CN207800547U - A kind of second order Proton-Transfer Reactions ion source device - Google Patents
A kind of second order Proton-Transfer Reactions ion source device Download PDFInfo
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- CN207800547U CN207800547U CN201721425033.6U CN201721425033U CN207800547U CN 207800547 U CN207800547 U CN 207800547U CN 201721425033 U CN201721425033 U CN 201721425033U CN 207800547 U CN207800547 U CN 207800547U
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- transfer reactions
- proton
- order proton
- drift tube
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- 238000006276 transfer reaction Methods 0.000 title claims abstract description 74
- 238000012372 quality testing Methods 0.000 claims description 15
- 238000006243 chemical reaction Methods 0.000 claims description 13
- 230000005684 electric field Effects 0.000 claims description 9
- 230000008878 coupling Effects 0.000 claims description 8
- 238000010168 coupling process Methods 0.000 claims description 8
- 238000005859 coupling reaction Methods 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- 208000002925 dental caries Diseases 0.000 claims description 5
- 239000011159 matrix material Substances 0.000 claims description 3
- 150000002500 ions Chemical class 0.000 abstract description 52
- 239000000126 substance Substances 0.000 abstract description 7
- 230000002452 interceptive effect Effects 0.000 abstract description 3
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000012855 volatile organic compound Substances 0.000 description 25
- 238000001184 proton transfer reaction mass spectrometry Methods 0.000 description 6
- 230000005945 translocation Effects 0.000 description 6
- 230000009471 action Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000001819 mass spectrum Methods 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000010884 ion-beam technique Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 102000006391 Ion Pumps Human genes 0.000 description 1
- 108010083687 Ion Pumps Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
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- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
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- 239000012495 reaction gas Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
Abstract
The utility model provides a kind of second order Proton-Transfer Reactions ion source device, including drift tube, its front end is equipped with ionization source region, the tube cavity that drifts about is equipped with single order Proton-Transfer Reactions area close to the part of ionization source region, the rear side in single order Proton-Transfer Reactions area is connected with the left side injection port of belt deflector structural cavity body, and the downside of belt deflector structural cavity body is equipped with second order Proton-Transfer Reactions area；The front side in single order Proton-Transfer Reactions area is equipped with the first introducing pipe for stretching into drift tube cavity, and molecular pump is equipped on the upside of the cavity of band-offset rotation structure；The main body of deflection structure is made of four deflecting electrodes, and the upside in second order Proton-Transfer Reactions area is equipped with the second introducing pipe for stretching into drift tube cavity.Second order Proton-Transfer Reactions ion source device described in the utility model so that Proton-Transfer Reactions has selectivity, can exclude the influence of some interfering ions, and efficiently differentiate isomerism chemical combination object.
Description
Technical field
The utility model belongs to mass spectrum ionization source engineering device technique field, turns more particularly, to a kind of second order proton of belt deflector
Move reactive ion source.
Background technology
Proton transfer reaction mass spectrometry (PTR-MS) is widely used in the quick and sensitive determination of trace volatile organic compounds,
Ionization source is one of mass spectrographic key building block.Proton-Transfer Reactions ionization is a kind of chemi-ionization, allows proton affinity
With reactive ion Proton-Transfer Reactions occurs for larger compound, is a kind of typical soft ionization mode.It passes through electron ionization
Mode the reaction gas of introducing is ionized to form reagent ion, then reagent ion and sample to be tested molecule occur a series of
Ion molecule reaction generate sample molecule quasi-molecular ion, be then detected by mass analyzer, thus can get compared with
A small number of purpose mass spectra peaks can more easily determine molecular weight.
For hollow cathode discharge source, hydrogen ion (H is produced using vapor glow discharge3O+), due to big
The proton affinity of most VOCs is more than water, the main component N in air2, O2And CO2Deng proton affinity be less than water, because
This, H3O+Proton-Transfer Reactions can occur with most of VOCs, without reacting with composition of air, be often used as main
Reaction reagent ion.Vapor generates H by ionization source region, through electric discharge3O+Ion, subsequently into drift tube, in drift tube
It is interior to collide during Driftdiffusion with determinand, H3O+(i.e. proton donor) gives proton translocation to determinand (i.e. proton
Acceptor), and make its ionization.As shown in formula (1), wherein R indicates VOCs to be measured for reaction.
H3O++R→H2O+RH+(1)
Above-mentioned reaction principle ensure that conventional constituents are not done in by air when measuring trace VOCs in air with PTR-MS
It disturbs, and sample need not be pre-processed.But traditional PTR-MS equally exists some limitations, such as：
(1) spectrogram of PTR-MS is using mass-to-charge ratio as abscissa, but for those isomerisms, the mass spectra peak of formation
Overlapping, can not distinguish；
(2) PTR-MS can be influenced when detecting the VOCs ingredients of sample to be tested by many interference components, spectral peak analysis
It is more complicated.
Invention content
In view of this, the utility model is directed to a kind of second order Proton-Transfer Reactions ion source device, it is above-mentioned to solve
The interference problem that isomerism and other compositions generate detection.
In order to achieve the above objectives, the technical solution of the utility model is realized in：
A kind of second order Proton-Transfer Reactions ion source device, including drift tube, front end are equipped with ionization source region, and drift tube is set
There are three sections of cavitys, the cavity portion close to ionization source region is equipped with single order Proton-Transfer Reactions area, single order Proton-Transfer Reactions area
The cavity portion of rear side is equipped with ion deflecting area, and the downside cavity portion in ion deflecting area is equipped with second order Proton-Transfer Reactions area；
The front side in single order Proton-Transfer Reactions area be equipped with stretch into drift tube cavity first introduce pipe, second order Proton-Transfer Reactions area it is upper
Side is equipped with the second introducing pipe for stretching into drift tube cavity.
Further, the short flowing that the ionization source region includes hollow cathode discharge area and is placed on rear side of hollow cathode discharge area
Area under control；Hollow cathode discharge area is connected to source of water vapor, and short flowing area under control is connected to mechanical pump.
Further, the end in the end in single order Proton-Transfer Reactions area and second order Proton-Transfer Reactions area, which is equipped with, draws
Go out electrode.
Further, the left end in the ion deflecting area, which is equipped with, introduces electrode, and lower end is equipped with extraction electrode；Ion deflecting area is logical
Cross and be provided thereon the LF flange-interfaces at end and connect with molecular pump, ion deflecting area be internally provided with four be in matrix distribution sectors
Deflecting electrode.
Further, the end of the drift tube is equipped with quality testing area, and molecule is equipped between quality testing area and drift tube
Pump.
Further, the quality testing area includes quadrupole rod mass analyzer.
Further, the ionization source region is connect with the coupling part of the drift tube, drift tube with the quality testing area
The coupling part between three sections of cavitys inside part and drift tube is placed in electric field.
Compared with the existing technology, second order Proton-Transfer Reactions ion source device described in the utility model has following excellent
Gesture：
Second order Proton-Transfer Reactions ion source device described in the utility model, sets up single order proton translocation separately in drift tube
Reaction zone, ion deflecting area and second order Proton-Transfer Reactions area so that reactant VOC1Elder generation and H3O+It is anti-that single order proton translocation occurs
It answers；Generated VOC1·H+Ion deflects under the action of ion deflecting area internal electric field, other neutral molecules do not occur partially
Turn to be extracted in drift tube chamber；The VOC to deflect1·H+Ion substitution H in the prior art3O+With determinand VOC2It carries out
Second order Proton-Transfer Reactions.Compared with the prior art so that chemical substance is specified in the detection that Proton-Transfer Reactions can be selective；
Secondly, isomer can be distinguished by second order Proton-Transfer Reactions；Finally, it can also be arranged by second order Proton-Transfer Reactions
Except the more interfering ion such as cluster.
Description of the drawings
The attached drawing for constituting the part of the utility model is used to provide a further understanding of the present invention, this practicality is new
The illustrative embodiments and their description of type are not constituted improper limits to the present invention for explaining the utility model.
In attached drawing：
Fig. 1 is the schematic diagram of the second order Proton-Transfer Reactions ion source device described in the utility model embodiment；
Fig. 2 is the second order Proton-Transfer Reactions ion source device described in the utility model embodiment in single order proton translocation
The Proton-Transfer Reactions schematic diagram of reaction zone；
Fig. 3 is the second order Proton-Transfer Reactions ion source device described in the utility model embodiment in ion deflecting area
Deflect schematic diagram.
Fig. 4 is the second order Proton-Transfer Reactions ion source device described in the utility model embodiment in second order proton translocation
The Proton-Transfer Reactions schematic diagram of reaction zone.
Reference sign：
1- hollow cathode discharges area；The short flowing areas under control 2-；3- first introduces pipe；4- second introduces pipe；5- quality testings area；
6- deflecting electrodes；7-LF flange-interfaces；8- single order Proton-Transfer Reactions area；9- ion deflectings area；10- second order Proton-Transfer Reactions
Area；11- mechanical pumps.
Specific implementation mode
It should be noted that in the absence of conflict, the feature in the embodiments of the present invention and embodiment can
To be combined with each other.
In the description of the present invention, it should be understood that term "center", " longitudinal direction ", " transverse direction ", "upper", "lower",
The orientation or positional relationship of the instructions such as "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outside" is
It is based on the orientation or positional relationship shown in the drawings, is merely for convenience of describing the present invention and simplifying the description, rather than indicate
Or imply that signified device or element must have a particular orientation, with specific azimuth configuration and operation, therefore cannot understand
For limitations of the present invention.In addition, term " first ", " second " etc. are used for description purposes only, and should not be understood as indicating
Or it implies relative importance or implicitly indicates the quantity of indicated technical characteristic." first ", " second " etc. are defined as a result,
Feature can explicitly or implicitly include one or more this feature.It is in the description of the present invention, unless another
It is described, the meaning of " plurality " is two or more.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " is pacified
Dress ", " connected ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or integrally
Connection；It can be mechanical connection, can also be electrical connection；Can be directly connected, can also indirectly connected through an intermediary,
It can be the connection inside two elements.For the ordinary skill in the art, on being understood by concrete condition
State the concrete meaning of term in the present invention.
The utility model will be described in detail below with reference to the accompanying drawings and embodiments.
Such as Fig. 1, the utility model proposes a kind of second order Proton-Transfer Reactions ion source device, including drift tube, front ends
Equipped with ionization source region, drift tube is equipped with three sections of cavitys, and the cavity portion close to ionization source region is equipped with single order Proton-Transfer Reactions area
8, the cavity portion of the rear side in single order Proton-Transfer Reactions area 8 is equipped with ion deflecting area 9, the downside cavity portion in ion deflecting area 9
It is arranged with second order Proton-Transfer Reactions area 10；The front side in single order Proton-Transfer Reactions area 8, which is equipped with, stretches into the first of drift tube cavity
Pipe 3 is introduced, the upside in second order Proton-Transfer Reactions area 10 is equipped with the second introducing pipe 4 for stretching into drift tube cavity.
Above-mentioned ionization source region includes hollow cathode discharge area 1 and the short flowing area under control for being placed in 1 rear side of hollow cathode discharge area
2；Hollow cathode discharge area 1 is connected to source of water vapor, and short flowing area under control 2 is connected to mechanical pump 11.
The end in above-mentioned single order Proton-Transfer Reactions area 8 and the end in second order Proton-Transfer Reactions area 9 are equipped with extraction electricity
Pole.After extraction electrode is as proton reaction, the extraction channel of each ion beam.
The left end in above-mentioned ion deflecting area 9, which is equipped with, introduces electrode, and lower end is equipped with extraction electrode；Ion deflecting area 9 is by setting
The LF flange-interfaces 7 held thereon are connect with molecular pump, and ion deflecting area 9 is internally provided with four sectors in matrix distribution partially
Turn electrode 6.
The rear end of above-mentioned drift tube is equipped with quality testing area 5, and molecular pump is equipped between quality testing area 5 and drift tube.
Above-mentioned quality testing area 5 includes quadrupole rod mass analyzer.
The coupling part of above-mentioned ionization source region and above-mentioned drift tube, drift tube and above-mentioned 5 coupling part of quality testing area with
And the coupling part between three sections of cavitys inside drift tube is placed in electric field.
The operation principle of the utility model is：
Vapor (d substances in Fig. 1) is discharged by source of water vapor, passes through hollow cathode discharge area 1 (HC) and short flowing successively
(SD) generates H afterwards in area under control 23O+Ion.H3O+Ion enters under the action of electric field in drift tube.In the process, extra
Aqueous vapor and other neutral gases are taken away by mechanical pump 11, ensure that vacuum degree is maintained at 200Pa or so in the cavity of drift tube.
Reactant (VOC is introduced into the cavity of drift tube by the first introducing pipe 31) line (a substances in Fig. 1), reaction
Object (VOC1) line and high flow velocities H3O+Ion beam current meets, and is brought into single order Proton-Transfer Reactions area 8.In single order matter
In sub- transfer reaction area 8, H3O+With specified VOC1Between by collision occur Proton-Transfer Reactions, generation include reactive ion
VOC1·H+And the reaction line of other ions (c substances in Fig. 1).Reactive ion VOC1·H+In the work of drift tube internal electric field
Under, ion deflecting area 9 is guided into.
The expression formula of above-mentioned reaction is：H3O++VOC1→VOC1·H++H2O
In the ion deflecting area 9 of drift tube (i.e. before single order Proton-Transfer Reactions area end and second order Proton-Transfer Reactions area
Between end), reactive ion VOC1·H+It deflects, is introduced under the action of deflecting electric field caused by four deflecting electrodes 6
Second order Proton-Transfer Reactions area 10.
Front end in the second order Proton-Transfer Reactions area 10 of drift tube is drawn by the second introducing pipe 4 into drift tube chamber
Enter determinand (VOC2) line (b substances in Fig. 1).Determinand (VOC2) line meets with line is reacted, it is brought into second order proton
In transfer reaction area 10.In the process, due to determinand (VOC2) proton affinity (PA) be more than VOC1, therefore, determinand
(VOC2) line with react line occur second order Proton-Transfer Reactions, generate VOC2·H+Ion.VOC2·H+Ion is in electric field
Enter quality testing area 5 under effect, and other ions then by molecule pumped drift tube cavity outside, to ensure quality testing area
5 vacuum degrees are maintained at 10-4Pa or so.
The expression formula of above-mentioned reaction is：VOC1·H++VOC2→VOC2·H++VOC1
Finally, VOC2·H+Ion, which enters in quadrupole rod mass analyzer, to be analyzed, and spectrogram is formed, and completes isomerism
The differentiation of body and other spectrum constituent analyses.
Second order Proton-Transfer Reactions ion source device described in the utility model and its application method, set up separately in drift tube
Single order Proton-Transfer Reactions area 8, ion deflecting area 9 and second order Proton-Transfer Reactions area 10 so that reactant VOC1Elder generation and H3O+Hair
Raw single order Proton-Transfer Reactions；Generated VOC1·H+Ion deflects under the action of deflecting electric field, with other neutrality point
Son separation；VOC after deflection1·H+Ion substitution H in the prior art3O+With determinand VOC2It is anti-to carry out second order proton translocation
It answers.Compared with the prior art so that chemical substance is specified in the detection that Proton-Transfer Reactions can be selective；Secondly, pass through second order
Proton-Transfer Reactions can distinguish isomer；Finally, can also to exclude cluster etc. by second order Proton-Transfer Reactions more
Interfering ion.
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this
Within the spirit and principle of utility model, any modification, equivalent replacement, improvement and so on should be included in the utility model
Protection domain within.
Claims (7)
1. a kind of second order Proton-Transfer Reactions ion source device, it is characterised in that：Including
Drift tube, front end are equipped with ionization source region, and drift tube is equipped with three sections of cavitys, and the cavity portion close to ionization source region is equipped with one
The cavity portion in rank Proton-Transfer Reactions area (8), the rear side in single order Proton-Transfer Reactions area (8) is equipped with ion deflecting area (9), from
The downside cavity portion of sub- deflecting region (9) is equipped with second order Proton-Transfer Reactions area (10)；Before single order Proton-Transfer Reactions area (8)
Side is equipped with the first introducing pipe (3) for stretching into drift tube cavity, and the upside in second order Proton-Transfer Reactions area (10), which is equipped with, stretches into drift
The second of tube cavity introduces pipe (4).
2. second order Proton-Transfer Reactions ion source device according to claim 1, it is characterised in that：The ionization source region packet
The short flowing area under control (2) for including hollow cathode discharge area (1) and being placed on rear side of hollow cathode discharge area (1)；Hollow cathode discharge area
(1) it is connected to source of water vapor, short flowing area under control (2) is connected to mechanical pump (11).
3. second order Proton-Transfer Reactions ion source device according to claim 2, it is characterised in that：The single order proton turns
The end of the end and second order Proton-Transfer Reactions area (10) of moving reaction zone (8) is equipped with extraction electrode.
4. second order Proton-Transfer Reactions ion source device according to claim 3, it is characterised in that：The ion deflecting area
(9) left end, which is equipped with, introduces electrode, and lower end is equipped with extraction electrode；Ion deflecting area (9) is connect by being provided thereon the LF flanges at end
Mouth (7) is connect with molecular pump, and ion deflecting area (9) are internally provided with four fan-shaped deflecting electrodes (6) in matrix distribution.
5. second order Proton-Transfer Reactions ion source device according to claim 4, it is characterised in that：The end of the drift tube
End is equipped with quality testing area (5), and quality testing area (5) are equipped with molecular pump between drift tube.
6. second order Proton-Transfer Reactions ion source device according to claim 5, it is characterised in that：The quality testing area
(5) include quadrupole rod mass analyzer.
7. second order Proton-Transfer Reactions ion source device according to claim 6, it is characterised in that：The ionization source region with
Coupling part, drift tube and the three sections of chambers inside quality testing area (5) coupling part and drift tube of the drift tube
Coupling part between body is placed in electric field.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721425033.6U CN207800547U (en) | 2017-10-31 | 2017-10-31 | A kind of second order Proton-Transfer Reactions ion source device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721425033.6U CN207800547U (en) | 2017-10-31 | 2017-10-31 | A kind of second order Proton-Transfer Reactions ion source device |
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| Publication Number | Publication Date |
|---|---|
| CN207800547U true CN207800547U (en) | 2018-08-31 |
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|---|---|---|---|
| CN201721425033.6U Withdrawn - After Issue CN207800547U (en) | 2017-10-31 | 2017-10-31 | A kind of second order Proton-Transfer Reactions ion source device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107768230B (en) * | 2017-10-31 | 2023-12-19 | 天津智谱仪器有限公司 | Second-order proton transfer reaction ion source device and application method thereof |
-
2017
- 2017-10-31 CN CN201721425033.6U patent/CN207800547U/en not_active Withdrawn - After Issue
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107768230B (en) * | 2017-10-31 | 2023-12-19 | 天津智谱仪器有限公司 | Second-order proton transfer reaction ion source device and application method thereof |
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