CN207619567U - A kind of electrostatic spinning capsule blank-maker - Google Patents
A kind of electrostatic spinning capsule blank-maker Download PDFInfo
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- CN207619567U CN207619567U CN201621427908.1U CN201621427908U CN207619567U CN 207619567 U CN207619567 U CN 207619567U CN 201621427908 U CN201621427908 U CN 201621427908U CN 207619567 U CN207619567 U CN 207619567U
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Abstract
A kind of electrostatic spinning capsule blank-maker being made capsule embryo using electrostatic spinning, is made of components such as storage tank, Electrospun nozzle, capsule die, transmitting device, oiler, drying machine, material receiving ports.The complete equipment utilizes electrostatic spinning principle, applies a positive charge high pressure to capsule original gelatin, is pulled on micron or nano level fiber jet to capsule die and formed a film by the spout on nozzle, after by it is of short duration it is cooling dry after fall off capsule idiosome be made.The capsule idiosome toughness made of the equipment is high, and capsule wall thickness is controllable, and idiosome size is accurate and stablizes.In addition, by the adjustment replacement to electrostatic spinning nozzle and capsule die, various different shapes, the capsule idiosome of different mechanical properties can be made.
Description
Technical field
The present invention relates to a kind of Novel capsule blank-makers, particularly relate to a kind of principle progress idiosome system using electrostatic spinning
The Novel capsule blank-maker of work.
Background technology
Capsule has just been widely used in drug, the health products even encapsulating of food, since it is to inclusion since birth
Good protective effect makes it possess irreplaceable status in pharmacy and health products processing and other fields.Current hard capsule system
Embryo machine is nearly all that pack is dipped in use, due to the limitation of manufacture craft, causes its capsule thickness and toughness unstable, and pull out capsule
The presence of the process also limit value diversification of capsule form.
Electrostatic spinning is more used to prepare nano fibrous membrane or minimum micro- of special pharmaceutical preparation such as grain size at present
Capsule.For example CN104818537A discloses rotary double needle electrostatic spinning apparatus and its prepares even tunica fibrosa side
Method, the device include rotation spinning appts, collection device and temperature-adjusting and humidity-adjusting device；It includes horizontal jet pipe, water to rotate spinning appts
Flat jet pipe is fixed on by crane on rotating platform, and rotating platform and rotation axis connection drive rotary shaft rotation by motor,
To drive rotating platform to rotate, micro-injection pump and high voltage direct current generator are additionally provided on rotating platform；Horizontal jet pipe top
Portion is provided with a pair of of metal needle, and horizontal jet pipe bottom is connect by conducting wire with high voltage direct current generator, the feed liquor of horizontal jet pipe
Mouth is connect by catheter with syringe, and syringe is driven by micro-injection pump and injected.
But these are high, at high price to ingredient requirement for electrostatic spinning, are not incorporated in actual production extensively,
There is no relevant report to use it for the production of the common hard capsule case of pharmaceutical field, in particular for gelatine capsule and starch capsule
In shell.
Invention content
In order to solve the problems, such as that the above-mentioned formula of dipping in of wrapping up in prepares that the product quality that capsule idiosome has is uncontrollable, and the present invention devises
A kind of electrostatic spinning capsule blank-maker.The stably and controllable of capsule idiosome parameters may be implemented, while possessing preferably tough
The selection of degree and more Multiple Shape.
The principle of its manufacturing process is：The capsule original gelatin prepared is fitted into storage tank, electrostatic spinning nozzle is passed through
Gelatin jet is transmitted at nanofiber and uniformly capsule die inner surface, capsule embryo is obtained by being shaped after Quick-air-drying
Body.
Technical solution provided by the invention is as follows：
A kind of electrostatic spinning capsule blank-maker, which is characterized in that filled by storage tank, Electrospun nozzle, capsule die, transmission
It sets, oiler, drying machine, material receiving port are constituted, wherein the Electrospun nozzle injects the storing pot bottom；The transmission dress
It sets to transport by numerical control crawler type and realize, possess capsule die jack on crawler belt, the glue is inserted into the capsule die jack
Capsule mold；Inner surface oiling of the oiler in the capsule die；The drying machine makes the die of capsule that the embryo processed finishes
The cooling drying of tool；The cooling dry capsule die finished is run to by transmitting device at material receiving port.
The electrostatic spinning capsule blank-maker, which is characterized in that storage tank is single material storage tank or more material storings
Tank, equipped with high voltage power supply device, temperature regulating device, numerical control motor, numerical control charge door and numerically-controlled machine tool.
The electrostatic spinning capsule blank-maker, which is characterized in that Electrospun nozzle is detachably replaced, hollow in jet pipe,
There is spout at the top of tube wall and nozzle.
The electrostatic spinning capsule blank-maker, which is characterized in that capsule die is the hollow barrel of one end open, by can
Two separated valves are closely engaged, and there is folding joint in root and has the plug of certain specification, and mold material is conductive material.
The electrostatic spinning capsule blank-maker, which is characterized in that transmitting device is the pedrail delivering strap of numerical control, transmission
The jack being inserted into for mold is taken, has the numerical controlled power device of control mould open/close at jack, has leading for ground wire in jack
Electric structure.
The electrostatic spinning capsule blank-maker, which is characterized in that oiler can provide the flexible and rotation function covered with paint or varnish.
The electrostatic spinning capsule blank-maker, which is characterized in that dry function carries out specific humiture to capsule idiosome
Cooling drying.
The electrostatic spinning capsule blank-maker, which is characterized in that there are one vertical at the top of the needle tubing of electrostatic spinning nozzle
Main injection jet, the side spout that needle tubing side has multiple positions not equal, nozzle abdomen has the mobilizable card slot of a circle.
Capsule of the present invention is not microcapsules, preferably oral hard capsule, further preferred gelatine capsule or starch
Capsule.
Description of the drawings
This illustrates a kind of embodiment only of the invention, rather than is further limited the present invention,
Under same principle, other electrostatic spinnings making capsule class Production equipment obtained without creative work equally belongs to
In protection scope of the present invention.
The full-automatic electrostatic spinning capsule blank-maker schematic diagrames of Fig. 1；
Wherein：1, vertical spout；2, side spout；3, numerical control motor；4, storage tank；5, high voltage power supply device；6, temperature control
Device；7, numerical control charge door；8, capsule die；9, automatic polish applying shoes-brush；10, transmitting device；11, constant temperature and humidity drying hair-dryer；
12, idiosome material receiving port；13, capsule idiosome.
Fig. 2 is single material storage tank schematic diagram；
Fig. 3 is 3 material storage tank schematic diagram.
Specific implementation mode
The principle of the present invention and implementation method are described below in conjunction with attached drawing, example used is to be expanded on further
The content of present invention, rather than the limitation to the invention protection domain.
Embodiment 1
1) the gelatin glue prepared is poured into storage tank, select suitable nozzle and be installed to below charge door, root
Single charge amount is adjusted according to the specification of nozzle, adjusting temperature regulating device makes temperature maintain 65 DEG C, adjusts the electricity of high voltage power supply device
Press setting value in 1000V, adjusting shower nozzle rotary speed is 30rad/s, and the spinning time is set as 1.5min；
2) mold for selecting corresponding shape and model, is installed on main body transmitting device, and mold is by transmitting on crawler belt
Metal interface be directly grounded, idiosome discharge port places items sheltering；
3) the transmitting device rotation dead time is set as the spinning time and adds time for moving up and down of head module, and covering with paint or varnish makes
With corn oil, covering with paint or varnish the oiling time is set as 5s, rotating speed 10rad/s, and the temperature of dry-air blower is set in 25 ± 5 DEG C, wet
Degree is set in 45%；
4) start the run switch of the equipment, under first mold by first-class oil is transferred to nozzle just by transmitting device
Side, by being put in mold under numerically-controlled machine tool, the gelatin glue in storage tank is added to by numerical control charge door in jet pipe nozzle,
Numerical control motor drives nozzle rotation, while high voltage power supply device applies high positive charge by metal clamp spring to nozzle, in electrostatic force
Under the action of centrifugal force, gelatin glue pulls into micron order by tiny spout or nano level spinning fibre uniformly sprays
To capsule die, the gelatine capsule embryo of one layer of fibrous reticular structure is attached to after the spinning time in capsule die inner wall
Body, after nozzle is moved up by numerically-controlled machine tool, transmitting device then send second Shang number oily mold to nozzle, under starting
The electrostatic spinning embryo of one wheel；
5) capsule die that embryo processed finishes, which is run to by transmitting device at constant temperature and humidity drying hair-dryer, carries out cooling do
Dry, since capsule idiosome is made of spinning, therefore it just has been obtained for certain drying effect during spinning,
And since the fibrous reticular structure of idiosome keeps moisture therein more volatile, therefore it is short to wrap up in drying time than traditional dipping in very much
It is more；
6) when the cooling dry capsule die finished is run to by transmitting device at material receiving port, capsule die root is opened
It attaches together and sets opening, capsule Automatic-falling is made to fall into material receiving port, if any the capsule idiosome being still adhered on mold, can be used artificial
Or automatically mode is brushed down with banister brush；
7) pass hull closure keeps its out of service after producing, and cuts off the power and waits for that it is cooled to room temperature, unloads lower nozzle and mould
Have and it is thoroughly cleaned, is stored neatly after dry, storage tank, numerical control charge door and automatic polish applying shoes-brush should also carry out
Cleaning and maintenance, mold jack should be cleaned, it is ensured that without spot residue, dryer outlet mouth and equipment others outer surface
It should all be cleaned and maintained.
Embodiment 2
1, the starch glue prepared is poured into storage tank, select suitable nozzle and be installed to below charge door, root
Single charge amount is adjusted according to the specification of nozzle, adjusting temperature regulating device makes temperature maintain 60 DEG C, adjusts the electricity of high voltage power supply device
Press setting value in 1000V, adjusting shower nozzle rotary speed is 35rad/s, and the spinning time is set as 2min；
2, the mold for selecting corresponding shape and model, is installed on main body transmitting device, and mold is by transmitting on crawler belt
Metal interface be directly grounded, idiosome discharge port places items sheltering；
3, the transmitting device rotation dead time is set as the spinning time and adds time for moving up and down of head module, and covering with paint or varnish makes
With corn oil, covering with paint or varnish the oiling time is set as 5s, rotating speed 10rad/s, and the temperature of dry-air blower is set in 25 ± 5 DEG C, wet
Degree is set in 45%；
4, start the run switch of the equipment, under first mold by first-class oil is transferred to nozzle just by transmitting device
Side, by being put in mold under numerically-controlled machine tool, the starch glue in storage tank is added to by numerical control charge door in jet pipe nozzle,
Numerical control motor drives nozzle rotation, while high voltage power supply device applies high positive charge by metal clamp spring to nozzle, in electrostatic force
Under the action of centrifugal force, starch glue pulls into micron order by tiny spout or nano level spinning fibre uniformly sprays
To capsule die, the gelatine capsule embryo of one layer of fibrous reticular structure is attached to after the spinning time in capsule die inner wall
Body, after nozzle is moved up by numerically-controlled machine tool, transmitting device then send second Shang number oily mold to nozzle, under starting
The electrostatic spinning embryo of one wheel；
5, the capsule die that embryo processed finishes, which is run to by transmitting device at constant temperature and humidity drying hair-dryer, carries out cooling do
It is dry；
6, when the cooling dry capsule die finished is run to by transmitting device at material receiving port, capsule die root is opened
It attaches together and sets opening, capsule Automatic-falling is made to fall into material receiving port, if any the capsule idiosome being still adhered on mold, can be used artificial
Or automatically mode is brushed down with banister brush.
As shown in Figure of description Fig. 1, embodiment 1 and the specific operating process of embodiment 2 are：
The capsule original gelatin prepared is packed into storage tank (4), by electrostatic spinning nozzle by gelatin jet at Nanowire
It ties up and uniformly projects capsule die (8) inner surface, capsule idiosome is obtained by Quick-air-drying aftershaping.
Storage tank possesses electron temperature-control system, and nozzle mounting socket is arranged at bottom, inside there is numerical control motor (3), high voltage supply dress
(5), temperature-controlling system (6) and numerical control charge door (7) are set, the number of numerical control charge door can be according to the type number of glue in storage tank
It is adjusted, entire module can be realized by numerically-controlled machine tool and be moved up and down；
There are one vertical main injection jet (1) at the top of the needle tubing of electrostatic spinning nozzle, needle tubing side has multiple positions not wait
Side spout (2), nozzle abdomen have the mobilizable card slot of a circle, according to the needs of production the shape, size and spout of nozzle
Shape, size and location has nothing in common with each other；It can pass through the transmission devices such as screw thread or rubber after nozzle is injected storing pot bottom
It links with numerical control motor, and is connect with high voltage power supply device by metal clamp spring, glue passes through the quantitative addition of numerical control charge door
Into nozzle.
Transmission system (10) is transported by numerical control crawler type and is realized, possesses capsule die jack on crawler belt, each jack is matched
A standby miniature numerical control power plant, is responsible for the opening and closing movement of mold；It is furnished with ground path in each jack, capsule die is made to connect
Logical ground wire；Mold is the retractable hollow barrel structure of all size and shape, can carry out freely opening after being inserted into Transmission system
Conjunction acts；Mold body is conductive material, and being inserted into the jack of Transmission system can connect with ground wire；
The brush head of automatic polish applying shoes-brush (9) can be changed according to the shapes and sizes of mold, and automatic polish applying shoes-brush can pass through number
It controls lathe and realizes flexible and rotation.
The temperature and humidity of dry section, Mobile state of going forward side by side real time monitoring is adjusted in constant temperature and humidity drying hair-dryer (10).
Comparative example 1
The gelatin glue prepared is routinely dipped in into embrane method, starch hollow capsule is made.
Comparative example 2
The starch glue prepared is routinely dipped in into embrane method, starch hollow capsule is made.
Experimental example
Capsule prepared by the various embodiments described above and comparative example is taken to the results are shown in Table its thickness, breakage and its disintegration time limited
One, two.
Thickness：Each 10 samples of prepared capsule are taken to measure its wall thickness.
Friability：Each 50 samples of prepared capsule are taken, are set in surface plate, is put into and fills the dry of magnesium nitrate saturated solution
In dry device, 25 DEG C of ± 1 DEG C of constant temperature is set 24 hours, take out, be put into the glass stood upright on plank (thickness 2cm) by grain respectively immediately
Manage (internal diameter 24mm, a length of 200mm) in, by cylindrical counterweight (material is polytetrafluoroethylene (PTFE), a diameter of 22mm, weight 20g ±
It 1g) freely falls from glass nozzle, whether is ruptured depending on capsule, if any rupture, must not exceed 5.
Elasticity：Each 10 samples of prepared capsule are taken, capsule both ends is gently pinched with thumb and index finger, there must not be bonding,
Denaturation or rupture, then fill talcum powder, and cap, body set merging is sealed, are directly fallen in the wood that thickness is 2cm in the eminence of 1m by grain
On plate, powder should not be leaked；If any a small amount of leakage powder, 1 is must not exceed, is such as more than, 10 retrials should be separately taken, regulation should all be met.
Disintegration time limited is detected：Each 6 samples of prepared capsule are taken, are placed in the sieve of disintegration time tester, baffle is capped,
Opening instrument record, it is disintegrated the required time, unqualified more than being considered as in 20min.(method is shown in《Chinese Pharmacopoeia 2015 editions》
Annex disintegration time limited inspection technique).
The thickness distribution of capsule is made in the different preparation methods of table one
The investigation situation of capsule is made in the different preparation methods of table two
Claims (10)
1. a kind of electrostatic spinning capsule blank-maker, which is characterized in that filled by storage tank, Electrospun nozzle, capsule die, transmission
It sets, oiler, drying machine, material receiving port are constituted, wherein
The Electrospun nozzle injects the storing pot bottom；
The transmitting device is transported by numerical control crawler type and is realized, capsule die jack is possessed on crawler belt, and the capsule die is inserted
The capsule die is inserted into hole；
Inner surface oiling of the oiler in the capsule die；
The drying machine makes the capsule die cooling drying that the embryo processed finishes；The cooling dry capsule die finished passes through transmission
Device is run at material receiving port.
2. electrostatic spinning capsule blank-maker according to claim 1, which is characterized in that storage tank be single material storage tank or
More material storage tanks, equipped with high voltage power supply device, temperature regulating device, numerical control motor, numerical control charge door and numerically-controlled machine tool.
3. electrostatic spinning capsule blank-maker according to claim 1, which is characterized in that Electrospun nozzle is detachably replaced,
It is hollow in jet pipe, there is spout at the top of tube wall and nozzle.
4. electrostatic spinning capsule blank-maker according to claim 1, which is characterized in that capsule die is in one end open
Empty barrel shape is closely engaged by separable two valve, and there is folding joint in root and has the plug of certain specification, and mold material is
Conductive material.
5. electrostatic spinning capsule blank-maker according to claim 1, which is characterized in that transmitting device is the crawler type of numerical control
Conveyer belt has the jack being inserted into for mold on conveyer belt, has the numerical controlled power device of control mould open/close at jack, has in jack
The conductive structure of ground wire.
6. electrostatic spinning capsule blank-maker according to claim 1, which is characterized in that oiler can provide cover with paint or varnish it is flexible
And rotation function.
7. electrostatic spinning capsule blank-maker according to claim 1, which is characterized in that dry function carries out capsule idiosome
The cooling drying of specific humiture.
8. electrostatic spinning capsule blank-maker according to claim 1, which is characterized in that at the top of the needle tubing of electrostatic spinning nozzle
There are one vertical main injection jet, needle tubing side has the side spout that multiple positions are not waited, nozzle abdomen to have the mobilizable card of a circle
Slot.
9. a kind of electrostatic spinning capsule blank-maker according to claim 1, which is characterized in that the capsule is oral ebonite
Capsule.
10. a kind of electrostatic spinning capsule blank-maker according to claim 9, which is characterized in that the oral hard capsule is
Gelatine capsule or starch capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621427908.1U CN207619567U (en) | 2016-12-24 | 2016-12-24 | A kind of electrostatic spinning capsule blank-maker |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621427908.1U CN207619567U (en) | 2016-12-24 | 2016-12-24 | A kind of electrostatic spinning capsule blank-maker |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207619567U true CN207619567U (en) | 2018-07-17 |
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ID=62817199
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621427908.1U Active CN207619567U (en) | 2016-12-24 | 2016-12-24 | A kind of electrostatic spinning capsule blank-maker |
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2016
- 2016-12-24 CN CN201621427908.1U patent/CN207619567U/en active Active
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