CN207894817U - Full-automatic fluorescence correlation spectroscopy instrument light path calibration mechanism - Google Patents
Full-automatic fluorescence correlation spectroscopy instrument light path calibration mechanism Download PDFInfo
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- CN207894817U CN207894817U CN201820230555.9U CN201820230555U CN207894817U CN 207894817 U CN207894817 U CN 207894817U CN 201820230555 U CN201820230555 U CN 201820230555U CN 207894817 U CN207894817 U CN 207894817U
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Abstract
The utility model discloses a kind of full-automatic fluorescence correlation spectroscopy instrument light path calibration mechanisms, the utility model can drive fiber adapter or pin hole to be moved in X and Y-axis by X-axis mobile mechanism and Y-axis moving mechanism, the focal point of the condenser lens on lens mount is moved to the optical fiber for enabling pin hole or being fixed on fiber adapter, certainly we also need to adjust the front and back position of condenser lens by Z axis mobile mechanism, to ensure pin hole or optical fiber in the focal point that the position of three dimensions is positioned at condenser lens, by above structure, we can be automatically controlled by software, to realize automatic adjustment light path focusing, not only difficulty is low but also easy to operate, working strength is low, significantly reduce the workload of operator, and the requirement to personnel is greatly reduced, to decrease the cost of enterprise.
Description
Technical field
The utility model is related to a kind of spectrum detection instrument light path calibration mechanism, especially a kind of full-automatic fluorescence correlation spectroscopy
Instrument light path calibration mechanism.
Background technology
Fluorescence correlation spectroscopy method is the principle using Laser Scanning Confocal Microscope, is isolated in by sample from extremely low concentration
Very small volume (being typically several microlitres to more than ten microlitres), by irradiating gaussian-shape exciting light into this micro volume, and
Detection micro volume in send out fluorescent intensity fluctuation situation, calculate auto-correlation function or hand over correlation function, to analysis by
Sample molecular concentration, molecular size and intermolecular interaction etc..Fluorescence correlation spectroscopy method be for scientific research,
One of very promising technologies in fields such as drug development, medical treatment detection.
However, the fluorescence correlation spectroscopy system that existing laboratory uses nearly all is manual calibration light path, due to the technology
It is very high to stability of layout and calibration accuracy requirement, it is required for calibrating light path before each use, this allows for fluorescence
The use of correlation spectrum technology is extremely difficult for layman.
Thus the applicant devises a kind of automatic light path calibration mechanism of fluorescence correlation spectroscopy instrument to solve the above problems.
Utility model content
For overcome the deficiencies in the prior art, the utility model provides a kind of full-automatic fluorescence correlation spectroscopy instrument light path calibration
Mechanism.
Technical solution adopted by the utility model to solve its technical problems is：
Full-automatic fluorescence correlation spectroscopy instrument light path calibration mechanism, it is characterised in that：Including fiber adapter or pin hole, lens
Seat connect with fiber adapter or pin hole and fiber adapter or pin hole can be driven in the X/Y plane movement moved in X/Y plane
Mechanism is connect and being capable of the Z axis mobile mechanism that is moved axially in Z axis of drive lens seat, the X/Y plane and optical axis with lens mount
Direction is vertical, and the Z axis is parallel with optical axis direction.
The X/Y plane mobile mechanism includes X-axis mobile mechanism and Y-axis moving mechanism, and the X-axis mobile mechanism includes X-axis
Driving unit, X-axis guide rail pair, X-axis connector, X-axis screw pair, the X-axis driving unit pass through X-axis connector and X-axis spiral
Pair makes fiber adapter or pin hole move along the x-axis, and the X-axis driving unit is connect by X-axis guide rail pair with rack；The Y-axis
Mobile mechanism includes Y-axis driving unit, Y-axis guide rail pair, Y-axis connector, Y-axis screw pair, and the Y-axis driving unit passes through Y-axis
Guideway is connect with rack, and the Y-axis driving unit makes fiber adapter or pin hole along Y by Y-axis connector and Y-axis screw pair
Axis moves；The Z axis mobile mechanism includes Z axis driving unit, Z axis guide rail pair, Z axis connector, Z axis screw pair, and the Z axis drives
Moving cell connects lens mount by Z axis connector and Z axis screw pair, and lens mount is connect by Z axis guide rail pair with rack.
The lens mount has support plate, and support plate is connect by Z axis guide rail pair with rack, and lens mount be equipped with
The connecting rod of Z axis connector connection, the Z axis connector are also connect with Z axis driving unit simultaneously.
The utility model has the beneficial effects that：The utility model can be driven by X-axis mobile mechanism and Y-axis moving mechanism
Fiber adapter or pin hole are moved in X-axis and Y-axis, to which the optical fiber for enabling pin hole or being fixed on fiber adapter is moved to
The focal point of condenser lens on lens mount, certain we also need to adjust the anteroposterior position of condenser lens by Z axis mobile mechanism
It sets, to ensure optical fiber in the focal point that the position of three dimensions is positioned at condenser lens, by above structure, we can lead to
It crosses software to automatically control, to realize automatic adjustment optical fiber focusing, not only difficulty is low but also easy to operate, and working strength is low, greatly
The big workload for alleviating operator, and the requirement to personnel is greatly reduced, to decrease the cost of enterprise.
Description of the drawings
The utility model is further illustrated with reference to the accompanying drawings and examples.
Fig. 1 is the stereochemical structure view of the utility model.
Specific implementation mode
Referring to Fig.1, the utility model discloses a kind of full-automatic fluorescence correlation spectroscopy instrument light path calibration mechanisms, including optical fiber
Adapter 1 or pin hole, lens mount 2 connect with fiber adapter 1 or pin hole and fiber adapter 1 or pin hole can be driven in XY
The X-axis mobile mechanism of move in plane and Y-axis moving mechanism, connect with lens mount 2 and can drive lens seat 2 in Z axis axial direction
Mobile Z axis mobile mechanism, specifically using fiber adapter 1 in this structure, the X/Y plane is vertical with optical axis direction, institute
It is parallel with optical axis direction to state Z axis, the X-axis mobile mechanism includes X-axis driving unit 3, X-axis guide rail pair 4, X-axis connector 5, X-axis
Screw pair, the X-axis driving unit 3 make fiber adapter 1 or pin hole move along the x-axis by X-axis connector 5 and X-axis screw pair,
The X-axis driving unit 3 is connect by X-axis guide rail pair 4 with rack；The Y-axis moving mechanism includes Y-axis driving unit 6, Y-axis
Guideway 7, Y-axis connector 8, Y-axis screw pair, the Y-axis driving unit 6 are connect by Y-axis guide rail pair 7 with rack, the Y-axis
Driving unit 6 makes fiber adapter 1 or pin hole be moved along Y-axis by Y-axis connector 8 and Y-axis screw pair；The Z axis moving machine
Structure includes Z axis driving unit 9, Z axis guide rail pair 10, Z axis connector 11, Z axis screw pair 12, and the Z axis driving unit 9 passes through Z
Shaft coupling piece 11 and Z axis screw pair 12 connect lens mount 2, and lens mount 2 is connect by Z axis guide rail pair 10 with rack, by upper
State the auto-focusing adjustment that structure realizes three dimensions.
As shown, specific structure is：The X-axis driving unit 3, Y-axis driving unit 6, Z axis driving unit 9 are equal
Stepper motor with encoder is used, and X-axis connector 5, Y-axis connector 8, Z axis connector 11 have been all made of rigid shaft coupling
Device；X-axis screw pair, Y-axis screw pair, Z axis screw pair 12 are that high-precision screw matches nut, therefore, along each of tri- axis of X, Y, Z
Direction has collectively constitutes torque drive system by a stepper motor, a positive coupling and a high-precision spiral screw pair
System；Each stepper motor is connect by a positive coupling with by screw rod to transmit torque, and X-axis guide rail pair 4, Y-axis guide rail
Pair 7, Z axis guide rail pair 10 are the linear guide used and sliding block, and the direction of motion of all stepper motors is corresponding straight by its
Line guide rail constrains, and to realize that high-precision drives, stepper motor can be replaced servo motor or piezoelectricity translation stage.
As shown, the specific mounting structure of lens mount 2 is：Lens mount 2 has support plate 13, and support plate 13 passes through
Z axis guide rail pair 10 is connect with rack, and the Z axis nut of Z axis screw pair 12 is fixed on lens mount 2, and Z axis screw rod is connected by Z axis
Part 11 is connect with Z axis driving unit 9, and condenser lens is fixed on lens mount 2.
The operation principle of this structure is summarized as follows：X-axis driving unit 3 is controlled by the scheduled program of control centre, Y-axis is driven
Moving cell 6, Z axis driving unit 9 start, and when X-axis driving unit 3, Y-axis driving unit 6 start, pass through X-axis connector 5 and X
Axis screw pair, Y-axis connector 8 and Y-axis screw pair drive fiber adapter 1 to be moved in X/Y plane, to make to be installed on optical fiber
The focus of optical fiber and condenser lens on adapter 1 is along optical axis direction, and then Z axis driving unit 9 passes through Z axis connector
11, Z axis screw pair 12 drives condenser lens linear motion, makes the focus and fiber congruent of condenser lens, entire right to complete
Burnt process.
Fiber adapter 1 or pin hole are all the components of state of the art manufacture among the above, thus its concrete structure exists
This is not described in detail.
A kind of full-automatic fluorescence correlation spectroscopy instrument light path calibration mechanism that the utility model embodiment is provided above, into
It has gone and has been discussed in detail, specific case used herein is expounded the principles of the present invention and embodiment, above
The explanation of embodiment is merely used to help understand the method and its core concept of the utility model；Meanwhile for the one of this field
As technical staff, according to the utility model thought, there will be changes in the specific implementation manner and application range, to sum up
Described, the content of the present specification should not be construed as a limitation of the present invention.
Claims (3)
1. full-automatic fluorescence correlation spectroscopy instrument light path calibration mechanism, it is characterised in that：Including fiber adapter or pin hole, lens
Seat connect with fiber adapter or pin hole and fiber adapter or pin hole can be driven in the X/Y plane movement moved in X/Y plane
Mechanism is connect and being capable of the Z axis mobile mechanism that is moved axially in Z axis of drive lens seat, the X/Y plane and optical axis with lens mount
Direction is vertical, and the Z axis is parallel with optical axis direction.
2. full-automatic fluorescence correlation spectroscopy instrument light path calibration mechanism according to claim 1, it is characterised in that：The XY is flat
Face mobile mechanism includes X-axis mobile mechanism and Y-axis moving mechanism, and the X-axis mobile mechanism includes X-axis driving unit, X-axis guide rail
Pair, X-axis connector, X-axis screw pair, the X-axis driving unit by X-axis connector and X-axis screw pair make fiber adapter or
Pin hole moves along the x-axis, and the X-axis driving unit is connect by X-axis guide rail pair with rack；The Y-axis moving mechanism includes that Y-axis is driven
Moving cell, Y-axis guide rail pair, Y-axis connector, Y-axis screw pair, the Y-axis driving unit are connect by Y-axis guide rail pair with rack,
The Y-axis driving unit makes fiber adapter or pin hole be moved along Y-axis by Y-axis connector and Y-axis screw pair；The Z axis moves
Motivation structure includes Z axis driving unit, Z axis guide rail pair, Z axis connector, Z axis screw pair, and the Z axis driving unit is connected by Z axis
Fitting and Z axis screw pair connect lens mount, and lens mount is connect by Z axis guide rail pair with rack.
3. full-automatic fluorescence correlation spectroscopy instrument light path calibration mechanism according to claim 1, it is characterised in that：The lens
Seat has support plate, and support plate connect by Z axis guide rail pair with rack, and lens mount with Z axis connector equipped with connecting
Connecting rod, the Z axis connector are also connect with Z axis driving unit simultaneously.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820230555.9U CN207894817U (en) | 2018-02-09 | 2018-02-09 | Full-automatic fluorescence correlation spectroscopy instrument light path calibration mechanism |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820230555.9U CN207894817U (en) | 2018-02-09 | 2018-02-09 | Full-automatic fluorescence correlation spectroscopy instrument light path calibration mechanism |
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| Publication Number | Publication Date |
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| CN207894817U true CN207894817U (en) | 2018-09-21 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108051378A (en) * | 2018-02-09 | 2018-05-18 | 广东中科奥辉科技有限公司 | Full-automatic fluorescence correlation spectroscopy instrument light path calibration mechanism |
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2018
- 2018-02-09 CN CN201820230555.9U patent/CN207894817U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108051378A (en) * | 2018-02-09 | 2018-05-18 | 广东中科奥辉科技有限公司 | Full-automatic fluorescence correlation spectroscopy instrument light path calibration mechanism |
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Address after: 528400 GMP Workshop, 2 Buildings, 3 Floors, East Sanwei, Cuihai Road, Cuiheng New District, Zhongshan City, Guangdong Province (Residence Declaration) Patentee after: Guangdong Ke'ao Hui Technology Co. Ltd. Address before: 528400 Room 406, 4th Floor, Building C, Linhai Workshop, Cuicheng Road, Linhai Industrial Park, Cuiheng New District, Zhongshan City, Guangdong Province Patentee before: Guangdong Ke'ao Hui Technology Co. Ltd. |
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