CN207472888U - Everted gut sac auxiliary device in a kind of in vitro intestinal absorption research of drug - Google Patents
Everted gut sac auxiliary device in a kind of in vitro intestinal absorption research of drug Download PDFInfo
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- CN207472888U CN207472888U CN201721710463.2U CN201721710463U CN207472888U CN 207472888 U CN207472888 U CN 207472888U CN 201721710463 U CN201721710463 U CN 201721710463U CN 207472888 U CN207472888 U CN 207472888U
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- glass bar
- bar ontology
- lug boss
- longitudinal cross
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Abstract
The utility model is related to Everted gut sac auxiliary devices in a kind of in vitro intestinal absorption research of drug, including glass bar ontology, the glass bar ontology is cylinder, the mastoid process shape lug boss extended along glass bar body length direction is equipped in a side end face of glass bar ontology, and the longitudinal cross-section product of lug boss is accumulated more than the longitudinal cross-section of glass bar ontology, recessed portion is equipped between glass bar ontology and lug boss, and the diameter of recessed portion is less than the diameter of glass bar ontology.The utility model makes intestines capsule be easier to be set on the end of glass bar by the lug boss of mastoid process shape, and survivable intestinal wall, meanwhile, glass bar is made to be easier to make for fixing with intestines capsule by recessed portion.
Description
Technical field：
The utility model belongs in vitro intestines capsule absorption experiment technical field, and in particular to a kind of in vitro intestinal absorption research of drug
Middle Everted gut sac auxiliary device.
Background technology：
In medicine and field of biology, enteron aisle is in the absorption and dynamics research of drug, nutrient etc., the side of generally use
Method includes body intestines circumfluence method, intestinal loop method, isolated mucosa, outer everted-gut technique and Caco-2 cell model methods etc., and for
In vitro intestinal absorption research uses outer everted-gut technique more.Outer everted-gut technique is one that Wilson in 1954 and Wiseman are established
The method of kind research intestinal absorption characteristic, animal is first anaesthetized and is immediately disconnected small intestine under non-pain state by this method, by intestines
Capsule one end is placed on glass bar, is turned up, then be placed in the K-R solution containing drug after other end ligation, periodically intracapsular outer from intestines
Both sides sample, and measure a kind of physiological test method of drug concentration change.In view of tissue activity, experimental period should not mistake
It is long.However during the real experimental implementation of outer Everted gut sac, the problem of being commonly encountered is between one side glass bar and intestines capsule
It is not fixed easily, it is easy to fall off, and intestines capsule rollover effect is bad；The end of another aspect glass bar is not easy by intestines cuff, Er Qierong
Destructible intestinal wall.
Utility model content：
The utility model provides a kind of intestines capsule and is easy to fixed with glass bar, and convenient for intestines capsule to overcome drawbacks described above
Everted gut sac auxiliary device in the in vitro intestinal absorption research of drug overturn.
The technical solution adopted in the utility model is：Everted gut sac auxiliary dress in a kind of in vitro intestinal absorption research of drug
It puts, including glass bar ontology, the glass bar ontology is cylinder, is equipped in a side end face of glass bar ontology along glass bar sheet
The mastoid process shape lug boss of body length direction extension, and the longitudinal cross-section product of lug boss is accumulated more than the longitudinal cross-section of glass bar ontology,
Recessed portion is equipped between glass bar ontology and lug boss, and the diameter of recessed portion is less than the diameter of glass bar ontology.
Preferably, the lug boss include front end protrusion and with raised connected horizontally central raised, the middle part in front end
Protrusion connect with recessed portion, it is central raised be spheroidal, the front end protrusion be semiellipsoid, the front end protrusion longitudinal cross-section
Diameter is less than central raised longitudinal cross-section diameter.
Preferably, the longitudinal cross-section diameter of the front end protrusion is to be gradually reduced along glass bar body length direction.
The beneficial effects of the utility model are：
1st, the end of glass bar is designed to the lug boss of mastoid process shape by the utility model, and the longitudinal cross-section product of lug boss is more than
The longitudinal cross-section product of glass bar ontology, the lug boss of the mastoid process shape make intestines capsule be easier to be set on the end of glass bar, while again
Survivable intestinal wall.
2nd, in order to make preferably be fixed between intestines capsule and glass bar, mastoid process shape lug boss and glass bar ontology it
Between be equipped with recessed portion, and the diameter of recessed portion is less than the diameter of glass bar ontology, by cord by intestines capsule and glass bar into line position
When putting fixed, recessed portion makes the two be easier to make for fixing.
3rd, two improvements can speed up the actual mechanical process of this experiment, greatly shorten needed for Everted gut sac when
Between.
Description of the drawings：
Fig. 1 is the structure diagram of the utility model；
Fig. 2 is the location diagram of glass bar and intestines capsule under traditional approach；
Fig. 3 is the location diagram of the utility model and intestines capsule；
Wherein：1 glass bar, 1.1 glass bar ontologies, 1.2 recessed portions, 1.3 lug bosses, 1.31 front ends protrusion, 1.32 middle parts
Protrusion, 2 intestines capsules.
Specific embodiment：
As shown in Figure 1 to Figure 3, the utility model is Everted gut sac auxiliary device in a kind of in vitro intestinal absorption research of drug,
Including glass bar ontology 1.1, the glass bar ontology 1.1 is cylinder, when carrying out outer Everted gut sac using conventional method, one
As using common experimental glass stick 1, but due to being not easy to put between glass bar 1 and intestines capsule 2, and the end of glass bar 1
The inner wall of intestines capsule 2 is easily destroyed, therefore on the end for being set to glass bar 1 to be easier intestines capsule 2, while survivable intestines again
One end of glass bar 1 is improved by wall, the utility model, is equipped in a side end face of glass bar ontology 1.1 along glass bar sheet
The mastoid process shape lug boss 1.3 of 1.1 length direction of body extension, and the longitudinal cross-section product design of lug boss 1.3 is more than glass bar ontology
1.1 longitudinal cross-section product, the structure make the end of glass bar 1 play a supporting role after stretching into for 1.1 part of glass bar ontology.For
Make preferably to be fixed between intestines capsule 2 and glass bar 1, recess is equipped between glass bar ontology 1.1 and lug boss 1.3
Portion 1.2, and the diameter of recessed portion 1.2 is less than the diameter of glass bar ontology 1.1, by cord by intestines capsule 2 and glass bar 1 into line position
When putting fixed, recessed portion 1.2 makes the two be easier to make for fixing.
In order to which the lug boss 1.3 for making mastoid process shape stretches into survivable intestinal wall after intestines capsule 2, lug boss 1.3 includes front end protrusion
1.31 and central raised 1.32, front end protrusion 1.31, central raised 1.32, recessed portion 1.2 and glass bar ontology 1.1 are horizontal successively
Connection, described central raised 1.32 be spheroidal, and front end protrusion 1.31 is semiellipsoid, and the longitudinal direction of front end protrusion 1.31
Diameter of section is less than central raised 1.32 longitudinal cross-section diameter, and the design of arc-shaped end makes glass bar 1 be connect with 2 inner wall of intestines capsule
It is more lubricated when tactile, intestinal wall will not be scratched.More smooth, front end protrusion when stretching into intestines capsule 2 for the end for making glass bar 1
1.31 longitudinal cross-section diameter is along 1.1 length direction of glass bar ontology to be gradually reduced.
The course of work：
In use, first opening abdominal cavity takes out small intestine, 2 side of intestines capsule is placed on rapidly by lug boss 1.3 on glass bar 1, when
After intestines capsule 2 reaches recessed portion 1.2, intestines capsule 2 is fixed at recessed portion 1.2 by cord, then rapidly turns over intestines capsule 2
Turn.
The preferable specific embodiment of the above, only the utility model, these specific embodiments are all based on this
Different realization methods under utility model general idea, and the scope of protection of the utility model is not limited thereto, it is any ripe
It knows in the technical scope that those skilled in the art disclose in the utility model, the change or replacement that can be readily occurred in, all
It should cover and be within the protection scope of the utility model.Therefore, the scope of protection of the utility model should be with claims
Subject to protection domain.
Claims (3)
1. Everted gut sac auxiliary device in a kind of in vitro intestinal absorption research of drug, including glass bar ontology (1.1), feature exists
In：The glass bar ontology (1.1) is cylinder, is equipped in a side end face of glass bar ontology (1.1) along glass bar ontology
(1.1) the mastoid process shape lug boss (1.3) of length direction extension, and the longitudinal cross-section product of lug boss (1.3) is more than glass bar ontology
(1.1) longitudinal cross-section product, is equipped with recessed portion (1.2), and recessed portion between glass bar ontology (1.1) and lug boss (1.3)
(1.2) diameter is less than the diameter of glass bar ontology (1.1).
2. Everted gut sac auxiliary device in the in vitro intestinal absorption research of a kind of drug as described in claim 1, it is characterised in that：Institute
It states lug boss (1.3) and includes front end raised (1.31) and central raised (1.32) connected horizontally, the institute with front end raised (1.31)
It states central raised (1.32) to connect with recessed portion (1.2), central raised (1.32) are spheroidal, and the front end raised (1.31) are
Semiellipsoid, raised (1.31) longitudinal cross-section diameter in the front end are less than the longitudinal cross-section diameter of central raised (1.32).
3. Everted gut sac auxiliary device in the in vitro intestinal absorption research of a kind of drug as claimed in claim 2, it is characterised in that：Institute
The longitudinal cross-section diameter of front end raised (1.31) is stated along glass bar ontology (1.1) length direction to be gradually reduced.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721710463.2U CN207472888U (en) | 2017-12-11 | 2017-12-11 | Everted gut sac auxiliary device in a kind of in vitro intestinal absorption research of drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721710463.2U CN207472888U (en) | 2017-12-11 | 2017-12-11 | Everted gut sac auxiliary device in a kind of in vitro intestinal absorption research of drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207472888U true CN207472888U (en) | 2018-06-08 |
Family
ID=62257878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721710463.2U Active CN207472888U (en) | 2017-12-11 | 2017-12-11 | Everted gut sac auxiliary device in a kind of in vitro intestinal absorption research of drug |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207472888U (en) |
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2017
- 2017-12-11 CN CN201721710463.2U patent/CN207472888U/en active Active
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