CN208172220U - Magnet field probe, weak magnetic signal detection device - Google Patents
Magnet field probe, weak magnetic signal detection device Download PDFInfo
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- CN208172220U CN208172220U CN201820600889.0U CN201820600889U CN208172220U CN 208172220 U CN208172220 U CN 208172220U CN 201820600889 U CN201820600889 U CN 201820600889U CN 208172220 U CN208172220 U CN 208172220U
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Abstract
This application involves technical field of biological, more particularly to a kind of magnet field probe, are applied to carry out magnetic signal detection to magnetic aggregation, including：Magnet offers baltimore groove, for magnetizing the magnetic aggregation；Magnetic Sensor is set in the central area for closing on the baltimore groove, for detecting the initial magnetic field strength signal in formed magnetic field after the magnetic aggregation is magnetized；Wherein, during being formed by magnetic field after the Magnetic Sensor is magnetized to the magnetic aggregation and detecting, the magnetism aggregation carries out translational motion relative to the Magnetic Sensor immediately below the Magnetic Sensor detection faces being located in the baltimore groove.Above-mentioned magnet field probe can be effectively reduced adverse effect caused by low-intensity magnetic field of the high-intensity magnetic field of magnet for magnetic aggregation, so that Magnetic Sensor detects that initial magnetic field strength signal is more accurate.
Description
Technical field
The utility model relates to technical field of biological, more particularly to a kind of magnet field probe and weak magnetic signal detection dress
It sets.
Background technique
Currently, in the fields such as medicine and clinical analysis, DNA analysis and environmental pollution monitoring, using nanoscale magnetic
Property particulate matter is marked the test objects such as cell, protein, antibody, pathogen, virus and DNA to form magnetic aggregation
Body, and after magnetizing to above-mentioned magnetic aggregation, pass through the magnetic aggregation after the detection magnetization of weak magnetic signal detection device
Magnetic field caused by body, and then the relevant parameters such as total amount of specific location or the test object where the above-mentioned test object of acquisition
Information.
But the low-intensity magnetic field caused by aggregation magnetic after to magnetization is during detect, Gu magnetic magnetic field can produce
Raw serious interference so that the precision of weak magnetic signal detection relevant apparatus in the market is not high, be unable to satisfy market for
The demand of weak magnetic signal high-precision detection.
Utility model content
Based on this, it is necessary in view of the above technical problems, provide a kind of magnet field probe and weak magnetic signal detection device, with
While carrying out effective fast-magnetic to magnetic aggregation, the precision of weak magnetic signal detection is effectively promoted, and then is met current
High-precision demand is detected in market for weak magnetic signal.
Present applicant proposes a kind of magnet field probe, can be applied to carry out magnetic signal detection, the magnetic field to magnetic aggregation
Probe includes：
Magnet offers baltimore groove, for magnetizing the magnetic aggregation；
Magnetic Sensor is set in the central area for closing on the baltimore groove, for detecting the magnetic aggregation by magnetic
The initial magnetic field strength signal in formed magnetic field after change；
Wherein, the process detected in magnetic field is formed by after the Magnetic Sensor is magnetized to the magnetic aggregation
In, the magnetism aggregation senses immediately below the Magnetic Sensor detection faces being located in the baltimore groove relative to the magnetic
Device carries out translational motion.
Above-mentioned magnet field probe, by using female groove structures magnet, can to magnetic aggregation carry out quickly, have
While effect, comprehensive magnetization operation, and utilized at the center position of the most weak baltimore groove of field strength in being located at magnets magnetic fields
Magnetic Sensor is formed by low-intensity magnetic field after being magnetized to above-mentioned magnetic aggregation and detects, to be effectively reduced the strong magnetic of magnet
Adverse effect caused by low-intensity magnetic field of the field for magnetic aggregation, so that Magnetic Sensor detects that initial magnetic field intensity is believed
It is number more accurate.
In an alternative embodiment, above-mentioned magnet field probe may also include：
Signal amplifying apparatus is connect with the Magnetic Sensor, for carrying out to the received initial magnetic field strength signal
Filter and amplification forms output magnetic field intensity signal.
In an alternative embodiment, above-mentioned magnet field probe may also include protective shell；
Wherein, the protective shell passes the magnet and the magnetic for accommodating the magnet and the Magnetic Sensor
Sensor is isolated with external electromagnetic field.
In an alternative embodiment, after the magnetic aggregation is by carrying out magnetic mark to biological detection sample
It is formed by aggregates of nanoparticles；
Wherein, the initial magnetic field strength signal is used to carry out quantitative analysis to the biological detection sample.
In an alternative embodiment, the Magnetic Sensor is the sensor of push-pull type favour stone full bridge structure, is used for
Differential voltage output is provided.
In an alternative embodiment, the sensor of the push-pull type favour stone full bridge structure is TMR sensing element institute
The sensor of composition.
Present invention also provides a kind of magnet field probe, can be applied to carry out magnetic signal detection, the magnetic to magnetic aggregation
Field probe includes：
Magnet has bar-shaped magnet magnetic field, for magnetizing the magnetic aggregation；
Magnetic Sensor, at the position of magnetic field strength approach zero, detecting the magnetism in the bar-shaped magnet magnetic field
The initial magnetic field strength signal in aggregation formed magnetic field after being magnetized；
Wherein, the process detected in magnetic field is formed by after the Magnetic Sensor is magnetized to the magnetic aggregation
In, the magnetism aggregation relatively described magnetic field Magnetic Sensor in the bar-shaped magnet magnetic field carries out translational motion.
Above-mentioned magnet field probe, by carrying out quick, effective, comprehensive magnetization behaviour to magnetic aggregation using spill magnetic field
While work, and in being located at the bar-shaped magnet magnetic field at the position of magnetic field strength approach zero, using Magnetic Sensor to above-mentioned
Magnetic aggregation is formed by low-intensity magnetic field after being magnetized and is detected, and magnetism is assembled to be effectively reduced the high-intensity magnetic field of magnet
Adverse effect caused by the low-intensity magnetic field of body, so that Magnetic Sensor detects that initial magnetic field strength signal is more accurate.
In an alternative embodiment, above-mentioned magnet field probe may also include：
Signal amplifying apparatus is connect with the Magnetic Sensor, for carrying out to the received initial magnetic field strength signal
Filter and amplification forms output magnetic field intensity signal.
In an alternative embodiment, after the magnetic aggregation is by carrying out magnetic mark to biological detection sample
It is formed by the aggregates of nanoparticles being carried in test strips；
Wherein, the initial magnetic field strength signal is used to carry out quantitative analysis to the biological detection sample.
Present invention also provides a kind of weak magnetic signal detection device, can be applied to carry out the magnetic aggregation in test strips
Magnetization and magnetic signal detection, described device include：
Kit carries the test strips for fixed；
Magnet field probe as described in above-mentioned any one, for so that the magnetic of the test strips in the baltimore groove
The translational motion relative to the magnet is carried out immediately below sensor detection faces.
Above-mentioned weak magnetic signal detection device, it is mobile relative to kit by driving magnetic field probe, so that being fixed on examination
Test strips on agent box carry out translational motion in the groove of magnet, so the magnetic aggregation that test strips can be carried into
Quick, effective, the comprehensive magnetization operation of row；Simultaneously as the most weak baltimore groove of field strength in Magnetic Sensor setting magnets magnetic fields
In central area, detected so that being formed by low-intensity magnetic field after being magnetized using Magnetic Sensor to above-mentioned magnetic aggregation
When, it can be effectively reduced interference caused by low-intensity magnetic field of the high-intensity magnetic field of magnet for magnetic aggregation, so that magnetic senses
Device detects that initial magnetic field strength signal is more accurate.
Detailed description of the invention
Fig. 1 is the overall structure diagram of magnet field probe in the embodiment of the present application；
Fig. 2 is the configuration schematic diagram of magnet field probe in the embodiment of the present application；
Fig. 3 is the bottom view of magnet and protective shell shown in Fig. 2；
Fig. 4 is the stereoscopic schematic diagram of magnet；
Fig. 5 is Distribution of Magnetic Field schematic diagram of the magnet shown in Fig. 4 from different location among groove；
Fig. 6 is the schematic equivalent circuit of Magnetic Sensor in the embodiment of the present application；
Fig. 7 is the schematic diagram of the output difference characteristics of signals curve of Magnetic Sensor in the embodiment of the present application；
Fig. 8 is the circuit diagram of signal amplifying apparatus in the embodiment of the present application；
Fig. 9 is the frequency response schematic diagram of circuit shown in Fig. 8；
Figure 10 a is the structural schematic diagram of weak magnetic signal detection device in the embodiment of the present application；
Schematic diagram when Figure 10 b is the work of weak magnetic signal detection device shown in Figure 10 a；
Figure 11 a-11e is the flowage structure signal that weak magnetic signal detection device carries out weak magnetic detection in the embodiment of the present application
Figure；
Figure 12 is variation resistance value response curve schematic diagram of magneto-resistor R1 shown in Fig. 6 (or R2) with magnets magnetic fields；
Figure 13 is variation resistance value response curve schematic diagram of magneto-resistor R4 shown in Fig. 6 (or R3) with magnets magnetic fields；
Figure 14 is the difference that Magnetic Sensor is exported when weak magnetic signal detection device carries out weak magnetic detection in the embodiment of the present application
Component voltage waveform diagram.
Specific embodiment
In order to which the purpose of this utility model, technical method and advantage is more clearly understood, below in conjunction with attached drawing and implementation
Example, the present invention will be further described in detail.It should be appreciated that specific embodiment described herein is only used to explain
The utility model is not used to limit the scope of the utility model.
Magnet field probe provided in embodiments herein and the weak magnetic signal detection device including the magnet field probe, can
It applies in the fields such as medicine and clinical analysis, DNA analysis and environmental pollution monitoring, nanoscale magnetic-particle can be based on
Object is marked in test strips the test objects such as cell, protein, antibody, pathogen, virus and DNA and forms magnetism
On the basis of aggregation, the magnetic aggregation carried in test strips is carried out fully and effectively using above-mentioned magnet field probe
Magnetization and synchronous realize precisely detect magnetic field caused by the magnetic aggregation after magnetization, and then obtain above-mentioned detection pair
As the relevant parameters information such as total amount of the specific location at place or the test object, test object (or sample) is determined with realizing
Amount detection and analysis.
In a preferred embodiment, magnet field probe may include magnet and Magnetic Sensor, offer spill in the magnet
Slot, and Magnetic Sensor then may be provided in the central area of above-mentioned baltimore groove.In the actual operation process, magnetic aggregation exists
When being moved immediately below the Magnetic Sensor detection faces in above-mentioned baltimore groove, the aggregation that is magnetic is entirely located in produced by magnet
High-intensity magnetic field in, and the magnetic field strength of the high-intensity magnetic field all directions is more average, and then can realize to different in magnetic aggregation
Magnetic-particle carry out quickly, comprehensive magnetization；Meanwhile when magnetic aggregation is moved to the central area of baltimore groove, due to
Distribution of Magnetic Field of the magnet with concave structure in the baltimore groove similar to bar magnet intermediate position Distribution of Magnetic Field, so more
It closes on its magnetic field strength of the central area of baltimore groove with regard to smaller, can even level off to zero at the position of the central point of baltimore groove,
The high-intensity magnetic field of magnet is most weak i.e. in the band of position, accordingly for the interference of low-intensity magnetic field caused by the magnetic aggregation after magnetization
With regard to smaller, from avoiding Magnetic Sensor magnetic field strength detected at this time just closer to the true field strength of above-mentioned low-intensity magnetic field,
The precision of the weak magnetic signal detection of magnetic aggregation after magnetizing thus can be further promoted, while also can effectively avoid magnetic
Sensor due to detecting magnetic saturation can not the weak magnetic signal to magnetic aggregation normally detected.
Preferably, above-mentioned magnet can be neodymium iron boron (NdFeB) permanent magnet, for providing one on magnetic aggregation periphery
A relatively stable magnetic field environment, with the magnetic nanoparticle carried in short distance Momentary magnetizing test strips during the scanning process
Marker (i.e. magnetic aggregation).
In an alternative embodiment, above-mentioned magnet field probe may also include the signal being electrically connected with Magnetic Sensor and put
Big device, i.e., above-mentioned Magnetic Sensor can detect output difference voltage signal (i.e. initial magnetic field strength signal) by magnetic resistance and extremely should
Signal amplifying apparatus, to be filtered, be amplified to weak magnetic signal detected by Magnetic Sensor using the signal amplifying apparatus
Operation, output treated voltage signal (i.e. output magnetic field intensity signal), the voltage signal are generally the voltage letter of 0~5V
Number, while further promoting weak magnetic signal accuracy, moreover it is possible to be amplified to weak magnetic signal, convenient for subsequent quantitative point
Analysis and detection.
In an alternative embodiment, above-mentioned magnet field probe may also include protective shell, above-mentioned Magnetic Sensor and magnetic
Body is placed in the protective shell, effectively to avoid being believed in carrying out the operating process such as magnetization and magnetic signal detection by external electromagnetic
Number interference.For example, the protective shell can be the shell of metal material, while armoured magnetic field pops one's head in periphery electromagnetic interference,
Support protective effect can also be provided for magnet, Magnetic Sensor etc..
In an alternative embodiment, above-mentioned Magnetic Sensor can be tunnel magneto resistance (Tunneling Magnetic
Resistance, abbreviation TMR), the linear transducers such as giant magnetoresistance (AMR) or anisotropic magnetoresistive (GMR)；TMR magnetic can be such as based on
Inductive effect realizes the detection to weak magnetic signal caused by such as magnetic nanoparticle reagent in field of biological detection.Wherein,
Above-mentioned magnetic aggregation can be for by being formed by the magnetic being carried in test strips after biological detection sample progress magnetic mark
Property aggregates of nanoparticles, carries out biological detection sample subsequently through weak magnetic signal detected by Magnetic Sensor quantitative
Detection and analysis.
Preferably, above-mentioned Magnetic Sensor may include four unmasked high sensitivity magnetic tunnel-junction (Magnetic Tunnel
Junction, abbreviation MTJ) element, realize such as push-pull type favour stone full bridge structure.Since favour stone full bridge structure is with higher
Temperature stability, therefore the Magnetic Sensor sense externally-applied magnetic field along be parallel to sensor sensing direction and change when, lead to
Above-mentioned push-pull type favour stone full bridge structure output difference voltage is crossed, and then is also able to achieve under different temperature environments to weak magnetic
The accurate detection of signal.
In another optional embodiment of the application, a kind of magnet field probe is additionally provided, specifically may include magnetic sensing
Device and magnet with bar-shaped magnet magnetic field, and Magnetic Sensor is set to magnetic field strength in the bar-shaped magnet magnetic field and levels off to zero
At position (i.e. in bar-shaped magnet magnetic field at the smallest position of magnetic field strength), translated in this way in magnetic aggregation magnet field probe
When movement, above-mentioned bar-shaped magnet magnetic field can carry out the magnetism aggregation comprehensively, effectively to magnetize, while after magnetization
When magnetic aggregation is moved near above-mentioned Magnetic Sensor, since the intensity in bar-shaped magnet magnetic field is minimum, thus utmostly
Reduce interference caused by low-intensity magnetic field of the magnet high-intensity magnetic field to aggregation magnetic after magnetization, effectively to promote above-mentioned magnetic sensing
The precision of device weak magnetic signal detection.
It should be noted that, in the present embodiment, all parts (such as magnet, Magnetic Sensor) of magnet field probe can be used
Above-mentioned modular construction, while can also correspond to including other components in above-described embodiment, but be also not limited to the application reality
The modular construction in example is applied, i.e., it has the magnet that can generate bar-shaped magnet magnetic field and Magnetic Sensor is set to the bar shaped magnetic
In body magnetic field at the minimum position of field strength, while above-mentioned bar-shaped magnet magnetic field is also changed to other kinds of magnetic field, only
It is wanted to can be realized comprehensive, the efficient magnetization to magnetic aggregation, and there are the lower position areas of relative field strength in magnetic field
Domain.
In another optional embodiment of the application, a kind of weak magnetic signal detection device is additionally provided, it may include examination
Any magnet field probe in agent box and the embodiment of the present application, i.e., by consolidating the test strips for carrying above-mentioned magnetic aggregation
Determine in mentioned reagent box, and above-mentioned magnet field probe is driven to be moved relative to the kit, so that test strips are in magnetic field
Translational motion in the bar-shaped magnet magnetic field of probe or groove, thus realize in the test strips magnetic aggregation carry out quickly,
Effectively, it while overall magnetization, is sensed using the magnetic that bar-shaped magnet field strength lowest point and/or groove center position is arranged in
Device accurately detects low-intensity magnetic field caused by the magnetic aggregation after magnetization.
In the actual operation process：Firstly, examination can be fixed on the test strips for carrying magnetic nanoparticle marker
In agent box, and the kit is placed at the lower section short distance position of above-mentioned magnet field probe detection faces.Secondly, the examination that driving is above-mentioned
Agent box is along the magnetic-field-sensitive direction of Magnetic Sensor, the mistake of the underface with pre-set constant speed translation Jing Guo magnet field probe detection faces
Cheng Zhong, so that the magnetic aggregation moment carried in above-mentioned test strips is magnet magnetized.Then, so that the magnetism after magnetization is poly-
After collective transverse translates the underface of short distance magnet field probe detection faces, since the magnetic field of the magnetic aggregation after magnetization is along parallel
Change in Magnetic Sensor sensitive direction, therefore the TMR in above-mentioned Magnetic Sensor sense with push-pull type favour stone full bridge structure can be utilized
Sensor element, the variation output difference voltage signal based on above-mentioned low-intensity magnetic field.Finally, utilizing pre-amplification circuit (i.e. signal
Amplifying device) processing such as be filtered, amplify to the differential voltage signal of above-mentioned output after, be transformed to corresponding voltage signal
(such as 0~5V voltage signal) is exported, and then precisely learns the low-intensity magnetic field field strength of current magnetic aggregation, is realized to detection sample
This quantitative detection and analysis.
In the above-described embodiment, since weak magnetic signal detection device uses tunnel magneto resistance magnetic induction effect technology,
The detection of magnetic nanoparticle bioprobe kit is carried out, that is, passes through the relatively flat movement of magnetic probe and kit short distance
It is dynamic, enable magnetic particle marker by Momentary magnetizing, and carry out to the magnetic field strength of magnetic particle marker after magnetization same
Step detection, and then realize the quantitative detection and analysis to above-mentioned magnetic-particle marker.For example, can in embodiments herein
Realize the highly sensitive detection of 7mV/O~15mV/Oe, and the dynamic range of saturation magnetic field can reach -30Oe~+30Oe, and its
Power consumption is then lower than 0.5 μ A/1V.
With reference to the accompanying drawing, the magnet field probe of the application and weak magnetic signal detection device are explained in detail：
Fig. 1 is the overall structure diagram of magnet field probe in the embodiment of the present application, and Fig. 2 is that magnetic field is visited in the embodiment of the present application
The configuration schematic diagram of head.As shown in Fig. 1~2, a kind of magnet field probe 1 may include signal amplification board (i.e. signal amplifying apparatus)
11, protective shell 12, magnet 13 and Magnetic Sensor mould group 14；It is provided with the first fixation hole 111 on signal amplification board 11, and protective shell
The position that above-mentioned first fixation hole 111 is arranged then is corresponded on 12 and is provided with the second fixation hole 121, and first fixation hole 111 can
It corresponds and bolts with the second fixation hole 121, and then above-mentioned protective shell 12 is fixed on the signal amplification board 11.
Fig. 3 is the bottom view of magnet and protective shell shown in Fig. 2, and Fig. 4 is the stereoscopic schematic diagram of magnet.Such as the institute of Fig. 2~3
Show, above-mentioned protective shell 12 there are also cavity 122 open at one end, above-mentioned magnet 13 and Magnetic Sensor mould group 14 it is stacked after can consolidate
Surely it is placed in the cavity 122, with the electromagnetic interference outside shielding.Meanwhile fluted 131 are opened up on above-mentioned magnet 13, magnetic
Sensor module 14 can be fixed in the groove 131 by modes such as stickups.In addition, as shown in Figure 2, above-mentioned Magnetic Sensor mould
It is provided with Magnetic Sensor 141 in group 14, and when Magnetic Sensor mould group 14 is fixed in the groove 131, above-mentioned Magnetic Sensor
141 are located at the center position of groove 131, i.e. Magnetic Sensor 141 is located at the region that 13 magnetic field strength of magnet is most weak in groove 131
In.Wherein, magnet surface magnetic field strength is greater than 3000GS, to ensure to can be realized magnetic aggregation flash magnetization operation.
Fig. 5 is Distribution of Magnetic Field schematic diagram of the magnet shown in Fig. 4 from different location among groove.As shown in Figures 4 and 5,
The groove 131 opened up on magnet 13 is bar shaped, and being located at groove two sides side wall 132 and 133 according to curve shown in Fig. 5 makes
The magnetic field of the magnet 13 is similar to the magnetic field at bar magnet center, i.e., the magnetic field strength of the center position of groove 131 most
It is weak.
Fig. 6 is the schematic equivalent circuit of Magnetic Sensor in the embodiment of the present application, and Fig. 7 is that magnetic senses in the embodiment of the present application
The schematic diagram of the output difference characteristics of signals curve of device.As shown in Fig. 2 and 6~7, Magnetic Sensor 141 can be favour stone full-bridge knot
The sensor of structure, such as by the way that four unmasked high sensitivity tunnel junction element solder masks are fixed on pcb board, and by drawing
Connecting terminal line constitutes favour stone full bridge structure as shown in Figure 6 out, and handling to be formed by differential signal has such as
The Magnetic Sensor mould group 14 of output characteristic curve shown in Fig. 7；The Magnetic Sensor mould group 14 can be pasted by resin glue etc. simultaneously
In the center position of above-mentioned groove 132, and by conducting wire be the Magnetic Sensor mould group 14 and above-mentioned signal amplification board 11
Electrical connection.
Fig. 8 is the circuit diagram of signal amplifying apparatus in the embodiment of the present application, and Fig. 9 is that the frequency response of circuit shown in Fig. 8 is shown
It is intended to.As shown in Fig. 2,8~9, the circuit in the embodiment of the present application on magnification circuit plate 11 can be circuit knot as shown in Figure 8
Structure, with frequency response curve characteristic as shown in Figure 9, i.e., in actual application, by adjusting circuit shown in Fig. 8
Band logical discharge parameter, enable to band logical frequency parameter and kit (or test strips) relative to magnet field probe translational motion
Speed matches, with the noise for the differential signal for further inhibiting Magnetic Sensor to export.
Figure 10 a is the structural schematic diagram of weak magnetic signal detection device in the embodiment of the present application, and Figure 10 b is shown in Figure 10 a
Schematic diagram when weak magnetic signal detection device works.As shown in Figure 10 a~10b, present invention also provides a kind of inspections of weak magnetic signal
Survey device, it may include magnet field probe 1 and kit 2 shown in above-mentioned Fig. 1~2, and fixed in the kit 2 carry magnetic
Property aggregation test strips (not shown) so that above-mentioned magnet field probe 1 and kit 2, in the inspection of the magnet field probe 1
On the magnetic-field-sensitive direction of survey face, closely moved with respect to uniform translation, so that magnet field probe 1 is to institute in test strips in kit 2
The flash magnetization and weak magnetic signal detection operation that the magnetic aggregation of carrying synchronizes.
In an alternative embodiment, above-mentioned test strips, which can be, carries laterally exempting from for superparamagnetic nano particle
Epidemic disease chromatograph test strip, and after the lateral immuno-chromatographic test paper strip carried out antigen-antibody reaction, utilize above-mentioned superparamagnetism
Nano particle forms the magnetic aggregation for being anchored magnetic aggregation or being fixed on a certain specific position, then using additional magnetic
Field magnetizes fixed magnetic aggregation, and the magnetic signal by detecting magnetic field produced by the magnetic aggregation after magnetizing,
To realize the Qualitative and quantitative analysis to test object.
Figure 11 a-11e is the flowage structure signal that weak magnetic signal detection device carries out weak magnetic detection in the embodiment of the present application
Figure, Figure 12 is variation resistance value response curve schematic diagram of magneto-resistor R1 shown in Fig. 6 (or R2) with magnets magnetic fields, and Figure 13 is Fig. 6
Shown in magneto-resistor R4 (or R3) with magnets magnetic fields variation resistance value response curve schematic diagram；The resistance of ordinate expression magneto-resistor
Value, abscissa indicate the magnetic moment of magnet, i.e. the resistance value of each magneto-resistor is assembled with magnetic after the magnetic moment of magnet and magnetization in Fig. 6
The variation of angle between the magnetic moment of object and change.
Referring to shown in 11a~11e, 12, when test strips 13 are moved to position shown in Figure 11 b from the position shown in Figure 11 a
During setting place, the reference point Sa in corresponding diagram 12 is to the curve characteristic between reference point Sb, magnet magnetic that test strips 3 are subject to
The magnetic field strength of field is gradually increased, and then can quickly be realized and be carried out magnetic to the magnetic aggregation carried in the test strips 3
Change.At this point, as shown in figure 11b, the magnetic moment direction A of magnet is parallel with the magnetism magnetic moment direction C of aggregation after magnetization, corresponding to scheme
Magneto-resistor R1 curve corresponds to low resistance state RL at the position La shown in 12, and magnetic poly- after the magnetic moment direction A of magnet and magnetization
(referring to shown in Figure 11 d) when the magnetic moment direction C of collection object is antiparallel, magneto-resistor R1 curve is corresponding at the position Lc shown in Figure 12
Low resistance state RH；When the magnetic moment direction A of magnet is vertical with the magnetism magnetic moment direction C of aggregation after magnetization (referring to shown in Figure 11 c),
It is the median between RL and RH, i.e. (RL+ that magneto-resistor R1 curve, which corresponds to resistance state R resistance value, at the position Lb shown in Figure 12
RH)/2；At this point, the optimum position that Magnetic Sensor works at the position Lb of i.e. Figure 11 c and corresponding Figure 12.That is the magnetic in Fig. 6
Resistance R2 corresponds to magneto-resistor R3, and magneto-resistor R4 corresponding with magneto-resistor R1 collectively constitutes push-pull type Huitong full bridge structure, and then realizes
Voltage differential output, to further decrease the noise of output signal, while promoting the amplitude of output signal.
In addition, shown in Figure 13, the sound of magneto-resistor R4 response curve under the conditions of magnets magnetic fields H and magneto-resistor R1
Answer curve in opposite variation tendency.As shown in figs. 6-7, the output characteristics through Magnetic Sensor difference processing shown in Fig. 6 is bent
For line as shown in fig. 7, i.e. under fixed bias voltage conditions, the output voltage characteristic curve of MTJ electric bridge is as shown in figure 14.Figure 14
It is that the differential voltage waveform that Magnetic Sensor is exported when weak magnetic signal detection device carries out weak magnetic detection in the embodiment of the present application shows
It is intended to.Wherein, reference point Sa, Sb, Sc, Sd and Se in Figure 14, which are corresponding in turn to, indicates Magnetic Sensor in Figure 11 a, Figure 11 b, figure
The voltage signal values exported at position shown in 11c, Figure 11 d and Figure 11 e.
For example, with reference to shown in Figure 11 a, during carrying out weak magnetic detection using above-mentioned weak magnetic signal detection device,
The be magnetic test strips 3 of aggregation of first carrying are placed at the position for closing on magnet 13, along the direction of arrow B as shown in the figure,
So that the test strips 3 with carry out translational motion on the magnetic moment direction of magnet 13 (i.e. arrow A direction) antiparallel direction,
I.e. the direction of motion of test strips 3 is with the magnetic moment direction of magnet 13 on the contrary, the reference point Sa in Figure 14 is that Magnetic Sensor is being schemed at this time
The voltage value that position place shown in 11a is exported, then the reference point Sa in Figure 14 to the curve between reference point Sb, that is, indicate examination
During paper slip 3 moves at position shown in Figure 11 b at the position shown in Figure 11 a, voltage that Magnetic Sensor is exported
Characteristic curve.And so on, can learn test strips 3 successively moved at the position shown in Figure 11 a Figure 11 b, Figure 11 c,
During at position shown in Figure 11 d and Figure 11 d, the voltage response that Magnetic Sensor is exported then successively from reference point Sa to
The curve that reference point Sb, reference point Sc, reference point Sd and reference point Se extend.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
Above-described embodiments merely represent several embodiments of the utility model, the description thereof is more specific and detailed,
But it cannot be understood as the limitations to utility model patent range.It should be pointed out that for the common skill of this field
For art personnel, without departing from the concept of the premise utility, various modifications and improvements can be made, these are belonged to
The protection scope of the utility model.Therefore, the scope of protection shall be subject to the appended claims for the utility model patent.
Claims (10)
1. a kind of magnet field probe is applied to carry out magnetic signal detection to magnetic aggregation, which is characterized in that the magnet field probe packet
It includes：
Magnet offers baltimore groove, for magnetizing the magnetic aggregation；
Magnetic Sensor is set in the central area for closing on the baltimore groove, for detecting after the magnetic aggregation is magnetized
The initial magnetic field strength signal in formed magnetic field；
Wherein, during being formed by magnetic field after the Magnetic Sensor is magnetized to the magnetic aggregation and detecting,
The magnetism aggregation is immediately below the Magnetic Sensor detection faces being located in the baltimore groove relative to the Magnetic Sensor
Carry out translational motion.
2. magnet field probe according to claim 1, which is characterized in that further include：
Signal amplifying apparatus is connect with the Magnetic Sensor, for being filtered to the received initial magnetic field strength signal
Amplification forms output magnetic field intensity signal.
3. magnet field probe according to claim 1, which is characterized in that further include protective shell；
Wherein, the protective shell is for accommodating the magnet and the Magnetic Sensor, by the magnet and the Magnetic Sensor
It is isolated with external electromagnetic field.
4. magnet field probe according to claim 1, which is characterized in that the magnetism aggregation is by biological detection sample
Aggregates of nanoparticles is formed by after this progress magnetic mark；
Wherein, the initial magnetic field strength signal is used to carry out quantitative analysis to the biological detection sample.
5. magnet field probe described in any one of -4 according to claim 1, which is characterized in that the Magnetic Sensor is push-pull type
The sensor of favour stone full bridge structure, for providing differential voltage output.
6. magnet field probe according to claim 5, which is characterized in that the sensor of the push-pull type favour stone full bridge structure
The sensor being made of TMR sensing element.
7. a kind of magnet field probe is applied to carry out magnetic signal detection to magnetic aggregation, which is characterized in that the magnet field probe packet
It includes：
Magnet has bar-shaped magnet magnetic field, for magnetizing the magnetic aggregation；
Magnetic Sensor, at the position of magnetic field strength approach zero, detecting the magnetic aggregation in the bar-shaped magnet magnetic field
The initial magnetic field strength signal in body formed magnetic field after being magnetized；
Wherein, during being formed by magnetic field after the Magnetic Sensor is magnetized to the magnetic aggregation and detecting,
The magnetism aggregation relatively described magnetic field Magnetic Sensor in the bar-shaped magnet magnetic field carries out translational motion.
8. magnet field probe according to claim 7, which is characterized in that further include：
Signal amplifying apparatus is connect with the Magnetic Sensor, for being filtered to the received initial magnetic field strength signal
Amplification forms output magnetic field intensity signal.
9. magnet field probe according to claim 7 or 8, which is characterized in that the magnetism aggregation is by examining to biology
The aggregates of nanoparticles being carried in test strips is formed by after test sample this progress magnetic mark；
Wherein, the initial magnetic field strength signal is used to carry out quantitative analysis to the biological detection sample.
10. a kind of weak magnetic signal detection device can be applied to carry out the magnetic aggregation in test strips magnetization and magnetic signal inspection
It surveys, which is characterized in that described device includes：
Kit carries the test strips for fixed；
Magnet field probe as described in any one of claim 1~9, for so that the test strips in the baltimore groove
The translational motion relative to the magnet is carried out immediately below the Magnetic Sensor detection faces.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820600889.0U CN208172220U (en) | 2018-04-25 | 2018-04-25 | Magnet field probe, weak magnetic signal detection device |
Applications Claiming Priority (1)
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109884562A (en) * | 2019-03-29 | 2019-06-14 | 中国电子产品可靠性与环境试验研究所（（工业和信息化部电子第五研究所）（中国赛宝实验室）） | Difference magnetic field detection module and magnet field probe |
| CN109884561A (en) * | 2019-03-29 | 2019-06-14 | 中国电子产品可靠性与环境试验研究所（（工业和信息化部电子第五研究所）（中国赛宝实验室）） | Magnetic field detection module and magnet field probe |
| CN110095656A (en) * | 2019-05-27 | 2019-08-06 | 中国电子产品可靠性与环境试验研究所（（工业和信息化部电子第五研究所）（中国赛宝实验室）） | Detecting module and probe |
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| CN111610474A (en) * | 2020-04-30 | 2020-09-01 | 联宝(合肥)电子科技有限公司 | Electronic equipment inspection method and device |
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| CN109884562A (en) * | 2019-03-29 | 2019-06-14 | 中国电子产品可靠性与环境试验研究所（（工业和信息化部电子第五研究所）（中国赛宝实验室）） | Difference magnetic field detection module and magnet field probe |
| CN109884561A (en) * | 2019-03-29 | 2019-06-14 | 中国电子产品可靠性与环境试验研究所（（工业和信息化部电子第五研究所）（中国赛宝实验室）） | Magnetic field detection module and magnet field probe |
| CN110095656A (en) * | 2019-05-27 | 2019-08-06 | 中国电子产品可靠性与环境试验研究所（（工业和信息化部电子第五研究所）（中国赛宝实验室）） | Detecting module and probe |
| CN110412488A (en) * | 2019-07-30 | 2019-11-05 | 大连海事大学 | A method of measurement magnetic microscope probe stray field strengths |
| CN110412488B (en) * | 2019-07-30 | 2021-05-07 | 大连海事大学 | Method for measuring stray field strength of probe of magnetic microscope |
| CN111610474A (en) * | 2020-04-30 | 2020-09-01 | 联宝(合肥)电子科技有限公司 | Electronic equipment inspection method and device |
| CN112816542A (en) * | 2021-01-04 | 2021-05-18 | 武汉市合众电气设备制造有限公司 | Trace iron powder detection device based on giant magnetoresistance effect |
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