CN207596761U - A kind of automatic liquid-feeding Peptide systhesis device of controllable temperature - Google Patents
A kind of automatic liquid-feeding Peptide systhesis device of controllable temperature Download PDFInfo
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- CN207596761U CN207596761U CN201820426993.2U CN201820426993U CN207596761U CN 207596761 U CN207596761 U CN 207596761U CN 201820426993 U CN201820426993 U CN 201820426993U CN 207596761 U CN207596761 U CN 207596761U
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Abstract
The utility model provides a kind of automatic liquid-feeding Peptide systhesis device of controllable temperature, which solve existing Peptide systhesis device cost of manufacture it is high, open wide the volatilization of the organic solvent of formula device it is serious, can not temperature controlled technical problem, it is equipped with liquid storage bottle, reactor, bottle,suction, nitrogen cylinder and temperature regulating device, it is additionally provided with solenoid valve and temperature-controlled box, and temperature regulating device is set on the box house；Liquid storage bottle is connected with reactor by solvent delivery tube, and sealing cover is equipped at reactor upper opening, and sealing cover is equipped with through-hole, and the solvent delivery tube is inserted into the through-hole；Solvent delivery tube is equipped with solenoid valve；Reactor is funnel-shaped structure, reactor is equipped with infundibular body and filler neck, infundibular body and filler neck are structure as a whole, it is inlayed in infundibular body equipped with sand core, the infundibular body of reactor is placed in box house, the filler neck of reactor lower part passes through lower box, and filler neck lower part is respectively equipped with drain pipe and nitrogen tube, can be widely applied to peptide synthesis technology field.
Description
Technical field
The utility model belongs to peptide synthesis technology field, and in particular to a kind of automatic liquid-feeding Peptide systhesis dress of controllable temperature
It puts.
Background technology
Polypeptide is keyed by the amide that the alpha-amido in α-carboxyl in amino acid and another molecule amino acid is formed
The compound formed.Polypeptide drug is to tools such as AIDS, cancer, hepatitis, diabetes, chronic ache and chronic idiopathic constipations
There is the effect of notable.
The synthesis of polypeptide mainly has two methods of liquid phase synthesis and synthesis in solid state at present.Liquid phase synthesis is excessively numerous with operating
Trivial, the shortcomings of step is long, the reaction time is long.Merrifield invention solid-phase synthesis in 1963, operating method is easy, is easy to point
From intermediate.The technology obtains the Nobel Prize in global rapid proliferation, and in 1984.Solid-phase synthesis peptides method has become
The preparation method of polypeptide drugs mainstream.With the development of solid phase synthesis technique, the development of Peptide systhesis device is also concerned.
The Peptide systhesis device used at present have it is semi-automatic and two kinds automatic, semi-automatic Peptide systhesis device be usually open wide
Formula, organic solvent (example piperidines, n,N-Dimethylformamide) is volatile in air, and operating personnel's frequency is needed in reaction process
Numerous pipettes in organic solvent to synthesizer, is unfavorable for the health of operating personnel.And synthesizer does not have temperature regulating device,
Many types resin reaction activity reduces when environment temperature is too low, and reaction is incomplete, and impurity is caused to increase, causes subsequent purification work
Make difficulty increasing.Automatic Peptide systhesis device is expensive mostly by external import, is difficult to universal for domestic laboratory and answers
With.
Invention content
The utility model be directed to shortcoming and defect in the prior art, it is proposed that a kind of low manufacture cost, closed type,
The automatic liquid-feeding Peptide systhesis device of controllable temperature.
For this purpose, the utility model provides a kind of automatic liquid-feeding Peptide systhesis device of controllable temperature, it is equipped with liquid storage bottle, reaction
Device, bottle,suction, nitrogen cylinder and temperature regulating device are additionally provided with solenoid valve and temperature-controlled box, and temperature-controlled box is body structure, and temperature regulating device is set
In box house；Liquid storage bottle is connected with reactor by solvent delivery tube, at reactor upper opening be equipped with sealing cover, sealing cover with
It is tightly connected at reactor upper opening, sealing cover is equipped with through-hole, and solvent delivery tube is inserted into through-hole；Solvent delivery tube is equipped with electromagnetism
Valve；Reactor is funnel-shaped structure, and reactor is equipped with infundibular body and filler neck, and infundibular body and filler neck are structure as a whole, funnel
It is inlayed in vivo equipped with sand core, the infundibular body of reactor is placed in box house, and the filler neck of reactor lower part passes through lower box, leakage
Bucket neck lower part is respectively equipped with drain pipe and nitrogen tube, and the lower end of filler neck is connected by triple valve with drain pipe and nitrogen tube.
Preferably, temperature regulating device be equipped with temperature sensing device, air blower and heating tube, temperature sensing device, air blower and
Heating tube is respectively placed in the box house of temperature-controlled box, and intelligent controlling device is additionally provided with inside temperature-controlled box, and intelligent controlling device passes through
Control circuit is connected respectively with temperature sensing device, air blower and heating tube.
Preferably, the air outlet of air blower is oppositely arranged with heating tube.
Preferably, sealing cover is butyl rubber plug.
Preferably, reactor is integrally formed for glass.
Preferably, scale is carried on liquid storage bottle.
The beneficial effects of the utility model are：
(1) the utility model proposes the automatic liquid-feeding Peptide systhesis dresses of a kind of low manufacture cost, closed type, controllable temperature
It puts.During synthetic reaction progress, the amino acid after resin, activation is put into reactor, it will by solenoid valve control
The desired amount of solvent is transferred to reactor by solvent pipe from liquid storage bottle, and organic reagent is automatically added to by solenoid valve, reduces
The aerial volatilization of organic solvent reduces the probability that operating personnel contact organic reagent.It needs to be roused with nitrogen in reaction process
Bubble, nitrogen are passed to by the control of nitrogen tube and triple valve in reactor；After reaction by controlling triple valve by reaction solution
Waste liquid bottle, peptide resin and waste liquid are drained by drain pipe with scrub raffinate, separation is realized by sand core funnel.
(2) when environment temperature is too low, the temperature regulating device in temperature control box can ensure reaction temperature in condition claimed range
It is interior, it is ensured that the efficient progress of reaction reaches target yield, reduces the generation of impurity, simplifies subsequent purification work difficulty.
Description of the drawings
Fig. 1 is the structure diagram of the utility model.
It is marked in figure：1. liquid storage bottle, 2. reactors, 3. infundibular bodies, 4. sand cores, 5. drain pipes, 6. nitrogen tubes, 7. threeways
Valve, 8. babinets, 9. air outlets, 10. solvent delivery tubes, 11. sealing covers, 12. through-holes, 13. solenoid valves, 14. air blowers, 15. heating
Pipe, 16. filler necks, 17. temperature sensing devices, 18. intelligent controlling devices.
Specific embodiment
The utility model is described in further detail in the following with reference to the drawings and specific embodiments, to help the utility model is understood
Content.Method used in the utility model is conventional method unless otherwise required；Used raw material and dress
It puts, is conventional commercial product unless otherwise required.
As shown in Figure 1, the utility model provides a kind of automatic liquid-feeding Peptide systhesis device of controllable temperature, it is equipped with liquid storage bottle
1st, reactor 2, bottle,suction, nitrogen cylinder and temperature regulating device are additionally provided with solenoid valve 13 and temperature-controlled box, and temperature-controlled box is 8 structure of babinet,
Temperature regulating device is set on inside babinet 8；Liquid storage bottle 1 and reactor 2 are connected by solvent delivery tube 10, are set at 2 upper opening of reactor
There is sealing cover 11, sealing cover 11 is butyl rubber plug, and sealing cover 11 at 2 upper opening of reactor with being tightly connected, on sealing cover 11
Equipped with through-hole 12, solvent delivery tube 10 is inserted into through-hole 12；Solvent delivery tube 10 is equipped with solenoid valve 13；It will by the control of solenoid valve 13
Aequum solvent is transferred to from liquid storage bottle 1 in reactor 2 during reaction, forms the controllable transmission line of closed type solvent, can be effective
Organic reagent (example piperidines, n,N-Dimethylformamide) aerial volatilization of irritant smell is reduced, is reduced to operation
The actual bodily harm of personnel.
Reactor 2 is funnel-shaped structure, and reactor 2 is equipped with infundibular body 3 and filler neck 16, and infundibular body 3 and filler neck 16 are
Integral structure is inlayed equipped with sand core 4 in infundibular body 3, and the infundibular body 3 of reactor 2 is placed in inside babinet 8, the leakage of 2 lower part of reactor
The neck 16 that struggles against passes through 8 lower part of babinet, and 16 lower part of filler neck is respectively equipped with drain pipe 5 and nitrogen tube 6, and the lower end of filler neck 3 passes through three
Port valve 7 is connected with drain pipe 5 and nitrogen tube 6；Temperature regulating device 18 is equipped with temperature sensing device 17, air blower 14 and heating tube
15, temperature sensing device 17, air blower 14 and heating tube 15 are respectively placed in inside the babinet 8 of temperature-controlled box, are also set inside temperature-controlled box
There is an intelligent controlling device 17, intelligent controlling device 17 is by control circuit respectively with temperature sensing device 17, air blower 14 and adding
Heat pipe 15 is connected.
When temperature is less than set temperature numerical value in babinet 8, temperature signal is transmitted to intelligence by the temperature sensing device 17
Electric current after intelligent controlling device 18 is by analysis, is increased signal transmission to heating tube 15, is heated by increasing by control device 18
The electric current of pipe 15 increases the temperature in babinet 8, while transmit a signal to air blower 14, and air blower 14 will be heated by air blast
The heat that pipe 15 generates is reached inside entire babinet 8, so as to which the temperature inside entire babinet 8 be increased；When temperature is high in babinet 8
When set temperature numerical value, temperature signal is transmitted to intelligent controlling device 18, intelligent controlling device by the temperature sensing device 17
After 18 by analysis, current reduction signal is transferred to heating tube 15, is reduced in babinet 8 by reducing the electric current of heating tube 15
Temperature, while transmit a signal to air blower 14, air blower 14 is reduced by 8 internal temperature of babinet by blast velocity, so as to
Temperature inside entire babinet 8 is reduced.Ensure reaction temperature in condition claimed range, it is ensured that the efficient progress of reaction reaches
To target yield, the generation of impurity is reduced, simplifies subsequent purification work difficulty.When the temperature of the surroundings is low, pass through air blower 14
Temperature-controlled box box house is heated with heating tube 15, can control Solid-phase Polypeptide reaction temperature, heating tube 15 is led to for heating
Crossing blower device 14 makes air heats in entire temperature-controlled box d babinets 8 uniform, to meet the needs of to reaction temperature.
The air outlet 9 of air blower 14 is oppositely arranged with heating tube 15, is conducive to 8 interior temperature distribution of babinet evenly.
Reactor 2 is integrally formed for glass, manufacture easy to process, and anti-available for Peptide systhesis under nitrogen protection
It should.
To sum up, the utility model proposes the automatic liquid-feeding Peptide systhesis dresses of a kind of low manufacture cost, closed type, controllable temperature
It puts.During synthetic reaction progress, the amino acid after resin, activation is put into reactor 2, by solvent delivery tube 10
It is controlled equipped with solenoid valve 13 and the desired amount of solvent is transferred to reactor 2 by solvent delivery tube 10 from liquid storage bottle 1, by such
Mode adds in organic reagent, reduces the aerial volatilization of organic solvent, reduces the probability that operating personnel contact organic reagent.Instead
It should need to use nitrogen bubbling in the process, nitrogen is passed to by the control of nitrogen tube 6 and triple valve 7 in reactor 2；After reaction
By controlling triple valve 7 that reaction solution and scrub raffinate are drained into waste liquid bottle by drain pipe 5, peptide resin and waste liquid are leaked by sand core
Bucket 4 realizes separation.
" on ", " under ", " top ", " bottom ", " interior ", " outer " etc. it is to be appreciated that term in the description of the present invention,
The orientation or position relationship of instruction are based on orientation shown in the drawings or position relationship, are for only for ease of description the utility model
Must have specific orientation, with the device or element for simplifying description rather than instruction or hint meaning with specific orientation structure
It makes and operates, therefore it is not intended that limitation to the utility model.
Only as described above, only specific embodiment of the utility model, when the utility model cannot be limited with this
The range of implementation, therefore the displacement of its equivalent assemblies or the equivalent variations made according to the utility model patent protection domain and modification,
It all should still belong to the scope that the utility model claims book is covered.
Claims (6)
1. a kind of automatic liquid-feeding Peptide systhesis device of controllable temperature is equipped with liquid storage bottle, reactor, bottle,suction, nitrogen cylinder and control
Warm device, which is characterized in that it is additionally provided with solenoid valve and temperature-controlled box, and the temperature-controlled box is body structure；The liquid storage bottle and institute
It states reactor to connect by solvent delivery tube, sealing cover is equipped at the reactor upper opening, the sealing cover is reacted with described
It is tightly connected at device upper opening, the sealing cover is equipped with through-hole, and the solvent delivery tube is inserted into the through-hole；The solvent is led
Pipe is equipped with solenoid valve；The reactor is funnel-shaped structure, and the reactor is equipped with infundibular body and filler neck, the infundibular body
It is structure as a whole, inlays in the infundibular body equipped with sand core with the filler neck, the infundibular body of the reactor is placed in the case
Internal portion, the filler neck of the reactor lower part pass through the lower box, the filler neck lower part be respectively equipped with drain pipe and
Nitrogen tube, the lower end of the filler neck are connected by triple valve with the drain pipe and the nitrogen tube.
A kind of 2. automatic liquid-feeding Peptide systhesis device of controllable temperature according to claim 1, which is characterized in that the temperature control
Device is equipped with temperature sensing device, air blower and heating tube, the temperature sensing device, the air blower and the heating tube point
It is not placed in the box house of the temperature-controlled box, intelligent controlling device, the intelligent controlling device are additionally provided with inside the temperature-controlled box
It is connected respectively with the temperature sensing device, the air blower and the heating tube by control circuit.
A kind of 3. automatic liquid-feeding Peptide systhesis device of controllable temperature according to claim 2, which is characterized in that the air blast
The air outlet of machine is oppositely arranged with the heating tube.
A kind of 4. automatic liquid-feeding Peptide systhesis device of controllable temperature according to claim 1, which is characterized in that the sealing
It covers as butyl rubber plug.
A kind of 5. automatic liquid-feeding Peptide systhesis device of controllable temperature according to claim 1, which is characterized in that the reaction
Device is integrally formed for glass.
A kind of 6. automatic liquid-feeding Peptide systhesis device of controllable temperature according to claim 1, which is characterized in that the liquid storage
Scale is carried on bottle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820426993.2U CN207596761U (en) | 2018-03-27 | 2018-03-27 | A kind of automatic liquid-feeding Peptide systhesis device of controllable temperature |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820426993.2U CN207596761U (en) | 2018-03-27 | 2018-03-27 | A kind of automatic liquid-feeding Peptide systhesis device of controllable temperature |
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| CN207596761U true CN207596761U (en) | 2018-07-10 |
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| CN201820426993.2U Active CN207596761U (en) | 2018-03-27 | 2018-03-27 | A kind of automatic liquid-feeding Peptide systhesis device of controllable temperature |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110283229A (en) * | 2019-07-24 | 2019-09-27 | 上海友尹化工科技有限公司 | A kind of production system for polypeptide drugs |
| CN114026107A (en) * | 2019-04-16 | 2022-02-08 | 巴克姆股份公司 | Production of disulfide peptides |
-
2018
- 2018-03-27 CN CN201820426993.2U patent/CN207596761U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114026107A (en) * | 2019-04-16 | 2022-02-08 | 巴克姆股份公司 | Production of disulfide peptides |
| CN110283229A (en) * | 2019-07-24 | 2019-09-27 | 上海友尹化工科技有限公司 | A kind of production system for polypeptide drugs |
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