CN207276609U - A kind of device for being used to capture biomolecule in cell or solution - Google Patents
A kind of device for being used to capture biomolecule in cell or solution Download PDFInfo
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- CN207276609U CN207276609U CN201720954998.8U CN201720954998U CN207276609U CN 207276609 U CN207276609 U CN 207276609U CN 201720954998 U CN201720954998 U CN 201720954998U CN 207276609 U CN207276609 U CN 207276609U
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Abstract
Description
Claims (10)
- A kind of 1. device for being used to capture biomolecule in cell or solution, it is characterised in that:Described device includes capture mechanism And the main body with entrance, first outlet and the cavity between the entrance and the first outlet, the catching machine Structure is fixed in the cavity, and the entrance, the first outlet are connected with the cavity respectively, and the capture mechanism includes one The capture sieve of a or multiple stackings, the trapping layer that the capture sieve includes reticulated matrix and is formed on the reticulated matrix, institute State the catches that trapping layer includes to specifically bind with target cell or biomolecule.
- 2. device according to claim 1, it is characterised in that:The catches is antibody, oligonucleotides or molecular engram Polymer.
- 3. the apparatus of claim 2, it is characterised in that:The biomolecule is signal transduction factor, described Target cell is circulating tumor cell, and the antibody is can be with being sticked by the epithelial cell in circulating tumor cell surface expression The anti-signal transduction factor antibody that molecular specificity combines.
- 4. device according to claim 1, it is characterised in that:The size of the reticulated matrix is 1-100 mm × 1-100 Mm, the hole of the sieve is 2 μm -800 μm.
- 5. device according to claim 4, it is characterised in that:The size of the reticulated matrix is 2-10 mm × 2-10 Mm, the hole of the sieve is 20 μm -100 μm.
- 6. device according to claim 1, it is characterised in that:The material of the reticulated matrix is noble metal;OrThe reticulated matrix includes:Body of stainless steel;AndThe protective layer on the body of stainless steel surface is formed at, the protective layer is made of noble metal or its alloy, the catches It is connected to the protective layer.
- 7. according to claim 1-6 any one of them devices, it is characterised in that:The cavity is divided into by the capture mechanism The central axis of two parts of first cavity and the second cavity, the entrance and the first outlet is in residing for the capture sieve Plane.
- 8. device according to claim 7, it is characterised in that:The capture sieve is horizontally disposed, and the entrance is positioned at described The top of capture mechanism is simultaneously communicated with first cavity, the first outlet be located at the lower section of the capture mechanism and with it is described Second cavity communicates.
- 9. according to claim 1-6 any one of them devices, it is characterised in that:The main body further has second outlet, Formed with being used to collect captured cell or biology point with what is communicated with the cavity and the second outlet in the main body The microfluidic channel of son.
- 10. device according to claim 9, it is characterised in that:Described device further comprises leading to arranged on the microfluid The counting mechanism for being used to count captured cell or biomolecule in road.
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CN201720954998.8U CN207276609U (en) | 2017-08-02 | 2017-08-02 | A kind of device for being used to capture biomolecule in cell or solution |
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CN201720954998.8U CN207276609U (en) | 2017-08-02 | 2017-08-02 | A kind of device for being used to capture biomolecule in cell or solution |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108707577A (en) * | 2018-05-25 | 2018-10-26 | 苏州博福生物医药科技有限公司 | The elution process and catching method of a kind of cell or biomolecule |
CN109609336A (en) * | 2018-11-19 | 2019-04-12 | 昆山汇先医药技术有限公司 | It is a kind of to be sieved for capturing biomolecule, cell or the capture of bacterium |
CN109874316A (en) * | 2018-05-25 | 2019-06-11 | 昆山汇先医药技术有限公司 | For enrichment isolation the object such as cell, bacterium or the device of biomolecule from sample |
WO2019223214A1 (en) * | 2018-05-25 | 2019-11-28 | 昆山汇先医药技术有限公司 | Apparatus for enriching and screening target object such as cell, bacteria or biomolecule from sample |
CN113124650A (en) * | 2019-12-31 | 2021-07-16 | 苏州博福生物医药科技有限公司 | Freeze-drying method of capture screen |
-
2017
- 2017-08-02 CN CN201720954998.8U patent/CN207276609U/en active Active
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108707577A (en) * | 2018-05-25 | 2018-10-26 | 苏州博福生物医药科技有限公司 | The elution process and catching method of a kind of cell or biomolecule |
CN109874316A (en) * | 2018-05-25 | 2019-06-11 | 昆山汇先医药技术有限公司 | For enrichment isolation the object such as cell, bacterium or the device of biomolecule from sample |
WO2019223214A1 (en) * | 2018-05-25 | 2019-11-28 | 昆山汇先医药技术有限公司 | Apparatus for enriching and screening target object such as cell, bacteria or biomolecule from sample |
CN108707577B (en) * | 2018-05-25 | 2023-11-10 | 江苏汇先医药技术有限公司 | Elution method and capture method of cells or biomolecules |
CN109609336A (en) * | 2018-11-19 | 2019-04-12 | 昆山汇先医药技术有限公司 | It is a kind of to be sieved for capturing biomolecule, cell or the capture of bacterium |
CN109609336B (en) * | 2018-11-19 | 2021-05-18 | 江苏汇先医药技术有限公司 | A catch sieve for catching biomolecule, cell or bacterium |
CN113124650A (en) * | 2019-12-31 | 2021-07-16 | 苏州博福生物医药科技有限公司 | Freeze-drying method of capture screen |
CN113124650B (en) * | 2019-12-31 | 2022-05-06 | 江苏汇先医药技术有限公司 | Freeze-drying method of capture screen |
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Legal Events
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GR01 | Patent grant | ||
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Effective date of registration: 20190226 Address after: 215300 Pilot Building 101, No. 168 Yuanfeng Road, Yushan Town, Kunshan City, Suzhou City, Jiangsu Province Patentee after: Kunshan Huixian Medical Technology Co., Ltd. Address before: 215633 Kechuangyuan Building A, No. 36 Huada Road, Zhangjiagang Bonded Zone, Suzhou City, Jiangsu Province Patentee before: SUZHOU BOFU BIOLOGICAL MEDICINE TECHNOLOGY CO., LTD. |
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CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: Room 12, no.1798, West Zhonghua Garden Road, Yushan Town, Kunshan City, Suzhou City, Jiangsu Province Patentee after: Jiangsu Huixian Pharmaceutical Technology Co.,Ltd. Address before: 215300 Pilot Building 101, No. 168 Yuanfeng Road, Yushan Town, Kunshan City, Suzhou City, Jiangsu Province Patentee before: KUNSHAN HUIXIAN MEDICAL TECHNOLOGY Co.,Ltd. |