CN208188118U - Intubation for the measurement of small arteries isolated preparation systolic and diastolic function - Google Patents

Abstract

The utility model relates to a kind of intubations for the measurement of small arteries isolated preparation systolic and diastolic function, it includes rigid pipe and is connected to the guidance set for guiding rigid tube end and small arteries to be socketed with rigid tube end；The guidance set is in the cone being gradually reduced along rigid tube end outward direction outer diameter, and after small arteries is socketed in guidance set periphery, guidance set expands in small arteries；The guidance set of the utility model is in the cone being gradually reduced along rigid tube end outward direction outer diameter, it is set to the front end of rigid tube end, the end being entirely intubated is allowed under normal conditions to be in tip-like, so that intubation and the socket of small artery become quick, accurate, set termination process is not damaged to vascular wall；Guidance set after expansion can prop up small arteries both ends, fix intubation with small arteries even closer, rigid pipe is effectively prevent to be separated with small arteries.

Description

Intubation for the measurement of small arteries isolated preparation systolic and diastolic function

Technical field

The utility model relates to a kind of intubations for the measurement of small arteries isolated preparation systolic and diastolic function.

Background technique

There are about 2,600,000 people for the annual number because of the heart, cerebrovascular related disease death in China, and average death per hour is about 300 people.For cardiovascular and cerebrovascular related disease as the most serious disease for endangering human life and health, morbidity key position is blood Pipe, and small artery determines the peripheral resistance of blood vessel, i.e. the resistance of peripheral blood circulation is mainly formed in tiny blood vessels, blood pressure Drop is up to 90%.Therefore, its importance and necessity is also just highlighted to the research of small artery.Utilize pressure myograph technology pair The research of small artery has become one of the main method of current biomedicine.Small artery is shunk using the technology, When diastolic function detects, need to record vasoactive agent to the variation width of external caliber after the effect of small artery isolated preparation Degree.On condition that being about respectively during the experiment 250 with lowest calibre by the both ends that length is the branchiess small artery of 2-3mm μm glass cannula be socketed.However, such socket operation difficulty is very big, the caliber pole of the small arterial blood pipeline section of one side Its is small, about 300 μm or so, only 50 μm bigger than glass cannula or so, is difficult to be inserted in the state of no-station pole canopy with fine forceps slotting Pipe；On the other hand difficulty is socketed to reduce, it is necessary to cannula tip bore is reduced, but so, glass cannula more holds Easy fracture.So tiny blood vessels are difficult the tip of quick, accurate, undamaged set access glass cannula, this leverages whole The process of a experiment.

Summary of the invention

It is simple the purpose of this utility model is to provide a kind of structure and can accurate, quick, convenient, nondestructively be inserted into micro- The intubation for the measurement of small arteries isolated preparation systolic and diastolic function of parteriole blood vessel.

The purpose of this utility model is achieved through the following technical solutions: one kind relaxes for small arteries isolated preparation and contracts The intubation of functional measurement, it include rigid pipe and be connected to rigid tube end the rigid tube end of guidance and small arteries into The guidance set of row socket；The guidance set is in the cone being gradually reduced along rigid tube end outward direction outer diameter, small After arteries is socketed in guidance set periphery, guidance set expands in small arteries.

For the prior art, utility model has the advantages that the guidance set of the utility model is in along rigid pipe The cone that end outward direction outer diameter is gradually reduced, it is set to the front end of rigid tube end, allows the end being entirely intubated normal It is in tip-like under state, so that intubation and the socket of small artery become quick, accurate, set termination process is not damaged to vascular wall；It is swollen Guidance set after swollen can prop up small arteries both ends, fix intubation with small arteries even closer, It effectively prevent rigid pipe to be separated with small arteries；In conclusion the utility model is in vitro for small arteries The intubation of sample systolic and diastolic function measurement has the advantages that operation is convenient and applicable.

Detailed description of the invention

Fig. 1 is the structural schematic diagram of the utility model embodiment one.

Fig. 2 is the status diagram after the expansion of one guidance set of the utility model embodiment.

Fig. 3 is the status diagram after the utility model embodiment one and the socket of small arteries.

Fig. 4 is the enlarged drawing of I in Fig. 1.

Fig. 5 is the structural schematic diagram of the utility model embodiment two.

Fig. 6 is the status diagram after the expansion of two guidance set of the utility model embodiment.

Fig. 7 is the status diagram after the utility model embodiment two and the socket of small arteries.

Label declaration: 1 rigid pipe, 2 closing coils, 3 wire A, 4 elastic protective films, 5 fixed rings, 6 wire B, 7 bullets Property overlay film, 8 small arteries, 9 grooves, 10 nylon wires, 11 perfusion slots.

Specific embodiment

The content of the present invention is described in detail with embodiment with reference to the accompanying drawings of the specification:

Embodiment one:

It is as shown in Figures 1 to 4 provided by the utility model a kind of for small arteries isolated preparation systolic and diastolic function The embodiment schematic diagram of the intubation of measurement.

It is a kind of for small arteries isolated preparation systolic and diastolic function measurement intubation, it include rigid pipe 1 and with it is rigid Property 1 end of pipe connection guidance 1 end of the rigid pipe and guidance set that is socketed of small arteries 8；The guidance set is in The cone being gradually reduced along 1 end outward direction outer diameter of rigid pipe, after small arteries 8 is socketed in guidance set periphery, Guidance set expands in small arteries 8.

The rigid pipe 1 is glass capillary.If drawing the end of glass capillary very sharp, although can make small Arteries 8 smoothly, accurately covers outside rigid pipe 1, but the end of glass capillary once becomes very sharp very thin, Jiu Huibian Must be very fragile, the end of glass capillary can gently be broken up at a touch.

And a guidance set is arranged in the end of rigid pipe 1 in the utility model, which is in along 1 end of rigid pipe The cone that outward direction outer diameter is gradually reduced, it connect with 1 end of rigid pipe, and the end being entirely intubated is allowed under normal conditions to be in needle It is pointed, it is socketed convenient for rigid pipe 1 and small arteries 8.After guidance set expands in small artery, blood is propped up Inside pipe wall strengthens the connection of rigid pipe 1 Yu small arteries 8, effectively prevent rigid pipe 1 de- with small 8 phase of arteries From.

The outer diameter of 1 end of rigid pipe is gradually reduced along 1 end outward direction of rigid pipe.

The guidance set includes on the left of 1 left end of rigid pipe and central axis is mutually be overlapped with the central axis of rigid pipe 1 The closing coil 2 of conjunction and several are connected between 1 left end of closing coil 2 and rigid pipe can the wire A3 that deformation occurs； The closing coil 2 is made of memory wire, and outer diameter is less than when being shrunk to petal and contraction under 2 normality of closing coil The outer diameter of 1 end of rigid pipe, outer diameter is greater than 1 end of rigid pipe after closing coil 2 expands into circular ring shape under heating and expands Outer diameter；As in Figure 2-4: closing coil 2 expands into circular ring shape by petal under heating, and entire guidance set has occurred swollen It is swollen, strengthen the connection of rigid pipe 1 Yu small arteries 8.

In order to prevent in 2 process of expansion of closing coil, wire A3 generates excessive tension to rigid pipe 1 and damages just Property pipe 1 tip, the wire A3 that the utility model is selected be can the wire A3 that deformation occurs, can the wire that deformation occurs A3 plays the role of centainly buffering, and when closing coil 2 is expanded, wire A3 bends.

The guidance set further includes covering in the elastic protective film 4 of the periphery wire A3.Occur in wire A3 outside After bending, elastic protective film 4 can prevent wire A3 from damaging small arteries 8, and prevent the fluid communication of extra vascular, To maintain endovascular fluid pressure.

The rigid pipe 1 is equipped with the groove 9 for holding nylon wire insertion in the outside wall surface of guidance set one end.When small dynamic After arteries and veins blood vessel 8 is socketed with the rigid pipe 1 with guidance set, rigid pipe 1 and small 8 phase of arteries are consolidated using nylon wire It is fixed, both prevented small artery from falling off, while preventing fluid seepage in experimentation.Nylon wire 10 is embedded in groove 9, can be prevented Nylon wire 10 horizontally slips.

As shown in figure 3, the intubation for the measurement of small artery isolated preparation systolic and diastolic function of embodiment one is to small dynamic It is as follows with the mode of small arteries 8 socket before arteries and veins blood vessel measures: branchiess in vitro small arteries 8 is put It is placed in the perfusion slot 11 of 4 DEG C of biological buffer solutions, one end of small arteries 8 is socketed in the rigidity with guidance set On pipe 1, then fastened in rigid pipe 1 and the belled position of small arteries 8 with nylon wire, then with syringe be intubated to Small intra-arterial is slowly injected into biological buffer, washes away endovascular remained blood；Later by the other end of small arteries 8 It is socketed and will be intubated with nylon wire with another intubation and fastened (such as with the connecting portion of the other end of small arteries 8 Shown in Fig. 3).After connecting to small arteries 8 with the cannula sleeve, the perfusion of small arteries 8 and intubation will be loaded with Slot 11 moves on the inverted microscope platform of pressure-type parteriole measuring instrument, and the biological buffer in perfusion slot 11 and in intubation is molten Liquid is warming up to 37 DEG C, carries out vessel retraction and diastolic function detection.In next whole experiment process, in perfusion slot 11 and Fluid temperature in intubation is kept at 37 DEG C or so, and dilatating and deformable can occur at such a temperature for the closing coil 2 of guidance set, It allows entire guidance set to expand, strengthens the connection of rigid pipe 1 Yu small arteries 8, while fluid flowing being allowed to become It is smooth.

Embodiment two:

It is as shown in Figures 5 to 7 provided by the utility model another for the easypro contracting function of small arteries isolated preparation The embodiment schematic diagram for the intubation being capable of measuring.

The cannula structures and embodiment one for the measurement of small arteries isolated preparation systolic and diastolic function in the embodiment Structure be substantially the same, the main distinction is: the guidance set include be set to 1 left end of rigid pipe on the left of and central axis with Fixed ring 5 that the central axis of rigid pipe 1 coincides, several be connected between 1 left end of fixed ring 5 and rigid pipe and can occur The wire B6 of deformation and it is overlying on the periphery wire B6 and can the elastic overlay film 7 that deformation occurs；It is outer under 5 normality of fixed ring Diameter is less than the pipe outside diameter of 1 end of rigid pipe, and fixed ring 5 is made of expandable material after absorbing water, fixed ring 5 expand after with it is small Arteries 8 is interference fitted, and can effectively prevent during the experiment, and intubation end and small arteries 8 are detached from；Fixed ring 5 It is still circular ring shape after expansion.

The fixed ring 5 is made of Merocel swellable polymer material.

The inflatable portion of the embodiment is divided into fixed ring 5, rather than the closing coil 2 in embodiment one.Embodiment two The intubation of intubation and embodiment one is also roughly the same with the socket mode of small arteries 8, but because of the guiding group of embodiment two Part contains expandable fixed ring 5 after water suction, so after the tip being entirely intubated and in vitro small arteries 8 are socketed, nothing It need to will be intubated using nylon wire and be bound with the connecting portion of small arteries 8, as long as the chance water of fixed ring 5 will be spontaneous swollen It is swollen, and expand after with small arteries 8 be interference fitted, in this way have fixed ring 5 rigid pipe 1 can firmly with it is micro- Parteriole blood vessel 8 connects, existing without having to worry about the sepage that is separated or occurs of rigid pipe 1 in experimentation and small arteries 8 As.

In order to prevent in 5 expansion process of fixed ring, wire B6 generates excessive tension to rigid pipe 1 and damages rigidity Pipe 1, the wire B6 that the utility model is selected be can the wire B6 that deformation occurs, can the wire B6 that deformation occurs play The effect centainly buffered.

Claims (8)

1. a kind of intubation for the measurement of small arteries isolated preparation systolic and diastolic function, it is characterised in that: it includes rigid pipe (1) and with rigid pipe (1) end it is connected to the guiding group that guidance rigid pipe (1) end and small arteries (8) are socketed Part；The guidance set is in the cone being gradually reduced along rigid pipe (1) end outward direction outer diameter, small arteries (8) After being socketed in guidance set periphery, guidance set expansion in small arteries (8).

2. the intubation according to claim 1 for the measurement of small arteries isolated preparation systolic and diastolic function, feature exist In: the rigid pipe (1) is glass capillary.

3. the intubation according to claim 1 for the measurement of small arteries isolated preparation systolic and diastolic function, feature exist In: the outer diameter of rigid pipe (1) end is gradually reduced along rigid pipe (1) end outward direction.

4. the intubation according to claim 1 for the measurement of small arteries isolated preparation systolic and diastolic function, feature exist In: the guidance set includes on the left of rigid pipe (1) left end and the central axis of central axis and rigid pipe (1) coincides Closing coil (2) and several be connected between closing coil (2) and rigid pipe (1) left end can the wire that deformation occurs A(3)；The closing coil (2) is made of memory wire, is shrunk to petal under closing coil (2) normality and shrinks When outer diameter be less than rigid pipe (1) end outer diameter, closing coil (2) expand under heating circular ring shape and expand after outer diameter be greater than The outer diameter of rigid pipe (1) end.

5. the intubation according to claim 4 for the measurement of small arteries isolated preparation systolic and diastolic function, feature exist In: the guidance set further includes covering in the elastic protective film (4) of wire A (3) periphery.

6. inserting for the measurement of small arteries isolated preparation systolic and diastolic function described in -5 any one according to claim 1 Pipe, it is characterised in that: the rigid pipe (1) is equipped in the outside wall surface of guidance set one end holds the recessed of nylon wire (10) insertion Slot (9).

7. the intubation according to claim 1 for the measurement of small arteries isolated preparation systolic and diastolic function, feature exist In: the guidance set includes on the left of rigid pipe (1) left end and the central axis of central axis and rigid pipe (1) coincides Fixed ring (5), several be connected between fixed ring (5) and rigid pipe (1) left end and can the wire B (6) that deformation occurs And it covers in the periphery wire B (6) and the energy elastic overlay film (7) that deformation occurs；Outer diameter is less than under fixed ring (5) normality The pipe outside diameter of rigid pipe (1) end, fixed ring (5) are made of expandable material after absorbing water, fixed ring (5) expansion after with it is small Arteries (8) interference fit.

8. the intubation according to claim 7 for the measurement of small arteries isolated preparation systolic and diastolic function, feature exist In: the fixed ring (5) is made of Merocel swellable polymer material.