CN207276533U - A kind of reaction bulb filtration apparatus for full-automatic solid phase peptide synthesizer - Google Patents
A kind of reaction bulb filtration apparatus for full-automatic solid phase peptide synthesizer Download PDFInfo
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- CN207276533U CN207276533U CN201721163051.1U CN201721163051U CN207276533U CN 207276533 U CN207276533 U CN 207276533U CN 201721163051 U CN201721163051 U CN 201721163051U CN 207276533 U CN207276533 U CN 207276533U
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- solid phase
- reaction bottle
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Abstract
The utility model discloses a kind of reaction bulb sealing filtration device for full-automatic solid phase peptide synthesizer, mainly solve that leakage existing for present filtration apparatus, filter effect be bad, the frequent technical problem of filter element replacing.The technical solution of the utility model is：A kind of reaction bulb filtration apparatus for full-automatic solid phase peptide synthesizer, it is characterised in that：Including a upper lower port glass reaction bottle and two reaction bottle caps with holes, the reaction bottle cap with holes is connected with glass reaction bottle screw socket, teflon seal is mounted with the hole of the reaction bottle cap with holes, the teflon seal one end threaded mouth connects polytetrafluoroethylene (PTFE) pipeline, solvent line built in polytetrafluoroethylene (PTFE) pipeline, teflon seal another port grafting filtering head, sealing ring is equipped with teflon seal and reaction bottle cap interface with holes.The utility model can be used for Solid phase peptide synthssis.
Description
Technical field
Full-automatic solid phase peptide synthesizer reaction unit field is the utility model is related to, is specially a kind of be used for automatically admittedly
The reaction bulb filtration apparatus of phase Peptide synthesizer.
Background technology
Americanized scholar professor Merrifield in 1963 has delivered first case with the tetrapeptide chemical combination that solid-phase resin is carrier
（Leu-Ala-Gly-Val）The article of synthesis, indicates the unlatching in contemporary Solid-phase organic synthesis chemical epoch.Due to solid phase mode
Synthetic peptide has unique superiority, a large amount of Duo Tai ﹑ hormones with important biomolecule activity and some protein short several
Synthesized one by one between year, the deep development of life science is greatly facilitated.First truly more in the world
Peptide synthesizer appears in generation nineteen sixty end to initial stage in the 1970's, it is that reactant is stirred using nitrogen bubbling, is used
Computer program control is automatically synthesized to realize, people can be freed from laboratory, greatly improves work efficiency, with
The development of technology, automation Peptide synthesizer develops into the third generation from the first generation, most of to close in existing third generation synthesizer
Either the filtration apparatus of Cheng Yi is filtered using single side glass sand core, or it is to use stainless steel sintering filtration core to be filled for filtering
Put, these designs have the defects of obvious, and leakage mainly occurs, filter effect is bad, and filter element replacing frequently causes to use
The shortcomings of maintenance cost is high.
Utility model content
The purpose of this utility model is to be to provide a kind of reaction bulb filtration apparatus for automatic solid phase peptide synthesizer,
Mainly solve that leakage existing for present filtration apparatus, filter effect be bad, the frequent technical problem of filter element replacing.
To achieve the above object, the utility model provides following technical solution：One kind is used for full-automatic Solid phase peptide synthssis
The reaction bulb filtration apparatus of instrument, including a upper lower port glass reaction bottle and two reaction bottle caps with holes, it is described with holes anti-
Answer bottle cap to be connected with glass reaction bottle screw socket, teflon seal is mounted with the hole of the reaction bottle cap with holes, it is described
Teflon seal one end threaded mouth connects polytetrafluoroethylene (PTFE) pipeline, solvent line built in polytetrafluoroethylene (PTFE) pipeline, and poly- four
Vinyl fluoride seal another port grafting filtering head, the filtering head are an end closures, and the other end is distributed miniature circular hole, the mistake
Filter is high density polyethylene (HDPE) part, and sealing ring is equipped with teflon seal and reaction bottle cap interface with holes, described
Sealing ring is EP rubbers part.The glass reaction bottle is that both ends are symmetrical and communicate, the reaction bulb that centre is closed up, the solvent pipe
Line is transparent Teflon part, and 1 is used for feed liquor and into gas, and another 1 is used as removal waste fluid.
Preferably, glass reaction bottle inner wall has silanization treatment layer.
The beneficial effects of the utility model are：Using the reaction bulb filtration apparatus of this design, reaction solution and resin can be made
Be sufficiently mixed reaction, improve coupling efficiency, at the same can quickly feed liquor and discharge opeing, while resin will not be missed, entirely fill
The leakproofness and resistance to corrosion put are all secure.The symmetrical cylindrical high density polyethylene (HDPE) filtering head in two is also than conventional glass
Glass sand core and the filter effect of stainless steel mode are more preferable, and service life is 5-10 times long, and it is convenient to replace, the stability of whole device
Height, has good economic benefit.
Brief description of the drawings
Fig. 1：For the utility model assembly structure diagram.
In figure：Reaction bulb Gai ﹑ 2- polytetrafluoroethylene (PTFE) Mi Feng Jian ﹑ 3- Guo Lv Tou ﹑ 4- Mi Feng Quan ﹑ 5- glass reactions with holes 1-
Ping ﹑ 6- solvent lines.
Embodiment
The following is a combination of the drawings in the embodiments of the present utility model, and the technical scheme in the embodiment of the utility model is carried out
It is clear, complete description, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiment in the utility model, those skilled in the art are obtained without making creative work
The every other embodiment obtained, shall fall within the protection scope of the present invention.
Referring to Fig. 1, a kind of reaction bulb filtration apparatus for full-automatic solid phase peptide synthesizer, including about one logical
Mouth glass reaction bottle 5 and two reaction bottle caps 1 with holes, the reaction bottle cap 1 with holes are connected with 5 screw socket of glass reaction bottle, institute
State in the hole of reaction bottle cap 1 with holes and be mounted with teflon seal 2,2 one end threaded of teflon seal
Mouth connects polytetrafluoroethylene (PTFE) pipeline, solvent line 6 built in polytetrafluoroethylene (PTFE) pipeline, 2 another port grafting of teflon seal
Filtering head 3, the filtering head 3 are an end closures, and the other end is distributed miniature circular hole, and the filtering head 3 is high density polyethylene (HDPE) part,
Filtering head 3 can only be by nitrogen and liquid, and resin can not pass through.In teflon seal 2 and reaction bottle cap 1 with holes
Interface is equipped with sealing ring 4, and the sealing ring 4 is EP rubbers part.The glass reaction bottle 5 is that both ends are symmetrical and communicate, in
Between the reaction bulb that closes up, it is preferred that 5 inner wall of glass reaction bottle has silanization treatment layer.The solvent line 6 is transparent Teflon
Imperial part, 1 is used for feed liquor and into gas, and another 1 is used as removal waste fluid.After reaction bulb upset 180 degree, from glass reaction bottle 5
3 feed liquor of filtering head and nitrogen of bottom, glass reaction bottle 5 are in nitrogen environmental protection, and glass reaction bottle 5 is again after having shifted liquid
180 degree is overturn, glass reaction bottle 5 returns to original state, and nitrogen is pressed into by filter by top pipeline, and waste liquid is from glass reaction
Bottom of bottle portion filtering head 3 is discharged, and resin is stayed in glass reaction bottle 5.
While there has been shown and described that the embodiment of the utility model, for the ordinary skill in the art,
It is appreciated that these embodiments can be carried out with a variety of changes, modification in the case where not departing from the principle of the utility model and mental condition
And modification, the scope of the utility model are defined by the appended claims and the equivalents thereof.
Claims (7)
- A kind of 1. reaction bulb filtration apparatus for full-automatic solid phase peptide synthesizer, it is characterised in that：It is logical including about one Mouth glass reaction bottle and two reaction bottle caps with holes, the reaction bottle cap with holes are connected with glass reaction bottle screw socket, the band Teflon seal is mounted with the hole of hole reaction bottle cap, the teflon seal one end threaded mouth connects poly- four Vinyl fluoride pipeline, solvent line built in polytetrafluoroethylene (PTFE) pipeline, teflon seal another port grafting filtering head, poly- Tetrafluoroethene seal is equipped with sealing ring with reaction bottle cap interface with holes.
- 2. a kind of reaction bulb filtration apparatus for full-automatic solid phase peptide synthesizer according to claim 1, its feature It is：The filtering head is an end closure, and the other end is distributed miniature circular hole.
- 3. a kind of reaction bulb filtration apparatus for full-automatic solid phase peptide synthesizer according to claim 1 or 2, it is special Sign is：The filtering head is high density polyethylene (HDPE) part.
- 4. a kind of reaction bulb filtration apparatus for full-automatic solid phase peptide synthesizer according to claim 1, its feature It is：The glass reaction bottle is that both ends are symmetrical and communicate, the reaction bulb that centre is closed up.
- 5. a kind of reaction bulb filtration apparatus for full-automatic solid phase peptide synthesizer according to claim 1, its feature It is：The sealing ring is EP rubbers part.
- 6. a kind of reaction bulb filtration apparatus for full-automatic solid phase peptide synthesizer according to claim 1, its feature It is：The solvent line is transparent Teflon part.
- 7. a kind of reaction bulb filtration apparatus for full-automatic solid phase peptide synthesizer according to claim 1 or 4, it is special Sign is：Glass reaction bottle inner wall has silanization treatment layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721163051.1U CN207276533U (en) | 2017-09-12 | 2017-09-12 | A kind of reaction bulb filtration apparatus for full-automatic solid phase peptide synthesizer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721163051.1U CN207276533U (en) | 2017-09-12 | 2017-09-12 | A kind of reaction bulb filtration apparatus for full-automatic solid phase peptide synthesizer |
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| CN207276533U true CN207276533U (en) | 2018-04-27 |
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| CN201721163051.1U Active CN207276533U (en) | 2017-09-12 | 2017-09-12 | A kind of reaction bulb filtration apparatus for full-automatic solid phase peptide synthesizer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108752418A (en) * | 2018-08-08 | 2018-11-06 | 湖南科技学院 | A kind of multichannel Peptide systhesis reaction unit and its operating method |
-
2017
- 2017-09-12 CN CN201721163051.1U patent/CN207276533U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108752418A (en) * | 2018-08-08 | 2018-11-06 | 湖南科技学院 | A kind of multichannel Peptide systhesis reaction unit and its operating method |
| CN108752418B (en) * | 2018-08-08 | 2024-01-30 | 湖南科技学院 | Multichannel polypeptide synthesis reaction device and operation method thereof |
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