CN207557285U - A kind of linkage of sample input/output - Google Patents
A kind of linkage of sample input/output Download PDFInfo
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- CN207557285U CN207557285U CN201720764846.1U CN201720764846U CN207557285U CN 207557285 U CN207557285 U CN 207557285U CN 201720764846 U CN201720764846 U CN 201720764846U CN 207557285 U CN207557285 U CN 207557285U
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Abstract
This application discloses a kind of linkage of sample input/output, including the first sample input/output element, the second sample input/output element, sample bin and driving device；Wherein described first sample input/output element includes first piston and the first liquid storage device, and cavity and the first piston of first liquid storage device are fitted close, and first liquid storage device is connected with the sample bin；Second sample input/output element includes second piston and the second liquid storage device, and cavity and the second piston of second liquid storage device are fitted close, and second liquid storage device is connected with the sample bin；The driving device is set to the first piston except the cavity for being exposed to first liquid storage device and is exposed to except the cavity of second liquid storage device between the second piston, the first piston and the second piston to be driven to move back and forth.
Description
Technical field
This application involves a kind of linkages of sample input/output, belong to bio-toxicity analysis field.
Background technology
In the prior art, the input/output of sample generally has two kinds of manual mode and mechanical system.Even but
Mechanical system, the input/output of sample is also often partition type, is so not easy the sample in holding container with constant volume
Product.
It is a kind of easy to operate therefore, it is necessary to develop, it disclosure satisfy that the linkage of the product input/output of above-mentioned requirements.
Utility model content
One of the application provides a kind of linkage of sample input/output, including the first sample input/output member
Part, the second sample input/output element, sample bin and driving device；Wherein
First sample input/output element includes first piston and the first liquid storage device, and the of first liquid storage device
One end has the first opening, and the first piston can enter the cavity of first liquid storage device through the described first opening, and
The cavity of first liquid storage device is fitted close with the first piston, second end and the sample bin of first liquid storage device
Connection；
Second sample input/output element includes second piston and the second liquid storage device, and the of second liquid storage device
One end has the second opening, and the second piston can enter the cavity of second liquid storage device through the described second opening, and
The cavity of second liquid storage device is fitted close with the second piston, second end and the sample bin of second liquid storage device
Connection；
The driving device is set to the first piston and the exposure being exposed to except the cavity of first liquid storage device
Between the second piston except the cavity of second liquid storage device, to drive the first piston and the second piston
Move back and forth.
In a specific embodiment, the length of the first piston be the cavity length of first liquid storage device extremely
It is 2 times few；When reaching the second end of the first liquid storage device in one end of the first piston, it is exposed to the cavity of first liquid storage device
Except part be the first outer piston；
The length of the second piston is at least 2 times of the cavity length of second liquid storage device；In the second piston
One end when reaching the second end of the second liquid storage device, be exposed to the part except the cavity of second liquid storage device for outside second
Piston.
In a specific embodiment, the outer surface of first outer piston is equipped with the protrusion for increasing frictional force, with
It is matched with the driving device；
The outer surface of second outer piston is equipped with the protrusion for increasing frictional force, to be matched with the driving device.
In a specific embodiment, the contact surface and described second of first outer piston and the driving device
Outer piston on the contact surface of the driving device with being respectively provided with and the matched dentalation of the gear.
In a specific embodiment, the dentalation is protruded from the outer surface of first outer piston；With/
Or the dentalation is protruded from the outer surface of second outer piston.
In a specific embodiment, the dentalation is depressed on the outer surface of first outer piston；With/
Or the dentalation is depressed on the outer surface of second outer piston.
In a specific embodiment, the driving device includes gear, and the linkage further includes drive gear
The motor of rotation and the electrode of the control motor, the gear can drive the first piston and the second piston
Move back and forth, and the direction of first piston movement is opposite with the direction that the second piston moves.
In a specific embodiment, gear rotation direction can be changed by being equipped in the first end of first liquid storage device
First gear reverse switch；The second gear of gear rotation direction can be changed by being equipped in the first end of second liquid storage device
Reverse switch；And it is provided on the first piston and reverses the first gear of switch cooperation that switch is reversed to match with first gear
Component is provided in the second piston and the second gear of switch cooperation is reversed to reverse switch counterpart with second gear；Institute
State electrode reverses switch or second gear to reverse switch control by the first gear.
In a specific embodiment, when first gear reverses switch and first gear to reverse switch counterpart contact
When, switch control is bounced off out first switch connecting element, and is contacted with second switch connecting element；When second gear reverses
When switch and second gear reverse switch counterpart contact, switch control is bounced off out second switch connecting element, and with the
One switch connecting element contact.
The two of the application provide a kind of detection analysis instrument, including the linkage dress as described in any one in one of the application
It puts.
The advantageous effect that the application can generate includes：
On the one hand the driving device of the application realizes sample input and the automation of output operation, on the other hand its structure
Simply, operability is strong.Using the resonant vibration platform biological quality sensor-based system of piezoelectric excitation, put down vibration using oscillator
Delta is to its resonant frequency, later using sample input/output system perseverance of bi-directional synchronization gear motor control slowly to sample
The material or product solution that input/output sample, needs are tested in storehouse keep the sample in sample bin to have constant volume to ensure
Amount is recorded the small amplitude variations of shaking platform using data collecting system, avoided to shaking platform for a long time, in real time
Influence of noise.In addition, permanent sample capacity also plays the effect for preventing sample spill-over damage instrument.
In addition, the capacity of the shaking platform of the application can change according to experiment demand, i.e., shaking platform is met largely
Detect the requirement of cell；And certain triangle vibrating cantalever capacity are very limited.
The shaking platform of the application be direction vibration, both can with up-down vibration, can also side-to-side vibrations, can be shaken with front and rear
It is dynamic, so as to reduce the vibration difference of each point on shaking platform, it ensure that the accuracy of measure；And certain triangle vibrating cantalevers
It is vibrated for unilateral side, the vibration and uneven generated, therefore, is difficult to reach accurate using the adhesive capacity of this device detection cell
Degree.
In this application, data processing system is directly connect with shaking platform, even if mechanical signal is converted directly into electricity
Signal, there is no the enhanced processing problems of data-signal, and not only acquisition data are directly easy, and avoid taking advantage of for data amplification
Deceiving property；And the detection of certain signals experienced the amplification process of a signal, thus the data obtained are on the one hand not direct enough, separately
The amplification of one side signal is easy to cause data error and becomes larger.
In this application, which can carry out real-time quantitative analysis, meet timely processing and analyze requirement in time, avoid
Time waste；Existing apparatus can not realize real-time quantitative analysis.
In this application, by filling the connection of parallel operation with laser, detection function of this instrument for material can be expanded, opened
New tupe has been warded off, has met the requirement of real-time optical treatment.Such as it can detect with optical dynamic therapy, photo-thermal therapy
Deng research of the nano particle for cell therapy procedures；Or it can also be used to detection research product using lasecon
Cure mechanism.
Description of the drawings
Fig. 1 shows the workflow schematic diagram of multi-modal dynamic biological toxicity Real_time quantitative detection analyzer.
Fig. 2 is shown corresponding to the instrument of Fig. 1 general flow charts and display interface figure.
Fig. 3 shows another structure diagram of sample bin and shaking platform matching relationship.
Fig. 4 shows the schematic diagram of the linkage of sample input/output.
Fig. 5 shows the schematic diagram of the linkage of another sample input and output.
Fig. 6 shows the reverse switch basic circuit schematic diagram of gear 4.
Component and reference numerals list：
1, oscillator；2, shaking platform；3, sample bin；4, gear；5, data collecting system；6, data display equipment；7, it moves
State amplitude normalization software interface；8, functional simulation software interface；9, the first sample input/output element；9 ', the second sample is defeated
Enter/output element；10, first piston；10 ', second piston；11, the first liquid storage device；11 ', the second liquid storage device；12,12 ', dentation
Structure；13, first gear reverses switch；13 ', second gear reverses switch；14, first gear reverses switch counterpart；14 ',
Second gear reverses switch counterpart；15, lasecon；16, motor；17, first switch connecting element；18, second switch
Connecting element；19, switch control.
Specific embodiment
The application is described in detail, but the application is not limited to these embodiments with reference to embodiment.
1 detection analysis instrument of embodiment
As shown in Figure 1, which show the letters of multi-modal, dynamic biological toxicity Real_time quantitative detection analyzer workflow
Figure.
Wherein, the effect of oscillator 1 is to drive shaking platform 2 (piezo-electric crystal) by the alternating voltage of application to fix frequency
Rate is vibrated.Oscillator 1 in a manner of Multi-contact, using depth positive feedback cross value, is closed back with shaking platform 2 by corner
Road controls driving frequency, to meet the stress vibration mode of low error oscillator.Oscillator 1 drives shaking platform 2 to reach resonance frequency
Rate, amplitude of the shaking platform 2 for a long time, during real-time testing down to V grades of 1 μ can also be acquired simultaneously by data collecting system 5
Data processing is carried out by processing software (such as dynamic amplitude normalization software and functional simulation software).
Shaking platform 2：It is driven by 1 driving frequency of oscillator, is vibrated under fixed frequency.Cell or biological tissue
When its surface adhesion or poisoning come off, the bending change of oscillator can be caused so as to produce amplitude by acting on the external pressure on surface
Raw corresponding polarization.Specifically, shaking platform 2 can be the structure with wafer type, may be the knot with square piece type
Structure.Shaking platform 2 is made of pressure sensitive or vibration quartz material.
Current collector (part for data collecting system 5)：Amplitude polarization signal is acquired in real time, is converted into filtering base
Line, and signal resolution meets 24bit or requirements above.
Data analysis module (part for data collecting system 5)：Carry out for a long time, real-time raw data acquisition
Meanwhile the filtering baseline from current collector is normalized, and cell detachment is obtained by calculation or biological tissue is different
Amplitude variations (carrying out dynamic amplitude normalized Analysis, see the dynamic amplitude normalization software interface 7 of Fig. 2) after change, then
By its degradation factor of exponential function (see the functional simulation software interface 8 of Fig. 2) sunykatuib analysis, so as to reach to bio-toxicity etc.
Characteristic carries out the purpose of quantitative analysis.Wherein, data collecting system 5 first employs dynamic amplitude normalization software and functional simulation
Software.Wherein, dynamic amplitude normalization software function be eliminate magnitude origin line drift, steady baseline, i.e., baseline correction and
Eliminate offset；The function of functional simulation software：When later data is analyzed, it can calculate and be provided in certain period according to demand
Amplitude variations amount.Dynamic amplitude normalizes software and functional simulation software and can be obtained by the ordinary skill in the art.
The foundation equation of amplitude normalization uses higher order polynomial, and in formula, f (t) is immediate movement function, and y is balance
The displacement of position：
The derivative of above-mentioned multinomial sum is 0, normalized is done to its amplitude balance point, shown in equation below：
anan-1…a1a0
Functional simulation program is according to exponential function equation, amplitudes of the A for shaking platform 2, A0Maximum for shaking platform 2 is shaken
Width, B pass add drop coefficient for the amplitude of shaking platform 2, and t is the time of vibration of shaking platform 2, acquires B coefficients detailed process such as
Under：
A (t)=A0e-Bt
LnA (t)=lnA0-Bt
Sample bin 3：Shaking platform 2 is internally provided with, side wall has the vertically and horizontally liquid for connecting a set of motor precision control
Input/output element 9,9 ' (see Fig. 4), for example, input/output element 9,9 ' can be controlled to 10 influenced on oscillator noiseless
The two-way flow velocity of μ L/min.By this system, can into sample bin 3 input/output specimen material.This set system can control
It is consistent to pass in and out flow velocity, makes to reach dynamic equilibrium in sample bin 3, the constant volume of the fluid in holding sample bin 3 is constant, and flow velocity
It is small, so as to keep shaking platform 2 in stable condition, avoid the influence of noise generated due to the variation of sample size to shaking platform 2.
In addition, this sample bin 3 is required due to meet observation living cells toxicity variation for a long time, so the biotic environment kept constant
It is the necessary condition of its detection.For example, 37 DEG C of constant temperature can be heated and kept, it is passed through 5%CO2Carbon dioxide is given birth to reach cell
The environmental condition deposited.
Lasecon 15：It is located at the lower section of sample bin 3, meets the different wave length exciting light needed for different materials and generates
Light-initiated biochemical reaction, so as to make tested organism that respective change occur.It can be used for product photo-thermal/optical dynamic therapy
Deng research.The data measured are finally shown in by high-resolution data collecting system on display screen.
As shown in Figure 2, it is shown that instrument and display interface figure corresponding to Fig. 1 general flow charts.It includes sample input/defeated
Go out element 9,9 ' (see Fig. 4), sample bin 3, shaking platform 2, oscillator 1, data collecting system 5 and data display equipment 6；Wherein,
Sample input/output element 9,9 ' is connected with the sample bin 3, is kept in sample bin 3 by the simultaneous implantation and output of sample
Sample keep；The shaking platform 2 is located in the sample bin 3；The oscillator 2 is located at outside the sample bin 3, and institute
Shaking platform 2 is stated to connect with the oscillator 3；Data collecting system 5 is located at outside the sample bin 3, and with the shaking platform 2
Connection；Data display equipment 6 is connect with data collecting system 5.
Specifically, the edge of shaking platform 2 extends downward into the lower surface of sample bin 3, to avoid the following table of shaking platform 2
Face is contacted with the sample in sample bin 3.
It wherein, the part that shaking platform 2 extends downwardly can be different from the material of shaking platform 2.
Alternatively, as shown in figure 3, the lower surface of sample bin 3 subregion downwards recess form sunk area 31, make vibration
Platform 2 covers the opening of the sunk area 31, is contacted to avoid the lower surface of shaking platform 2 with the sample in sample bin 3.
Wherein, the side wall 32 for forming sunk area 31 can be identical with the material of sample bin, can also be with the material of sample bin
Matter is different.It is preferable that the material for forming the lower surface 33 of sunk area 31 is transparent material, more preferably glass.
In addition, the edge of shaking platform 2 is fixedly connected with elastic element 34, elastic element 34 is connect with external voltage.Bullet
Property element 34 by the insulating materials such as silica gel coat.
As shown in figure 4, mainly show the schematic diagram of the linkage of sample input/output.Sample input/the output
Linkage includes the first sample input/output element 9, the second sample input/output element 9 ', sample bin 3 and driving device.
First sample input/output element 9 includes 10 and first liquid storage device 11 of first piston, first liquid storage device 11
First end has the first opening, and the first piston 10 can enter the chamber of first liquid storage device 11 through the described first opening
Body, the cavity of first liquid storage device 11 are fitted close with the first piston 10, the second end of first liquid storage device 11 with
The sample bin 3 connects；
Second sample input/output element 9 ' includes second piston 10 ' and the second liquid storage device 11 ', second storage
The first end of liquid device 11 ' has the second opening, and the second piston 10 ' can enter second liquid storage through the described second opening
The cavity of device 11 ', cavity and the second piston 10 ' of second liquid storage device 11 ' are fitted close, second liquid storage device
11 ' second end is connected with the sample bin 3；
The driving device is set between the first piston 10 and the second piston 10 ', to drive described
One piston 10 and the second piston 10 ' move back and forth.
The driving device includes gear 4, and linkage further includes the motor of drive gear rotation and the control horse
The electrode reached, gear 4 can drive first piston 10 and second piston 10 ' to move back and forth, and the side that first piston 10 moves
It is opposite to the direction moved with second piston 10 '；4 rotation direction of gear can be changed by being equipped in the first end of the first liquid storage device 11
First gear reverse switch 13；The of 4 rotation direction of gear can be changed by being equipped in the first end of second liquid storage device 11 '
Two gears reverse switch 13 '；And the first gear that 13 cooperation of switch is reversed with first gear is provided on first piston 10
Switch counterpart 14 is reversed, the second gear that 13 ' cooperation of switch is reversed with second gear is provided in the second piston 10 '
Reverse switch counterpart 14 '；The electrode reverses switch 13 or second gear to reverse 13 ' control of switch by the first gear.
Specifically, such as Fig. 5, first gear reverses switch 13 to be arranged on the first opening, and protrude from the first liquid storage device 11
On housing；Second gear reverses switch 13 ' to be arranged on the second opening, and protrude from 11 ' housing of the second liquid storage device.In addition,
It is the protrusion for protruding from first piston 10 that first gear, which reverses switch counterpart 14, is generally located on the middle part of first piston 10,
Or the place close to middle part；It is the protrusion for protruding from second piston 10 ' that second gear, which reverses switch counterpart 14 ', general to set
In the middle part of second piston 10 ' or the place close to middle part.It is moved through in the second end of first piston 10 to the first liquid storage device 11
Cheng Zhong, first gear reverses switch counterpart 14 that can move closer to first gear and reverses switch 13, until being reversed with first gear
13 contact of switch triggers gear and reverses at this time.Or in second piston 10 ' to the second end motion process of the second liquid storage device 11 '
In, second gear reverses switch counterpart 14 ' that can move closer to second gear and reverses switch 13 ', until being reversed with second gear
13 ' contact of switch triggers gear and reverses at this time.And so on.
First piston 10 on the contact surface and second piston 10 ' of gear 4 and the contact surface of gear 4 with being respectively provided with and gear 4
Matched dentalation 12,12 '.
Dentalation 12 is protruded from the surface of first piston 10；And/or dentalation 12 ' protrudes from second piston 10 '
Surface on.The length that particularly can be designed as first piston 10 is at least 2 times of the cavity length of the first liquid storage device 11；
When one end of first piston 10 reaches the second end of the first liquid storage device 11, it is exposed to the part except the cavity of the first liquid storage device 11
It is the first internal piston (with color depth in figure into the part within the cavity of the first liquid storage device 11 for the first outer piston
It is shallow to be distinguished with the first outer piston)；At this point, dentalation 12 is protruded from the surface of the first outer piston.Second piston 10 '
Length is at least 2 times of the cavity length of the second liquid storage device 11 '；The second liquid storage device 11 ' is reached in one end of second piston 10 '
During second end, the part being exposed to except the cavity of the second liquid storage device 11 ' is the second outer piston, into the second liquid storage device 11 '
Cavity within part for the second internal piston (in figure with shade and the second outer piston differentiation)；At this point, dentation
Structure 12 ' is protruded from the surface of the second outer piston.
In addition, dentalation 12 can also be depressed on the surface of first piston 10；Dentalation 12 ' is depressed in the second work
On the surface of plug 10 '.The length that particularly can be designed as first piston 10 is at least the 2 of the cavity length of the first liquid storage device 11
Times；When reaching the second end of the first liquid storage device 11 in one end of first piston 10, it is exposed to except the cavity of the first liquid storage device 11
Part for the first outer piston, into the part within the cavity of the first liquid storage device 11 for the first internal piston (in figure with
Shade and the first outer piston are distinguished)；At this point, dentalation 12 can also be depressed on the surface of the first outer piston.
The length of second piston 10 ' is at least 2 times of the cavity length of the second liquid storage device 11 '；The is reached in one end of second piston 10 '
During the second end of two liquid storage devices 11 ', it is the second outer piston to be exposed to the part except the cavity of the second liquid storage device 11 ', is entered
Part within the cavity of second liquid storage device 11 ' is the second internal piston (with shade and the second outer piston area in figure
Point)；At this point, dentalation 12 ' can also be depressed on the surface of the second outer piston.
First gear reverses switch counterpart 14 that can also be arranged on the first internal piston, and at this point, first gear
Switch counterpart 14 is reversed to be positioned proximate to the position of the first outer piston；Second gear reverses switch counterpart 14 ' that can also set
It puts on the second internal piston, and at this point, second gear, which reverses, switchs the position that counterpart 14 ' is positioned proximate to the second outer piston
It puts.
Preferably, first gear, which reverses, switchs the handing-over that counterpart 14 is arranged on the first outer piston and the first internal piston
Place；Second gear, which reverses, switchs the junction that counterpart 14 ' is arranged on the second outer piston and the second internal piston.
As shown in fig. 6, the reverse for gear 4 switchs basic circuit schematic diagram.Wherein 16 be motor, when first gear reverses
When switch 13 and first gear reverse the switch contact of counterpart 14, switch control 19 is bounced off out first switch connecting element
17, and contacted with second switch connecting element 18；When second gear reverses switch 13 ' and second gear to reverse switch counterpart
During 14 ' contact, switch control 19 is bounced off out second switch connecting element 18, and is contacted with first switch connecting element 17.
This dynamic biological toxicity Real_time quantitative detection analyzer can acquire the initial data of at least 24 hours, and adopt
The high resolution of collection, amplitude wave deformationization is subtle as it can be seen that organism slight change is visible in real time and easily quantitative inspection so as to reach
.In addition, multi-modal laser is coordinated to meet the requirement of multi-mode organism stress reaction, the bio-toxicity for detecting detected materials becomes
Change process, so as to help to analyze the toxicity type and mechanism of action of the material, this provides organism toxicologic study
Effective experiment is supported, and provide completely new detection platform to the research and development of newtype drug.
Embodiment 2 is applied
The preparation of nano-particle
Method (Journal of Nanobiotechnology, 2017,15 (1) provided according to document:23) lemon), is used
Lemon acid sodium reduction synthesizes common nano Au particle in present nanosecond medical science, is as follows：Add in three-necked flask
Enter 144ml ultra-pure waters, be heated to boiling, the citric acid (60mM) for adding 3.5ml sodium citrates (60mM) and 1.5ml acutely stirs
It mixes.100 microlitres of EDTA is added in, adds 1ml gold chlorides (25mM).When the color of mixture becomes claret, close and add
Heat when falling to a certain temperature, is dipped in ice water and stops reaction.Synthesize the ball shaped nano gold particle that grain size is 13nm.
Later by ligand exchange after, nanometer gold surface coat polyethylene glycol, to improve the biology of this nano-particle
Compatibility and stability.
Test maximal oxygen taken amount of the Hela cells to nano-particle
Method (Journal of Nanobiotechnology, 2017,15 (1) provided according to document:23), this experiment
Herein cover dynamic biological toxicity Real_time quantitative detection analyzer on carry out, by certain density Hela cells by sample input/
Output element is with the slow constant speed of speed of 10 μ l/min in input/output sample bin 3, and the environment of sample bin 3 is maintained
37 DEG C, 5%CO2Controlled condition under, observation 2 amplitude of shaking platform passes through amplitude in data display equipment 6 when increasing to stationary value
Variation, obtain the number of cells being adhered on shaking platform.
Later, the slow constant speed of certain density nano Au particle is injected in sample bin 3, the rising of Observable amplitude reaches
Certain altitude can stablize a period of time, then since exponential decay can be presented in cytotoxic amplitude.It can be calculated by calculating
Hela cells are to the maximal oxygen taken amount of gold nanoparticle.
Monitor the optical dynamic therapy process of up-conversion nanoparticles
Nano Au particle is changed into NaGdF4:Yb/Tm@TiO2Upper conversion particles, wherein TiO2Make photosensitizer.When cancer is thin
After born of the same parents absorb up-conversion nanoparticles, multi-modal lasecon is transformed into 980nm, irradiates shaking platform, there is light
The nano-particle of dynamic therapy effect can discharge active oxygen and kill cancer cell under the irradiation of laser.This process reaction is being shaken
In the variation of width, can further it analyze whereby.
The above is only several embodiments of the application, any type of limitation is not done to the application, although this Shen
Please disclosed as above with preferred embodiment, however not to limit the application, any person skilled in the art is not taking off
In the range of technical scheme, make a little variation using the technology contents of the disclosure above or modification is equal to
Case study on implementation is imitated, is belonged in the range of technical solution.
The above is only several embodiments of the application, any type of limitation is not done to the application, although this Shen
Please disclosed as above with preferred embodiment, however not to limit the application, any person skilled in the art is not taking off
In the range of technical scheme, make a little variation using the technology contents of the disclosure above or modification is equal to
Case study on implementation is imitated, is belonged in the range of technical solution.
Claims (10)
1. a kind of linkage of sample input/output, which is characterized in that it includes the first sample input/output element, second
Sample input/output element, sample bin and driving device；Wherein
First sample input/output element includes first piston and the first liquid storage device, the first end of first liquid storage device
With the first opening, the first piston can enter the cavity of first liquid storage device through the described first opening, and described
The cavity of first liquid storage device is fitted close with the first piston, and second end and the sample bin of first liquid storage device connect
It is logical；
Second sample input/output element includes second piston and the second liquid storage device, the first end of second liquid storage device
With the second opening, the second piston can enter the cavity of second liquid storage device through the described second opening, and described
The cavity of second liquid storage device is fitted close with the second piston, and second end and the sample bin of second liquid storage device connect
It is logical；
The driving device is set to the first piston being exposed to except the cavity of first liquid storage device and is exposed to institute
Between stating the second piston except the cavity of the second liquid storage device, to drive the first piston and the second piston back and forth
It is mobile.
2. linkage according to claim 1, which is characterized in that the length of the first piston is first liquid storage
At least 2 times of the cavity length of device；When reaching the second end of the first liquid storage device in one end of the first piston, it is exposed to described
Part except the cavity of first liquid storage device is the first outer piston；
The length of the second piston is at least 2 times of the cavity length of second liquid storage device；The one of the second piston
When end reaches the second end of the second liquid storage device, the part being exposed to except the cavity of second liquid storage device is living for the second outside
Plug.
3. linkage according to claim 2, which is characterized in that the outer surface of first outer piston, which is equipped with, to be increased
The protrusion of frictional force, to be matched with the driving device；
The outer surface of second outer piston is equipped with the protrusion for increasing frictional force, to be matched with the driving device.
4. linkage according to claim 2, which is characterized in that the driving device includes gear；Outside described first
Portion's piston is with the contact surface of the driving device and second outer piston with being respectively provided on the contact surface of the driving device
With the matched dentalation of the gear.
5. linkage according to claim 4, which is characterized in that it is living that the dentalation protrudes from first outside
On the outer surface of plug；And/or the dentalation is protruded from the outer surface of second outer piston.
6. linkage according to claim 4, which is characterized in that it is living that the dentalation is depressed in first outside
On the outer surface of plug；And/or the dentalation is depressed on the outer surface of second outer piston.
7. according to the linkage described in any one in claim 1-6, which is characterized in that the driving device includes tooth
Wheel, the linkage further include the motor of drive gear rotation and the electrode of the control motor, the gear and can drive
It moves the first piston and the second piston moves back and forth, and the direction of first piston movement and the second piston
Mobile direction is opposite.
8. linkage according to claim 7, which is characterized in that being equipped in the first end of first liquid storage device can
The first gear for changing gear rotation direction reverses switch；Gear turn can be changed by being equipped in the first end of second liquid storage device
The second gear in dynamic direction reverses switch；And it is provided on the first piston and the of switch cooperation is reversed with first gear
One gear reverses switch counterpart, is provided in the second piston and reverses the second gear of switch cooperation inverse with second gear
Turn on pass counterpart；The electrode reverses switch or second gear to reverse switch control by the first gear.
9. linkage according to claim 8, which is characterized in that when first gear reverses switch and first gear to reverse
When switching counterpart contact, switch control is bounced off out first switch connecting element, and is contacted with second switch connecting element；
When second gear reverses switch and second gear reverses switch counterpart contact, switch control is bounced off out second switch company
Element is connect, and is contacted with first switch connecting element.
10. a kind of detection analysis instrument, which is characterized in that it includes the linkage as described in any one in claim 1-9.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720764846.1U CN207557285U (en) | 2017-06-28 | 2017-06-28 | A kind of linkage of sample input/output |
| PCT/CN2018/071835 WO2019000902A1 (en) | 2017-06-28 | 2018-01-09 | Detection analyzer |
| EP18822637.7A EP3591394B1 (en) | 2017-06-28 | 2018-01-09 | Detection analyzer |
| US16/486,587 US11333661B2 (en) | 2017-06-28 | 2018-01-09 | Detection analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720764846.1U CN207557285U (en) | 2017-06-28 | 2017-06-28 | A kind of linkage of sample input/output |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207557285U true CN207557285U (en) | 2018-06-29 |
Family
ID=62671808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720764846.1U Active CN207557285U (en) | 2017-06-28 | 2017-06-28 | A kind of linkage of sample input/output |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207557285U (en) |
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2017
- 2017-06-28 CN CN201720764846.1U patent/CN207557285U/en active Active
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