CN207284946U - A kind of stem cell cryopreserving box - Google Patents
A kind of stem cell cryopreserving box Download PDFInfo
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- CN207284946U CN207284946U CN201721041874.7U CN201721041874U CN207284946U CN 207284946 U CN207284946 U CN 207284946U CN 201721041874 U CN201721041874 U CN 201721041874U CN 207284946 U CN207284946 U CN 207284946U
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- box
- cryopreservation tube
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Abstract
The utility model discloses a kind of stem cell cryopreserving box, it is related to cell biology, the stem cell cryopreserving box includes box body, box lid installed in box body side, installed in the pipe support of tray interior, cryopreservation tube, unilateral cooling box and double-sided cooled box, the inner wall of box body is provided with two pieces of installing plates, installing plate vertically offers multiple mounting grooves, pipe support is installed in mounting groove, mounting hole is offered on pipe support, cryopreservation tube is laid in mounting hole, wrapped up by unilateral cooling box and double-sided cooled box the outside of cryopreservation tube, the side of unilateral cooling box sets half groove of L-type along long side, the both sides of double-sided cooled box set half groove of L-type along long side.The utility model is simple in structure, design is reasonable, cooling box can fully wrap up cryopreservation tube, ensure the quality for freezing effect and stem cell, while cooling box uses modularized design scheme, easily it can load and take out from babinet, realize the quick-replaceable of cooling agent.
Description
Technical field
It the utility model is related to cell biology, more particularly to a kind of stem cell cryopreserving box.
Background technology
Cellular replacement therapy, is an advanced medical technology, and hope is brought for the treatment of some difficult and complicated cases.It is dry
Cellular transplantation therapy is that patient's body is arrived in the stem cell transplantation of health, to reach reparation or replacement damaged cell or tissue, from
And achieve the purpose that healing.Cellular replacement therapy scope is very wide, can generally treat the nervous system disease, disease of immune system,
Some also other Medicine and Surgery diseases.The stem cell products applied to transplantation treatment are mainly done carefully including umbilical cord mesenchyma at present
Born of the same parents and perinatal period candidate stem cell.In order to ensure the quality of stem cell products, it is necessary to be frozen.Existing stem cell freezing is protected
Depositing case, Shortcomings part, the cooling agent in it are not easy to be replaced, are dropped for a long time using postcooling effect in use
It is low, it can not ensure the quality of stem cell products.
Utility model content
In view of this, the utility model is simple in structure, design is reasonable, and cooling box can fully wrap up cryopreservation tube, ensures
Freeze effect and the quality of stem cell, while cooling box uses modularized design scheme, in that context it may be convenient to from babinet load and
Take out, realize the quick-replaceable of cooling agent.
The utility model is solved the above problems by following technological means：
A kind of stem cell cryopreserving box, it is characterised in that box lid including box body, installed in box body side, installed in box body
Internal pipe support, cryopreservation tube, unilateral cooling box and double-sided cooled box, wherein：The top of box lid is installed on box body by hinge plate
On, the bottom of box lid is fixed by snap on box body；The inner wall both sides of box body correspond to and are provided with two pieces of installing plates, installing plate edge
Vertical direction offers multiple mounting grooves, and pipe support both sides are installed in the mounting groove of installing plate, and fixation is uniformly provided with pipe support
Hole, cryopreservation tube is laid in mounting hole, and the outside of cryopreservation tube is wrapped up by unilateral cooling box and double-sided cooled box, unilateral cooling box
Side sets half groove of L-type along long side, and the both sides of double-sided cooled box set half groove of L-type, unilateral cooling box and bilateral along long side
It is mounted on shaking hands on the outside of cooling box.
Further, the bottom of half groove of L-type is provided with cambered surface, and the cambered surface can fit closely the bottom of cryopreservation tube
Portion's curved surface.
Further, three row's mounting holes are evenly arranged with the pipe support, three row's cryopreservation tubes, three rows are laid in mounting hole
Cryopreservation tube includes first row cryopreservation tube, second row cryopreservation tube and the 3rd row's cryopreservation tube, and the bottom of first row cryopreservation tube is close to box body
Inner wall side is provided with unilateral cooling box, and the bottom of first row cryopreservation tube is provided with double-sided cooled away from inboard wall of cartridge opposite side
Box, half groove of L-type of unilateral cooling box and half groove of L-type of double-sided cooled box cooperatively form long recess, and long recess is by first row
The bottom tight of cryopreservation tube；The two bottom sides of second row cryopreservation tube are respectively arranged with two double-sided cooled boxes, two bilaterals
Half groove of L-type of cooling box cooperatively forms long recess, and long recess is by the bottom tight of second row cryopreservation tube；3rd row freezes
The bottom of pipe is provided with unilateral cooling box close to inboard wall of cartridge side, and the bottom of the 3rd row's cryopreservation tube is away from the another of inboard wall of cartridge
Side is provided with double-sided cooled box, and half groove of L-type of unilateral cooling box cooperatively forms long recessed with half groove of L-type of double-sided cooled box
Groove, long recess is by the bottom tight of the 3rd row's cryopreservation tube.
Further, the top of first row cryopreservation tube is provided with unilateral cooling box close to inboard wall of cartridge side, and first row freezes
Opposite side of the top away from inboard wall of cartridge for depositing pipe is provided with double-sided cooled box, and half groove of L-type and bilateral of unilateral cooling box are cold
But half groove of L-type of box cooperatively forms long recess, and long recess is by the top tight of first row cryopreservation tube；Second row cryopreservation tube
Top both sides be respectively arranged with two double-sided cooled boxes, half groove of L-type of two double-sided cooled boxes cooperatively forms long recess, long
Groove is by the top tight of second row cryopreservation tube；The top of 3rd row's cryopreservation tube is provided with one side close to inboard wall of cartridge side
Cooling box, opposite side of the top away from inboard wall of cartridge of the 3rd row's cryopreservation tube are provided with double-sided cooled box, the L-type of unilateral cooling box
Half groove of L-type of half groove and double-sided cooled box cooperatively forms long recess, and long recess closely wraps at the top of the 3rd row's cryopreservation tube
Wrap up in.
Further, the buckle includes postive stop baffle and baffle shaft, and postive stop baffle is installed on box body by baffle shaft
It is upper and can be rotated around baffle shaft, be arranged with torsional spring in baffle shaft, one end of torsional spring connects postive stop baffle, torsional spring it is another
End connection baffle shaft.
Further, the cartridge inner surface, which is sticked, insulating layer, and insulating layer includes alumina-silicate ceramic fibre layer.
Further, the inner wall of the cryopreservation tube is provided with albumin coated layer, albumin coated layer with physical absorption or
The mode of covalent cross-linking is attached on the inner wall of cryopreservation tube, and the albumin coated layer is human serum albumin coated layer.
A kind of stem cell cryopreserving box of the utility model has the advantages that：
The utility model is simple in structure, design is reasonable, and cooling box can fully wrap up cryopreservation tube, ensured freeze effect with
And the quality of stem cell, while cooling box uses modularized design scheme, in that context it may be convenient to load from babinet and take out, realize cold
But the quick-replaceable of agent.By opening side box lid, quickly unilateral cooling box and double-sided cooled box can be pulled out and loaded,
Half groove of L-type, which forms, to be formed long recess cooling box can be allowed directly to be contacted with cryopreservation tube.Compared with traditional test tube, the utility model
Reduce the absorption for freezing inside pipe wall to neural stem cell in one layer of albumin coated layer of inner wall surface addition of cryopreservation tube, so that
Greatly reduce residual rate of the neural stem cell in cryopreservation tube.
Brief description of the drawings
, below will be to attached needed in embodiment in order to illustrate more clearly of the technical solution of the utility model
Figure is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the utility model, for
For those of ordinary skill in the art, without creative efforts, other can also be obtained according to these attached drawings
Attached drawing.
Fig. 1 is a kind of internal structure schematic diagram of stem cell cryopreserving box of the utility model；
Fig. 2 is a kind of external structure schematic diagram of stem cell cryopreserving box of the utility model；
Fig. 3 is a kind of double-sided cooled box first embodiment structure diagram of stem cell cryopreserving box of the utility model；
Fig. 4 is a kind of double-sided cooled box second embodiment structure diagram of stem cell cryopreserving box of the utility model；
Fig. 5 is a kind of unilateral cooling box first embodiment structure diagram of stem cell cryopreserving box of the utility model.
The title of each number designation is respectively in figure：The unilateral cooling of 1- box bodys, 2- box lids, 3- pipe supports, 4- cryopreservation tubes, 5-
Box, 6- double-sided cooleds box, half groove of 7-L types, 8- knobs, 9- installing plates, 10- knob, 101- hinge plates, 102- postive stop baffles,
103- shafts, 901- mounting grooves.
Embodiment
In the description of the utility model, it is to be understood that term " " center ", " on ", " under ", "front", "rear",
The orientation or position relationship of the instruction such as "left", "right", " vertical ", " level ", " top ", " bottom ", " interior ", " outer " is based on attached drawing institutes
The orientation or position relationship shown, is for only for ease of description the utility model and simplifies description, rather than indicates or imply and is signified
Device or element must have specific orientation, with specific azimuth configuration and operation, therefore it is not intended that to this practicality
New limitation.Term " first ", " second " are only used for description purpose, and it is not intended that instruction or hint relative importance
Or the implicit quantity for indicating indicated technical characteristic.Thus, define " first ", the feature of " second " can be expressed or
Implicitly include one or more this feature.In the description of the utility model, unless otherwise indicated, the implication of " multiple "
It is two or more.
The utility model is described in detail below with reference to attached drawing.
As shown in Figure 1, 2, a kind of stem cell cryopreserving box, including box body 1, the box lid 2 installed in 1 side of box body, be installed on
Pipe support 3, cryopreservation tube 4, unilateral cooling box 5 and double-sided cooled box 6 inside box body 1, wherein：The top of box lid 2 passes through hinge plate
101 are installed on box body 1, and the bottom of box lid 2 is fixed by snap on box body 1；The inner wall both sides of box body 1 correspond to and are provided with two
Block installing plate 9, installing plate 9 vertically offer multiple mounting grooves 91, and 3 both sides of pipe support are installed on the mounting groove of installing plate 9
In 91, mounting hole is uniformly provided with pipe support 3, cryopreservation tube 4 is laid in mounting hole, the outside of cryopreservation tube 4 is by unilateral cooling box 5
Wrapped up with double-sided cooled box 6, the side of unilateral cooling box 5 sets half groove 7 of L-type along long side, and the both sides of double-sided cooled box 6 are along length
Side sets half groove 7 of L-type, and the outside of unilateral cooling box 5 and double-sided cooled box 6 is mounted on knob 8.
As shown in figure 3, the bottom of half groove 7 of L-type is provided with cambered surface, the cambered surface can fit closely cryopreservation tube 4
Bottom curved surface.It should be noted that the bottom of half groove 7 of L-type may be set to be planar structure, as shown in Figure 4,5.It is unilateral
Cooling box 5 and the inside of double-sided cooled box 6 are filled with reusable cold-storage material.
Specifically, in the present embodiment, three row's mounting holes are evenly arranged with the pipe support 3, three rows are laid in mounting hole
Cryopreservation tube 4, three row's cryopreservation tubes 4 include first row cryopreservation tube 4,4 and the 3rd row's cryopreservation tube 4 of second row cryopreservation tube, and first row freezes
The bottom of pipe 4 is provided with unilateral cooling box 5 close to 1 inner wall side of box body, and the bottom of first row cryopreservation tube 4 is away from 1 inner wall of box body
Opposite side is provided with double-sided cooled box 6, and half groove 7 of L-type of unilateral cooling box 5 coordinates with half groove 7 of L-type of double-sided cooled box 6
Long recess is formed, long recess is by the bottom tight of first row cryopreservation tube 4；The two bottom sides of second row cryopreservation tube 4 are set respectively
It is equipped with two double-sided cooled boxes 6, half grooves 7 of L-type of two double-sided cooled boxes 6 cooperatively forms long recess, and long recess is by second row
The bottom tight of cryopreservation tube 4；The bottom of 3rd row's cryopreservation tube 4 is provided with unilateral cooling box 5 close to 1 inner wall side of box body,
Opposite side of the bottom of 3rd row's cryopreservation tube 4 away from 1 inner wall of box body is provided with double-sided cooled box 6, the L-type half of unilateral cooling box 5
Groove 7 and half groove 7 of L-type of double-sided cooled box 6 cooperatively form long recess, and long recess is close by the bottom of the 3rd row's cryopreservation tube 4
Parcel.
Specifically, the top of first row cryopreservation tube 4 is provided with unilateral cooling box 5 close to 1 inner wall side of box body, first row freezes
Deposit opposite side of the top of pipe 4 away from 1 inner wall of box body and be provided with double-sided cooled box 6, half groove 7 of L-type of unilateral cooling box 5 with it is double
Half groove 7 of L-type of side cooling box 6 cooperatively forms long recess, and long recess is by the top tight of first row cryopreservation tube 4；Second
The top both sides of row's cryopreservation tube 4 are respectively arranged with two double-sided cooled boxes 6, and half groove 7 of L-type of two double-sided cooled boxes 6 coordinates
Long recess is formed, long recess is by the top tight of second row cryopreservation tube 4；The top of 3rd row's cryopreservation tube 4 is in box body 1
Wall side is provided with unilateral cooling box 5, and it is cold that opposite side of the top of the 3rd row's cryopreservation tube 4 away from 1 inner wall of box body is provided with bilateral
But box 6, half groove 7 of L-type of unilateral cooling box 5 and half groove 7 of L-type of double-sided cooled box 6 cooperatively form long recess, and long recess will
The top tight of 3rd row's cryopreservation tube 4.
Specifically, the buckle includes postive stop baffle 102 and baffle shaft 103, postive stop baffle 102 is by baffle shaft 103
It can rotate on box body 1 and around baffle shaft 103, torsional spring, one end connection limit of torsional spring are arranged with baffle shaft 103
Position baffle 102, the other end connection baffle shaft 103 of torsional spring.
Specifically, 1 inner surface of box body, which is sticked, insulating layer, insulating layer includes alumina-silicate ceramic fibre layer.
Specifically, the inner wall of the cryopreservation tube 4 is provided with albumin coated layer, albumin coated layer is with physical absorption or altogether
The crosslinked mode of valency is attached on the inner wall of cryopreservation tube 4, and the albumin coated layer is human serum albumin coated layer.Need to illustrate
, the albumin coated layer 5 in the present embodiment can manufacture or realize by the following means：1st, using mould and polyphosphazene polymer
Compound material such as polypropylene is fabricated to required shape；2nd, 8% albumin solution is added in pipe, is positioned on horizontal shaker 10 DEG C
14 hours are reacted, form albumin coated layer 5；3rd, with milli-Q water, dry.
A kind of stem cell cryopreserving box of the utility model has the advantages that：
The utility model is simple in structure, design is reasonable, and cooling box can fully wrap up cryopreservation tube 4, ensured and frozen effect
And the quality of stem cell, while cooling box uses modularized design scheme, in that context it may be convenient to load from babinet and take out, realize
The quick-replaceable of cooling agent.By opening side box lid 2, quickly unilateral cooling box 5 and double-sided cooled box 6 can be pulled out and
Load, half groove 7 of L-type composition, which forms long recess, can allow cooling box directly to be contacted with cryopreservation tube 4.Compared with traditional test tube, this
Utility model adds one layer of albumin coated layer in the inner wall surface of cryopreservation tube 4 reduces 4 inner wall of cryopreservation tube to neural stem cell
Absorption, so as to greatly reduce residual rate of the neural stem cell in cryopreservation tube 4.
Finally it should be noted that：Above example is only to illustrate the technical solution of the utility model, rather than its limitations；
Although the utility model is described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that：
It can still modify the technical solution described in foregoing embodiments, or which part technical characteristic is carried out etc.
With replacement；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the utility model technology
The spirit and scope of scheme.
Claims (7)
- A kind of 1. stem cell cryopreserving box, it is characterised in that box lid including box body, installed in box body side, in box body Pipe support, cryopreservation tube, unilateral cooling box and the double-sided cooled box in portion, wherein：The top of box lid is installed on box body by hinge plate, The bottom of box lid is fixed by snap on box body；The inner wall both sides of box body, which correspond to, is provided with two pieces of installing plates, and installing plate edge is perpendicular Nogata is installed in the mounting groove of installing plate to multiple mounting grooves, pipe support both sides are offered, and mounting hole is uniformly provided with pipe support, Cryopreservation tube is laid in mounting hole, the outside of cryopreservation tube is wrapped up by unilateral cooling box and double-sided cooled box, and the one of unilateral cooling box Side sets half groove of L-type along long side, and the both sides of double-sided cooled box set half groove of L-type along long side, and unilateral cooling box and bilateral are cold But it is mounted on shaking hands on the outside of box.
- 2. stem cell cryopreserving box as claimed in claim 1, it is characterised in that the bottom of half groove of L-type is provided with cambered surface, The cambered surface can fit closely the bottom curved surface of cryopreservation tube.
- 3. stem cell cryopreserving box as claimed in claim 2, it is characterised in that three rows are evenly arranged with the pipe support and are fixed Hole, three row's cryopreservation tubes are laid in mounting hole, and three row's cryopreservation tubes include first row cryopreservation tube, second row cryopreservation tube and the 3rd row and freeze Pipe is deposited, the bottom of first row cryopreservation tube is provided with unilateral cooling box close to inboard wall of cartridge side, and the bottom of first row cryopreservation tube is remote Opposite side from inboard wall of cartridge is provided with double-sided cooled box, and half groove of L-type and the L-type half of double-sided cooled box of unilateral cooling box are recessed Groove cooperatively forms long recess, and long recess is by the bottom tight of first row cryopreservation tube；The two bottom sides of second row cryopreservation tube point It is not provided with two double-sided cooled boxes, half grooves of L-type of two double-sided cooled boxes cooperatively forms long recess, and long recess is by second row The bottom tight of cryopreservation tube；The bottom of 3rd row's cryopreservation tube is provided with unilateral cooling box close to inboard wall of cartridge side, and the 3rd Opposite side of the bottom away from inboard wall of cartridge of row's cryopreservation tube is provided with double-sided cooled box, half groove of L-type of unilateral cooling box with it is double Half groove of L-type of side cooling box cooperatively forms long recess, and long recess is by the bottom tight of the 3rd row's cryopreservation tube.
- 4. stem cell cryopreserving box as claimed in claim 3, it is characterised in that the top of first row cryopreservation tube is close to inboard wall of cartridge Side is provided with unilateral cooling box, and opposite side of the top away from inboard wall of cartridge of first row cryopreservation tube is provided with double-sided cooled box, Half groove of L-type of unilateral cooling box cooperatively forms long recess with half groove of L-type of double-sided cooled box, and long recess freezes first row The top tight of pipe；The top both sides of second row cryopreservation tube are respectively arranged with two double-sided cooled boxes, two double-sided cooleds Half groove of L-type of box cooperatively forms long recess, and long recess is by the top tight of second row cryopreservation tube；3rd row's cryopreservation tube Top is provided with unilateral cooling box close to inboard wall of cartridge side, and opposite side of the top away from inboard wall of cartridge of the 3rd row's cryopreservation tube is set Double-sided cooled box is equipped with, half groove of L-type of unilateral cooling box cooperatively forms long recess with half groove of L-type of double-sided cooled box, long Groove is by the top tight of the 3rd row's cryopreservation tube.
- 5. stem cell cryopreserving box as claimed in claim 4, it is characterised in that the buckle includes postive stop baffle and baffle turns Axis, postive stop baffle, which is installed on box body by baffle shaft and can surround baffle shaft, to be rotated, and is arranged with torsional spring in baffle shaft, is turned round One end connection postive stop baffle of spring, the other end connection baffle shaft of torsional spring.
- 6. stem cell cryopreserving box as claimed in claim 5, it is characterised in that the cartridge inner surface, which is sticked, insulating layer, protects Warm layer includes alumina-silicate ceramic fibre layer.
- 7. stem cell cryopreserving box as claimed in claim 6, it is characterised in that the inner wall of the cryopreservation tube is provided with albumin bag Tegillum, albumin coated layer are attached on the inner wall of cryopreservation tube in a manner of physical absorption or covalent cross-linking, the albumin bag Tegillum is human serum albumin coated layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721041874.7U CN207284946U (en) | 2017-08-20 | 2017-08-20 | A kind of stem cell cryopreserving box |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721041874.7U CN207284946U (en) | 2017-08-20 | 2017-08-20 | A kind of stem cell cryopreserving box |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207284946U true CN207284946U (en) | 2018-05-01 |
Family
ID=62444892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721041874.7U Expired - Fee Related CN207284946U (en) | 2017-08-20 | 2017-08-20 | A kind of stem cell cryopreserving box |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207284946U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022099452A1 (en) * | 2020-11-10 | 2022-05-19 | 南通市多乾新材料科技有限公司 | Umbilical cord mesenchymal stem cell cryotube containing poly-l-arginine coating |
-
2017
- 2017-08-20 CN CN201721041874.7U patent/CN207284946U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022099452A1 (en) * | 2020-11-10 | 2022-05-19 | 南通市多乾新材料科技有限公司 | Umbilical cord mesenchymal stem cell cryotube containing poly-l-arginine coating |
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180501 Termination date: 20200820 |
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| CF01 | Termination of patent right due to non-payment of annual fee |