CN207276614U - A kind of integrated tubular reactor device - Google Patents
A kind of integrated tubular reactor device Download PDFInfo
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- CN207276614U CN207276614U CN201721202950.8U CN201721202950U CN207276614U CN 207276614 U CN207276614 U CN 207276614U CN 201721202950 U CN201721202950 U CN 201721202950U CN 207276614 U CN207276614 U CN 207276614U
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Abstract
A kind of integrated tubular reactor device is the utility model is related to, including：Reaction vessel, reaction vessel include at least two tubular chambers, connect the passage and opening of at least two tubular chambers；Lid, lid can coordinate with opening, and lid includes through hole；Seal, seal include the sealing-plug that can coordinate with through hole.The integrated tubular reactor device of the utility model solves reaction product pollution problem during multiple or multi-step biological enzyme reaction, and multiple or multi-step biological enzyme reaction can be realized in same device.
Description
Technical field
It the utility model is related to biochemical reaction device field, and in particular to one kind can carry out multiple synchronous or continuous
Multistep reaction, and being capable of capping device, the integrated tubular reactor device that prevents product from polluting.
Background technology
With the development of biotechnology, modern molecular biology technique or technique for gene engineering are just increasingly applied
Into various biotechnology industries, especially it is applied in medical diagnosis.The application of this kind of technology often relates to multiple or continuous
Multistep enzyme reaction.For example, when needing to be detected RNA virus, need to purify viral RNA first, then RNA is carried out
Reverse transcription into cDNA, finally carry out cDNA amplified reactions.Typical DNA（Or cDNA）Amplified reaction is polymerase chain reaction, i.e.,
PCR.In similar multistep enzyme reaction, the prior art needs to carry out every single step reaction respectively, specifically, each reacts independent
Separated test tube in carry out, operated by either manually or mechanically hand.
However, using when individually separated test tube carries out multistep reaction, it is transferred in reaction product from a test tube
During another test tube, product molecule can be exposed to outside test tube, easily product molecule is polluted working environment, caused
There is false positive reaction in future samples detection.Also, multistep reaction is carried out using individually separated test tube, occupied space is big,
It is time-consuming to take material, thus improve use cost.
In order to more easily carry out multiple or continuous steps enzyme reaction, the prior art also provides new technical solution, uses
Microflow control technique integrates different step, to achieve the purpose that automation mechanized operation.The product createed with microflow control technique
Frequently referred to integrated biochip.It can be polluted using integrated biochip to avoid product molecule, but its is complicated, cost of manufacture
It is high.In addition, integrated biochip structure is small, mismatched with the volume of general biological sample.Therefore, the practicality of integrated biochip
It is worth relatively low.
Utility model content
In order to solve the problem above-mentioned, the purpose of this utility model is to provide a kind of anti-available for multiple or continuous steps
Product, should can be avoided to produce pollution and the integrated tubular reactor device having practical value.
To realize above-mentioned main purpose, the utility model provides a kind of integrated tubular reactor device, including：Reaction is held
Device, reaction vessel include at least two tubular chambers, connect the passage and opening of at least two tubular chambers；Lid, lid
It can coordinate with closure of openings, lid includes through hole；Seal, seal include the sealing-plug that can coordinate with through hole.
The integrated tubular reactor device of the utility model is one mainly formed by reaction vessel, lid, seal
Enclosed entirety, effectively can avoid reaction product from polluting, prevent false positive reaction.Can between reaction vessel and lid
To be closed using existing any sealing means.
Wherein, lid is equipped with through hole, and through hole is closed by sealing-plug, through hole can be used for be loaded and sample, when need sample and
During sample-adding, through hole only need to be opened, without opening whole lid, avoids reaction system from being come into contact in a large area with air；When completion samples
During with sample-adding, sealing, operation facility can be achieved in insertion sealing-plug.
At least two tubular chambers can carry out identical or different reaction, and tubular chambers preferably separate setting, avoid pipe
Shape chamber temperature interference close to each other brought etc..At least two tubular chambers are connected by least one passage at the same time, passage
Tubular type or channeltype can be used, reaction product can be made to be transmitted between tubular chambers, to realize multistep reaction, such as two or
More than two enzyme reactions.The methods of transmission mode can be physically or chemically, such as spread by molecule, convection current or machinery side
Formula transfer etc., can automatically realize multi-step biological chemistry enzyme reaction.
In addition, the integrated tubular reactor device of the utility model becomes one multiple tubular chambers, equipment instrument
It is small, material is saved, cost is low, and occupied space is few, and easy to operate, can shorten the operating time, fast and effeciently have
Value as a result, having great practical value.
Further technical solution is that passage is arranged on the upper end of at least two tubular chambers；Opening is arranged on passage
Upper end.
At least two tubular chambers of the utility model are connected by passage, and connecting portion can be arranged in tubular chambers
End, middle or lower end.Optimal situation is connected by upper end, and the material for being conducive to suppress between different tubular chambers exists
It is not intended to mix in the case of mixing.On this basis, it is preferable that opening is arranged on the upper end of passage, opening and tubular chambers
Upper end it is opposite so that by with the lid that opening coordinates toward tubular chambers be loaded and sample more convenient.
Further technical solution is that through hole is correspondingly arranged with tubular chambers.
Through hole is identical with tubular chambers number or differs, and the position of through hole and the position of tubular chambers functionally one
One is arranged in correspondence with.After the opening of lid and reaction vessel coordinates, the through hole on lid is corresponded with tubular chambers so that
Each tubular chambers, which is in communication with the outside or closes, individually to be carried out, and prevent from polluting, and be loaded and sample and is more convenient.
Further technical solution, which is that at least one seal further includes to seal with least a portion of tubular chambers, matches somebody with somebody
The sealing bar of conjunction.Further technical solution is that sealing bar regularly or is movably connected with sealing-plug.
Seal can include sealing bar, and sealing bar can coordinate with tubular chambers, for closing or opening tubular chambers, often
One tubular chambers can autonomous closure or opening, it is possible to achieve the separating or connecting functionally of multiple tubular chambers.Sealing
Bar can regularly or be movably connected with sealing-plug.For example, sealing bar movably runs through sealing-plug, when needing to open
During tubular chambers, sealing bar is pulled up from sealing-plug.Sealing bar can also be used for sample collection before the reaction.
Further technical solution is, reaction vessel includes being arranged between at least two adjacent tubular chambers and to logical
The arc connecting portion of road internal projection.
Arc connecting portion to passage internal projection is set between at least two adjacent tubular chambers, can to avoid dead angle,
Be conducive to the transmission of the reaction product between adjacent tubular chambers with exchanging.
Further technical solution is, tubular chambers are cylindricality or taper, its interior diameter 0.1 millimeter to 10 millimeters it
Between, pipe thickness is between 0.05 to 5 millimeter；The depth of tubular chambers and the ratio of interior diameter are greater than or equal to 2.
For the interior diameter of tubular chambers between 0.1 millimeter to 10 millimeters, the depth of tubular chambers and the ratio of interior diameter are big
When 2, it can meet the needs of general biological enzyme reaction.Pipe thickness can ensure to pacify between 0.05 to 5 millimeter
It is complete to stablize, and save cost.
Further technical solution is that integrated tubular reactor device is made of transparent material.
In the closed state, reaction result can qualitatively or quantitatively be detected by optics or electrical method.Using saturating
Bright material prepares integrated tubular reactor device, and reaction result is optically detected, convenient rapid.
Further technical solution is, reaction vessel further include positioned at tubular chambers side be used for placing response reagent or
The storage chamber of sample.
Integrated tubular reactor device is also provided with storage chamber, and storage chamber can be separated with tubular chambers, is used for
Placing response reagent or sample, easy to be loaded.
Further technical solution is that different reagents is placed with different tubular chambers；In passage filled with a kind of or
A variety of media.
Identical or different reagent is placed in different tubular chambers, to complete multiple reactions reacted or multistep is different.
Filled with one or more media in passage, tubular chambers is functionally communicated, spread using medium by molecule, liquid pair
The methods of stream is the transmission that tubular chambers reaction product can be achieved.Reagent can also be stored in tubular chambers in advance, after closing
Storage and transport are carried out, when use need only add sample to be tested.
Brief description of the drawings
Fig. 1 is the overall structure exploded view of the integrated tubular reactor device embodiment of the utility model.
Fig. 2 is the structure diagram that reaction vessel is overlooked in the integrated tubular reactor device embodiment of the utility model.
Fig. 3 is the positive structure diagram of reaction vessel in the integrated tubular reactor device embodiment of the utility model.
Fig. 4 is the structure diagram of lid in the integrated tubular reactor device embodiment of the utility model.
Fig. 5 is the structure diagram of seal in the integrated tubular reactor device embodiment of the utility model.
Embodiment
The integrated tubular reactor device of the utility model is described further below in conjunction with drawings and examples.
As shown in Figure 1, the integrated tubular reactor device of the present embodiment includes reaction vessel 1, lid 2 and seal 3, by
Reaction vessel 1, lid 2 and seal 3 form an enclosed entirety, so as to avoid reaction product from causing dirt to working environment
Dye, prevents false positive reaction, and reagent will not pollute the external world.
As shown in Fig. 2 to 3, reaction vessel 1 includes at least two tubular chambers 11, and different tubular chambers 11 can carry out more
Different reactions, can also carry out multiple identical reactions in step reaction.The number of tubular chambers 11 can be according to real reaction
Depending on needing.Tubular chambers 11 can be connected by one or more passages 12 in the upper end of tubular chambers 11, centre or lower end, be led to
Road 12 can be such that reaction product is transmitted under sealing condition between tubular chambers 11, to realize multistep reaction.Transmission mode can be with
Using physically or chemically the methods of, such as spread by molecule, the sampling of liquid convection or mechanical timer the methods of, can automate
Realize multi-step biological chemistry enzyme reaction in ground.Specifically in the present embodiment, multiple tubular chambers 11 the upper end of tubular chambers 11 by
One passage 12 connects, and the mode of this upper end connection is conducive to prevent that the reaction mass between different tubular chambers 11 is unnecessary
Ground mixes.Passage 12 can be designed to different shapes, such as tubulose, canal shape etc. as needed.
In the present embodiment, the interior diameter of tubular chambers 11 is between 0.1 millimeter to 10 millimeters, pipe thickness 0.05 to
Between 5 millimeters；The depth of tubular chambers 11 and the ratio of interior diameter are greater than or equal to 2.The size of tubular chambers 11 is in above-mentioned model
In enclosing, you can meet the needs of general multi-step biological enzyme reaction, and safety and stability, save cost.
Reaction vessel 1 further includes opening 13, and in the present embodiment, opening 13 is located at the upper end of passage 12, opening 13 and pipe
The upper end of shape chamber 11 is opposite or substantially opposite.Opening 13 can be closed with lid 2 to be coordinated, and the mode of cooperation can use existing
Any sealing means, such as bonding etc..As shown in figure 4, lid 2 is equipped with through hole 21, can be loaded by through hole 21
And sampling.In the present embodiment, the number of through hole 21 is identical with the number of tubular chambers 11 or can differ, both are in position
It is and functionally corresponding.When lid and opening 13 coordinate, through hole 21 is located at the top of tubular chambers 11, in order to be loaded and take
Sample.
It can be inserted into seal 3 in through hole 21.Each through hole 21 can be with seal 3 that is individually separated or being connected
Coordinate, each through hole 21 independently or is uniformly opened or closed to realize.As shown in figure 5, each seal 3 include can
The sealing-plug 31 coordinated with through hole 21, sealing-plug 31 can be sealed with through hole 21 to be coordinated.Seal 3 can also include can be with tubular cavity
The sealing bar 32 that at least a portion of room 11 coordinates, sealing bar 32 are used to closing or opening tubular chambers 11, each tubular cavity
Room 11 can autonomous closure or opening.
Sealing bar 32 can regularly or be movably connected with sealing-plug 31, such as sealing bar 32 can be up or down
Through sealing-plug 31, when needing to open tubular chambers 11, sealing bar 32 is pulled up from sealing-plug 31.Sealing bar 32 can
To be used for sample collection before the reaction, reacted after being sent into reactor by 32 biological samples adopted of sealing bar.For example,
Sample collection can be carried out by the bottom of sealing bar 32.In another example it is smaller 32 lower end of sealing bar can be provided with diameter
Specimen holder or sample pin, specimen holder or sample pin preferably diametrically include rough surface, for low-volume samples sample-adding or take
Sample.Or specimen holder or sample pin are directly set on the sealing-plug 31 without sealing bar 32, for being loaded and sampling.Sample
Bar or sample pin can be fixedly connected or are movably connected with sealing-plug 31, and preferably specimen holder or sample pin can move up and down
Ground runs through sealing-plug 31, easy to lift specimen holder or sample pin after the completion of sample-adding.Preferably, the end of specimen holder or sample pin
Equipped with hydrophilic surface, for dipping sample, hydrophilic surface can be completely smooth surface with right and wrong.
When sealing bar 32 is fixedly connected with sealing-plug 31, for multiple sealings in an integrated tubular reactor device
Part 3, can carry sealing bar 32, partial seal 3 is without sealing bar 32, by using with sealing bar with partial seal 3
32 and the seal 3 without sealing bar 32, it is possible to achieve the connection or partition of multiple tubular chambers 11.Or pass through
The sealing-plug 31 with sealing bar 32 is moved up and down in through hole 21, realizes the connection or partition of multiple tubular chambers 11.
The arc connecting portion 14 of 12 internal projection of directed walk is set between at least two adjacent tubular chambers 11, and arc connects
Socket part 14 to avoid dead angle, can be conducive to the transmission of reaction product between adjacent tubular chambers 11 with exchanging.
In the enclosed integrated pipe reaction device of the present embodiment, reaction result can pass through optics or electricity side
Method is qualitatively or quantitatively detected.Preferably, integrated pipe reaction device is made using transparent material such as plastics, glass
Into, therefore there is transparent appearance, reaction result can be continuously detected readily through optical means in real time.Integrated pipe
The all parts of formula reaction unit can use mechanical processing shaping or be integrally formed.
In addition, for the ease of placing response reagent or sample, storage chamber 15 can also be set in reaction vessel 1, stored
Chamber 15 can be separated with tubular chambers 11.For example, through hole can be also provided with 15 corresponding position of storage chamber in lid 2
21, for picking and placeing reaction reagent or sample, reuse seal 3 and sealed, you can separate storage chamber 15.
The device of the present embodiment can be applied to multiple synchronous reactions, can also be applied to multistep successive reaction.The present embodiment
When device is used for multiple synchronous reactions, identical or different reaction reagent can be placed in different tubular chambers 11.When this
When the device of embodiment is applied to multistep successive reaction, different reaction reagents can be placed in different tubular chambers 11, with
Complete the different reaction of multistep.Reaction reagent can also be stored in tubular chambers 11 in advance, and storage and transport are carried out after closing, are made
Used time need only add sample to be tested.Before use, then by manually or automatically method tubular chambers 11 can also be filled out
Fill reaction reagent and biological sample.For the biological enzyme reaction carried out under sealing condition, reaction reagent include enzyme, buffer solution,
The organic or inorganic material such as nucleic acid.
After adding sample and reaction reagent, integrated tubular reactor device is closed, then controls temperature to carry out anti-
Should.Biological enzyme reaction generally carries out between 15 DEG C to 99 DEG C.The method being currently known can be used to come to the indoor life of tubular cavity
Thing enzyme reaction carries out temperature control, such as utilizes infrared light, hot/cold wind, cold heat solid or liquid substance, electromagnetic induction etc..Can
Reacted so that the reaction unit after closing is inserted into temperature control instrument.According to the requirement of reaction, any tubular chambers 11
Steady temperature or mechanical periodicity temperature can be subjected to, the temperature or gradient temperature that can also have equilibrium in cast chamber 11.For example, with biography
The PCR temperature controls of uniting similarly, using periodicity samming temperature control method when, the temperature of temperature control instrument is in computer program
Control is lower to carry out cyclically-varying, such as keeps the several seconds at a certain temperature to several minutes, and 11 fully-inserted temperature of tubular chambers
Spend in the heating part of controller unit, be substantially balanced in the fluid temperature during this alternating temperature in tubular chambers 11.Example again
Such as, in the gradient temperature temperature control method of constant temperature, the temperature of temperature control instrument is kept not under the control of computer program
Become, and tubular chambers 11 only have part and contacted with the heating part of temperature control instrument.When bottom is heated, bottom temp meeting
Higher than head temperature, the liquid in tubular chambers 11 has a temperature gradient at this time.Since the low liquid of upper temp has relatively
The liquid of high density or proportion, top and lower part can produce convection current, its effect is to drive the indoor molecule flowing of tubular cavity, and
Different temperature is subjected to, so as to meet different enzyme reaction condition requirements, reaches the mesh for realizing the amplification of 11 nucleic acid of tubular chambers
's.The tubular structure of tubular chambers 11 brings more flexibilities to Instrument Design.
Molecular transport between different tubular chambers 11 can use form actively or passively.Such as can be in passage
Filled with one or more media in 12, tubular chambers 11 is functionally communicated, pass through molecule diffusion or liquid using medium
The modes such as convection current realize molecular transport in tubular chambers 11.It can also be sampled and add by way of physics or machinery
Sample.
After reaction product is transferred in another tubular chambers 11, the temperature control similar with above-mentioned reaction can be used
Method, carries out second step reaction.
After the completion of reaction, by the combination of molecular probe or affinity substance and reaction product, obtain related to product amount
Optics or electrical signal, so as to qualitatively or quantitatively be detected to reaction product.Optical signalling includes fluorescence signal, light absorbs
Signal, red place's absorption signal, Raman scattering signal, chemiluminescence signal etc..Reaction complete after can to whole reaction unit into
The processing such as row high temperature or burning, prevents product pollution.
Therefore the integrated tubular reactor device of the utility model is integrally closing, solves multi-step biological
The pollution problem of reaction product during enzyme reaction.And multi-step biological chemistry enzyme reaction can be completed in same device, such as
Nest-type PRC reaction, RT-PCR reactions, multi-PRC reaction etc., can also realize automation using the methods of molecule diffusion, convection current
Multi-step biological chemistry enzyme reaction.The installation cost of the utility model is low, and occupied space is few, and easy to operate, has great
Practical value.
Finally it is emphasized that these are only the preferred embodiment of the utility model, it is new to be not limited to this practicality
Type, for those skilled in the art, the utility model can have various change and change, all essences in the utility model
Within god and principle, any modification, equivalent substitution, improvement and etc. done, should be included in the scope of protection of the utility model it
It is interior.
Claims (10)
- A kind of 1. integrated tubular reactor device, it is characterised in that including：Reaction vessel, the reaction vessel include at least two tubular chambers, connect the passage of at least two tubular chambers And opening；Lid, the lid can coordinate with the closure of openings, and the lid includes through hole；Seal, the seal include the sealing-plug that can coordinate with the through hole.
- A kind of 2. integrated tubular reactor device according to claim 1, it is characterised in that：The passage is arranged on the upper end of at least two tubular chambers；Described be open is arranged on the upper end of the passage.
- A kind of 3. integrated tubular reactor device according to claim 1 or 2, it is characterised in that：The through hole is correspondingly arranged with the tubular chambers.
- A kind of 4. integrated tubular reactor device according to claim 1 or 2, it is characterised in that：At least one seal, which further includes, to close the sealing bar coordinated with least a portion of the tubular chambers.
- A kind of 5. integrated tubular reactor device according to claim 4, it is characterised in that：The sealing bar regularly or is movably connected with the sealing-plug.
- A kind of 6. integrated tubular reactor device according to claim 1 or 2, it is characterised in that：The reaction vessel includes being arranged between adjacent at least two tubular chambers and to the passage internal projection Arc connecting portion.
- A kind of 7. integrated tubular reactor device according to claim 1 or 2, it is characterised in that：The tubular chambers are cylindricality or taper, its interior diameter is between 0.1 millimeter to 10 millimeters, and pipe thickness is 0.05 to 5 Between millimeter；The depth of the tubular chambers and the ratio of interior diameter are greater than or equal to 2.
- A kind of 8. integrated tubular reactor device according to claim 1 or 2, it is characterised in that：The integrated tubular reactor device is made of transparent material.
- A kind of 9. integrated tubular reactor device according to claim 1 or 2, it is characterised in that：The reaction vessel further includes the storage chamber for being used for placing response reagent or sample positioned at the tubular chambers side.
- A kind of 10. integrated tubular reactor device according to claim 1 or 2, it is characterised in that：Identical or different reaction reagent is placed with the different tubular chambers；Filled with one or more media in the passage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721202950.8U CN207276614U (en) | 2017-09-18 | 2017-09-18 | A kind of integrated tubular reactor device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721202950.8U CN207276614U (en) | 2017-09-18 | 2017-09-18 | A kind of integrated tubular reactor device |
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| Publication Number | Publication Date |
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| CN207276614U true CN207276614U (en) | 2018-04-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201721202950.8U Active CN207276614U (en) | 2017-09-18 | 2017-09-18 | A kind of integrated tubular reactor device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107523487A (en) * | 2017-09-18 | 2017-12-29 | 星源智（珠海）生物科技有限公司 | A kind of integrated tubular reactor device |
| WO2019052522A1 (en) * | 2017-09-18 | 2019-03-21 | 星源智（珠海）生物科技有限公司 | Nucleic acid determination method |
-
2017
- 2017-09-18 CN CN201721202950.8U patent/CN207276614U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107523487A (en) * | 2017-09-18 | 2017-12-29 | 星源智（珠海）生物科技有限公司 | A kind of integrated tubular reactor device |
| WO2019052522A1 (en) * | 2017-09-18 | 2019-03-21 | 星源智（珠海）生物科技有限公司 | Nucleic acid determination method |
| WO2019052521A1 (en) * | 2017-09-18 | 2019-03-21 | 星源智（珠海）生物科技有限公司 | Integrated tubular reaction device |
| CN107523487B (en) * | 2017-09-18 | 2024-03-19 | 星源智（珠海）生物科技有限公司 | Integrated tubular reaction device |
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