CN207923779U - The on-line mass spectroscopy detection device of nutritional ingredient change procedure during a kind of Chinese medicine steams - Google Patents
The on-line mass spectroscopy detection device of nutritional ingredient change procedure during a kind of Chinese medicine steams Download PDFInfo
- Publication number
- CN207923779U CN207923779U CN201820194578.9U CN201820194578U CN207923779U CN 207923779 U CN207923779 U CN 207923779U CN 201820194578 U CN201820194578 U CN 201820194578U CN 207923779 U CN207923779 U CN 207923779U
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- connecting pipe
- gas
- pipe
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
The on-line mass spectroscopy detection device of nutritional ingredient change procedure, belongs to detection technique field during a kind of Chinese medicine steams.It is made of Chinese medicine steamer, sample solution conveyer, EFI fog generator and mass spectrograph, the flow direction for the charged particle that EFI fog generator generates is parallel with mass spectrometric Way in;Sample solution conveyor end is placed between EFI fog spray head and mass spectrometer inlet, the flow direction for the target analytes droplet that sample solution conveyer generates is vertical with the flow direction of EFI fog generator generation charged particle and mass spectrometric Way in, and the target analytes droplet for taking charge enters the subsequent analysis detection of mass spectrograph progress under the action of electric field and air-flow by mass spectrometer inlet.Utility model device is realized carries out in situ, online, non-demolition, high throughput quick detection under the premise of without any sample pretreatment to the nutritional ingredient in traditional Chinese medicine sample, simple in structure, manufacturing cost is low, detection is quick.
Description
Technical field
The utility model belongs to detection technique field, and in particular to nutritional ingredient change procedure during a kind of Chinese medicine steams
On-line mass spectroscopy detection device.
Background technology
Chinese medicine has thousands of years of applicating history in China, is generally divided into animal drugs, autonomic drug, mineral drug three classes.Chinese medicine
Include a plurality of types of chemical compositions, such as starch, carbohydrate, polypeptide, protein and various trace elements, can be used for prevent and
It treats disease and there is rehabilitation and health-care effect.Chinese medicine usually needs, by steam treatment, to have the benefit that before the use:
One, change pharmaceutical properties, expand scope of medication;Two, it heightens the effect of a treatment;Three, pharmacological property is mitigated;Four, side effect is reduced;Five, it is convenient for soft
Change cutting.But steaming time or steam that mode is improper, the content of some nutritional ingredients can be caused to change instead, in turn
Lead to the difference of certain pharmacological actions.Therefore, probe into Chinese medicine during steaming nutritional ingredient change procedure for utmostly
The medical value of ground exploitation Chinese medicine is of great significance.
But the interference of large amount of complex matrix makes existing analytical technology be needed by complicated with detection means in sample
Sample pretreatment process, seriously affected analysis speed, sensitivity and selectivity.The matter to grow up in recent decades
The features such as spectral analysis technology is because of its high sensitivity, high specificity, quick, high-throughput, sample consumption is few detection is in each front line science
And production field is widely used and develops.As mass spectrometry in field of food science is to food trace additives
Detection, in environment measuring to environmental pollutants it is quick detection etc..Therefore, the development and utilization of analytical technique of mass spectrum is to work as
One important topic of modern Institute of Science research.
The core of analytical technique of mass spectrum is ionization techniques, and neutral target analytes just can be with after having to pass through ionization
It is arrived by Mass Spectrometer Method.Therefore, do not need complex sample it is pretreated under the premise of, how by the determinand in sample quickly, it is high
The ionization of effect, non-demolition, high throughput is detected it is current science urgent problem to be solved by mass spectrograph in turn.
Chinese medicine is mainly crushed by the traditional detection method of nutriment change procedure in traditional Chinese medicine sample, is ground
The processing such as mill, centrifugation, purification, can just be analyzed by mass spectrometry after obtaining the target analytes of removal complex matrices.These are processed
Journey is cumbersome, time-consuming, and sample can be damaged and be polluted with the process of chemical substance treatment, has seriously affected traditional Chinese medicine sample
The detection and utilization of middle nutritional ingredient.
Therefore, the research and development of the on-line mass spectroscopy detection device of nutritional ingredient change procedure during a kind of Chinese medicine steams, for
It need not carry out any sample pretreatment, nutrition in situ, online, in the quick detection traditional Chinese medicine sample of non-demolition, high throughput
Ingredient has a very important significance.
Utility model content
The purpose of this utility model is to provide one kind and needing the preprocessing means such as sample comminution, grinding, centrifugation, separation
Under the premise of Chinese medicine is steamed during nutritional ingredient change procedure on-line mass spectroscopy detection device.
On-line mass spectroscopy detection device described in the utility model is sent out by Chinese medicine steamer, sample solution conveyer, electron spray
Raw device and mass spectrograph composition;
Wherein, Chinese medicine steamer by water-level gauge 1, thermometer 2, metal shell 4, the heating furnace 5 of power adjustable, water injection pipe 6,
Exhaust pipe 7, traditional Chinese medicine sample 8, the supporting table 9 that surface is inclined-plane and porous plummer 10 form;The heating furnace 5 of power adjustable is arranged
Bottom side outside metal shell 4, water injection pipe 6 and exhaust pipe 7 are arranged at the top of metal shell 4, and porous plummer 10 is arranged
At upper middle position inside metal shell 4, surface is that the supporting table 9 on inclined-plane is placed on porous plummer 10, Chinese medicine
Sample 8 is placed in supporting table 9;Water 3 is injected into metal shell 4 by water injection pipe 6, the liquid level of water 3 is away from porous plummer 10
Distance monitored in real time by water-level gauge 1;The power for adjusting heating furnace 5 carries out heating and by heat transfer to metal shell 4
Water supply 3 observes the registration of thermometer 2, so that water is gradually heating to constantly boiling state, vapor is discharged by exhaust pipe 7;Water steams
Gas steams traditional Chinese medicine sample 8, to generate the juice containing target analytes;
Sample solution transmitter is by juice collection slot 11, the first connecting pipe 12, the gas with first gas inlet 14
Jet pipe 13 forms;The bottom on 9 inclined-plane of supporting table is arranged in juice collection slot 11, is cylindrical structure, after point diameter is more than
Diameter is held, the rear end of juice collection slot 11 connects the first connecting pipe 12, in wrapping around for 12 exit of the first connecting pipe
It is provided with the gas spray pipe 13 with first gas inlet 14;Be passed through by first gas inlet 14 carrier gas (nitrogen as carrier gas,
Control nebulizer gas pressure is 0.1~0.6MPa) so that the gas in gas spray pipe 13 is enclosed in 12 exit of the first connecting pipe
Outer periphery causes to form negative pressure in the interface of the first connecting pipe 12 and juice collection slot 11;The angle of inclination of supporting table 9
Make to steam the juice containing target analytes generated in the process and be flowed into juice collection slot 11;In the booster action of air-flow
Under, the onwards transmission in the first connecting pipe 12 of the juice containing target analytes, to be formed in the end of gas spray pipe 13
A large amount of fine droplet sprays;The diameter of gas spray pipe 13 is slightly larger than the diameter of the first connecting pipe 12, ensures that gas enters and is
It can.
EFI fog generator by with second gas inlet 16 EFI fog spray head 15, with high input voltage interface 18
Second connecting pipe 17 and electron spray reagent generator 19 form;One end connection electron spray reagent of second connecting pipe 17 generates
Device 19, the EFI fog spray head 15 with second gas inlet 16 are circumferentially positioned at the outer of 17 other end exit of the second connecting pipe
Side;Electron spray reagent generator 19 can be chromatogram pump, sampling pump etc., make EFI in the high voltage that high input voltage interface 18 applies
Charge in the electron spray reagent strip that mist reagent generator 19 generates, takes the electron spray reagent of charge in the second connecting pipe 17
It is flowed to exit;It is passed through electron spray carrier gas at second gas inlet 16, makes the second connecting pipe in EFI fog spray head 15
Surrounding's gassy in 17 exits, the electron spray reagent through the outflow of 17 exit of the second connecting pipe under gas auxiliary is in electricity
15 exit of spraying nozzle forms electron spray charged particle;The EFI fog generator that the utility model uses selects methanol as electricity
Spraying reagent, the sample introduction flow velocity for controlling chromatogram pump or sampling pump is 5~25 μ L/min, and nitrogen controls nitrogen as electron spray carrier gas
Gas 0.5~1.2MPa of air pressure adds the voltage of 2~5kV at high input voltage interface 18, and methanol is under the action of air-flow and electric field
Charged particle is formed in 15 exit of EFI fog spray head.
The internal diameter of first connecting pipe 12 is more bigger than the internal diameter of the second connecting pipe 17, in embodiment the first connecting pipe
12 manage for PEEK, and the second connecting pipe 17 is capillary.
EFI fog spray head 15 is placed in mass spectrometric inlet, the flow direction for the charged particle that EFI fog generator generates with
Mass spectrometric Way in is parallel;The end of gas spray pipe 13 is placed between EFI fog spray head 15 and mass spectrometer inlet, sample
The flow direction for the target analytes droplet that solution conveyer generates generates the flowing side of charged particle with EFI fog generator
To and mass spectrometric Way in it is vertical.
The target analytes droplet that the charged particle that EFI fog generator generates is generated with sample solution transmitter is in matter
Droplet-droplet extraction and electric charge transfer occur in space before spectrometer entrance, charged particle is by charge transfer to target analytes
Droplet, and make charge on originally neutral target analytes droplet band.These take the target analytes droplet of charge
Mass spectrograph is entered by mass spectrometer inlet under the action of electric field and air-flow and carries out subsequent analysis detection.
The on-line mass spectroscopy detection device of nutritional ingredient change procedure, breaches biography during the Chinese medicine of the utility model steams
The analytical technology of sample in complicated substrate and detection means are needed by complicated sample pretreatment process in system method
Limitation, realize under the premise of without any sample pretreatment to the nutritional ingredient in traditional Chinese medicine sample carry out it is in situ, online,
Non-demolition, high-throughput quick detection.The present apparatus is simple in structure, manufacturing cost is low, detection is quick, and being one kind can examine well
Measure the device of nutritional ingredient change procedure during Chinese medicine steams.
Description of the drawings
Fig. 1 is that the on-line mass spectroscopy structure of the detecting device of nutritional ingredient change procedure during the utility model Chinese medicine steams shows
It is intended to;
Fig. 2 is electron spray generator architecture schematic diagram;
Fig. 3 is sample solution conveyer;
Fig. 4 is Chinese medicine steamer structural schematic diagram;
Fig. 5 be 1 samples of Ginseng of embodiment analysis gained first mass spectrometric fingerprint chromatogram (scanning range m/z be 50~500,
50~800,50~1200 first mass spectrometric fingerprint chromatogram, difference corresponding diagram a, figure b and figure are c);
Fig. 6 is the signal strength of three kinds of substances in 1 samples of Ginseng of embodiment with the variation relation figure of steaming time.
As shown in Figure 1, a kind of Chinese medicine steam during nutritional ingredient change procedure on-line mass spectroscopy detection device, by EFI
Fog generator, Chinese medicine steamer, sample solution conveyer and mass spectrograph composition;Wherein, Chinese medicine steamer is by water-level gauge 1, temperature
Meter 2, water 3, metal shell 4, the heating furnace 5 of power adjustable, water injection pipe 6, exhaust pipe 7, traditional Chinese medicine sample 8, surface are the branch on inclined-plane
It supports platform 9 and porous plummer 10 forms;Sample solution transmitter is by juice collection slot 11, the first connecting pipe 12, gas spray pipe
13, first gas inlet 14 forms;EFI fog generator is by EFI fog spray head 15, second gas inlet 16, the second connecting pipe
17, high input voltage interface 18 and electron spray reagent generator 19 form.
As shown in figure 4, the size of the metal shell 4 of Chinese medicine steamer is long 15~20cm, wide 10~15cm, high by 30~
40cm, metal shell 4, water injection pipe 6,7 supporting table 9 of exhaust pipe and porous plummer 10 are stainless steel.Supporting table 9 is inclined
Rake angle is 15~25 degree, and the aperture of porous plummer 10 is 2~4mm, and the front inner diameter of juice collection slot 11 is 3~8mm, after
End internal diameter is 1~3mm, and distance of the water surface 3 away from porous plummer 10 is in 5~12cm, and porous plummer 10 is away from 4 top of metal shell
Distance be 5~10cm.
Specific implementation mode
Embodiment 1:
By taking the ginseng tissue used when testing as an example, to illustrate the on-line mass spectroscopy detection of nutritional ingredient during Chinese medicinal steaming system
The use step of device.
1. the size of the metal shell 4 of Chinese medicine steamer is long 16cm, wide 12cm, high 35cm, metal shell 4, water injection pipe
6, exhaust pipe 7, supporting table 9 (20 degree of angle of inclination) and porous plummer 10 (3 mm of aperture) are stainless steel.It is porous to hold
Distance of the microscope carrier 10 away from 4 top of metal shell is 5cm.The front inner diameter of juice collection slot 11 is 5mm, back end inside diameter 1.5mm.
Using kerosene thermometer 2,0~200 DEG C of range;6 internal diameter 4cm of water injection pipe, 7 internal diameter 4cm of exhaust pipe.Water-level gauge 1 is glass material,
It can be used to observe height of water level.0~1000W of power bracket of heating furnace 5.
2. utilizing experimental bench, iron stand, iron clamp, PKKE pipes (internal diameter 0.75mm, outer diameter 1/16inch), quartz capillary
Nutritional ingredient change procedure is online during supports such as (internal diameter 0.10mm, outer diameter 0.19mm) steam Chinese medicine with connecting component
Mass Spectrometer Method device is put up, and keeps the flow direction of the charged particle of EFI fog generator generation and mass spectrometric Way in flat
Row;The end of gas spray pipe 13 is placed between EFI fog spray head 15 and mass spectrometer inlet, the mesh that sample solution conveyer generates
The flow direction and EFI fog generator for marking analyte droplet generate the flow direction of charged particle and mass spectrometric entrance
Direction is vertical.
Water is added into Chinese medicine steamer by water injection pipe 6, real time monitoring is carried out so that the water surface 3 by observing water-level gauge 1
Distance away from porous plummer 10 opens heating furnace 5 in 8cm, and heating power is adjusted to 1000W, observes the registration of thermometer 2,
Water 3 is set to be gradually heating to constantly boiling state (about 98 DEG C), heating power, which is adjusted to 600W, keeps 65min, vapor to pass through row
Tracheae 7 is discharged.Samples of Ginseng 8 is placed in supporting table 9, can be flowed out containing target analytes by the samples of Ginseng 8 steamed
Juice, this part juice are flowed into the juice collection slot 11 of polypropylene material, and nitrogen is passed through at first gas inlet 14, control
Nitrogen pressure processed is 0.4MPa, and the juice for being steamed out under the auxiliary of gas is through first connecting pipe 12 (PEEK pipes) quilt
Sample solution conveyer is transmitted to mass spectrometer inlet front end and forms target analytes droplet.Second connecting pipe 17 is stone
English capillary, internal diameter 0.10mm, outer diameter 0.19mm.15 material of EFI fog spray head is stainless steel, internal diameter 0.22mm.
3. electricity consumption spray generator is tested, by Orbitrap FusionTM ThibridTMMass spectrograph (U.S. Thermo
Scientific companies) liquid chromatogram part provide methanol electron spray reagent, control chromatogram pump sample introduction flow velocity be 15 μ L/
Min, nitrogen control nitrogen pressure 0.8MPa as electron spray carrier gas, add the voltage of 4kV in high input voltage interface, methanol exists
Charged particle is formed under the action of electric field, and forms electron spray in the end of EFI fog spray head under the action of air-flow and electric field.
4. the charged particle that EFI fog generator generates and the target analytes droplet sent out through sample transfer device
Electric charge transfer occurs in mass spectrometer inlet front end, charge is transferred to target analytes droplet from charged particle, after ionization
Target analytes droplet enters mass spectrograph by mass spectrometer inlet and carries out analysis detection.
5. mass spectrograph condition:Mass spectrograph model Orbitrap FusionTM TribridTM, positive ion detection mould is set
Formula, 250 DEG C of ion transfer tube temperature, 50~1200 other parameters of mass scan range m/z are by mass spectrograph Automatic Optimal.
To carrying out direct mass spectral analysis without any pretreated samples of Ginseng under Mass Spectrometry Conditions after optimization, one is obtained
Grade mass spectrum fingerprint chromatogram, as shown in figure 5, respectively scanning range is the level-one of m/z 50~500,50~800,50~1200
Fingerprint chromatogram.As shown in Figure 5, m/z 104 is that choline is sloughed after a hydrone in conjunction with a hydrogen ion (H+) obtained letter
Number;M/z 175 is that arginine molecule combines a hydrogen ion (H+) signal;M/z 219 is that a glucose molecule combines one
A potassium ion (K+) obtained signal;M/z 381 is that a sucrose molecule combines a potassium ion (K+) obtained signal.Explanation
Device described in the utility model can be successfully detected the property material signal in samples of Ginseng.
Using the time as abscissa, choline (m/z 104), arginine (m/z 175), sucrose (m/z 381) signal strength
It maps for ordinate, obtains the signal strength of three kinds of substances with the change curve (Fig. 6) of steaming time, it can be seen that in 32min
Maximum value is presented in the signal strength of left and right choline (m/z 104);It is in the signal strength of 38min or so arginine (m/z 175)
Existing maximum value;Maximum value is presented in the signal strength of 42min or so sucrose (m/z 381).As a result prove that ginseng is steaming process
Different variations is presented in the Different Nutrition component content of middle generation at any time, and utilizes utility model device clearly online
Detect these ingredients and their variation tendency.
Claims (6)
- The on-line mass spectroscopy detection device of nutritional ingredient change procedure during 1. a kind of Chinese medicine steams, it is characterised in that:By Chinese medicine Steamer, sample solution conveyer, EFI fog generator and mass spectrograph composition;Wherein, Chinese medicine steamer is by water-level gauge (1), temperature Degree meter (2), metal shell (4), the heating furnace (5) of power adjustable, water injection pipe (6), exhaust pipe (7), traditional Chinese medicine sample (8), surface It is formed for the supporting table (9) and porous plummer (10) on inclined-plane;Power adjustable heating furnace (5) setting metal shell (4) outside At the top of metal shell (4), porous plummer (10) is arranged in metal for the bottom side in face, water injection pipe (6) and exhaust pipe (7) setting At the internal upper middle position of shell (4), surface is that the supporting table (9) on inclined-plane is placed on porous plummer (10), Chinese medicine Sample (8) is placed in supporting table (9);By water injection pipe (6) to injection water (3) in metal shell (4), the liquid level of water (3) away from The distance of porous plummer (10) is monitored in real time by water-level gauge (1);The power for adjusting heating furnace (5), to metal shell (4) Water (3) is heated and is transferred heat to, the registration of observation thermometer (2) makes water be gradually heating to constantly boiling state, water Steam is discharged by exhaust pipe (7);Vapor steams traditional Chinese medicine sample (8), to generate the juice containing target analytes Liquid;Sample solution transmitter is by juice collection slot (11), the first connecting pipe (12), the gas for carrying first gas inlet (14) Body jet pipe (13) forms;Juice collection slot (11) setting is cylindrical structure in the bottom on supporting table (9) inclined-plane, and front end is straight Diameter is more than rear end diameter, and the rear end of juice collection slot (11) connects the first connecting pipe (12), goes out in the first connecting pipe (12) The gas spray pipe (13) being provided with first gas inlet (14) is wrapped around at mouthful;It is passed through by first gas inlet (14) Carrier gas make the gas in gas spray pipe (13) be enclosed in the outer periphery in the first connecting pipe (12) exit, cause The interface of one connecting pipe (12) and juice collection slot (11) forms negative pressure;The angle of inclination of supporting table (9) makes to steam process The juice containing target analytes of middle generation is flowed into juice collection slot (11);Under the booster action of air-flow, contain mesh The juice of mark analyte onwards transmission in the first connecting pipe (12), to be formed largely in the end of gas spray pipe (13) Fine droplet sprays;EFI fog generator is by carrying the EFI fog spray head (15) of second gas inlet (16), carrying high input voltage interface (18) Second connecting pipe (17) and electron spray reagent generator (19) composition;One end connection electron spray examination of second connecting pipe (17) Agent generator (19), it is another that the EFI fog spray head (15) with second gas inlet (16) is circumferentially positioned at the second connecting pipe (17) The outside in one end exit;Make the electricity that electron spray reagent generator (19) generates in the high voltage that high input voltage interface (18) applies Charge in reagent strip of spraying, the electron spray reagent for taking charge flow in the second connecting pipe (17) to exit;Second Gas access is passed through electron spray carrier gas at (16), makes around the second connecting pipe (17) exit in EFI fog spray head (15) Gassy, the electron spray reagent through the outflow of the second connecting pipe (17) exit under gas auxiliary is in EFI fog spray head (15) Exit forms electron spray charged particle;EFI fog spray head (15) is placed in mass spectrometric inlet, the flow direction for the charged particle that EFI fog generator generates and matter The Way in of spectrometer is parallel;The end of gas spray pipe (13) is placed between EFI fog spray head (15) and mass spectrometer inlet, sample The flow direction for the target analytes droplet that product solution conveyer generates generates the flowing of charged particle with EFI fog generator Direction and mass spectrometric Way in are vertical;The target analytes droplet that the charged particle that EFI fog generator generates is generated with sample solution transmitter is in mass spectrograph Droplet-droplet extraction occurs in space before entrance and charge transfer is given target analytes small liquid by electric charge transfer, charged particle Drop, and make charge on originally neutral target analytes droplet band;These take the target analytes droplet of charge in electricity Mass spectrograph is entered by mass spectrometer inlet under the action of field and air-flow and carries out subsequent analysis detection.
- The on-line mass spectroscopy detection device of nutritional ingredient change procedure during 2. a kind of Chinese medicine as described in claim 1 steams, It is characterized in that:The carrier gas that first gas inlet (14) is passed through is nitrogen, and pressure is 0.1~0.6MPa.
- The on-line mass spectroscopy detection device of nutritional ingredient change procedure during 3. a kind of Chinese medicine as described in claim 1 steams, It is characterized in that:Electron spray reagent generator (19) is chromatogram pump or sampling pump, selects methanol as electron spray reagent, controls color Spectrum pump or sampling pump sample introduction flow velocity be 5~25 μ L/min, nitrogen be used as electron spray carrier gas, control nitrogen pressure 0.5~ 1.2MPa adds the voltage of 2~5kV at high input voltage interface (18).
- The on-line mass spectroscopy detection device of nutritional ingredient change procedure during 4. a kind of Chinese medicine as described in claim 1 steams, It is characterized in that:Metal shell (4), water injection pipe (6), exhaust pipe (7), supporting table (9) and porous plummer (10) material be Stainless steel;The material of juice collection slot (11) is polypropylene, and the first connecting pipe (12) is managed for PEEK, the second connecting pipe (17) For quartz capillary.
- The on-line mass spectroscopy detection device of nutritional ingredient change procedure during 5. a kind of Chinese medicine as described in claim 1 steams, It is characterized in that:The size of the metal shell (4) of Chinese medicine steamer is long 15~20cm, wide 10~15cm, high 30~40cm;Branch The angle of inclination for supportting platform (9) is 15~25 degree, and the aperture of porous plummer (10) is 2~4mm;The front end of juice collection slot (11) Internal diameter is 3~8mm, and back end inside diameter is 1~3mm;Distance of the water surface (3) away from porous plummer (10) is in 5~12cm, porous carrying Platform (10) is 5~10cm away from the distance at the top of metal shell (4).
- The on-line mass spectroscopy detection device of nutritional ingredient change procedure during 6. a kind of Chinese medicine as described in claim 1 steams, It is characterized in that:Mass spectrograph model Orbitrap FusionTM TribridTM, positive ion detection pattern, ion transmission are set 250 DEG C of tube temperature degree, mass scan range m/z 50~1200.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201820194578.9U CN207923779U (en) | 2018-02-05 | 2018-02-05 | The on-line mass spectroscopy detection device of nutritional ingredient change procedure during a kind of Chinese medicine steams |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201820194578.9U CN207923779U (en) | 2018-02-05 | 2018-02-05 | The on-line mass spectroscopy detection device of nutritional ingredient change procedure during a kind of Chinese medicine steams |
Publications (1)
Publication Number | Publication Date |
---|---|
CN207923779U true CN207923779U (en) | 2018-09-28 |
Family
ID=63602962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201820194578.9U Expired - Fee Related CN207923779U (en) | 2018-02-05 | 2018-02-05 | The on-line mass spectroscopy detection device of nutritional ingredient change procedure during a kind of Chinese medicine steams |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN207923779U (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108414609A (en) * | 2018-02-05 | 2018-08-17 | 吉林大学 | The on-line mass spectroscopy detection device of nutritional ingredient change procedure during a kind of Chinese medicine steams |
-
2018
- 2018-02-05 CN CN201820194578.9U patent/CN207923779U/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108414609A (en) * | 2018-02-05 | 2018-08-17 | 吉林大学 | The on-line mass spectroscopy detection device of nutritional ingredient change procedure during a kind of Chinese medicine steams |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105181784B (en) | A kind of method of 40 kinds of violated antibiotic in rapid screening cosmetics | |
CN105223291B (en) | A kind of authentication method of animal hide | |
CN108414609A (en) | The on-line mass spectroscopy detection device of nutritional ingredient change procedure during a kind of Chinese medicine steams | |
CN105699537A (en) | Synchronous detection method for plurality of types of drug residues in water body | |
CN108444946A (en) | A kind of Practice for Pesticide Residue in Agricultural Products detection method and device | |
Liang et al. | Data fusion of laser induced breakdown spectroscopy (LIBS) and infrared spectroscopy (IR) coupled with random forest (RF) for the classification and discrimination of compound salvia miltiorrhiza | |
CN105047519B (en) | In-situ spraying ionization device | |
CN108008026B (en) | Method for synchronously detecting 13 colorants in hawthorn pills | |
CN207923779U (en) | The on-line mass spectroscopy detection device of nutritional ingredient change procedure during a kind of Chinese medicine steams | |
CN106483186A (en) | A kind of ionization massspectrum detection means and its application | |
CN105203496A (en) | Near-infrared online detecting method for lame impediment tablet concentration process | |
CN105929033A (en) | System and method for measuring trace lactic acid ion in lobaplatin by using column switching-ion chromatography method | |
CN112611816B (en) | Hawthorn standard reference substance and preparation method, detection method and application thereof | |
CN104390926A (en) | Online rapid detection method of herba andrographis concentrated decolorization process | |
US20220260497A1 (en) | Gas mixture-based libs signal enhancement apparatus and heavy metal detection method | |
CN107894467A (en) | The method of 4 class antibiotic in Liquid Chromatography-Tandem Mass Spectrometry Simultaneous Determination river deposit | |
CN107462656A (en) | A kind of method of galanthamine content in quick detection amrallid | |
CN109374774B (en) | Content determination method for simultaneously determining 4 components in cassia seeds by HPLC isocratic elution | |
CN103969374B (en) | Method for determining retention capacity of albendazole in mulberry leaves | |
CN105493225B (en) | Sample mount and charged particle devices | |
CN102175640A (en) | Near-infrared online detecting method in herba epimedii processing production | |
CN206161642U (en) | Extraction and desorption device | |
CN108982703A (en) | A kind of LC-MS detection method of polyphenols | |
CN102788855B (en) | On-line detection device and detection method for atomizing extraction for volatile organic matters in water | |
CN103575823A (en) | Detection method of 8 chemical components in Tangminling preparation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180928 Termination date: 20210205 |
|
CF01 | Termination of patent right due to non-payment of annual fee |