CN207703781U - capillary and DNA sequencer - Google Patents
capillary and DNA sequencer Download PDFInfo
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- CN207703781U CN207703781U CN201820143682.5U CN201820143682U CN207703781U CN 207703781 U CN207703781 U CN 207703781U CN 201820143682 U CN201820143682 U CN 201820143682U CN 207703781 U CN207703781 U CN 207703781U
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Abstract
The utility model provides a kind of capillary and DNA sequencer, and the capillary for being applied to DNA sequencer includes that the first son pipe and the second son are managed, and the first son pipe is fixedly connected with the second sub- pipe；The internal diameter of first sub- pipe is more than the internal diameter of the second sub- pipe.The capillary of the variable-diameter structure, in the case where not influencing other devices and broadening, the sample size of macromolecule sample is increased, the sample size difference of the sample of different molecular weight is reduced, the detection for being conducive to macromolecule sample, to improve the accuracy of testing result.
Description
Technical field
The utility model is related to biochemical equipment technical fields, more particularly, to a kind of capillary and DNA sequencer.
Background technology
Currently, DNA (deoxyribonucleic acid, DNA) sequenator generally use Capillary Electrophoresis
Technology detaches the nucleic acid molecules of different molecular weight, during Capillary Electrophoresis, generally by electrokinetic injection, such as in capillary
Both ends between add high voltage electric field, i.e., close to the port of sample solution and far from sample solution port between add high-voltage electricity
, allow sample to enter capillary under electric field action.
The sample size n of substance in electrokinetic injectionaIt is represented by：
na=(μa+μEOF)r2πUinjtinjCa/ L,
Wherein μaFor the electrophoretic mobility of substance, μEOFFor the mobility of electroosmotic flow, r is the inside radius of capillary, and L is hair
Tubule overall length, UinjFor sample introduction voltage, tinjFor sample injection time, CaFor the molar concentration of substance.
Above-mentioned sample introduction voltage crosses conference and electric current is caused to increase, and fever increases, and sample solution volume is limited, heat dissipation effect
Difference, fever can cause specimen breakdown, therefore sample introduction voltage cannot be excessive.In the case of sample introduction voltage and certain sample injection time,
Since capillary is relatively thin (unified internal diameter is 50 μm or so), the chance that the sample of different molecular weight enters can be by capillary inner diameter institute
Limitation, because in the mobility [mu] of electric fieldaOn advantage, the sample number that small-molecular-weight sample enters capillary can be more than macromolecular
Measure sample.Subsequent electrophoresis process can be impacted in this way, i.e., macromolecule sample enters the quantity meeting of comparing of electrophoresis process
Few, after the corresponding institute of the macromolecule sample in detection process band fluorescence is excited, the fluorescence signal sent out can be lower, and be unfavorable for
The detection of macromolecule sample, to influence the accuracy of testing result.
Utility model content
In view of this, the purpose of this utility model is to provide a kind of capillary and DNA sequencer, to reduce different molecular
The sample size difference of the sample of amount, to improve the accuracy of testing result.
In a first aspect, the utility model embodiment provides a kind of capillary, it is applied to DNA sequencer, the capillary
It is managed including the first son pipe and the second son, the first son pipe is fixedly connected with the described second sub- pipe；
The internal diameter of the first sub- pipe is more than the internal diameter of the described second sub- pipe.
With reference to first aspect, the utility model embodiment provides the first possible embodiment of first aspect,
In, the internal diameter of the first sub- pipe is 75-95 μm.
With reference to first aspect, the utility model embodiment provides second of possible embodiment of first aspect,
In, the internal diameter of the second sub- pipe is 45 μm.
With reference to first aspect, the utility model embodiment provides the third possible embodiment of first aspect,
In, the length of the first sub- pipe is 10-50mm.
With reference to first aspect, the utility model embodiment provides the 4th kind of possible embodiment of first aspect,
In, the overall length of the capillary is one of the following：22cm、36cm、50cm、80cm.
With reference to first aspect, the utility model embodiment provides the 5th kind of possible embodiment of first aspect,
In, the outer surface of the first sub- pipe is coated with electrode.
The 5th kind of possible embodiment with reference to first aspect, the utility model embodiment provide the of first aspect
Six kinds of possible embodiments, wherein the material of the electrode is stainless steel.
With reference to first aspect, the utility model embodiment provides the 7th kind of possible embodiment of first aspect,
In, the material of the first son pipe and the described second sub- pipe is quartz.
Second aspect, the utility model embodiment also provide a kind of DNA sequencer, including high-tension connector and such as above-mentioned the
Capillary described in one side or its any possible embodiment；
The first son pipe is connect with sample solution, and the second son pipe is connect with the high-tension connector.
In conjunction with second aspect, the utility model embodiment provides the first possible embodiment of second aspect,
In, the DNA sequencer includes multiple capillaries of array structure.
The utility model embodiment brings following advantageous effect：
In the utility model embodiment, the capillary for being applied to DNA sequencer includes that the first son pipe and the second son are managed, and first
Son pipe is fixedly connected with the second sub- pipe；The internal diameter of first sub- pipe is more than the internal diameter of the second sub- pipe.Due to the first sub- pipe internal diameter compared with
Greatly, the sample size of macromolecule sample can be increased, and the internal diameter of the second sub- pipe is smaller, follow-up electrophoresis process haves no need to change
The size of the related device of DNA sequencer, the size popped one's head in such as CCD (Charge-coupled Device, charge coupled cell)
Or the size of optical lens, and not increasing the time of sample introduction, broadening does not increase.Therefore the capillary of the variable-diameter structure,
In the case of not influencing other devices and broadening, the sample size of macromolecule sample is increased, the sample of different molecular weight is reduced
The sample size difference of product, is conducive to the detection of macromolecule sample, to improve the accuracy of testing result.
Other feature and advantage of the utility model will illustrate in the following description, also, partly from specification
In become apparent, or understood by implementing the utility model.The purpose of this utility model and other advantages are illustrating
Specifically noted structure is realized and is obtained in book, claims and attached drawing.
To enable the above objects, features, and advantages of the utility model to be clearer and more comprehensible, preferred embodiment cited below particularly, and
The appended attached drawing of cooperation, is described in detail below.
Description of the drawings
It, below will be right in order to illustrate more clearly of specific embodiment of the present invention or technical solution in the prior art
Specific implementation mode or attached drawing needed to be used in the description of the prior art are briefly described, it should be apparent that, it is described below
In attached drawing be that some embodiments of the utility model are not paying creativeness for those of ordinary skill in the art
Under the premise of labour, other drawings may also be obtained based on these drawings.
Fig. 1 is a kind of structural schematic diagram for capillary that the utility model embodiment provides；
Fig. 2 is the electrophoretogram using 50 μm of unified internal diameter capillary tubes；
Fig. 3 is the electrophoretogram of the variable-diameter structure capillary provided using the utility model embodiment；
Fig. 4 is a kind of structural schematic diagram for DNA sequencer that the utility model embodiment provides.
Icon：
100- the first son pipes；200- the second son pipes；10- capillaries；20- high-tension connectors；30- capillary detection windows.
Specific implementation mode
To keep the purpose, technical scheme and advantage of the utility model embodiment clearer, below in conjunction with attached drawing to this
The technical solution of utility model is clearly and completely described, it is clear that described embodiment is that the utility model part is real
Example is applied, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not making
The every other embodiment obtained under the premise of creative work, shall fall within the protection scope of the present invention.
Current existing capillary is the relatively fine inner diameter of unification, and the chance that the sample of different molecular weight enters can be by capillary
Internal diameter is limited to, and the sample number that small-molecular-weight sample enters capillary can be more than macromolecule sample, be unfavorable for macromolecule sample
The detection of product, to influence the accuracy of testing result.Based on this, a kind of capillary that the utility model embodiment provides and
DNA sequencer is increased the sample size of macromolecule sample, is reduced different molecular weight using the capillary of variable-diameter structure
The sample size difference of sample, to improve the accuracy of testing result.
For ease of understanding the present embodiment, a kind of capillary disclosed in the utility model embodiment is carried out first
It is discussed in detail.
Embodiment one：
The broadening of component zone is an important factor for influencing separating degree in capillary zone electrophoresis, and broadening is wide to cause sample
Product electrophoresis error increases, population variance (R2) be：
R2=R2 inj+R2 det+R2 dif+R2 heat,
R in above formula2 inj、R2 det、R2 dif、R2 heatRespectively sample introduction zone strip length (related with the time of sample introduction), detection window width
Degree, diffusion, Joule heat are to R2Contribution, wherein R2 inj=L2/ 12, L are sample introduction zone strip length, therefore sample introduction zone strip length increases
Error can be caused to sharply increase, control sample introduction zone strip length is an important factor for zone of influence band broadens (error).Based on above-mentioned interior
Hold, in order to allow the sample size of macromolecule sample to increase, and cannot directly use the time (sample introduction zone strip length) for increasing sample introduction
In the case of, a kind of capillary of variable-diameter structure is present embodiments provided to eliminate the difference problem of sample size.
Fig. 1 is a kind of structural schematic diagram for capillary that the utility model embodiment provides, which surveys applied to DNA
Sequence instrument.As shown in Figure 1, the capillary includes the first sub- pipe 100 and the second sub- pipe 200, the first sub- pipe 100 and the second sub- pipe 200
It is fixedly connected.The size of width means internal diameter in Fig. 1 between two dotted lines, as shown in Figure 1, the internal diameter of the first sub- pipe 100 is big
In the internal diameter of the second sub- pipe 200.
When applied in DNA sequencer, the first sub- pipe 100 is connect with sample solution, i.e., the first sub- pipe 100 is inserted into
In sample solution, sample solution enters capillary from the first larger sub- pipe 100 of internal diameter.
It is generally known that capillary is thinner, the sample size difference of the sample of different molecular weight is bigger.If however directly increasing hair
The internal diameter of tubule can cause the size of the related device of existing DNA sequencer to mismatch, such as the electrophoresis that CCD probe is shot
It is too small to scheme imperfect or optical lens sizes, part fluorescence can be missed, so as to cause test result inaccuracy.If increasing hair
While the internal diameter of tubule, change the size of related device, then workload is larger, and cost is higher.And change provided in this embodiment
The capillary of gauge structure, on the one hand, the internal diameter of the second sub- pipe 200 is smaller, haves no need to change the ruler of the related device of DNA sequencer
It is very little；On the other hand, the internal diameter of the first sub- pipe 100 is larger, can increase the sample size of macromolecule sample, and does not increase sample introduction
Time, broadening do not increase；I.e. the capillary has the advantages that at low cost, workload is small, is not influencing other devices and exhibition
In the case of width, the sample size of macromolecule sample is also added, the sample size difference of the sample of different molecular weight is reduced, has
Conducive to the detection of macromolecule sample, to improve the accuracy of testing result.
In the utility model embodiment, the capillary for being applied to DNA sequencer includes that the first son pipe and the second son are managed, and first
Son pipe is fixedly connected with the second sub- pipe；The internal diameter of first sub- pipe is more than the internal diameter of the second sub- pipe.Due to the first sub- pipe internal diameter compared with
Greatly, the sample size of macromolecule sample can be increased, and the internal diameter of the second sub- pipe is smaller, follow-up electrophoresis process haves no need to change
The size of the related device of DNA sequencer, such as the size of CCD probe or the size of optical lens, and do not increase sample introduction when
Between, broadening does not increase.Therefore the capillary of the variable-diameter structure is increased in the case where not influencing other devices and broadening
The sample size of macromolecule sample reduces the sample size difference of the sample of different molecular weight, is conducive to macromolecule sample
Detection, to improve the accuracy of testing result.
Further, in some preferably embodiment, the internal diameter of above-mentioned first sub- pipe 100 is 75-95 μm.For example, the
The internal diameter of one sub- pipe 100 is 85 μm.
Further, in some preferably embodiment, the internal diameter of above-mentioned second sub- pipe 200 is 45-50 μm, for example, the
The internal diameter of two sub- pipes 200 is 45 μm.
Further, in some preferably embodiment, the length of above-mentioned first sub- pipe 100 is 10-50mm.For example, the
The length of one sub- pipe 100 is 30mm.
Further, the overall length of above-mentioned capillary can be one of the following：22cm、36cm、50cm、80cm.
Further, the material of the above-mentioned first sub- pipe 100 and the second sub- pipe 200 is quartz.
When in view of DNA sequencer for electrokinetic injection, need that electrode is installed on the capillary, in the present embodiment,
The outer surface of one sub- pipe 100 is coated with electrode.The capillary of integrated setting can facilitate the peace in DNA sequencer in this way
Dress improves installation effectiveness to simplify installation process.
Further, it is contemplated that the electrode of the above-mentioned outer surface for being located at the first sub- pipe 100 is often contacted with solution, this implementation
In example, which uses anticorrosive property conductive material, can be, but not limited to as stainless steel.Stainless steel refers to resistance to air, steam, water etc.
The steel of the chemical etchings dielectric corrosion such as weak corrosive medium and acid, alkali, salt, also known as stainless acid resistant steel.
In order to verify application effect of the capillary provided in this embodiment in DNA sequencer, the present embodiment additionally provides
The electrophoresis result comparing result of one group of difference capillary.Fig. 2 is the electrophoretogram using 50 μm of unified internal diameter capillary tubes, wherein should
The overall length of capillary is 36cm, quartz material.Fig. 3 is the electricity of the variable-diameter structure capillary provided using the utility model embodiment
Swimming figure, wherein the internal diameter of the first sub- pipe 100 is 85 μm, and the internal diameter of the second sub- pipe 200 is 45 μm, and the length of the first sub- pipe 100 is
30mm, the overall length of capillary are 36cm, and the material of the first sub- pipe 100 and the second sub- pipe 200 is quartz.
In Fig. 2 and Fig. 3, horizontal axis is the frame number of the fluorescence photo of shooting, represents the time；The longitudinal axis is that the fluorescence of shooting shines
The accumulated result of fluorescence intensity, represents relative intensity of fluorescence in piece.Since the movement velocity of small-molecular-weight sample is fast, macromolecule
The movement velocity of sample is slow, and in Fig. 2 and Fig. 3, from left to right, molecular weight is incremental.
Comparison diagram 2 and Fig. 3 are significantly carried it is found that having corresponding to the fluorescence intensity of 4500 to 5000 frames of macromolecule in Fig. 3
Height, i.e. big component peak height in Fig. 3 when 4500 to 5000 frame are significantly increased, and broadening does not increase.Thus it demonstrates, this reality
The capillary for applying example offer increases the sample size of macromolecule sample in the case where not influencing broadening.
Embodiment two：
Fig. 4 is a kind of structural schematic diagram for DNA sequencer that the utility model embodiment provides, as shown in figure 4, the DNA
Sequenator includes high-tension connector 20 and the capillary 10 such as above-described embodiment one.
Specifically, the first son pipe of capillary 10 is connect with sample solution, the second son pipe and high pressure of capillary 10
Connector 20 connects.
Sample introduction process is as follows：First sub- pipe of capillary 10 is inserted into sample solution, the first son pipe of capillary 10
Electrode on added with negative high voltage, as shown in figure 4, high-tension connector 20 is grounded, (the capillary in this way between the both ends of capillary 10
In 10) high voltage electric field is formed, sample enters from the first sub- pipe of capillary 10 in capillary 10 under the action of electric field.
As shown in figure 4, the second son pipe in capillary 10 is arranged at high-tension connector 20 in capillary detection window 30.
Above-mentioned DNA sequencer further includes laser, spectro-grating, CCD camera etc., and detection process is as follows：The laser that laser is sent out
It can be shone by laser detector window on capillary detection window 30.When the fluorophor on fluorescent label DNA chain passes through hair
When tubule detection window 30, characteristic fluorescence spectrum is generated by the excitation of laser, fluorescence is thrown after spectro-grating is divided
It is mapped to synchronous imaging on CCD camera.
Further, above-mentioned capillary 10 can be single or array structure.
As shown in figure 4, above-mentioned DNA sequencer includes multiple capillaries 10 of array structure, each capillary 10 is for examining
Survey a sample.The number of capillary 10 can be, but not limited to be 4,8,16,32,48,96 etc., as shown in figure 4, capillary 10
Number is 8.
Using the DNA sequencer of multiple capillaries 10 of array structure, multiple samples can be detected simultaneously, therefore can carry
High detection efficiency.
In the utility model embodiment, the capillary for being applied to DNA sequencer includes that the first son pipe and the second son are managed, and first
Son pipe is fixedly connected with the second sub- pipe；The internal diameter of first sub- pipe is more than the internal diameter of the second sub- pipe.Due to the first sub- pipe internal diameter compared with
Greatly, the sample size of macromolecule sample can be increased, and the internal diameter of the second sub- pipe is smaller, follow-up electrophoresis process haves no need to change
The size of the related device of DNA sequencer, such as the size of CCD probe or the size of optical lens, and do not increase sample introduction when
Between, broadening does not increase.Therefore the DNA sequencer for including the variable-diameter structure capillary is not influencing other devices and broadening
In the case of, the sample size of macromolecule sample is increased, the sample size difference of the sample of different molecular weight is reduced, is conducive to big
The detection of molecular species, to improve the accuracy of testing result.
It is apparent to those skilled in the art that for convenience and simplicity of description, the DNA of foregoing description is surveyed
The specific work process of sequence instrument can refer to the corresponding process in aforementioned capillary embodiment, and details are not described herein.
The DNA sequencer that the utility model embodiment provides, the capillary skill having the same provided with above-described embodiment
Art feature reaches identical technique effect so can also solve identical technical problem.
In the utility model embodiment, unless specifically stated otherwise, component, the number otherwise illustrated in these embodiments
Word expression formula and numerical value are not intended to limit the scope of the utility model.
In all examples being illustrated and described herein, any occurrence should be construed as merely illustrative, without
It is as limitation, therefore, other examples of exemplary embodiment can have different values.
It should be noted that：Similar label and letter indicate similar terms in following attached drawing, therefore, once a certain Xiang Yi
It is defined, then it further need not be defined and explained in subsequent attached drawing in a attached drawing.
In addition, in the description of the utility model embodiment unless specifically defined or limited otherwise, term " installation ",
" connected ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or integrally connect
It connects；It can be mechanical connection, can also be electrical connection；It can be directly connected, can also indirectly connected through an intermediary, it can
To be the connection inside two elements.For the ordinary skill in the art, it can understand above-mentioned term with concrete condition
Concrete meaning in the present invention.
It is in the description of the present invention, it should be noted that term "center", "upper", "lower", "left", "right", " perpendicular
Directly ", the orientation or positional relationship of the instructions such as "horizontal", "inner", "outside" is to be based on the orientation or positional relationship shown in the drawings, and is only
The utility model and simplifying describes for ease of description, do not indicate or imply the indicated device or element must have it is specific
Orientation, with specific azimuth configuration and operation, therefore should not be understood as limiting the present invention.In addition, term " the
One ", " second ", " third " are used for description purposes only, and are not understood to indicate or imply relative importance.
Finally it should be noted that：Embodiment described above, only specific embodiment of the present utility model, to illustrate this
The technical solution of utility model, rather than its limitations, the scope of protection of the utility model is not limited thereto, although with reference to aforementioned
The utility model is described in detail in embodiment, it will be understood by those of ordinary skill in the art that：It is any to be familiar with this skill
The technical staff in art field within the technical scope disclosed by the utility model, still can be to the skill recorded in previous embodiment
Art scheme modify or can readily occur in variation or equivalent replacement of some of the technical features；And these modifications,
Variation is replaced, the spirit and model of the utility model embodiment technical solution that it does not separate the essence of the corresponding technical solution
It encloses, should be covered within the scope of the utility model.Therefore, the scope of protection of the utility model is answered described is wanted with right
Subject to the protection domain asked.
Claims (10)
1. a kind of capillary, which is characterized in that it is applied to DNA sequencer, the capillary includes that the first son pipe and the second son are managed,
The first son pipe is fixedly connected with the described second sub- pipe；
The internal diameter of the first sub- pipe is more than the internal diameter of the described second sub- pipe.
2. capillary according to claim 1, which is characterized in that the internal diameter of the first sub- pipe is 75-95 μm.
3. capillary according to claim 1, which is characterized in that the internal diameter of the second sub- pipe is 45 μm.
4. capillary according to claim 1, which is characterized in that the length of the first sub- pipe is 10-50mm.
5. capillary according to claim 1, which is characterized in that the overall length of the capillary is one of the following：22cm、
36cm、50cm、80cm。
6. capillary according to claim 1, which is characterized in that the outer surface of the first sub- pipe is coated with electrode.
7. capillary according to claim 6, which is characterized in that the material of the electrode is stainless steel.
8. capillary according to claim 1, which is characterized in that the material of the first son pipe and the described second sub- pipe is equal
For quartz.
9. a kind of DNA sequencer, which is characterized in that including high-tension connector and as described in any one of the claims 1-8
Capillary；
The first son pipe is connect with sample solution, and the second son pipe is connect with the high-tension connector.
10. DNA sequencer according to claim 9, which is characterized in that the DNA sequencer includes the more of array structure
A capillary.
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|---|---|---|---|
| CN201820143682.5U CN207703781U (en) | 2018-01-26 | 2018-01-26 | capillary and DNA sequencer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201820143682.5U CN207703781U (en) | 2018-01-26 | 2018-01-26 | capillary and DNA sequencer |
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| CN207703781U true CN207703781U (en) | 2018-08-07 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108593748A (en) * | 2018-01-26 | 2018-09-28 | 南京溯远基因科技有限公司 | capillary and DNA sequencer |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108593748A (en) * | 2018-01-26 | 2018-09-28 | 南京溯远基因科技有限公司 | capillary and DNA sequencer |
| CN108593748B (en) * | 2018-01-26 | 2024-04-30 | 南京溯远基因科技有限公司 | Capillary and DNA sequencer |
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