CN207591321U - Calcium pantothenate crystallizes preparation facilities - Google Patents
Calcium pantothenate crystallizes preparation facilities Download PDFInfo
- Publication number
- CN207591321U CN207591321U CN201721582677.6U CN201721582677U CN207591321U CN 207591321 U CN207591321 U CN 207591321U CN 201721582677 U CN201721582677 U CN 201721582677U CN 207591321 U CN207591321 U CN 207591321U
- Authority
- CN
- China
- Prior art keywords
- calcium pantothenate
- crystallizes
- preparation facilities
- crystallization
- lifter plate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 title claims abstract description 44
- 229960002079 calcium pantothenate Drugs 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 40
- 238000002425 crystallisation Methods 0.000 claims abstract description 23
- 230000008025 crystallization Effects 0.000 claims abstract description 23
- 238000007789 sealing Methods 0.000 claims abstract description 14
- 238000007599 discharging Methods 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 6
- 239000011575 calcium Substances 0.000 abstract description 5
- 229910052791 calcium Inorganic materials 0.000 abstract description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 4
- 235000019161 pantothenic acid Nutrition 0.000 abstract description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical class OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 14
- 238000006243 chemical reaction Methods 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000000706 filtrate Substances 0.000 description 4
- FAPWYRCQGJNNSJ-UHFFFAOYSA-L Calcium DL-pantothenate Chemical compound [Ca+2].OCC(C)(C)C(O)C(=O)NCCC([O-])=O.OCC(C)(C)C(O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UHFFFAOYSA-L 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- AMIMRNSIRUDHCM-UHFFFAOYSA-N Isopropylaldehyde Chemical compound CC(C)C=O AMIMRNSIRUDHCM-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 206010029240 Neuritis Diseases 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 208000007642 Vitamin B Deficiency Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 210000002583 cell-derived microparticle Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- MNWBNISUBARLIT-UHFFFAOYSA-N sodium cyanide Chemical compound [Na+].N#[C-] MNWBNISUBARLIT-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The utility model discloses calcium pantothenates to crystallize preparation facilities, crystallizes preparation tank ontology including calcium pantothenate, is equipped with cover at the top of calcium pantothenate crystallization preparation tank, is internally provided with agitating device, bottom is equipped with discharge port；It is characterized in that：The cover is surrounded by sealing device, and diversion trench is equipped at the top of cover, and calcium pantothenate crystallization prepares pot bottom equipped with lifting gear, and the lifting gear includes lifter plate, and telescopic rod is equipped with below lifter plate.By setting the lifter plate of bottom, the angle between lifter plate and discharge port is adjusted, improves the efficiency of discharging.
Description
Technical field
The utility model is related to calcium pantothenate production fields, are exactly calcium pantothenate crystallization preparation facilities.
Background technology
Calcium pantothenate is now widely used for medicine, food and feed additive field, is the ingredient of coacetylase, participates in carbon water
The metabolism of compound, fat and protein, is clinically used for treatment Vitamin B deficiency disease, peripheral neuritis, and postoperative intestine twists
Bitterly.Participate in protein, fat, the metabolism of sugar in vivo.With isobutylaldehyde etc. for raw material, the preparation of calcium pantothenate is through methylol
Change, hydrolysis, is acidified, lactonizes, being acylated and obtain addition, and formaldehyde and Anhydrous potassium carbonate are put into reaction pot, dripped at 14-20 DEG C
Add isobutylaldehyde, add rear insulated and stirred reaction 3h, then stand 0.5h at 14-18 DEG C, obtain upper strata grease 2,2- dimethyl-
3-HPA.2,2- pentaldols are dissolved in 4 times of water, Cymag is dissolved in 6 times of water, and calcium chloride is dissolved in 2 times
Water, and successively by above-mentioned solution add in reaction pot, under stiring add in 50% sulfuric acid solution, react 6h when 60-65 DEG C,
It is warming up to 80-85 DEG C of reaction 3h again, until being concentrated under reduced pressure into stiff, adding in 95% ethyl alcohol filters off inorganic salts precipitation, filtrate
After vacuum distillation recycling ethyl alcohol, 130-145 DEG C of (1.33-2.39Kpa) fraction, i.e. gamma-butyrolacton are collected, successively by beta-amino third
Acid, 5/6 methanol and lime add in reactor, are warming up to 40 DEG C, and be stirred to react 2h.By supernatant liquor pressure after reaction solution standing
Filter.Press filtration after solid residue is washed again with 1/6 methanol in pot.Filtrate is placed in another reaction pot, and it is molten to add in gamma-butyrolacton stirring
Solution places 40h reaction generation calcium pantothenates at room temperature.Add water stirring postcooling to -5-0 DEG C, and add in crystal seed stirred crystallization
For 24 hours, racemic calcium pantothenate is filtered to obtain, the racemic calcium pantothenate of 2/3 amount and left-handed calcium pantothenate are put into reaction pot, add in first alcohol and water,
40 DEG C of stirring and dissolvings are heated to, and are filtered while hot, filtrate is cooled to 15 DEG C, adds in a small amount of left-handed calcium pantothenate crystal seed, educates brilliant 2h.When
After specific rotatory power reaches+6 ° -+8 °, separation crystallization, and washed with a small amount of methanol, obtain left-handed calcium pantothenate (being still used to split).By remaining
For 1/3 racemic calcium pantothenate stirring and dissolving in 35-40 DEG C of filtrate, filtering postcooling adds in a small amount of dextro calcium pantothenate to 15 DEG C
Crystal seed educates brilliant 2h.Crystallization is isolated, and washed with a small amount of methanol when -0.8 ° -0.6 ° of specific rotatory power, be dried in vacuo to obtain dextrorotation
Calcium pantothenate.Poor to the sealing effect of equipment in the prior art, security performance is poor, and production equipment bottom is substantially smooth
, the product of preparation are not easily taken out, and consume a large amount of manpower and materials, of high cost, efficiency is low.
Utility model content
The technical problems to be solved in the utility model be it is poor to the sealing effect of equipment in the prior art, security performance compared with
Difference, and production equipment bottom is substantially smooth, and the product of preparation are not easily taken out, and consume a large amount of manpower and materials, of high cost, efficiency
It is low.
In order to solve the above technical problems, the utility model uses following technological means：
Calcium pantothenate crystallizes preparation facilities, crystallizes preparation tank ontology including calcium pantothenate, is equipped at the top of calcium pantothenate crystallization preparation tank
Cover, is internally provided with agitating device, and bottom is equipped with discharge port；It is characterized in that：The cover is surrounded by sealing device, lid
Diversion trench is equipped at the top of body, calcium pantothenate crystallization prepares pot bottom equipped with lifting gear, and the lifting gear includes lifter plate, rises
It drops and telescopic rod is equipped with below plate.By setting the lifter plate of bottom, the angle between lifter plate and discharge port is adjusted, improves discharging
Efficiency.
Preferably, the further technical solution of the utility model is：
The diversion trench is arranged on the top of calcium pantothenate crystallization preparation tank for annular.Prevent toxic and harmful gas from volatilizing,
According to the gas to volatilize under different situations, the liquid in diversion trench is adjusted.
The sealing device is the rubber seal for being arranged on cover edge.Sealing effect is improved, improves security performance.
The lifter plate is arranged on the left and right sides of discharge port, and stretching for telescopic rod can adjust lifter plate and discharging
Angle of inclination between mouthful.It inside can be in terms of set temperature, pressure gauge, shot-light visor, CIP rotating wash bowls.
The telescopic rod is set for internal and external casing, and sealing shroud is equipped with outside telescopic rod.Product safety performance is improved, is improved
Efficiency.
The calcium pantothenate crystallization preparation tank is equipped with observation window.
The calcium pantothenate crystallization preparation tank side is equipped with liquid-inlet and liquid outlet.Liquid-inlet and liquid outlet are equal
Equipped with valve, switch can be controlled.
Safety valve is equipped at the top of the calcium pantothenate crystallization preparation tank.
The agitating device includes agitating shaft, stirring blade and stirring motor, and stirring motor is stirred by drive link connection
Axis is mixed, agitating shaft could be provided as two.
The utility model ectosome is made of import stainless steel, and inner wall using mirror finish or mechanical polishing, adopt by outer surface
Handled with minute surface or matt, equipped with thermometer, pressure gauge, shot-light visor, CIP rotating wash bowls, respirator, nitrogen inlet, material into
Multiple process interfaces such as outlet, the sealing of axis use the sanitation-grade mechanical seal of high-quality, and sterile sampling valve etc. ensures material not
Contaminated, mode of heating has steam, electrical heating, conduction oil, to meet the different works such as acidproof broken, high temperature resistant, wear-resistant, anti scuffing
Make the technique needs of environment.
Description of the drawings
Fig. 1 is a kind of structure diagram of specific embodiment of the utility model.
Reference sign：1- calcium pantothenates crystallize preparation tank；2- covers；3- rubber seal；4- diversion trenches；5-
Observation window；6- liquid-inlets；7- liquid outlets；8- safety valves；9- discharge ports；10- lifter plates；11- telescopic rods.
Specific embodiment
With reference to embodiment, the utility model is further illustrated.
Referring to Fig. 1 it is found that the utility model calcium pantothenate crystallizes preparation facilities, 1 ontology of preparation tank is crystallized including calcium pantothenate, it is general
Sour 1 top of calcium crystallization preparation tank is equipped with cover 2, is internally provided with agitating device, bottom is equipped with discharge port 9；It is characterized in that：It is described
Cover 2 be surrounded by sealing device, 2 top of cover is equipped with diversion trench 4, and 1 bottom of calcium pantothenate crystallization preparation tank is equipped with lifting and fills
It puts, the lifting gear includes lifter plate 10, and 10 lower section of lifter plate is equipped with telescopic rod 11, and diversion trench 4 is arranged on general for annular
The top of sour calcium crystallization preparation tank 1, sealing device is the rubber seal 3 for being arranged on 2 edge of cover, and lifter plate 10 is arranged on out
The left and right sides of material mouth 9, stretching for telescopic rod 11, can adjust the angle of inclination between lifter plate 10 and discharge port 9, telescopic rod
11 are set for internal and external casing, and 11 outside of telescopic rod is equipped with sealing shroud, and calcium pantothenate crystallization preparation tank 1 is equipped with observation window 5, calcium pantothenate
It crystallizes 1 side of preparation tank and is equipped with liquid-inlet 6 and liquid outlet 7,1 top of calcium pantothenate crystallization preparation tank is equipped with safety valve 8, stirring
Device includes agitating shaft, stirring blade and stirring motor, and stirring motor connects agitating shaft by drive link, and agitating shaft can be set
It is two.
Due to the foregoing is merely specific embodiment of the present utility model, but the protection of the utility model is without being limited thereto,
Any those skilled in the art it is contemplated that the equivalent variation of the technical program technical characteristic or replacement, all cover
Within the scope of protection of the utility model.
Claims (9)
1. calcium pantothenate crystallizes preparation facilities, preparation tank ontology is crystallized including calcium pantothenate, lid is equipped at the top of calcium pantothenate crystallization preparation tank
Body, is internally provided with agitating device, and bottom is equipped with discharge port；It is characterized in that：The cover is surrounded by sealing device, cover
Top is equipped with diversion trench, and calcium pantothenate crystallization prepares pot bottom equipped with lifting gear, and the lifting gear includes lifter plate, lifting
Telescopic rod is equipped with below plate.
2. calcium pantothenate according to claim 1 crystallizes preparation facilities, it is characterised in that：The diversion trench is set for annular
At the top of calcium pantothenate crystallization preparation tank.
3. calcium pantothenate according to claim 1 crystallizes preparation facilities, it is characterised in that：The sealing device is is arranged on
The rubber seal of cover edge.
4. calcium pantothenate according to claim 1 crystallizes preparation facilities, it is characterised in that：The lifter plate is arranged on discharging
The left and right sides of mouth, stretching for telescopic rod, can adjust the angle of inclination between lifter plate and discharge port.
5. calcium pantothenate according to claim 1 crystallizes preparation facilities, it is characterised in that：The telescopic rod is internal and external casing
Setting, telescopic rod outside are equipped with sealing shroud.
6. calcium pantothenate according to claim 1 crystallizes preparation facilities, it is characterised in that：The calcium pantothenate crystallization preparation tank
It is equipped with observation window.
7. calcium pantothenate according to claim 1 crystallizes preparation facilities, it is characterised in that：The calcium pantothenate crystallization preparation tank
Side is equipped with liquid-inlet and liquid outlet.
8. calcium pantothenate according to claim 1 crystallizes preparation facilities, it is characterised in that：The calcium pantothenate crystallization preparation tank
Top is equipped with safety valve.
9. calcium pantothenate according to claim 1 crystallizes preparation facilities, it is characterised in that：The agitating device includes stirring
Axis, stirring blade and stirring motor, stirring motor connect agitating shaft by drive link, and agitating shaft could be provided as two.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721582677.6U CN207591321U (en) | 2017-11-23 | 2017-11-23 | Calcium pantothenate crystallizes preparation facilities |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721582677.6U CN207591321U (en) | 2017-11-23 | 2017-11-23 | Calcium pantothenate crystallizes preparation facilities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207591321U true CN207591321U (en) | 2018-07-10 |
Family
ID=62760539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721582677.6U Expired - Fee Related CN207591321U (en) | 2017-11-23 | 2017-11-23 | Calcium pantothenate crystallizes preparation facilities |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207591321U (en) |
-
2017
- 2017-11-23 CN CN201721582677.6U patent/CN207591321U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180710 |