CN207356366U - A kind of divergence type brain pacemaker - Google Patents
A kind of divergence type brain pacemaker Download PDFInfo
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- CN207356366U CN207356366U CN201720167776.1U CN201720167776U CN207356366U CN 207356366 U CN207356366 U CN 207356366U CN 201720167776 U CN201720167776 U CN 201720167776U CN 207356366 U CN207356366 U CN 207356366U
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Abstract
The utility model proposes a kind of divergence type brain pacemaker, including at least a pair of interior electrode for being used to be embedded on skull, the interior electrode is made of titanium alloy layer parcel neodymium-iron-boron magnetic material, electrode can be formed through scalp with the first external electrode being removably arranged on the left temporo side scalp of head and is electrically connected in be wherein used to be embedded on the left temporo laterocranium bone of head first, the second inner electrode for being embedded on the right temporo laterocranium bone of head can be formed with the second external electrode being removably arranged on the right temporo side scalp of head through scalp to be electrically connected, the first external electrode and the second external electrode are connected to the positive and negative anodes of Pulser apparatus through conducting wire respectively.Divergence type brain pacemaker involved by the utility model is performed the operation not open cranium, it is simple and safe, Small side effects, it is cheap, easy to use, efficacy result is good, and therapeutic domain is wide, it changes the abnormal electrical activity of cerebral nerve fiber using the physical action of magnetic field and electric field, so as to treat a series of thus caused the nervous system diseases.
Description
Technical field
It the utility model is related to the field of medical instrument technology, more particularly to a kind of divergence type brain pacemaker.
Background technology
The movement of human body is completed by the contraction and diastole of muscle, and the contraction and diastole of muscle are by receiving the telecommunications of brain centres
Number realize, commanding and coordinating human body movement has two maincenters, i.e. pyramidal system and extrapyramidal system, the two maincenters provide spy respectively
Determine the electric signal instruction of frequency and amplitude, target spot, commander and the contraction and diastole for coordinating muscle reached by downlink nerve fibre,
Keep the muscular strength and Muscle tensility of normal condition.If above-mentioned two maincenter reactivity under the action of pathogenic factor is overexcited,
Too strong aberrant electrical signals will be provided, target spot muscle receives such too strong electric signal, execute instruction, and muscle is excessively received
Contracting, hypermyotonia, human body occur as soon as pathological state.If pyramidal system provides this aberrant electrical signals, muscle will be received excessively
Contracting has a convulsion, and here it is the pathologic basis of epilepsy invasion.Flesh occurs if extrapyramidal system provides this aberrant electrical signals
Tension force increases or dysequilibrium, and here it is the pathologic basis of the diseases such as Parkinson, myodystony, incoordination, chorea.
In medical industry, the doctor such as maincenter type brain pacemaker (DBS) can be used by being directed to the nervous system diseases such as Parkinson
Treat equipment to be treated, maincenter type brain pacemaker considers the specific god using electric pulse local excitation brain deep from physics angle
Certain clinical effectiveness is achieved through tissue treatment the nervous system disease.DBS is by interior electrode, conducting wire and Pulser apparatus three parts
Form.Interior electrode is implanted into encephalic nerve fiber privileged site by opening cranium, and Pulser apparatus is implanted under pectoralis major, and conducting wire is then implanted into
Subcutaneously to connect Pulser apparatus and interior electrode.Its main operational principle is that Pulser apparatus provides pulse electrical signal by leading
Line reaches the specific cranial nerve of interior electrode pair and carries out electric-impulse stimulation, so as to achieve the purpose that to treat disease.
The main deficiency of DBS is:1st, operation risk is big:DBS Pulser apparatus, conducting wire and interior electrode connect together,
It is required for implanting, it is big opens cranium risk.2nd, price:The material requirements that implants is high, price, and operation is big, medical expense
It is high.3rd, therapeutic effect:It is limited to treat disease.
Utility model content
In order to solve the problems in the existing technology, the utility model proposes a kind of cheap, easy to use, peace
Full Small side effects and the wide divergence type brain pacemaker of therapeutic domain.
To achieve these goals, the utility model proposes a kind of divergence type brain pacemaker, including at least a pair is used for
The interior electrode being embedded on skull, the interior electrode is made of titanium alloy layer parcel neodymium-iron-boron magnetic material, wherein for inlaying
On the left temporo laterocranium bone of head first in electrode and the first external electrode that is removably arranged on the left temporo side scalp of head
It can be formed and be electrically connected through scalp, for the second inner electrode being embedded on the right temporo laterocranium bone of head and removably be arranged on head
The second external electrode on the scalp of right temporo side can be formed through scalp to be electrically connected, and the first external electrode and the second external electrode are respectively through leading
Line is connected to the positive and negative anodes of Pulser apparatus.
Preferably, the interior electrode is in button cell shape, its a diameter of 10 ~ 12mm, thickness is 3 ~ 7mm, and the titanium closes
The thickness of layer gold is 0.03 ~ 0.05mm.
Preferably, the divergence type brain pacemaker includes two pairs to five inner electrodes, except electrode in described first and the
In two outside electrode, the divergence type brain pacemaker is further included to be embedded in skull top and/or occipital lobe for symmetrical
Electrode.
Preferably, the first external electrode and the second external electrode use silver electrode.
The beneficial effect of the program of the utility model is that above-mentioned divergence type brain pacemaker is performed the operation not open cranium, simple peace
Entirely, Small side effects, cheap, easy to use, efficacy result is good, and therapeutic domain is wide, it is made using the physics of magnetic field and electric field
For changing the abnormal electrical activity of cerebral nerve fiber, so as to treat a series of thus caused the nervous system diseases.
Brief description of the drawings
Fig. 1 shows that the interior electrode involved by the utility model is embedded in the structure diagram on skull.
Fig. 2 shows the structure of divergence type brain pacemaker and the schematic diagram of use state involved by the utility model.
Fig. 3 shows the cure mechanism schematic diagram of the divergence type brain pacemaker involved by the utility model.
Reference numeral:1- Pulser apparatus, 2- the first external electrodes, electrode in 3- first, 4- the second inner electrodes, outside 5- second
Electrode, 6- conducting wires, 7- nerve fibres, electrode in 8- the 3rd, electrode in 9- the 4th.
Embodiment
Specific embodiment of the present utility model is further described below in conjunction with the accompanying drawings.
As shown in Figure 1, divergence type brain pacemaker (the Transcranial magnetic involved by the utility model
Electric stimulation, TMES) include an at least inner electrode, the interior electrode is to wrap up neodymium iron boron by titanium alloy layer
Magnetic material is formed, and the effect in this interior existing magnetic field of electrode plays the role of conduction again, so electrode also referred to as in magnetic field,
In the present embodiment, the interior electrode is in button cell shape, its a diameter of 10 ~ 12mm, thickness is 3 ~ 7mm, the titanium alloy layer
Thickness is 0.03 ~ 0.05mm.In specific treatment, the quantity of the interior electrode can be determined according to the head size of patient,
A pair can generally be used, and to five inner electrodes, interior electrode needs to be embedded in the skull of patient respectively by Minimally Invasive Surgery
On, electrode needs to be embedded on the skull of head or so temporo side in one pair of which, which is denoted as 3 He of electrode in first
The second inner electrode 4;When the divergence type brain pacemaker includes two pairs to five inner electrodes, except electrode 3 in described first and the
In two outside electrode 4, the divergence type brain pacemaker is further included to be embedded in skull top and/or occipital lobe for symmetrical
Electrode.In this example, it is assumed that using two inner electrodes, including electrode 3 in first, electrode 8 in the second inner electrode the 4, the 3rd
And electrode 9 in the 4th, electrode 9 is symmetrical as needed is embedded in patient's skull in electrode 8 and the 4th in the described 3rd
Top.
As shown in Fig. 2, the divergence type brain pacemaker further includes a pair of of external electrode(It is denoted as outside the first external electrode 2 and second
Electrode 5)With Pulser apparatus 1, in the present embodiment, the first external electrode 2 and the second external electrode 5 use silver electrode, described
A pair of of external electrode is removably arranged on the scalp of head or so temporo side(For example with the mode of headgear), it is comfortable in order to increase
Degree, can set conductive sponge in external electrode and scalp contact position.Electrode 3 and the second inner electrode 4 can be distinguished in described first
Formed and be electrically connected with the first external electrode 2 and the second external electrode 5 through scalp, the first external electrode 2 and the second external electrode 5 pass through respectively
Conducting wire 6 is connected to the positive and negative anodes of the Pulser apparatus 1, and the Pulser apparatus 1 can be used pacifies rich electricity by Weihai hospital of Guoan
The Pulser apparatus of the model GY-V of sub- Co., Ltd's development & production.
When treating disease, can only be treated using the interior electrode being embedded in skull, it passes through the interior electrode
The magnetostatic field of generation has an impact come the conduction to nerve fibre, and then corrects brain abnormal electrical activity, eliminates slow wave, reduces thin
Born of the same parents' excitability, as shown in figure 3, its specific cure mechanism is as follows:Carrier in nerve fibre 7 is done in the absence of a magnetic field
Linear motion, after electrode applies magnetic field in insertion, carrier is subject to the effect of Lorentz force into magnetic field and that track occurs is inclined
Move, and charge accumulated is produced in nerve fibre both sides, form the electric field perpendicular to current direction, the Lip river for being finally subject to carrier
Lun Zili balances each other with electric field repulsion, so as to set up a stable electrical potential difference i.e. Hall voltage in nerve fibre both sides.Suddenly
Your galvanomagnetic-effect changes the conductive process of nerve fibre 7, is suppressed overwrought abnormal current conduction.On the other hand
Magnetic field can make cerebral nervous system that a series of biochemical changes occur, and mainly dopamine suppresses mediator increase, and acetylcholine is emerging
Putting forth energy property mediator is reduced, it is suppressed that cell excitability.But only using the interior electrode being embedded in skull treated as control
Therapeutic effect is relatively weak.
Divergence type brain pacemaker involved by the utility model is by the first external electrode 2 and when treating disease
Two external electrodes 5 are separately fixed on the scalp of head or so temporo side, the Pulser apparatus 1 is provided pulse current, the arteries and veins afterwards
Rush electric current and be transmitted to the first external electrode 2 through conducting wire 6, made by the electric action of scalp electric in the first external electrode 2 and first
Pole 3 connects, and pulse current just is directed into encephalic at this time, which is exported after brain by the second inner electrode 4, it
The anode of the Pulser apparatus 1 is flowed to by scalp, the second external electrode 5 and conducting wire 6.
In first electrode 3 and the second inner electrode 4 have pulse current by when, just generate pulsed magnetic field, pulsed magnetic field
Penetrate radius bigger, magnetic force is stronger, this just cause in the described 3rd in electrode 8 and the 4th electrode 9 produce it is magnetostatic
While field, electrode 3 and the second inner electrode 4 produce pulsed magnetic field in described first, to increase the magnetic field applied to patients head
Intensity, increases the dynamics for the treatment of.
The cerebral tissue of normal condition servant is wrapped by skull, and the resistance of skull is larger, and impressed current is not easily accessible
Encephalic, so DBS need to get through skull and interior electrode is placed in brain tissue, and TMES is maximum by resistance value during electrode in implantation
Skull cortex is removed, and resistance value greatly reduces.By being measured to 1212 preoperative and postoperative patient's skull resistance values, post-surgery skull resistance value ratio
Preoperative averagely to reduce 68%, such pulse current enters encephalic with regard to that can pass through skull, realizes and the electricity of cranial nerve tissue is pierced
Swash, it is this to stimulate the only partial points different from DBS to stimulate, but a comprehensive brain stimulation, clinical effectiveness are more preferable.When without using this
During divergence type brain pacemaker involved by utility model, the first external electrode 2 and the second external electrode 5 are removed, it is and described interior
Electrode separation.
Divergence type brain pacemaker cure mechanism involved by the utility model is as follows:
(1)Magnetic fields:
After the divergence type brain pacemaker involved by the utility model is used, electrode 9 in electrode 8 and the 4th in the described 3rd
While producing magnetostatic field, electrode 3 and the second inner electrode 4 have pulse current by producing pulsed magnetic field in described first, so
After applying magnetic field to patient's skull, Hall galvanomagnetic-effect will occur, as shown in figure 3, the carrier in nerve fibre 7 is not having
Move along a straight line in the case of magnetic field, after magnetic field is applied, carrier is subject to the effect of Lorentz force into magnetic field and rail occurs
Trace displacement, and charge accumulated is produced in nerve fibre both sides, the electric field perpendicular to current direction is formed, is finally subject to carrier
Lorentz force balance each other with electric field repulsion so that set up in nerve fibre both sides a stable electrical potential difference i.e. Hall electricity
Pressure.Hall galvanomagnetic-effect changes the conductive process of nerve fibre 7, is suppressed overwrought abnormal current conduction.Separately
One side magnetic field can make cerebral nervous system that a series of biochemical changes occur, and mainly dopamine suppresses mediator increase, acetyl
Choline excitatory transmitter is reduced, it is suppressed that cell excitability.Here it is the theoretical foundation of TMES applying a magnetic fields treatment disease.
(2)Electric field action:Two external electrodes of TMES are respectively acting on the two temporo side of left and right of patient, and Pulser apparatus 1 is sent out
The supraliminal stimulus equal to or more than normal brain wave frequency is put, falls the brain wave frequency increase in slow wave repolarization relative refractory period, it is different
Normal slow wave reduces or eliminates, and cell excitability declines.Another aspect electro photoluminescence makes the synthesis increase of the inhibitory transmitters such as dopamine, second
Phatidylcholine excitatory transmitter declines, cause post-synapse film potential process to suppress, and cell excitability declines.Pulse current at the same time
Pulsed magnetic field is generated when passing through magnetostatic field, adds the magnetic field intensity of moment, enhances the effect in magnetic field.Electric field and magnetic field
Collective effect curative effect is more prominent.
Compared with maincenter type brain pacemaker (DBS), the divergence type brain pacemaker involved by the utility model mainly has following
Advantage:
(1)Interior electrode is implanted into skull --- and without opening cranium, operation is simple, Small side effects;
(2)Pulser apparatus and conducting wire be in vitro --- and it is cheap using common material;
(3)External charging --- it is easy to use, replace battery without performing the operation again;
(4)Magnetic fields --- Hall effect suppresses brain electricity new concept;
(5)Electric field action --- full electrical brain stimulation, sphere of action are wide;
(6)Magnetic field electric field collective effect --- function doubles, better efficacy;
(7)Electric field magnetic field can unicom separate --- novel, scientific structure.
Divergence type brain pacemaker involved by the utility model is set based on nerve fibers conduct there are Hall galvanomagnetic-effect
Meter, this effect can correct brain abnormal electrical activity, eliminate slow wave, reduce cell excitability, the divergence type brain pacemaker energy
Enough treat epilepsy, Parkinson, stroke hemiplegia, myodystony (Meijer's syndrome, accessory cramp, torsion-spasm), mutual aid
The diseases such as imbalance, chorea, Gilles de la Tourette's syndrome, brain paralysis, encephalatrophy, essential tremor.
The therapeutic effect of divergence type brain pacemaker for many years involved by the utility model is summarized as follows:
(1)Epileptics:Epileptic from January, 2007 to diagnosis and treatment in January, 2,010 1085, all cases meet state
Border anti-epileptic alliance classifies and 2001 editions diagnostic criteria of the term committee, and man 689, female 396, at 5 months ~ 83 years old age, put down
Equal 23.4 years old, the course of disease 10 days ~ 30 years was 10.9 average.Tonic 690, simple partial seizure 79, part
Property the secondary Generalized seizure 83 of breaking-out, complex partial seizures 233.Wherein idiopathic epilepsy 669, secondary epilepsy
416.All patients do 16 lead brain electrical activity mapping inspection of standard before and after treatment, and 6 months ~ 10 annual bearing of follow-up is as follows:Breaking-out
Stop 749 (69.03%), effective 205(18.89%) it is, effective 106 (9.77%), invalid 25 (2.31%).
Electroencephalogram changes:Inspection electroencephalogram topographic map before treatment, severe abnormality 158, moderate abnormality 179 are slight different
Normal 400, normal 348,30 minutes check electroencephalograms after treatment, severe abnormality 11, declines 93.04%, moderate abnormality 61
Example, declines 65.92%, mile abnormality 165, declines 58.75%, do not change normally.
(2)Parkinson's:Parkinsonian from January, 2010 to diagnosis and treatment in May, 2,016 698, all case symbols
Britain think-tank PD diagnostic criteria is closed, man 387, female 311 is 35 ~ 85 years old age, 67 years old average, the course of disease 8 years, follow-up 6 months ~
7 years.Symptom disappears 79 (11.32%) after treatment, and the big portion of symptom disappears 193 (27.65%), symptom partial disappearance 292
(41.83%), symptom is without change 134 (19.20%).
(3)Essential tremor:It is 66 male from January, 2010 to the essential tremor patient 115 of diagnosis and treatment in May, 2016,
Female 49,20 ~ 75 years old age, 67.1 years old average, the course of disease 7.8 years, follow-up 6 months ~ 7 years.Symptom disappears 7 after treatment
(6.09%), the big portion of symptom disappears 24 (20.87%), and symptom partial disappearance 64 (55.65%), symptom is without change 20
(17.39%)。
(4)Cerebral apoplexy:Patients with cerebral apoplexy from January, 2010 to diagnosis and treatment in May, 2,016 1101, all cases through CT or
MRI is diagnosed as cerebral apoplexy, wherein hemorrhagic apoplexy 369, cerebral arterial thrombosis 732, man 598, female 503, age
It is 33 ~ 82 years old, 56.7 years old average, the course of disease 4.2 years, follow-up 6 months ~ 7 years.Drawn according to the grade scale of British Medical Research Council
It is divided into 0 ~ 5 grade, it is as follows that pretherapy and post-treatment homonymy muscular strength changes result:Muscular strength improves 5 grades 5 (0.45%), and muscular strength improves 4 grades 12
(1.09%), muscular strength improves 3 grades 37 (3.36%), and muscular strength improves 2 grades 370 (33.61%), and muscular strength improves 1 grade 535
(48.59%), muscular strength improves 0 grade 142 (12.90%).
(5)Myodystony:Patients with dystonia from January, 2010 to diagnosis and treatment in May, 2,016 311, institute are ill
Example meets《Neurology》(2006 the 1st edition) diagnostic criteria, wherein Meijer's syndrome 146, accessory cramp 91, is reversed
Spasm 74.
(a)Meijer's syndrome 146, man 52, female 94, at 19 ~ 74 years old age, 55.3 years old average, the course of disease 4.7 years, is controlled
Follow-up 6 months ~ 7 years after treatment.Symptom disappears 22 (15.07%) after treatment, and the big portion of symptom disappears 75 (51.36%), symptom portion
Divide and disappear 33 (22.60%), symptom is without change 16 (10.96%).
(b)Accessory cramp 91, man 47, female 44 is 11 ~ 71 years old age, 41.5 years old average, the course of disease 4.9 years, treatment
Follow-up 6 months ~ 7 years afterwards.Symptom disappears 19 (20.88%) after treatment, and the big portion of symptom disappears 47 (51.65%), symptom part
Disappear 16 (17.58%), symptom is without change 9 (9.89%).
(c)Torsion-spasm 74, man 46, female 28 is 11 ~ 65 years old age, 32.4 years old average, the course of disease 4.2 years, after treatment
Follow-up 6 months ~ 7 years.Symptom disappears 12 (16.21%) after treatment, and the big portion of symptom disappears 34 (45.95%), and symptom part disappears
Lose 16 (21.62%), symptom is without change 14 (18.92%).
(6)Incoordination:From in January, 2010 to diagnosis and treatment in May, 2016 related ataxia 292, man 173, female 119
Example, 4 ~ 72 years old age, 46.2 years old average, the course of disease 6.4 years, follow-up 6 months ~ 7 years.Symptom disappears 3 (1.02%) after treatment, disease
The big portion of shape disappears 34 (11.64%), and symptom partial disappearance 87 (29.79%), symptom is without change 168 (57.55%).
(7)Chorea:From in January, 2010 to the dancing patient 67 of diagnosis and treatment in May, 2016, man 35, female 32, year
It is 21 ~ 72 years old age, 43.6 years old average, the course of disease 3.7 years, follow-up 6 months ~ 7 years after treatment.Symptom disappears 2 (2.99%) after treatment,
The big portion of symptom disappears 32 (47.76%), and symptom partial disappearance 21 (31.34%), symptom is without change 12 (17.91%).
(8)Gilles de la Tourette's syndrome:From in January, 2010 to the Gilles de la Tourette's syndrome patient 39 of diagnosis and treatment in May, 2016,
All cases meet《International disease and classification》10th edition (ICD-10) diagnostic criteria, man 33, female 6, at 8 ~ 56 years old age, put down
Equal 22.4 years old, the course of disease 7.5 years, follow-up 6 months ~ 7 years after treatment.Symptom disappears 6 (15.4%) after treatment, and the big portion of symptom disappears
22 (56.4%), symptom partial disappearance 7 (17.9%), symptom is without change 4 (10.2%).
Claims (5)
- A kind of 1. divergence type brain pacemaker, it is characterised in that:Including two pairs to five pairs for the interior electrode being embedded on skull, institute Stating interior electrode is made of titanium alloy layer parcel neodymium-iron-boron magnetic material, in button cell shape, wherein for being embedded in a head left side On temporo laterocranium bone first in electrode and the first external electrode that is removably arranged on the left temporo side scalp of head can be through scalp shape Into electrical connection, for the second inner electrode being embedded on the right temporo laterocranium bone of head and removably the right temporo side scalp of head is arranged on On the second external electrode can through scalp formed be electrically connected, the first external electrode and the second external electrode are connected to arteries and veins through conducting wire respectively Rush the positive and negative anodes of generator;In addition to electrode in described first and the second inner electrode, the divergence type brain pacemaker, which further includes, to be used for The symmetrical interior electrode for being embedded in skull top and/or occipital lobe.
- 2. divergence type brain pacemaker according to claim 1, it is characterised in that:The inner electrode diameter is 10 ~ 12mm, thick Spend for 3 ~ 7mm, the thickness of the titanium alloy layer is 0.03 ~ 0.05mm.
- 3. according to any divergence type brain pacemakers of claim 1-2, it is characterised in that:The first external electrode and second External electrode uses silver electrode.
- 4. divergence type brain pacemaker according to claim 1, it is characterised in that:Outside the first external electrode and described second Electrode forms pullover type structure.
- 5. divergence type brain pacemaker according to claim 1, it is characterised in that:Outside the first external electrode and described second Electrode sets conductive sponge with scalp contact position.
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CN201720167776.1U CN207356366U (en) | 2017-02-24 | 2017-02-24 | A kind of divergence type brain pacemaker |
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