CN207210406U - Capillary heating box - Google Patents
Capillary heating box Download PDFInfo
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- CN207210406U CN207210406U CN201721202169.0U CN201721202169U CN207210406U CN 207210406 U CN207210406 U CN 207210406U CN 201721202169 U CN201721202169 U CN 201721202169U CN 207210406 U CN207210406 U CN 207210406U
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Abstract
The utility model discloses a kind of capillary heating box, wherein, the capillary heating box includes：Barrier assembly；Heating component, heating component are arranged on the inside of barrier assembly；Wherein, barrier assembly contacts with each other with Capillary Electrophoresis component and can carry out heat transfer, and heating component can carry out temperature adjustment to the capillary in Capillary Electrophoresis component and maintain the operating temperature in capillary.Capillary heating box of the present utility model can be applied in DNA integrated analysis systems, to solve its miniaturization and automation problem.
Description
Technical field
It the utility model is related to DNA test technique automatics field, more particularly to it is a kind of for DNA integrated analysis instrument
Capillary heating box.
Background technology
Capillary Electrophoresis (CE) is also known as HPCE (HPCE) -- High Performance Capillary
Electrophoresis or the electrically separated method of capillary (CESM), it is ion or charged particle using high-voltage dc as driving
Power, a kind of new technology being separated efficiently and rapidly in capillary by its mobility or/and distribution coefficient difference.
The emerging isolation technics that Capillary Electrophoresis organically combines as a kind of classical electrophoretic techniques and modern Micro-Column Separation, closely
Develop swift and violent over year and be used widely.Because Capillary Electrophoresis is shown to biomolecule such as amino acid, protein, nucleosides
The great potential of acid, nucleic acid separation analysis etc., meets using bioengineering as separation of the life science of representative to various objects point
Analysis and the demand of micropreparation, so it just progressively turns into a kind of conventional analysis means.
Wherein, capillary is the core of capillary electrophoresis separation system, preferable capillary must be electric insulation, it is ultraviolet/
Visible transparent and flexible, what can be used at present has glass, vitreous silica or polytetrafluoroethylplastic plastic etc..According to quilt
The solute of separation and the making material and internal diameter that need to select capillary of detecting system, capillary inner diameter are generally 10~100 μ
m.Wherein, the existing shiploads of merchandise of elastic vitreous silica capillary is sold, thus is commonly used, the capillary drawn by vitreous silica
Very crisp, frangibility is managed, and with the Kapton clad capillary outer wall of protective, so that it may make its high resilience, this
It is exactly commodity capillary.
For the integrated apparatus of biological detection analysis field, such as the DNA integrated analysis systems in current more forward position,
The characteristics of based on its miniaturization, automation, capillary electrophoresis separation system has natural advantage, but how to realize capillary point
Capillary quick-replaceable that is simplified from the structure of system, how solving the problems, such as fragility and accurate temperature control seem particularly prominent
Go out.
Utility model content
The purpose of this utility model can be applied in DNA integrated analysis systems in offer one kind, small to solve its
The capillary heating box of typeization and automation problem.
To achieve the above object, the concrete technical scheme of capillary heating box of the present utility model is：
A kind of capillary heating box, wherein, including：Barrier assembly；Heating component, heating component are arranged on barrier assembly
It is internal；Wherein, barrier assembly contacts with each other with Capillary Electrophoresis component and can carry out heat transfer, and heating component can be to capillary electricity
Capillary in swimming component carries out temperature adjustment and maintains the operating temperature in capillary.
Further, barrier assembly is plank frame, and barrier assembly and Capillary Electrophoresis component are bonded to each other setting, isolation group
Heating component in part can carry out heat transfer by being bonded position with the capillary in Capillary Electrophoresis component.
Further, heating component is plank frame, and heating component is arranged on barrier assembly and Capillary Electrophoresis component phase
The side of fitting.
Further, barrier assembly is fixedly installed in capillary electrophoresis separation system, and Capillary Electrophoresis component is installed to hair
After in cons electrophoresis piece-rate system, barrier assembly and Capillary Electrophoresis component contact with each other.
Further, heat-conducting pad is provided between barrier assembly and Capillary Electrophoresis component, heat-conducting pad can make capillary
Capillary in electrophoresis modules is heated evenly.
A kind of capillary heating box, wherein, including heating box body, heating box body are plank frame, heating plate, which is arranged on, to be added
The inside of hot box body, heating box body are bonded to each other with Capillary Electrophoresis component and can carry out heat transfer, and heating plate can be to capillary
Capillary in electrophoresis modules carries out temperature adjustment and maintains the operating temperature in capillary.
Further, heating box body includes bottom plate, support frame and protective housing, and heating plate is plank frame, and heating plate is solid
Surely it is arranged on bottom plate, support frame is fixedly connected with bottom plate, and protective housing is set in the outside of bottom plate and support frame.
Further, the bottom plate and Capillary Electrophoresis component for heating box body are bonded to each other.
Further, heating plate is connected with temperature sensor, and temperature sensor is connected by signal wiring with control system, with
The temperature of heating plate is monitored in real time.
Further, the heating plate in support frame and bottom plate, protection bed course is provided between temperature sensor.
Capillary heating box of the present utility model has advantages below：
1) capillary heating box and Capillary Electrophoresis box adjoining dimensions, in the operating condition, can be pasted with Capillary Electrophoresis box
Close, improve the efficiency of heating surface.
2) using ultra-thin heating plate be used as thermal source, in the case of heating effect needed for realization, can significantly reduce energy consumption with
Save space.
Brief description of the drawings
Fig. 1 is the structural representation of an embodiment of capillary electrophoresis separation system of the present utility model；
Fig. 2 is the structural representation of the Capillary Electrophoresis box in Fig. 1；
Fig. 3 is the broken away view of the Capillary Electrophoresis box in Fig. 1；
Fig. 4 is the structural representation of the capillary heating box in Fig. 1；
Fig. 5 is the broken away view of the capillary heating box in Fig. 1；
Fig. 6 is the structural representation of the cassette electromagnetic locking device in Fig. 1；
Fig. 7 is the broken away view of the cassette electromagnetic locking device in Fig. 1.
Embodiment
In order to be better understood by the purpose of this utility model, structure and function, below in conjunction with the accompanying drawings, to of the present utility model
A kind of capillary heating box does further detailed description.
Traditional capillary electrophoresis separation system critical piece has power supply, capillary, slot electrode, detector and sample introduction dress
Put.Wherein, power supply can be selected 0~30kV adjustable current regulator power supplies, capillary can be selected internal diameter be less than 100 μm (conventional 50~
75 μm), length be generally 30~100cm quartz capillary, ultraviolet/vis spectroscopy detector can be selected in detector, laser lures
Lead fluorescence detector and electrochemical detector.In addition, complete sets of instrument be typically also equipped with auto-flushing, auto injection, temperature control,
The parts such as data acquisition and processing (DAP).Capillary electrophoresis separation system in the utility model concern is primarily with capillary portion,
Especially it is concerned with the protection of capillary, changes, and the heating problems during use, so as to suitable for integration
In DNA analysis system.
Capillary electrophoresis separation system in the utility model includes Capillary Electrophoresis component, temperature-controlling module and fast
Fast locked component.Wherein, Capillary Electrophoresis component is used to house capillary, and a reliable and stable ring is provided for electrophoretic separation
Border, capillary is avoided to be damaged in use or when changing.Temperature-controlling module can provide for Capillary Electrophoresis component
Temperature control in electrophoretic separation, to ensure being smoothed out for electrophoretic separation.Quick lock in component is in order to which capillary is electric
Swimming component is temporarily locked in integral device, such as DNA integrated analysis instrument, to facilitate the replacing of capillary.
Wherein, Capillary Electrophoresis component, which includes capillary and the guard assembly for protecting capillary, capillary, to adopt
With commercially available prod, such as the elastic vitreous silica capillary that Polymicro Technologies (PT) company produces, usually adopt
Drawn and formed with artificial vitreous silica semi-finished product, similar can also use day hot quartz, Pyrex, a variety of plastics or melting
Silicon materials synthetic manufactures, and this depends primarily on actual application demand.
Carrier of the capillary as electrophoretic separation, preferably bending are arranged on the inside of guard assembly, form smooth radian,
Reach the optimum efficiency of electrophoretic separation, it is of course also possible to capillary be seated in the inside of guard assembly using other modes, such as
The capillary of linear type is directly arranged on to inside of guard assembly etc..In addition, as a rule, a Capillary Electrophoresis component
Inside is provided only with a capillary, but sometimes, in order to improve analysis throughput or analysis efficiency, can also use more hairs
Tubule is in parallel arranged to form the form of bundle of capillary tubes.
Guard assembly outside capillary mainly plays a part of protecting capillary, and its concrete form can use protection
Housing, capillary are directly seated in the inside of protective housing, and protective housing and capillary form an entirety, so can not only
The effect that protection capillary avoids damage to is played, but also can effectively improve the substitute mode of capillary.If in capillary electricity
Exposed capillary is directly used in swimming piece-rate system, it is when requiring replacement, extremely careful because capillary belongs to running stores
To avoid it from fractureing or crush, but when capillary is arranged on when being internally formed an entirety of protective housing, it is whole directly to change this
Body component.
Certainly, this mode may have the problem of waste of resource, but purpose and convenience in view of using, its
And acceptable, it is preferred that protective housing should try one's best to be made from cheap material, such as ABS material, because it is led
If for the protection of capillary, as long as certain intensity can be ensured, simultaneously as to capillary in the utility model
The mode of heating of pipe is designed, if so protective housing can have thermal conductivity more preferable.In addition, if it is considered that material
If recycling, guard assembly can also be made to reusable structure type, such as buckle type structure, when needing to change
During capillary, Capillary Electrophoresis component is unloaded from integral device, opens the capillary that guard assembly is replaceable inside.
Due to being provided with a guard assembly in the utility model on the outside of capillary, so in order to meet subsequent detection
Needs, detection window should be provided with guard assembly, detection means can be made in capillary by the detection window
Electrophoretic separation tested and analyzed.Wherein, Capillary Electrophoresis has many potential detection methods, such as optical absorption method, electrification
Method, conductance method and chemiluminescence, phosphorescence, fluorescence, mass-spectrometric technique etc., fluoroscopic examination side is preferably used in the utility model
Method, concrete structure applicant individually propose patent application.
Capillary Electrophoresis component is alternatively provided in integral device, is changed for convenience, should be set in integral device
Quick lock in component is equipped with, using quick lock in component Capillary Electrophoresis component can be made to be quickly locked in integral device,
And when requiring replacement, also easily Capillary Electrophoresis component can be removed from integral device.Wherein, quick lock in component can
To be existing elastic latching structure, Capillary Electrophoresis component, which is directly inserted into the elastic latching structure, can realize locking, or
Person's quick lock in component can also be regular screw threads closing component structure, and Capillary Electrophoresis component is directly threaded into the screw thread closing component structure i.e.
Locking can be achieved, certain similar structures are also a lot, as long as being that by quick lock in.
DNA integrated analysis instrument etc. is used in fine in view of the capillary electrophoresis separation system in the utility model
Change in the equipment that control requires higher, it may be preferred that the sealed of Capillary Electrophoresis component is realized by automaton,
Such as solenoid component, can so avoid because space is too small or misoperation and occur the problem of cause to change difficulty.
It is corresponding, the structure being engaged with quick lock in component, such as fast lock should be also provided with Capillary Electrophoresis component
Determine the elastic latching structure that component uses solenoid component control, then setting and lock head component are just needed on Capillary Electrophoresis component
The locking holes being interlocked, the position of the locking holes should determine according to installation site of the Capillary Electrophoresis component in integral device
It is fixed, typically it is arranged on the edge of Capillary Electrophoresis component.Thus, can be with by the above-mentioned closing component structure being used cooperatively
Realize the quick-replaceable of Capillary Electrophoresis component.
There can be special requirement to temperature during Capillary Electrophoresis, for example, temperature influence separation reappearance and separation
Efficiency, control temperature can regulate and control the size of EOF, temperature rise, and buffer viscosity reduces, the light base dissociation capability of tube wall silicon
Enhancing, electric osmose speed become big, and analysis time shortens, and analysis efficiency improves, but such as temperature is too high, then can cause capillary column internal diameter
Increase to the temperature difference, joule heating effect enhancing, post effect reduces, and separative efficiency can also reduce.So in capillary electrophoresis separation system
Also temperature-controlling module can be all provided with, temperature-controlling module is mainly that the temperature of capillary is adjusted, to ensure electrophoresis
Process is smoothed out.
Wherein, the inside of guard assembly has been provided in based on the capillary in the utility model, so temperature control is just
It can become not quite alike with existing way, such as the side for the temperature-controlling module that is directly sticked in the outside of guard assembly can be used
Formula, such a mode can not only shorten heat transfer path, and the convenient temperature to capillary carries out quick adjustment control, dropped significantly
Low experimental period, but also the effect being supported to Capillary Electrophoresis component can be played, because temperature-controlling module one
As be all to be directly anchored on the whole.
Temperature-controlling module is preferably located at the side of Capillary Electrophoresis component in integral device, shape and Capillary Electrophoresis
The shape of component matches, when Capillary Electrophoresis component is locked in integral device, temperature-controlling module and Capillary Electrophoresis
Component is fitted, and the temperature of capillary is controlled using contact heat conductien.Wherein, the heating group in temperature-controlling module
Part can use common heating arrangement in this area, such as resistance-type heating plate, and preferably use ultra-thin resistance heating plate, with
In the case of heating effect needed for realization, energy consumption can be significantly reduced and save space, branch is provided for the miniaturization of integral device
Hold.
Due to the miniaturization feature of integral device, the distance of each part can be relatively small in equipment, in order to avoid to entirety
The miscellaneous part of equipment impacts, and the outside of heating component should be provided with barrier assembly, and barrier assembly can mainly play
Heating component is supported, and the environment of relative closure is provided for heating component.Wherein, the set-up mode of barrier assembly can be with analogy
The set-up mode of protective casing outside above-mentioned capillary, monolithic construction or Demountable etc. are made, and used
When the barrier assembly of temperature-controlling module and the guard assembly of Capillary Electrophoresis component can contact with each other and carry out heat transfer.
In order to ensure heat transfer effect, the barrier assembly of temperature-controlling module and the guard assembly of Capillary Electrophoresis component are all
The material that heat-transfer effect should be selected to compare makes, and makes capillary and heating component as far as possible close to the side to contact with each other, with contracting
Short heat transfer path.Meanwhile heat-conducting pad, heat conductive pad are also provided between temperature-controlling module and Capillary Electrophoresis component
Piece may be provided on Capillary Electrophoresis component, may also be arranged on temperature-controlling module, it is contemplated that using effect, heat-conducting pad is most
It is provided in well on Capillary Electrophoresis component, so as to which temperature is uniformly delivered on capillary.
As shown in Figures 1 to 7, it illustrates a preferred embodiment of capillary electrophoresis separation system of the present utility model
Structural representation.
As shown in figure 1, in the present embodiment, capillary electrophoresis separation system includes Capillary Electrophoresis box 1, capillary heating box
2 and quick-connect mechanism 3, wherein, Capillary Electrophoresis box 1 is the sub-assembly for accommodating capillary, for the enforcement division of electrophoretic separation
Part；Capillary heating box 2 is the sub-assembly for accommodating heating plate, and the part of temperature adjustment is provided for electrophoretic separation；Quick lock in
Mechanism 3 is by the detachable part being locked in integral device of Capillary Electrophoresis box, to facilitate Capillary Electrophoresis box more
Change.
Further, as shown in Figures 2 and 3, Capillary Electrophoresis box 1 includes electrophoresis box body 10, and electrophoresis box body 10 is in the form of sheets, interior
Portion is arranged in the receiving space of electrophoresis box body 10 formed with receiving space, capillary 11, and electrophoresis box body 10 can be to capillary 11
Play a protective role.Wherein, as shown in figure 3, in the present embodiment, electrophoresis box body 10 is by 12 groups of the first housing 13 and the second housing
Conjunction is formed, and capillary 11 is gone back between the first housing 13 and the second housing 12 between the first housing 13 and capillary 11
Protection pad 14 is may be provided with, protection pad 14 can select the foam pad either pad made of other elastomeric materials, with
For providing further protection to capillary 11.It should be noted that it is only in the first housing 13 and capillary 11 in the present embodiment to be
Between set protection pad 14 because the second housing 12 need be in contact with capillary heating box 2, with the temperature to capillary 11
It is controlled, it is advantageous to be not provided with protecting pad, in order to avoid influence the transmission of heat.
11 U-shaped bending of capillary, the main part of capillary 11 are all located in electrophoresis box body 10, wherein, capillary
The length of 11 fluid inlet end is more than the length of fluid outlet, thus, when capillary 11 is arranged in electrophoresis box body 10,
The fluid inlet end of capillary 11 can stretch out from electrophoresis box body 10, to facilitate the filling of fluid in capillary.Simultaneously as hair
The fluid inlet end of tubule 11 stretches out from electrophoresis box body 10, so being preferably arranged with protection on the fluid inlet end of capillary 11
Sleeve pipe 18, protection sleeve pipe 18 can be protected to the fluid inlet end of capillary 11, avoid causing in use or moving process
The damage of capillary.
Corresponding to the U-bend of capillary 11, in the centre position shape of U-bend on the first housing 13 and the second housing 12
Into there is fixedly connected hole 17, it is three shown in Fig. 2, can makes capillary 11 by three fixedly connected holes 17 of the opening position
Position in electrophoresis box body 10 is relatively fixed, avoids movement of the capillary 11 in electrophoresis box body 10.Certainly,
The edge of one housing 13 and the second housing 12 should also be provided with multiple fixedly connected holes accordingly, to realize the first housing 13
With being fixedly connected for the second housing 12.
In addition, the opening position of the fluid outlet corresponding to capillary 11, detection window 18 is provided with electrophoresis box body 10,
Detection window 18 is that the electrophoretic separation in capillary is seen in order to facilitate the detection means in capillary electrophoresis separation system
Survey, if detection means can be fluorescence detection device, then laser can be entered by detection window 18 to carry out the detection of signal.
At detection window 18 it is relatively exposed accordingly, due to capillary 11, so closed group should be provided with detection window 18
Part 16, when needing to be detected, the closing assembly 16 is removed, makes detection window 18 in opened condition, in fluorescence detection device
Laser can enter, to carry out the detection of signal, after detection, closing assembly 16 is installed at detection window 18,
So that detection window 18 is in closed mode, capillary 11 is avoided to have an accident damage.
The side of capillary heating box 2 is provided with heat-conducting pad 15 on second housing 12, also may be used on heat-conducting pad 15
It is corresponding formation three fixedly connected holes 17, be fixedly connected with facilitating with the second housing 12, when Capillary Electrophoresis box 1 be installed to it is whole
When in body equipment, the side of heat-conducting pad 15 is provided with Capillary Electrophoresis box 1 to be bonded to each other with capillary heating box 2, led to
Cross setting heat-conducting pad 15, capillary 11 can be made to be heated evenly in the course of the work, and heat-conducting pad 15 and capillary 11 it
Between distance it is shorter, be greatly improved the efficiency of heating surface, and then improve conventional efficient.Certainly, heat-conducting pad 15 may also be arranged on hair
In tubule heating box 2, but whole structure may be not so good as to be set directly on Capillary Electrophoresis box 1.
In addition, being also provided with quick buckling groove 19 on electrophoresis box body 10, quick buckling groove 19 is used for and integral device
Quick shackle member be attached, in order to quick disassembly and installation of the Capillary Electrophoresis box 1 in integral device.
In the present embodiment, capillary is installed in electrophoresis cartridge body, and electrophoresis box body can protect it from being vulnerable to damage.And
And capillary and the electrophoresis cartridge bodily form are integral, when needing to change capillary, direct integral replacing, enormously simplify more
Step is changed, more without operating personnel there is higher technical capability could change.
Further, as shown in Figure 4 and Figure 5, capillary heating box 2 includes heating box body 20, and the shape for heating box body 20 is excellent
The shape with above-mentioned electrophoresis box body 10 is selected to match, also in the form of sheets, heating box body 20 is internally formed accommodating chamber, heating plate 22
It is arranged in the accommodating chamber, heating box body 20 can play protective action to heating plate 22, avoid heating plate 22 from being destroyed, and
And it can also prevent the temperature of heating plate 22 from being impacted to miscellaneous part.
Wherein, as shown in figure 5, heating box body 20 include bottom plate 21, bottom plate 21 has heat transfer property, when heat box body 20 and
When above-mentioned electrophoresis box body 10 is in contact, bottom plate 21 can be in contact with the heat-conducting pad 15 on electrophoresis box body 10, to realize heat
Transmit.Preferably, heating plate 22 is fixedly installed on bottom plate 21, with as far as possible shorten with intercapillary heat transfer path,
Heating plate 22 is located at the middle position of bottom plate 21, and is connected with temperature sensor 27, and temperature sensor 27 passes through signal wiring
28 are connected with control system, to realize the real-time monitoring to the temperature of heating plate 22.Wherein, in the present embodiment, heating plate 22 is excellent
Choosing uses ultra-thin resistance heating plate, and its thickness may be designed as 10-20mm, can not only in the case of heating effect needed for realization
Energy consumption is significantly reduced, and the purpose of miniaturization can be realized.
Bottom plate 21 is connected with support frame 23, and support frame 23 is frame-type structure, bottom plate 21 and the side of support frame 23
Locked component 26 is correspondingly arranged at edge, bottom plate 21 can be fixedly connected with support frame 23 by locked component 26.Wherein, prop up
On support frame frame 23 corresponding to heating plate 22 opening position formed with cavity, after support frame 23 is connected with bottom plate 21, on bottom plate 21
Heating plate 22 be located at the central cavity of support frame 23, it is preferred that guarantor is provided between bottom plate 21 and support frame 23
Protection pad layer 24, protection bed course 24 can use cystosepiment or other elastomeric materials to be made, and protection bed course 24 can be to heating plate 22, temperature
Spend sensor 27 and form protection.
Bottom plate 21 can be arranged with protective housing 25, protective housing and bottom plate 21 in outside after being fixedly connected with support frame 23
It can be connected with support frame 23 using snapping or card with by the way of, protective housing 25 makes heating plate 22 and temperature on bottom plate 21
Sensor 27 has been in the environment of a relative closure, is avoided and is interfered with external environment condition.In addition, support frame 23
Edge be also provided with lock connector 29, capillary heating box 2 can be fixed on by entirety by the locking connector 29
In equipment.
In the present embodiment, capillary heating box is designed to the cassette shapes suitable with the size of Capillary Electrophoresis box, and
When Capillary Electrophoresis box is installed in integral device, capillary heating box can be bonded to each other with Capillary Electrophoresis box, ensure that
Being smoothed out for heat transfer, shortens heat transfer path, improves the efficiency of heating surface, at the same it also avoid in integral device other
The influence of part.
Further, as shown in Figure 6 and Figure 7, quick-connect mechanism 3 includes locking underframe 30, and one end of locking underframe 30 is set
Lock swinging chute 31 is equipped with, latches and snap close piece 32 is movably set with swinging chute 31, snap close piece 32 and above-mentioned Capillary Electrophoresis box 1
On quick buckling groove 19 be used cooperatively, snap close piece 32 can move back and forth in swinging chute 31 is latched, with realize to capillary electricity
The release and locking of swimming box 1.Wherein, as shown in fig. 7, the correspondence position on the bottom of snap close piece 32 and lock swinging chute 31 is punished
Not formed with rotational axis hole, rotational axis hole is internally provided with rotating shaft, and snap close piece 32 can be around the rotating shaft reciprocally swinging.
The other end on locking underframe 30 is provided with actuator installing plate 33, and the end of solenoid component 34 may pass through driving
It is fixedly connected after mounting hole on part installing plate 33 with latch assembly 35, solenoid component 34 is fixed on locking underframe 30
On.Wherein, the end set of the plunger 36 of solenoid component 34 has drive connection part 37, and the middle and upper part of snap close piece 32 is provided with drive
Dynamic connecting hole, drive connection part 37 can be connected with the drive connection hole on snap close piece 32, and the plunger 36 of solenoid component 34 can lead to
Connector 37 of overdriving drives snap close piece 32 to swing, to discharge Capillary Electrophoresis box 1.
Opening position on the plunger 36 of solenoid component 34 close to snap close piece 32 is provided with block packing ring 38, block packing ring 38
Side be in contact with snap close piece 32, back-moving spring 39, back-moving spring 39 are provided between opposite side and actuator installing plate 33
It is set on the plunger 36 of solenoid component 34.Thus, when needing to open snap close piece 32, the plunger 36 of solenoid component 34 can
Snap close piece 32 is driven to swing by drive connection part 37, snap close piece 32 can be in contact with block packing ring 38, and extrude block packing ring
38 and back-moving spring 39, back-moving spring 39 is in compressive deformation state；, can be directly using multiple when needing to close snap close piece 32
The position spring 39 deformation power saved bit by bit promotes block packing ring 38, and then resets snap close piece 32.
In the present embodiment, moved by the mobile drive snap close piece of solenoid component to reach quick lock in Capillary Electrophoresis
The purpose of box, the locking efficiency of Capillary Electrophoresis box is improved, facilitate the replacing of Capillary Electrophoresis box, automaticity height.
The utility model is further described by specific embodiment above, it should be understood that, have here
The description of body, should not be construed as the restriction to spirit and scope of the present utility model, and one of ordinary skilled in the art is readding
The various modifications made after reader specification to above-described embodiment, belong to the scope that the utility model is protected.
Claims (10)
- A kind of 1. capillary heating box, it is characterised in that including：Barrier assembly；Heating component, heating component are arranged on the inside of barrier assembly；Wherein, barrier assembly contacts with each other with Capillary Electrophoresis component and can carry out heat transfer, and heating component can be to capillary electricity Capillary in swimming component carries out temperature adjustment and maintains the operating temperature in capillary.
- 2. capillary heating box according to claim 1, it is characterised in that barrier assembly is plank frame, barrier assembly Setting is bonded to each other with Capillary Electrophoresis component, and the heating component in barrier assembly can be by being bonded position and Capillary Electrophoresis group Capillary in part carries out heat transfer.
- 3. capillary heating box according to claim 2, it is characterised in that heating component is plank frame, heating component It is arranged on the side to be fitted on barrier assembly with Capillary Electrophoresis component.
- 4. capillary heating box according to claim 1, it is characterised in that barrier assembly is fixedly installed on Capillary Electrophoresis In piece-rate system, after Capillary Electrophoresis component is installed in capillary electrophoresis separation system, barrier assembly and Capillary Electrophoresis group Part contacts with each other.
- 5. capillary heating box according to claim 4, it is characterised in that between barrier assembly and Capillary Electrophoresis component Heat-conducting pad is provided with, heat-conducting pad can be heated evenly the capillary in Capillary Electrophoresis component.
- 6. a kind of capillary heating box, it is characterised in that including heating box body, heating box body is plank frame, and heating plate is set In the inside of heating box body, heating box body is bonded to each other with Capillary Electrophoresis component and can carry out heat transfer, and heating plate can be to hair Capillary in cons electrophoresis component carries out temperature adjustment and maintains the operating temperature in capillary.
- 7. capillary heating box according to claim 6, it is characterised in that heating box body include bottom plate, support frame and Protective housing, heating plate are plank frame, and heating plate is fixedly installed on bottom plate, and support frame is fixedly connected with bottom plate, protection Housing is set in the outside of bottom plate and support frame.
- 8. capillary heating box according to claim 7, it is characterised in that heat the bottom plate and Capillary Electrophoresis group of box body Part is bonded to each other.
- 9. capillary heating box according to claim 6, it is characterised in that heating plate is connected with temperature sensor, temperature Sensor is connected by signal wiring with control system, is monitored in real time with the temperature to heating plate.
- 10. capillary heating box according to claim 9, it is characterised in that heating plate, temperature in support frame and bottom plate Protection bed course is provided between degree sensor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721202169.0U CN207210406U (en) | 2017-09-19 | 2017-09-19 | Capillary heating box |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721202169.0U CN207210406U (en) | 2017-09-19 | 2017-09-19 | Capillary heating box |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207210406U true CN207210406U (en) | 2018-04-10 |
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ID=61821842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721202169.0U Active CN207210406U (en) | 2017-09-19 | 2017-09-19 | Capillary heating box |
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| Country | Link |
|---|---|
| CN (1) | CN207210406U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110470720A (en) * | 2019-09-20 | 2019-11-19 | 贵州申科生物科技有限公司 | A kind of device in temperature for capillary electrophoresis |
-
2017
- 2017-09-19 CN CN201721202169.0U patent/CN207210406U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110470720A (en) * | 2019-09-20 | 2019-11-19 | 贵州申科生物科技有限公司 | A kind of device in temperature for capillary electrophoresis |
| CN110470720B (en) * | 2019-09-20 | 2022-05-13 | 贵州申科生物科技有限公司 | Temperature standing device for capillary electrophoresis apparatus |
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