A kind of adaptive sample panel of flux
Technical field
The utility model belongs to biotechnology, more particularly, to a kind of adaptive sample panel of flux.
Background technology
With the development of technology, more and more Bioexperiment employ automation equipment, by taking nucleic acid extraction is tested as an example,
Nucleic acid extraction is a kind of technology of current almost each Molecular Biology Lab's indispensability, in genomics, disease control medical treatment, food
The fields such as safety, forensic identification are widely used.But its extraction step is not only cumbersome, but also time-consuming and laborious.In order to solve this
Problem has emerged large quantities of automatic nucleic acid extraction systems in the market, and the independent packing reagent of single sample is extracted by coordinating,
In operation, it is only necessary to add in sample action, instrument is automatically performed the overall process of nucleic acid extraction purifying, does not need to addition and carries
Required reagent process during taking, so as to fulfill automatically extracting for nucleic acid.
Automatic nucleic acid extraction system on the market mainly has two major class at present:One kind is large-scale automation, generally
The referred to as nucleic acid extraction system of automated fluid work station;Another kind of is small-sized automatic instrument for extracting nucleic acid, is matched using packaged
Set reagent is automatically performed extraction purification process.For large-scale automated fluid work station because equipment cost is high, operating cost is high, is suitble to
Thousands of a one species samples are once extracted, so what is be really applied is fewer;And the instrument of small automatic, because of instrument
Device equipment and operating cost are low, easy to operate more and more to be applied.Wherein especially with the nucleic acid based on magnetic bionanoparticles
Extraction apparatus application is more extensive.
Since more instrument for extracting nucleic acid is 32 holes or 96 holes on the market at present, mating sample panel also can only be 32
Hole or 96 holes, and in practice, user's sample size be it is uncertain or when it is more when it is few, then, according to the prior art,
It then needs to prepare two or more instrument for extracting nucleic acid that the waste of sample panel while guaranteed efficiency, could be reduced.But nucleic acid carries
Take instrument price generally higher, while prepare two or more instrument for extracting nucleic acid to cause the increase of cost, if only preparing one
Platform instrument for extracting nucleic acid, such as the instrument for extracting nucleic acid in 96 holes is selected, mating sample panel is also 96 holes, if user's sample number at this time
Amount is less than 96, and it will cause the wastes of sample panel.
Likewise, in other biological experiment, such as protein detection experiment, glucose detection assay etc., due to instrument
The sample panel specification of adaptation is fixed, when sample size do not know or when it is more when it is few when, the serious waste of sample panel can be caused, together
When, when can also influence laboratory apparatus machine, reduce conventional efficient.
Therefore, user wants to design a kind of adaptive sample panel of flux, can according to the transformation of sample size, into
Row is adaptively adjusted, and to reduce waste, improves conventional efficient.
Invention content
For the disadvantages described above or Improvement requirement of the prior art, the utility model provides a kind of adaptive sample of flux
Plate its object is to be directed to sample size to be adaptively adjusted, thus solves caused sample panel waste during sample size variation
The technical issues of.
To achieve the above object, according to the one side of the utility model, a kind of adaptive sample panel of flux is provided,
It is characterized in that, including sample housing unit, the housing unit includes joint face and one or more be arranged on joint face
A depressed body for being used to accommodate sample, the multiple housing unit are integrated into the sample that the depressed body is default specification in which can expand
Product plate, to adapt to the variation of flux.
Preferably, the adaptive sample panel of the flux, multiple housing units, joint face are expanded or are assisted from splicing
The sample panel for being integrated into default specification is expanded in splicing.
Preferably, the adaptive sample panel of the flux, its joint face auxiliary splicing of multiple housing units, which is expanded, to be integrated
To preset the sample panel of specification, the sample panel further includes the adapter rack for assisting splicing, and the adapter rack is according to default rule
Lattice include multiple housing unit mounting holes, each of which mounting hole is used to install unique sample housing unit.
Preferably, the adaptive sample panel of the flux, adapter rack include the mounting hole four side by side, to expand installation
At most four sample housing units;The sample housing unit is installed into one or more mounting holes, and the sample holds
Receive unit multiple depressed bodies in 3*8 specifications arrange.
Preferably, the adaptive sample panel of the flux, multiple housing units, joint face have splicing construction with certainly
The sample panel for default specification is expanded in splicing, and the splicing construction is buckle structure, spoke structure or tongue structure.
Preferably, the adaptive sample panel of the flux, the depressed body of housing unit is deep hole specification.
Preferably, the adaptive sample panel of the flux further includes cover board, the cover board and the housing unit
Match, for sealing the housing unit.
Preferably, the adaptive sample panel of the flux, cover board are matched widenable to the sample panel, to adapt to lead to
The variation of amount.
Preferably, the adaptive sample panel of the flux further includes isolated location, the isolated location and the recess
Body matches, and is directly contacted to avoid the sample in the depressed body with laboratory apparatus.
Preferably, the adaptive sample panel of the flux, isolated location are bar magnet set.
In general, have the above technical solutions conceived by the present invention are compared with the prior art, with following
Beneficial effect:
(1), the adaptive sample panel of a kind of flux provided by the utility model, by the way that its sample housing unit to be designed as connecting
Junction and the one or more being arranged on joint face are used to accommodate the depressed body of sample, also, according to the change of sample size
Change, the multiple housing unit is expanded, is integrated into a new sample panel, and make it have suitable for sample size
Depressed body so as to reach sample panel depressed body quantity and sample size matching, and then avoids the waste of sample panel;
(2), the adaptive sample panel of a kind of flux provided by the utility model by providing one kind is used to that sample panel to be assisted to spell
The adapter rack connect, the adapter rack include multiple mounting holes, and each mounting hole can place a sample housing unit;Work as sample
When quantity changes, the quantity for being positioned over the sample housing unit in the mounting hole can be changed according to sample size, from
And sample panel has flexibly been expanded, improve conventional efficient.
Description of the drawings
Fig. 1 is a kind of adaptive sample panel schematic diagram of flux provided by the utility model;
Fig. 2 is a kind of adaptive sample panel adapter rack schematic diagram of flux provided by the utility model;
Fig. 3 is a kind of cover plate schematic diagram of the adaptive sample panel of flux provided by the utility model;
Fig. 4 is a kind of bar magnet set schematic diagram of the adaptive sample panel of flux provided by the utility model;
In all the appended drawings, identical reference numeral is used for representing identical element or structure, wherein:1- sample panels;12-
Sample panel depressed body;13- sample panel joint faces;2- adapter racks;22- adaptation frame aperture position;3- cover boards;4- bar magnet sets.
Specific embodiment
In order to make the purpose of the utility model, technical solutions and advantages more clearly understood, below in conjunction with attached drawing and implementation
Example, the present invention is further described in detail.It should be appreciated that specific embodiment described herein is only used to explain
The utility model is not used to limit the utility model.In addition, institute in the various embodiments of the present invention described below
The technical characteristic being related to can be combined with each other as long as they do not conflict with each other.
The utility model provides a kind of adaptive sample panel of flux, as shown in Figure 1:Including sample housing unit 1, the appearance
Unit of receiving includes joint face 13 and the one or more being arranged on joint face is used to accommodate the depressed body 12 of sample, described more
A housing unit is integrated into the sample panel that the depressed body is default specification in which can expand, to adapt to the variation of flux:
Further, the multiple housing unit, joint face from splice expand or auxiliary splicing expand be integrated into it is default
The sample panel of specification;
In one embodiment of the utility model, its joint face of the multiple housing unit can be designed as to buckle knot
The connection structures such as structure or spoke structure or tongue structure, so that the multiple housing unit is connected through face
Splicing construction carries out expanding the sample panel for default specification from splicing;
In another embodiment of the utility model, the adapter rack 2 for assisting splicing, the adapter rack can be increased
Including multiple housing unit mounting holes according to default specification, each of which mounting hole is used to install unique sample housing unit,
So that the sample panel for being integrated into default specification is expanded in its joint face auxiliary splicing of the multiple housing unit;
Due to the adaptive sample panel of flux provided by the utility model, main application is in Bioexperiment, and Bioexperiment
Sample is often the liquid such as blood, saliva, and such sample is different from other kinds of sample, has mobility and not easy to maintain
Property, it is therefore, very high to the requirement on flexibility of splicing construction.So the utility model assists splicing preferably by increasing
Adapter rack so that the sample panel for being integrated into default specification is expanded in the auxiliary splicing of the multiple housing unit its joint face.
Since in most of Bioexperiment, the instrument of a variety of adaptations, such as PCR instrument, Multi-channel liquid transfer device etc. are maximum logical
Amount is 96 samples.It is therefore preferred that the adapter rack includes the mounting hole four side by side, the sample housing unit peace
It is filled in one or more mounting holes, for once expanding installation minimum of one sample panel, most 4 sample panels;
Further, multiple depressed bodies of the sample housing unit can be plurality of specifications, such as 3*8 specifications, 4*6 advise
Lattice, 1*8 specifications, 2*6 specifications etc.;Described its specification of sample housing unit determines according to customer demand and experimental situation, this
Due to being Bioexperiment, most of preferred sample panel specification of Bioexperiment is 3*8 specifications at place, it is therefore preferable that the sample accommodates
Multiple depressed bodies of unit are arranged in 3*8 specifications.
Certainly, the adaptive sample panel of flux provided by the utility model, the joint face of sample housing unit can also be adopted
Expansion splicing is carried out from splicing construction with buckle structure or spoke structure or tongue structure etc., so as to reach the sample
Plate is according to the purpose of sample size automatic adjusument.
Due to the adaptive sample panel of flux provided by the utility model, main application is in Bioexperiment, and Bioexperiment
Sample is often the liquid such as blood, saliva, and therefore, the depressed body of the housing unit is deep hole specification, cracking for sample,
With reference to, washing and elution;Direct injected after sample is handled in deep-well plates eliminates pipette samples back and forth, puts sample, lid lid
Son inserts the cumbersome work such as interpolation pipe, cleaning bottle;
Further, if sample size is less than 24, most of user will not select self-reacting device to operate substantially, and
And the operating quantity of general centrifuge is 24 times, therefore the deep-well plates preferably have 24 independent apertures, also, individually
24 hole depth orifice plates can be very easy to use with individual packages.
The adaptive sample panel of flux provided by the utility model further includes cover board 3, the cover board and the housing unit
Match, for sealing the housing unit, so as to carry out sample grinding, and/or test the preservation of final product;
Further, the cover board is matched widenable to the sample panel, to adapt to the variation of sample size.
The adaptive sample panel of flux provided by the utility model, which is characterized in that further include isolated location 4, the isolation
Unit matches with the depressed body size, and the isolated location is matched with laboratory apparatus, for when being tested, keeping away
Exempt from the sample in the depressed body directly to contact with the laboratory apparatus and sample is caused to pollute.
Since automatic extracting instrument, such as the instrument for extracting nucleic acid based on magnetic bionanoparticles are generally selected in Bioexperiment, therefore,
In order to avoid, because instrument bar magnet is in direct contact sample, sample being caused to pollute, while reduce conventional efficient etc. and ask in experimentation
Topic, the isolated location is preferably bar magnet set, and the bar magnet set is on the bar magnet of the extraction apparatus, and the bar magnet set is with matching
The bar magnet size of the instrument for extracting nucleic acid of set is coincide, and to ensure that bar magnet will not be contacted with the liquid in sample, and is ensured between sample
It will not pollute mutually.
It is described further below in conjunction with specific embodiment:
Embodiment one:
A kind of adaptive sample panel of flux, including:Sample housing unit 1, adapter rack 2, cover board 3 and isolated location 4;
Wherein:The sample panel for being integrated into default specification is expanded in the multiple sample housing unit auxiliary splicing, it is preferable that institute
It states sample panel to further include for assisting the adapter rack spliced, the adapter rack includes multiple housing units according to default specification and installs
Hole, each of which mounting hole is for installing unique sample housing unit, so that its joint face of the multiple housing unit
The sample panel for being integrated into default specification is expanded in auxiliary splicing;
Further, in the present embodiment, the adapter rack be instrument adapter rack, the instrument adapter rack external dimensions with
Mating instrument for extracting nucleic acid is mating, after can ensureing that 24 hole depth orifice plates are placed wherein, the center of each aperture and instrument for extracting nucleic acid
On the center of bar magnet be concentric;And the hole position that there are four the instrument adapter racks side by side, each hole position can be put into one
A 24 hole depth orifice plate, 4 holes position, once can at least operate 24 samples, can at most operate 96 samples altogether.
The sample housing unit is 24 hole depth orifice plates, has 24 independent apertures, and the volume of each aperture is
2ml, for the cracking of sample, combination, washing and elution;
Individual 24 hole depth orifice plate can be 3*8 specifications, 4*6 specifications or other specifications, also, individual 24 hole depth orifice plate
It can be with individual packages.
The cover board is deep-well plates lid, and the deep-well plates lid is consistent with 24 hole depth plate sizes, and quantity corresponds to, the deep hole
Plate lid is used cooperatively with the 24 hole depth orifice plate, can be used for:1. the grinding of sample in the nucleic acid extraction first step, 2. nucleic acid extraction
In final step, the preservation of the final product of extraction.
The isolated location is bar magnet set, and the bar magnet set is consistent with 24 hole depth plate sizes, and quantity corresponds to, the bar magnet
Set is matched with the 24 hole depth orifice plate, for minimum primary operable 24 samples, at most can once operate 96 samples
Product.The bar magnet of the bar magnet set and mating instrument for extracting nucleic acid can coincide, and can ensure that bar magnet will not be with the liquid in sample
Contact, and ensure to pollute mutually between sample.
Carry out the poba gene group DNA's with 48 samples using the adaptive sample panel of flux provided by the utility model
Extraction experiment:
User, which will need 48 blood samples extracting to be separately added into packing in advance, has 2 24 hole depth orifice plates of lysate each
It in sample hole, marks, then 24 hole depth orifice plate of above-mentioned two is placed on to 2 Kong Weizhong of instrument adapter rack, will be equipped with deep
The instrument adapter rack of orifice plate is positioned on the station of instrument for extracting nucleic acid, selects 2 magnetic consistent with above-mentioned 24 hole depth orifice plate specification
Stick set, is installed on the bar magnet of instrument for extracting nucleic acid, it is made to be matched with sample size;Then start extraction procedure, be after forty minutes
48 nucleic acid extractives can be obtained on final station, at this point it is possible to 2 with the cover boards of 24 hole depth orifice plate units specifications by 2
A 24 hole depth orifice plate covers, and is temporarily stored into temperature setting as 4 degree of refrigerators.
Certainly, can be 1*8 specifications by deep-well plates specifications design, 4*6 according to user demand and the change of sample size
Adaptation frame aperture position can also be designed as 4,6,8 equal-specifications, to adapt to sample number by the different sizes such as specification, 2*6 specifications
The change of amount.For example, when needing to carry out 96 sample experiments, the deep-well plates of 4 4*6 specifications can be selected, are positioned over adaptation
Mating cover board and bar magnet set specification so as to be expanded, also, are also synchronized expansion by 4 Kong Weizhong of frame;Work as needs
When carrying out 32 sample experiments, the deep-well plates of 4 1*8 specifications can be selected, are positioned over 4 Kong Weizhong of adapter rack, thus into
Row is expanded, also, mating cover board and bar magnet set specification are also synchronized expansion;The change of other sample sizes can lead to
It crosses similar mode to be expanded, so as to which volume completes experiment.
Embodiment two:
A kind of adaptive sample panel of flux, including:Sample housing unit 1, cover board 3 and isolated location 4;Wherein:
The multiple housing unit, joint face have splicing construction to expand the sample panel for default specification from splicing,
The splicing construction is buckle structure, spoke structure or tongue structure;
Further, in the present embodiment, the splicing construction is buckle structure, more specifically, the housing unit,
Joint face is provided with tongue on one side, and another side is set as the connecting groove agreed with the tongue;
The sample housing unit is deep-well plates, has 8 independent apertures, the volume of each aperture is 2ml, is used for
Cracking, combination, washing and the elution of sample;
Individual deep-well plates can be 1*8 specifications, also, individually deep-well plates can be with individual packages.
The cover board is deep-well plates lid, and the deep-well plates lid is consistent with deep hole board size, and quantity corresponds to, the deep-well plates lid
It is used cooperatively, can be used for the deep-well plates:1. the grinding of sample in the Protein Extraction first step, 2. Protein Extraction is last
In one step, the preservation of the final product of extraction.
The isolated location is bar magnet set, and bar magnet set is consistent with deep hole board size, and quantity corresponds to, the bar magnet set and
The deep-well plates match, for minimum primary operable 8 samples;The magnetic of the bar magnet set and mating instrument for extracting nucleic acid
Stick can coincide, and can ensure that bar magnet will not be contacted with the liquid in sample, and ensure to pollute mutually between sample.
The automation protein purification with 16 samples is carried out using the adaptive sample panel of flux provided by the utility model
Experiment:
User will need extract 16 to express the E. coli Culture Samples for having target protein and be separately added into advance to divide
It in 2 deep-well plates various kinds holes equipped with lysate, marks, centrifuges, remove culture medium supernatant, add in cell pyrolysis liquid, so
Above-mentioned 2 deep-well plates are connected through to the click-on design in face afterwards, splicing is assembled into the sample panel of 2*8 specifications, then by sample
Plate is positioned on the station of extraction apparatus, selects 2 bar magnet sets consistent with above-mentioned deep-well plates specification, is installed on the bar magnet of extraction apparatus
On, it is made to be matched with sample size;Then start extraction procedure, can obtain protein extraction on final station after sixty minutes
Object at this point it is possible to be covered 2 deep-well plates with the cover board of 2 and deep-well plates units specification, deposits in the environment of -20 degree.
Certainly, can be 1*8 specifications by deep-well plates specifications design, 4*6 according to user demand and the change of sample size
The sample housing unit joint face, can also be designed as spoke structure by the different sizes such as specification, 2*6 specifications, buckle structure,
To adapt to the change of sample size.For example, when needing to carry out 96 sample experiments, the deep hole of 4 4*6 specifications can be selected
Plate, the mode of being connected by a snap carries out expansion splicing, also, mating cover board and bar magnet set specification are also synchronized expansion;
When needing to carry out 32 sample experiments, the deep-well plates of 4 1*8 specifications can be selected, are expanded by spoke connection mode
Splicing, also, mating cover board and bar magnet set specification are also synchronized into expansion;The change of other sample sizes can pass through
Similar mode is expanded, so as to which volume completes experiment.
As it will be easily appreciated by one skilled in the art that the above is only the preferred embodiment of the utility model only, not
To limit the utility model, any modification made within the spirit and principles of the present invention, equivalent replacement and change
Into etc., it should be included within the scope of protection of this utility model.