CN207528693U - A kind of solid-phase extraction device - Google Patents

Abstract

The utility model discloses a kind of solid-phase extraction device, it is characterised in that：Babinet includes interior glass and outer glass, a cavity is formed between interior glass and outer glass, on interior glass a discharge stomata is equipped with by bottom position, venthole communicates cabinets cavity and cavity, pump-line is connected on outer glass, coupling adapter on through-hole on case lid, crossover sub medium position is equipped with one or six side nuts, gasket is equipped between cushion cap and six side nut contact surfaces, crossover sub is placed in the threaded upper ends connection dish shape nut of case lid outer end, and the tapered setting of inner wall of end interface, crossover sub upper end connects control valve, control valve connects solid-phase extraction column, crossover sub lower thread connects extension, extension is threadedly coupled conical head, extension wherein one end is equipped with the internal thread to cooperate with external screw thread on crossover sub, the extension other end is equipped with external screw thread, corresponding taper cephalic par is equipped with internal thread.The utility model advantage has：Simple in structure, working efficiency is high, easy to clean.

Description

A kind of solid-phase extraction device

Technical field

The invention belongs to chemical analysis instrument technical fields, and in particular to a kind of solid-phase extraction device.

Background technology

Solid Phase Extraction（Solid-Phase Extraction, SPE）It is a kind of sample that the eighties mid-term grows up Preconditioning technique is combined by liquid-solid extraction and liquid chromatography technology and developed, and is mainly used for the separation of sample, purifying and dense Contracting.The rate of recovery of analyte can be relatively improved compared with traditional liquid-liquid extraction method, more effectively by analyte and interfering component Separation reduces sample pretreatment process, easy to operate, time saving, laborsaving.It is widely applied to medicine, food, environment, commodity inspection, change The fields such as work.At present, in sample analysis, pretreatment is a particularly significant step.The direct shadow of effect of sample pretreatment Ring analysis result it is accurate whether.Solid Phase Extraction is the original detached using selective absorption with the liquid chromatogram of selective elution Reason.More common way is that fluid sample is made to pass through adsorption stuffing, retains target components therein, then selects the molten of appropriate intensity Agent is rinsed to remove interfering component, then with a small amount of good solvent elution target components, so as to reach quick separating, purify with it is dense The purpose of contracting；Also selective absorption interfering component can be selected, and target components is allowed to flow out；Or adsorptive hindrance component and target simultaneously Component reuses suitable solvent selectivity elution target components.General Solid Phase Extraction is using following operation：Activation-loading- Elution-elution.

The main body of solid-phase extraction device of the prior art is the babinet of an air-tightness, and body side is equipped with and vacuum pump The exhaust outlet of connection covers thereon equipped with a socket hole, solid-phase extraction column is inserted into jack.In solid-phase extraction column just simultaneously Side is equipped with test tube or similar fluid collection device to collect the liquid flowed out from solid-phase extraction column.It is evacuated to babinet, Top instills leacheate from extraction column, and lower section can be collected into the extract eluted.In actual application, vacuum Pump by pump-line directly connects cabinets cavity, and the air of close pump-line is caused first to be extracted out, similarly, by pressure factor, Solid-phase extraction column close to pump-line can first ooze extract, and the solid-phase extraction column far from pump-line is made finally to ooze in this way Extract can seriously cause can not extract extract；Existing extension is overall structure, is directly anchored on case lid, In operating process, the height of test tube need to be adjusted, is placed it in test tube, it is very inconvenient；In addition, extension is also inconvenient clear It washes, does not wash clean clearly, next time is in use, will occur cross contamination, so as to cause the obtained extract of final Solid Phase Extraction It is contaminated, so as to influence the accuracy of final liquid chromatographic detection.Therefore, it is just particularly heavy for the solution of the above problem It will.

Invention content

The present invention has overcome the deficiencies of the prior art and provide a kind of solid phase simple in structure, working efficiency is high, easy to clean Extraction equipment.

In order to achieve the above object, the technical solution adopted in the present invention is：A kind of solid-phase extraction device, including Solid Phase Extraction Column, babinet, case lid, pump-line, stent, support plate and block, the case lid lid, which is located on babinet, makes box sealing, the case lid The through-hole being inserted into for solid-phase extraction column in babinet is equipped with, the babinet side is equipped with pump-line, and the box house is equipped with Vertical stent is clamped support plate on the stent, and the babinet is placed on block, it is characterised in that：The babinet includes interior glass Glass and outer glass form a cavity, are set on the interior glass by bottom position between the interior glass and the outer glass There is a discharge stomata, the venthole communicates cabinets cavity and cavity, and pump-line, the case lid are connected on the outer glass On the through-hole on coupling adapter, the crossover sub both ends are equipped with external screw thread, the crossover sub medium position Equipped with one or six side nuts, six side nut is placed on the cushion cap of case lid bottom, and the cushion cap and through-hole are coaxial, and with six sides Nut matches, and gasket is equipped between the cushion cap and the six sides nut contact surface, and the crossover sub is placed in outside case lid The threaded upper ends connection dish shape nut at end, and the tapered setting of inner wall of end interface, the crossover sub upper end connection control Valve processed, the control valve connect solid-phase extraction column, and the crossover sub lower thread connects extension, and the extension pipe screw thread connects Conical head is connect, the extension wherein one end is equipped with the internal thread to cooperate with external screw thread on the crossover sub, described to prolong The pipe other end is stretched equipped with external screw thread, and corresponding taper cephalic par is equipped with internal thread.

Further, the interior six-sided nut is integrally formed with crossover sub.

Further, block side symmetric position is equipped with handle.

Compared with prior art, it is an advantage of the invention that：By glass in setting and outer glass, babinet be divided into inner cavity and Cavity, pump-line connection cavity, at work, the air of cabinets cavity is uniformly entered by venthole in cavity, finally Aggregation discharge, the pressure that such solid-phase extraction column is subject to is identical, can extract extract simultaneously, so as to improve work effect Rate；Extension both ends are respectively provided with screw thread, can be spliced according to actual conditions, in cleaning, are also convenient for dismantling, so as to It quickly cleans up, is extracted work again, cross contamination will not occur, further, improve liquid chromatographic detection Accuracy.

Description of the drawings

Fig. 1 is a kind of structural representation front view of solid-phase extraction device of the present invention.

Fig. 2 is a kind of partial structurtes schematic sectional view of solid-phase extraction device of the present invention, wherein illustrating only case lid with consolidating The connection structure of phase extraction column.

Fig. 3 is a kind of interior glass of babinet of solid-phase extraction device of the present invention and the structure diagram of outer glass structure.

1. solid-phase extraction column in the figure, 2. babinets, 3. case lids, 4. pump-lines, 5. stents, 6. support plates, 7. blocks, 8. Through-hole, glass in 9., 10. outer glass, 11. ventholes, 12. crossover subs, 13. six-sided nuts, 14. cushion caps, 15. gaskets, 16. dish shape nut, 17. control valves, 18. extensions, 19. conical heads, 20. handles.

Specific embodiment

The invention will be further described, but is not to be construed as to the scope of the present invention for example given below plan Limitation, those skilled in the art still fall within this according to some the nonessential modifications and adaptations of the content of present invention to the present invention The protection domain of invention.

Unless otherwise explicitly stated, otherwise in entire disclosure and claims, term " comprising " or its change It changes such as "comprising" or " including " etc. and will be understood to comprise stated element or component, and do not exclude other members Part or other component parts.

In the description of the present invention, it should be noted that term " " center ", " on ", " under ", "left", "right", " vertical ", The orientation or position relationship of the instructions such as " level ", " interior ", " outer " be based on orientation shown in the drawings or position relationship, merely to Convenient for the description present invention and simplify description rather than instruction or imply signified device or element must have specific orientation, With specific azimuth configuration and operation, therefore it is not considered as limiting the invention.In addition, term " first ", " second ", " third " is only used for description purpose, and it is not intended that instruction or hint relative importance.

In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase Even ", " connection " should be interpreted broadly, for example, it may be being fixedly connected or being detachably connected or be integrally connected；It can To be mechanical connection or be electrically connected；It can be directly connected, can also be indirectly connected by intermediary, Ke Yishi Connection inside two elements.For the ordinary skill in the art, above-mentioned term can be understood at this with concrete condition Concrete meaning in invention.

In Fig. 1 to Fig. 3,1. solid-phase extraction columns, 2. babinets, 3. case lids, 4. pump-lines, 5. stents, 6. support plates, 7. casees Seat, 8. through-holes, glass in 9., 10. outer glass, 11. ventholes, 12. crossover subs, 13. six-sided nuts, 14. cushion caps, 15. Gasket, 16. dish shape nuts, 17. control valves, 18. extensions, 19. conical heads, 20. handles.

A kind of solid-phase extraction device, including solid-phase extraction column 1, babinet 2, case lid 3, pump-line 4, stent 5,6 and of support plate Block 7, the lid of case lid 3, which is located on babinet 2, seals babinet 2, and case lid 3 is equipped with the through-hole being inserted into for solid-phase extraction column 1 in babinet 2 8,2 side of babinet is equipped with pump-line 4, and babinet 2 is internally provided with vertical stent 5, is clamped support plate 6 on stent 5, babinet 2 is placed in On block 7, it is characterised in that：Babinet 2 includes interior glass 9 and outer glass 10, and a sky is formed between interior glass 9 and outer glass 10 Chamber is equipped with a discharge stomata 11 on interior glass 9 by bottom position, and venthole 11 communicates 2 inner cavity of babinet and cavity, outer glass Pump-line 4 is connected on 10, coupling adapter 12 on the through-hole 8 on case lid 3,12 both ends of crossover sub are equipped with external screw thread, 12 medium position of crossover sub is equipped with one or six side nuts 13, and six side nuts 13 are placed on the cushion cap 14 of 3 bottom of case lid, cushion cap 14 with Through-hole 8 is coaxial, and matches with six side nuts 13, and gasket 15 is equipped between 14 and six side nut of cushion cap, 13 contact surface, turns Changing-over head 12 is placed in the threaded upper ends connection dish shape nut 16 of 3 outer end of case lid, and the tapered setting of inner wall of end interface, turns 12 upper end of changing-over head connects control valve 17, and control valve 17 connects solid-phase extraction column 1,12 lower thread of crossover sub connection extension 18, extension 18 is threadedly coupled conical head 19, and the wherein one end of extension 18 is equipped with and cooperates with external screw thread on crossover sub 12 Internal thread, 18 other end of extension be equipped with external screw thread, corresponding 19 end of conical head be equipped with internal thread.

Six side nuts 13 are integrally formed with crossover sub 12.

7 side symmetric position of block is equipped with handle 20.

As shown in Figure 1 to Figure 3, solid-phase extraction column 1 be in liquid phase chromatography detection method for target compound or component into Row separation, a kind of device of purification and enrichment, generally use medical grade polypropylene or glass are made.One end is charge door, sample Product are put into from charge door；The other end is narrow meshed column cap, and column cap is inserted on control valve 17, and control valve 17 is inserted into crossover sub On 12, gasket 15 that crossover sub 12 is set by 3 bottom of case lid makes it be tightly connected with case lid 3, and 12 screw thread of crossover sub connects Extension 18 is connect, conical head 19 is finally connected on extension 18, conical head 19 is made to stretch into the test tube set in babinet 2, and Ensure that conical head 19 and test tube are contactless.Several test tubes, opening and the solid-phase extraction column 1 of test tube are usually set in babinet 2 Column cap is corresponding, with the liquid that pillar is received to flow out.Babinet 2 includes interior glass 9 and outer glass 10, is equipped with and takes out on outer glass 10 Feed channel 4 can connect vacuum pump, arranged on interior glass 9 and be equipped with venthole 11, air can be made uniformly to be arranged from 2 intracavitary of babinet Go out.Vacuum pump just forms negative pressure in the air in extracting babinet 2 in babinet 2 makes sample quickly through Solid Phase Extraction （Solid-Phase Extraction,SPE）Filler is adsorbed the target components in sample using solid phase extraction filler, by sample The target components and interfering component of product are detached, and are then adsorbed the target components in filler using elution, are reached Separation and the purpose of enrichment target components.

Claims (3)

1. a kind of solid-phase extraction device, including solid-phase extraction column（1）, babinet（2）, case lid（3）, pump-line（4）, stent（5）、 Support plate（6）And block（7）, the case lid（3）Lid is located at babinet（2）On make babinet（2）Sealing, the case lid（3）It is equipped with and supplies Solid-phase extraction column（1）It is inserted into babinet（2）Interior through-hole（8）, the babinet（2）Side is equipped with pump-line（4）, the babinet （2）It is internally provided with vertical stent（5）, the stent（5）Upper clamping support plate（6）, the babinet（2）It is placed in block（7）On, It is characterized in that：The babinet（2）Including interior glass（9）With outer glass（10）, the interior glass（9）With the outer glass（10）It Between formed a cavity, in the interior glass（9）It is upper to be equipped with a discharge stomata by bottom position（11）, the venthole（11）Make Babinet（2）Inner cavity and cavity communicate, the outer glass（10）Upper connection pump-line（4）, the case lid（3）On the through-hole （8）Upper coupling adapter（12）, the crossover sub（12）Both ends are equipped with external screw thread, the crossover sub（12）Middle position One or six side nuts are installed（13）, six side nut（13）It is placed in case lid（3）The cushion cap of bottom（14）On, the cushion cap（14） With through-hole（8）Coaxially, and with six side nuts（13）It matches, in the cushion cap（14）With six side nut（13）Contact surface Between be equipped with gasket（15）, the crossover sub（12）It is placed in case lid（3）The threaded upper ends connection dish shape nut of outer end（16）, and And the tapered setting of inner wall of end interface, the crossover sub（12）Upper end connects control valve（17）, the control valve（17） Connect solid-phase extraction column（1）, the crossover sub（12）Lower thread connects extension（18）, the extension（18）Screw thread connects Connect conical head（19）, the extension（18）Wherein one end is equipped with and the crossover sub（12）Upper external screw thread cooperates interior Screw thread, the extension（18）The other end is equipped with external screw thread, corresponding conical head（19）End is equipped with internal thread.

2. a kind of solid-phase extraction device according to claim 1, it is characterised in that：Six side nut（13）It is connect with conversion Head（12）It is integrally formed.

3. a kind of solid-phase extraction device according to claim 1, it is characterised in that：The block（7）Side symmetric position Equipped with handle（20）.