angle
Spend the low-angle photodiode of scattering light and the middle angle photodiode for angle scattering light in collecting.
9. optical system according to claim 8, which is characterized in that the low-angle photodiode and middle angle photoelectricity
Diode is separately installed on respective supporting element or integrated installation is on supporting element.
10. optical system according to claim 7, which is characterized in that the scattering optical detecting unit further includes lateral dissipates
Penetrate light collection assembly, side scattered light collection assembly and forward scattering light collection assembly right angle setting.
11. optical system according to claim 10, which is characterized in that side scattered light collection assembly includes collecting lens
With lateral photodiode.
12. optical system according to claim 11, which is characterized in that collecting lens are aspherical mirror, numerical aperture
Greater than 0.4, the distance between collecting lens to sample flow chamber are greater than 2mm.
13. optical system according to claim 1, which is characterized in that sample flow chamber is rectangular parallelepiped structure, in cuboid
The heart has through-hole.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820574258.6U CN208206768U (en) | 2018-04-22 | 2018-04-22 | A kind of optical system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820574258.6U CN208206768U (en) | 2018-04-22 | 2018-04-22 | A kind of optical system |
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| Publication Number | Publication Date |
|---|---|
| CN208206768U true CN208206768U (en) | 2018-12-07 |
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| CN201820574258.6U Active CN208206768U (en) | 2018-04-22 | 2018-04-22 | A kind of optical system |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109870816A (en) * | 2019-03-16 | 2019-06-11 | 南京华群光电技术有限公司 | A kind of optical system and its displacement measurement method of laser displacement sensor |
| CN112304864A (en) * | 2019-06-26 | 2021-02-02 | 株式会社岛津制作所 | Light scattering detection device and light scattering detection method |
| CN113624644A (en) * | 2020-05-08 | 2021-11-09 | 深圳迈瑞生物医疗电子股份有限公司 | Optical detection system and blood cell analyzer |
| CN115015178A (en) * | 2022-08-05 | 2022-09-06 | 天津迈科隆生物科技有限公司 | Optical detection device and blood analyzer |
-
2018
- 2018-04-22 CN CN201820574258.6U patent/CN208206768U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109870816A (en) * | 2019-03-16 | 2019-06-11 | 南京华群光电技术有限公司 | A kind of optical system and its displacement measurement method of laser displacement sensor |
| CN112304864A (en) * | 2019-06-26 | 2021-02-02 | 株式会社岛津制作所 | Light scattering detection device and light scattering detection method |
| CN113624644A (en) * | 2020-05-08 | 2021-11-09 | 深圳迈瑞生物医疗电子股份有限公司 | Optical detection system and blood cell analyzer |
| CN115015178A (en) * | 2022-08-05 | 2022-09-06 | 天津迈科隆生物科技有限公司 | Optical detection device and blood analyzer |
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