CN207640401U - A kind of noninvasive cerebral blood flow (CBF) measuring system - Google Patents
A kind of noninvasive cerebral blood flow (CBF) measuring system Download PDFInfo
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- CN207640401U CN207640401U CN201720403735.8U CN201720403735U CN207640401U CN 207640401 U CN207640401 U CN 207640401U CN 201720403735 U CN201720403735 U CN 201720403735U CN 207640401 U CN207640401 U CN 207640401U
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- blood flow
- cbf
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- photoelectric detector
- brain
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Abstract
The utility model belongs to cerebral blood flow (CBF) measurement method technical field, and in particular to the noninvasive cerebral blood flow (CBF) measuring system of a kind of combination near infrared spectrum and pulse pigment method.The system includes transmission-type ear-lobe ICG measurement of concetrations module, master controller and the host computer that brain forehead ICG measurement of concetrations module, two wavelength diodes and the ear-lobe photoelectric detector being made of three wavelength diodes and brain forehead photoelectric detector form, brain forehead photoelectric detector, ear-lobe photoelectric detector are connect with master controller respectively, by the signal detected AD conversion in the host controller, master controller connects host computer, and transformed signal is sent to host computer and is calculated.This system measurement process is easy, to clinically predicting that cerebral infarction, the diseases such as cerebral thrombus have prodigious effect.
Description
Technical field
The utility model belongs to cerebral blood flow (CBF) measurement method technical field, and in particular to a kind of combination near infrared spectrum and arteries and veins
The noninvasive cerebral blood flow (CBF) measuring system for pigment method of fighting.
Background technology
In human normal physiological activity, cerebrovascular blood flowing dynamics parameter such as brain blood flow, cerebral blood oxygen saturation, the cerebrovascular
Pipe bed circulation time etc., the generation of individual cerebrovascular function, early warning headstroke and cerebral hemorrhage can be assessed.
Tissue blood flow is to recycle automatic adjustment by brain blood flow to maintain, and is the injury-free prerequisite of nervous activity.
Cerebral blood flow (CBF), which drastically declines, can lead to part or full cranium drastically ischemic, and prestige is constituted to brain tissue activity and human life health
The side of body.With the development of science and technology, clinically the method for measure cerebral blood flow has Xe at present133Or Kr85Isotope-labelling method, hernia
Gas enhanced CT, the technologies such as PET, MRI, but these technologies are complex, are not suitable for all groups and are also unfavorable for clinical quickly survey
Amount.
There are certain clinical value, measurement process that patient is needed to suck hernia though measuring brain blood flow using hernia enhanced CT method
Gas.Hernia concentration has anesthetic effect when being more than 50% to human body.Different people reacts different to hernia when sucking a small amount of.Such method
Measurement process is needed to be very careful, it is very unhealthy to human body.
It is a kind of method clinically approved the most at present that PET, which measures brain blood flow method, and 18O-H2O tracers PET is considered
It is that brain blood flow measures " goldstandard ".But such method fancy price cost allows its popularization to be restricted.It can not large area
It is universal, nor a kind of medical detecting method that ordinary people can bear.
MRI mr techniques have been applied to the imaging diagnosis of each system of whole body.Best results be cranium brain and its spinal cord,
Cardiovascular injuries, joint bone, soft tissue and pelvic cavity etc..Each chamber, big blood vessel and valve can be not only observed angiocardiopathy
The dissection of film changes, and can make Ventricle Analysis, carries out qualitative and sxemiquantitative diagnosis, can make multiple sectional drawings, spatial discrimination
Rate is higher, shows heart and lesion overall picture, and its relationship with surrounding structure.But using the technology measure brain blood flow need into
Enter special magnetic resonance measurement room.MRI needs huge instrument and equipment to support its measurement process, is unable to reach desired clinic
Quickly detection can not provide physicians with the real-time brain blood flow variation of patient.
Utility model content
In order to be suitble to the quick detection of clinically cerebral blood flow (CBF), the utility model to provide a kind of noninvasive cerebral blood flow (CBF) measurement
System.
The utility model provides a kind of noninvasive cerebral blood flow (CBF) measuring system, including by three wavelength diodes and brain forehead light
The brain forehead ICG measurement of concetrations module of photodetector composition, the transmission-type of two wavelength diodes and ear-lobe photoelectric detector composition
Ear-lobe ICG measurement of concetrations module, master controller and host computer, brain forehead photoelectric detector, ear-lobe photoelectric detector respectively with master
Controller connects, and by the signal detected AD conversion in the host controller, master controller connects host computer, by transformed signal
Host computer is sent to be calculated.
The master controller is made of filter module connected in sequence, AD conversion module and bluetooth sending module.
Three kinds of wavelength lengths of the three wavelength diodes transmitting are respectively 760nm, 810nm, 840nm；Two wavelength
Two kinds of wavelength lengths of diode emitter are respectively 760nm, 840nm.
The distance between three wavelength diode and brain forehead photoelectric detector are 2cm.
Compared with prior art, the utility model has the advantage of：1, the utility model can be with using multi-wavelength diode
Realize that quickly noninvasive brain blood flow measures；2, the utility model total system small in volume can realize portable inspectiont；3、
The utility model measurement process is easy, to clinically predicting that cerebral infarction, the diseases such as cerebral thrombus have prodigious effect.
Description of the drawings
Fig. 1 is noninvasive cerebral blood flow (CBF) measuring system structural schematic diagram provided by the utility model；
Fig. 2 is that the utility model cerebral blood flow (CBF) measures sequence diagram；
Fig. 3 is three wavelength diodes, three kinds of wavelength Absorption Coefficient Curves of Step in the utility model；
Fig. 4 is the photoelectricity volume wave signal graph of the utility model；
Fig. 5 is the pulse wave signal figure of the utility model；
Fig. 6 is the brain blood flow experiment curv figure of the utility model.
Specific implementation mode
In order to make the purpose of the utility model, technical solutions and advantages more clearly understood, with reference to embodiments with it is attached
Figure, the present invention will be further described in detail.It should be appreciated that specific embodiment described herein is only used to explain
The utility model is not used to limit the utility model.
In the present system, using NIRS and DDG technologies, the mesh of clinical quickly detection brain blood flow is can reach using ICG pigments
's.The method needs to measure ICG concentration in brain tissue ICG concentration and artery, then applies Fei Shi methods (Fick ' s
Method cerebral blood flow (CBF)) is calculated.To the nontoxic pigments of human injection ICG as tracer after, multi-wavelength diode is put
Brain forehead is set, the light intensity received is sent to host computer and calculated, and bright rich Beer law is corrected in host computer application, is calculated in brain tissue
The variation of ICG concentration.At the same time, ICG concentration in ear-lobe model measurement artery, since the contraction of arteriopalmus will produce friendship directly
The signal that stream mixes is detached alternating current-direct current amount using alternating current-direct current isolation technics, then can be calculated and be set out using bright rich Beer law
Arteries and veins ICG concentration.
As shown in Figure 1, the present embodiment includes the brain forehead ICG being made of three wavelength diodes and brain forehead photoelectric detector
Measurement of concetration module, the transmission-type ear-lobe ICG measurement of concetrations module of two wavelength diodes and ear-lobe photoelectric detector composition, master control
Device and host computer processed, brain forehead photoelectric detector, ear-lobe photoelectric detector are connect with master controller respectively, and master controller is by sequentially
The filter module of connection, AD conversion module and bluetooth sending module composition, by the signal detected AD conversion in the host controller,
Master controller connects host computer, and transformed signal is sent to host computer and is calculated.
Three wavelength diodes emit the light of different wave length, sequential such as attached drawing using timesharing actuation techniques to Prefrontal Cortex
2.Photon passes through brain tissue, HbO2, Hb, ICG received by brain forehead photoelectric detector after absorbing reflection, the light of different wave length inhaled
The intensity of receipts is different.The light intensity of varying strength is sent to host computer for digital quantity via master controller AD conversion and is calculated, and counts
It calculates according to bright rich Beer law：
A=log (I0/ I)=ελ·C·DPF(λ)·r+G (1)
A indicates absorbance, I in formula0, I be respectively incident light and emergent light light intensity, ελThe extinction system of substance when for wavelength being λ
Number, r are the distance of light source and photodetector, and C is the concentration of tested substance.DPF (λ) is the differential path factor, and G indicates water
Light attenuation coefficient caused by absorption Deng other substances, it is difficult to by Absolute quantification.
According to formula 1, the concentration variable quantity of extinction color group is indicated using optical attenuation：
It is influenced since skin histology scatters, the light propagation distance ratio r in the tissue that wavelength is λ is averaged big DPF (λ)
Times.DPF (λ) is path differential sampling parameter constant, to correct the optical path length in L-B laws.For less than 2 years old newborn and
Baby DPF=4.39, for more than 2 years old children and adult DPF=5.93.
In the brain, main endogenous extinction color rolls into a ball HbO2It is 700-1000nm with Hb absorption spectrum ranges.ICG is a kind of
The external source extinction material of intravenous administration, relative molecular mass 774.96, absorptivity peak value between 795-805nm it
Between.3 HbO provided with reference to the accompanying drawings2, Hb, ICG and H2The absorption spectrum curve of O, this method selects wavelength for 760,810,840nm
Near-infrared laser detected as light source.By HbO after the photon of different wave length enters brain2, HbR, ICG absorb it is anti-
It penetrates, light intensity attenuation is different.Via signal condition appropriate, AD conversion is sent into host computer analysis.Three wavelength can be obtained to exist
The figure line decayed after reflection is subsequently absorbed in the material in brain, such as attached drawing 4.
During ear-lobe ICG measurement of concetrations, select the near-infrared laser of 760nm, 840nm as light source according to attached drawing 3.Point
When drive light source, different wave length light beam is irradiated to ear-lobe surface, and photon is by multi-layer biologicals groups such as skin, muscle, fat, blood
Hair-weaving life reflection, transmission, scattering, cause a degree of light absorption and decaying, emergent light to be received by a photoelectric detector.In artery
Light path changes caused by changing due to arteriopalmus blood vessel thickness in measurement.The size of transmitted light intensity can be with pulse wave rate
In periodically-varied, such as Fig. 5, the signal in attached drawing 5 obtains more via the drift for being filtered the limit that can eliminate signal
Accurate alternating current-direct current component.The light intensity changes delta I caused by pulse be much smaller than transmitted light intensity I, Δ A can approximation write
The form of an accepted way of doing sth (3)
In this case, if the light source lambda 4 of two different wave lengths and λ 5 is selected to measure, and by measure two groups of light
The variation delta A4 and Δ A5 of density are compared, so that it may which the influence of Δ D caused by eliminate pulse beating obtains
Referred to as pulsating quantity ratio can be calculated by measuring transmitted light light intensity and its variable quantity, and Hb and ICG are in different waves
Absorptivity under long is constant, as long as in this way, detecting the concentration C of Hb H b before pigment injectionhIt can basis
Formula (4) calculates CIValue.
Bring calculated value obtained by upper two step into Fei Shi formula：
In can calculate to obtain cerebral blood flow (CBF), such as attached drawing 6.Three curves are shared in figure 6, and No. 2 lines are Hb, Line 1 HbO2,
No. 3 lines are ICG.This three curves represent the concentration variation of these three substances.When not injecting ICG, here it is apparent that figure
Middle a concentration of 0, Hb and HbO of ICG2There is certain initial value.After human body is felt suffocated to a certain extent, here it is apparent that Hb concentration it is fast
Speed rises, HbO2Drastically decline, ICG concentration is held essentially constant, HbO2Drastically decline ICG concentration is slightly influenced, but
In error tolerance interval.
Above-described embodiment is merely to illustrate the utility model, and structure and size, installation position and the shape of each component are all can
It is all that individual part is carried out according to the utility model principle on the basis of technical solutions of the utility model with what is be varied from
Improvement and equivalents, should not exclude except the scope of protection of the utility model.
Claims (4)
1. a kind of noninvasive cerebral blood flow (CBF) measuring system, which is characterized in that including by three wavelength diodes and brain forehead Photoelectric Detection
The brain forehead ICG measurement of concetrations module of device composition, the transmission-type ear-lobe ICG of two wavelength diodes and ear-lobe photoelectric detector composition
Measurement of concetration module, master controller and host computer, brain forehead photoelectric detector, ear-lobe photoelectric detector connect with master controller respectively
It connects, by the signal detected, AD conversion, master controller connect host computer, transformed signal are sent in the host controller
Position machine is calculated.
2. noninvasive cerebral blood flow (CBF) measuring system as described in claim 1, which is characterized in that the master controller is by being sequentially connected with
Filter module, AD conversion module and bluetooth sending module composition.
3. noninvasive cerebral blood flow (CBF) measuring system as described in claim 1, which is characterized in that the three wavelength diodes transmitting
Three kinds of wavelength lengths are respectively 760nm, 810nm, 840nm；Two kinds of wavelength lengths of two wavelength diode transmitting are respectively
760nm、840nm。
4. noninvasive cerebral blood flow (CBF) measuring system as described in claim 1, which is characterized in that before three wavelength diode and brain
The distance between volume photoelectric detector is 2cm.
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| CN201720403735.8U CN207640401U (en) | 2017-04-17 | 2017-04-17 | A kind of noninvasive cerebral blood flow (CBF) measuring system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106923814A (en) * | 2017-04-17 | 2017-07-07 | 吉林大学 | A kind of noninvasive cerebral blood flow (CBF) measuring system and measuring method |
| CN114521894A (en) * | 2022-02-21 | 2022-05-24 | 智普测医疗科技(成都)有限公司 | Blood oxygen saturation monitoring and liver function testing system based on central venous catheter |
-
2017
- 2017-04-17 CN CN201720403735.8U patent/CN207640401U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106923814A (en) * | 2017-04-17 | 2017-07-07 | 吉林大学 | A kind of noninvasive cerebral blood flow (CBF) measuring system and measuring method |
| CN114521894A (en) * | 2022-02-21 | 2022-05-24 | 智普测医疗科技(成都)有限公司 | Blood oxygen saturation monitoring and liver function testing system based on central venous catheter |
| CN114521894B (en) * | 2022-02-21 | 2024-01-12 | 智普测医疗科技(成都)有限公司 | Blood oxygen saturation monitoring and liver function testing system based on central venous catheter |
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