CN207532824U - One kind is used for pefloxacin mesilate crystal system - Google Patents
One kind is used for pefloxacin mesilate crystal system Download PDFInfo
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- CN207532824U CN207532824U CN201721594086.0U CN201721594086U CN207532824U CN 207532824 U CN207532824 U CN 207532824U CN 201721594086 U CN201721594086 U CN 201721594086U CN 207532824 U CN207532824 U CN 207532824U
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- crystallization tank
- filter plate
- storehouse
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- cooler
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Abstract
One kind includes heating reaction kettle, cooler, crystallization tank, cycle storehouse for pefloxacin mesilate crystal system, and heating reaction kettle connects cooler by the first valve, and cooler discharge port is connect with crystallization tank feed inlet, and cooler discharge port is equipped with the second valve；Filter plate is set in crystallization tank, filter plate is equipped with filter hole, and filter plate one end is higher than other end vertical position, and the low one end of filter plate vertical position passes through crystallization cell wall to be connect with rewinding case, crystallization tank lower end liquid outlet is connect with cycle storehouse, and cycle storehouse is connect by pump with heating reaction kettle.The utility model can be not increased in impurity content, greatly improves crystalline rate.
Description
Technical field
The utility model belongs to industrial gasses detection field, and in particular to one kind is used for pefloxacin mesilate system of crystallization
System.
Background technology
Pefloxacin mesilate is Comprecin, is medical insurance class prescription medicine.It can treat by Pefloxacin sensitive bacteria
Caused various infection：Urinary tract infections；Respiratory tract infection；Ear, nose, larynx infection；Gynaecology, genital system infection；Abdomen and liver, courage
System infections；Bone and the infection of joint；Skin infection；Septicemia and endocarditis；Meningitis, in order to avoid impurity in crystallization process
Exceeded, existing crystalline rate is relatively low, has seriously constrained the production-scale expansion of company.
Invention content
The purpose of this utility model be in view of the above-mentioned problems, provide it is a kind of for pefloxacin mesilate crystal system, can
With not increased in impurity content, crystalline rate is greatly improved.
The technical solution of the utility model is a kind of to include heating reaction kettle, cold for pefloxacin mesilate crystal system
But device, crystallization tank, cycle storehouse, heating reaction kettle connect cooler by the first valve, and cooler discharge port is fed with crystallization tank
Mouth connection, cooler discharge port are equipped with the second valve；
Filter plate is set in the crystallization tank, filter plate is equipped with filter hole, and filter plate one end is higher than other end vertical position,
The low one end of filter plate vertical position passes through crystallization cell wall to be connect with rewinding case, and crystallization tank lower end liquid outlet is connect with cycle storehouse,
Cycle storehouse is connect by pump with heating reaction kettle.
Further, cycle storehouse upper end is equipped with electronics outage, and pump is connect with cycle storehouse lower end；
The pump is connect with the electronics outage by controller with timer respectively.
Further, electronic level inductor is equipped in the cycle storehouse, the electronic level inductor connects with controller
It connects.
Further, the cycle storehouse lower end is equipped with aeration tube, and aeration tube is connect by electric control valve with air source, electrically-controlled valve
Door is connect by controller with timer.
The beneficial effects of the utility model are：After heating reaction kettle carries out being heated up to 80-90 degrees Celsius, in cooler
（Can be that multiple cooling devices are composed）10 degrees centigrades are cooled to rapidly, later in crystallization tank（Temperature is taken the photograph in crystallization tank
Family name's degree is further reduced to 8 degrees centigrades, and the filter plate in crystallization tank is dropped in the gap that liquid passes through using cold water
Temperature）The initial gross separation of crystalline solid and liquid is carried out, while with can further make the crystal structure in liquid, so as to substantially degree Celsius
The efficiency of crystallization is improved, and entire crystallization process does not have other liquid to participate in, change is physical condition, avoids the increasing of impurity
Add.
Description of the drawings
The utility model is described in further detail with reference to the accompanying drawings and examples.
Fig. 1 is the utility model structure diagram.
In figure：Heat reaction kettle 1, cooler 2, crystallization tank 3, cycle storehouse 4, the first valve 5, the second valve 6, filter plate 7,
Rewinding case 8, pump 9, electronics outage 10, controller 11, electronic level inductor 12, aeration tube 13, electric control valve 14, timer
15。
Specific embodiment
As shown in Figure 1, a kind of include heating reaction kettle 1 for pefloxacin mesilate crystal system（It is preferred a diameter of
30-40 centimetres, height is at 80-90 centimetres, and pefloxacin mesilate liquid per treatment is in 0.2 side or so）, cooler 2（At least by
Three water coolings or air cooling equipment are composed in series, and temperature degree Celsius is made to drop to 10 or so from 80-90 degrees Celsius in 5 to 10 minutes）、
Crystallization tank 3, cycle storehouse 4, heating reaction kettle 1 connect cooler 2 by the first valve 5,2 discharge port of cooler and crystallization tank 3 into
Material mouth connects, and 2 discharge port of cooler is equipped with the second valve 6；
Filter plate 7 is set in the crystallization tank 3（When 7 surface of filter plate is not by pefloxacin mesilate liquid, cleaning is utilized
Ice water fill washing to 7 surface of filter plate, mainly cools down to 7 surface of filter plate, and it is Celsius 2 to 5 to be allowed to temperature degree Celsius
Degree）, filter plate 7 is equipped with filter hole, and 7 one end of filter plate is higher than other end vertical position, the low one end of 7 vertical position of filter plate
It is connect across 3 wall of crystallization tank with rewinding case 8,3 lower end liquid outlet of crystallization tank is connect with cycle storehouse 4, and cycle storehouse 4 is by pump 9 with adding
Warm reaction kettle 1 connects.
Operation principle：A certain amount of pefloxacin mesilate liquid crystallized is needed to be first input into heating reaction kettle 1 to add
Heat is entered by the first valve 5 in cooler 2, to 80-90 degrees Celsius when heating pefloxacin mesilate in reaction kettle 1 later
Liquid enters after cooler 2, and the first valve 5 is closed（Heat is prevented in heating reaction kettle 1 to scatter and disappear too fast, while next group first
Sulfonic acid Pefloxacin liquid enters heating reaction kettle 1 and is heated）, pefloxacin mesilate liquid is after subcooler 2, temperature
Drop to 10 or so（Have major part crystal to be precipitated）, crystallization tank 3 is entered by the second valve 6 later, when first in cooler 2
Sulfonic acid Pefloxacin liquid（Most of crystal of precipitation）After fully entering crystallization tank 3, the second valve 6 is closed（Delay 2-3 minutes
The pefloxacin mesilate liquid heated afterwards in heating reaction kettle 1, enters further through the first valve 5 in cooler 2）, first
Filter plate 7 is general only to need one minute or so to sulfonic acid Pefloxacin liquid by setting in crystallization tank 3, and crystallographic is along filter plate 7
Upper surface simultaneously enters rewinding case 8 from low side discharge crystallization tank 3, and liquid is then passed through under the filter hole of filter plate 7 and crystallization tank 3
End liquid outlet enters cycle storehouse 4, and the pefloxacin mesilate liquid that next group enters crystallization tank 3 from cooler 2 needs 7-8
Minute, crystallization tank 3 does not have pefloxacin mesilate liquid therebetween, then is cooled down with pure ice water to filter plate 7.
Preferably, cycle 4 upper end of storehouse is equipped with electronics outage 10, and pump 9 is connect with cycle 4 lower end of storehouse；
Pump 9 is connect with electronics outage 10 by controller 11 with timer 15 respectively, and timer 14 carries out timing, reaches
After giving directions the time, the liquid for recycling storehouse lower end is pumped into, and pass through and open electronics outage by heating reaction kettle 1 by pump 9 again
The 10 liquid discharge heating reaction kettles 1 that will recycle storehouse upper end.
Preferably, electronic level inductor 12 is equipped in cycle storehouse 4, the electronic level inductor 12 connects with controller 11
It connects, controller 11 acquires the liquid level in cycle storehouse 4 by electronic level inductor 12, when liquid level reaches designated value
When, controller 11 then sends out signal to timer 14 or other electronic original parts.
Preferably, cycle 4 lower end of storehouse is equipped with aeration tube 13, and aeration tube 13 is connect by electric control valve 14 with air source, automatically controlled
Valve 14 is connect by controller 11 with timer 10, and after 10 timing of timer, after reaching setting time, controller 11 is then opened
Electric control valve 14 makes aeration tube 13 generate gas, flows the liquid in cycle storehouse 4.
Cycle storehouse 4 operation principle be, using recycle storehouse 4 recycling without crystallization pefloxacin mesilate liquid, it is preceding its
By natural sedimentation, pefloxacin mesilate is made to be concentrated to cycle 4 bottom of storehouse, fed back re-using with pump 9 later, and on
Layer liquid is then expelled directly out, and timer 15, then carries out time control to processes such as natural sedimentations.
Claims (4)
1. one kind is used for pefloxacin mesilate crystal system, it is characterized in that：Crystal system includes heating reaction kettle（1）, cooling
Device（2）, crystallization tank（3）, cycle storehouse（4）, heat reaction kettle（1）Pass through the first valve（5）Connect cooler（2）, cooler（2）
Discharge port and crystallization tank（3）Feed inlet connects, cooler（2）Discharge port is equipped with the second valve（6）；
The crystallization tank（3）Inside set filter plate（7）, filter plate（7）It is equipped with filter hole, filter plate（7）It is erected than the other end one end
To position height, filter plate（7）The low one end of vertical position passes through crystallization tank（3）Wall and rewinding case（8）Connection, crystallization tank（3）Under
Hold liquid outlet and cycle storehouse（4）Connection recycles storehouse（4）Pass through pump（9）With heating reaction kettle（1）Connection.
2. it is according to claim 1 a kind of for pefloxacin mesilate crystal system, it is characterized in that：The cycle storehouse
（4）Upper end is equipped with electronics outage（10）, pump（9）With recycling storehouse（4）Lower end connects；
The pump（9）With the electronics outage（10）Pass through controller respectively（11）With timer（15）Connection.
3. it is according to claim 2 a kind of for pefloxacin mesilate crystal system, it is characterized in that：The cycle storehouse
（4）It is interior to be equipped with electronic level inductor（12）, the electronic level inductor（12）It is connect with controller.
4. it is according to claim 2 a kind of for pefloxacin mesilate crystal system, it is characterized in that：The cycle storehouse
（4）Lower end is equipped with aeration tube（13）, aeration tube（13）Pass through electric control valve（14）It is connect with air source, electric control valve（14）Pass through control
Device processed（11）With timer（15）Connection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721594086.0U CN207532824U (en) | 2017-11-24 | 2017-11-24 | One kind is used for pefloxacin mesilate crystal system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721594086.0U CN207532824U (en) | 2017-11-24 | 2017-11-24 | One kind is used for pefloxacin mesilate crystal system |
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| Publication Number | Publication Date |
|---|---|
| CN207532824U true CN207532824U (en) | 2018-06-26 |
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ID=62614970
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721594086.0U Active CN207532824U (en) | 2017-11-24 | 2017-11-24 | One kind is used for pefloxacin mesilate crystal system |
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| Country | Link |
|---|---|
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111097192A (en) * | 2019-12-27 | 2020-05-05 | 宁波乐维实业有限公司 | Separation device and separation method for triethylene diamine and ethanolamine |
-
2017
- 2017-11-24 CN CN201721594086.0U patent/CN207532824U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111097192A (en) * | 2019-12-27 | 2020-05-05 | 宁波乐维实业有限公司 | Separation device and separation method for triethylene diamine and ethanolamine |
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