CN207198164U - It is a kind of to be used for the kit that tumour cell detects in body fluid - Google Patents
It is a kind of to be used for the kit that tumour cell detects in body fluid Download PDFInfo
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- CN207198164U CN207198164U CN201720903826.8U CN201720903826U CN207198164U CN 207198164 U CN207198164 U CN 207198164U CN 201720903826 U CN201720903826 U CN 201720903826U CN 207198164 U CN207198164 U CN 207198164U
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- reagent bottle
- plate
- tumour cell
- kit
- body fluid
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Abstract
It the utility model is related to kit field, it is especially a kind of to be used for the kit that tumour cell detects in body fluid, it includes support, box body, reagent bottle and magnetic frame, support is arranged in box body, for fixating reagent bottle and row buffering is entered to external impact, reagent bottle is placed in kit more stable, extend the service life of reagent；Bar magnet on magnetic frame is located at the middle position of detection pipe, the middle part that detection pipe is concentrated on by the tumour cell of magnetic bead absorption can be made, after removing aqueous supernatant, it is easy to separate the tumour cell adsorbed by magnetic bead, reduces the loss for the tumour cell by magnetic bead absorption that bottom retains；Reagent bottle of the present utility model can detect to the tumour cell in body fluid, quick, sensitive, easy to operate.
Description
Technical field
Kit field is the utility model is related to, it is especially a kind of to be used for the kit that tumour cell detects in body fluid.
Background technology
The kit for detecting tumour cell in body fluid requires higher to shockproof, particularly with the reagent containing magnetisable material
Box, easily influences the magnetic of magnetic bead after collision, vibration, existing kit shockproof effect is still unsatisfactory.Magnetic frame is to use
In the liquid to be checked containing magnetisable material is placed thereon, magnetisable material is adsorbed, is enriched with its displacement,
So as to be separated, existing magnetic frame upper magnet is completely covered by the coronal-plane of magnetic frame more, and exceeds and be positioned over magnetic frame
The scope of upper detection bottom of the tube so that the bottom of detection pipe also has many magnetisable materials by the magnet adsorption on magnetic frame in tube wall
Side.During the supernatant during detection pipe is discarded after being adsorbed using magnetic frame to magnetic bead, because ttom of pipe is sharper, thin,
Experiment is discarded with the magnetisable material of bottom of the tube and its tumour cell of absorption easily during supernatant is abandoned, caused in experiment
The loss of the tumour cell of absorption, has an impact to experimental result.
Utility model content
In view of this, the purpose of this utility model is to provide a kind of kit for being used for tumour cell detection in body fluid, its
Magnetic frame is easy to the tumour cell that separation is adsorbed by magnetic bead, and integral shock-absorbing performance is strong, can keep the stabilization of reagent bottle, detection
Quickly, it is sensitive, it is easy to operate.
For the above-mentioned purpose, the technical solution adopted in the utility model is as follows：
A kind of kit for being used for tumour cell detection in body fluid, including：Magnetic frame, the magnetic frame include detection pipe,
Horizontal fixed mount for fixed test pipe top, horizontal shore, vertical plate and bar shaped magnetic for supporting detection bottom of the tube
Iron, the vertical plate are two, and the both ends of the horizontal fixed mount and horizontal shore are fixedly connected with vertical plate；The bar
Shape magnet is between horizontal fixed mount and horizontal shore and its underpart is hanging, and both ends and the vertical plate of the bar magnet are consolidated
Fixed connection.
Preferably, offer the first hole on the horizontal fixed mount, the detection pipe passed through from the first hole and its underpart with
Horizontal shore is in contact, and the detection pipe top is stretched out from the first hole.
Preferably, the bar magnet is located at the medium position under the vertical laying state of detection pipe, and bar magnet top
There is interval between horizontal fixed mount.
Preferably, in addition to box body and reagent bottle, the reagent bottle include magnetic bead dispersion liquid bottle and magnetic bead bottle.
Preferably, in addition to support, the support are fixedly connected with box body, and the support, which surrounds, can place reagent bottle
U-shaped space, the support include being used to push down the upper cover plate of reagent bottle body, the side block for surrounding reagent bottle body and be used for
The supporting plate of reagent bottle is supported, the upper cover plate is located at the top of support, and the upper cover plate surrounds U-shaped region, the supporting plate
Positioned at the bottom of support, the side block is fixed between the upper cover plate, side block and supporting plate between upper cover plate and supporting plate
Connection, the support are made up of the carrier unit of two speculars；
The box body includes foreboard, top plate, side plate, buckling plate and bottom plate, and the top plate is rotatablely connected with foreboard, foreboard with
Buckling plate is rotatablely connected, and the bottom plate is provided with the caulking groove for buckling plate insertion, and the foreboard is provided with the side close to reagent bottle
For limiting reagent bottle to the anterior mobile position-limit mechanism of support.
Preferably, the position-limit mechanism has stopper section and connecting portion, and the stopper section is formed to reagent bottle curving
The radian to be matched with reagent bottle body, the stopper section are fixedly connected by connecting portion with foreboard.
Preferably, the stopper section is elastomeric material.
Preferably, the support rear portion surrounds reagent bottle body, and the side block rear portion has and can place padded coaming
Receiving space, the anterior side wall of the side block are provided with the card article for being used for blocking position-limit mechanism.
Preferably, the distance of the stopper section and contact surface to the foreboard of reagent bottle body is more than the length of the connecting portion
Degree.
Preferably, the position-limit mechanism vertical direction length by close to the side of reagent bottle one laterally closer foreboard by
It is cumulative to add.
Preferably, the diameter in the U-shaped region that the upper cover plate surrounds is less than the diameter of reagent bottle body and is more than reagent bottle
The diameter of bottle cap.
Preferably, the supporting plate is provided with damping.
Preferably, the damping is raised line.
Magnet on magnetic frame is arranged to hanging by the utility model, and its height is located at detection pipe medium position, in this way, can
Make the middle part for being affixed on detection pipe by the tumour cell of magnetic bead absorption, after supernatant is abandoned in suction, be easy to separation thin by the tumour of magnetic bead absorption
Born of the same parents, while reduce the loss for the tumour cell by magnetic bead absorption that bottom retains；By by support Design into upper cover plate, side block
With the form of supporting plate, cooperation improvement is carried out to each several part mechanism, and sets position-limit mechanism to coordinate support on box body, and to box
The on-off mode of body is improved, and so as to enhance the damping effect of kit, makes magnetic bead and magnetic bead dispersion liquid in kit
Middle placement is more stable, extends the service life of reagent；Reagent bottle of the present utility model can be to the tumour cell in body fluid
Detected, it is quick, sensitive, it is easy to operate.
Brief description of the drawings
By the description to the utility model embodiment referring to the drawings, of the present utility model above-mentioned and other mesh
, feature and advantage will be apparent from, in the accompanying drawings：
Fig. 1 shows that the utility model removes the top view after top plate and upper cover plate；
Fig. 2 shows that the utility model removes the top view after top plate；
Fig. 3 shows the stereoscopic mechanism figure of the utility model carrier unit；
Fig. 4 shows the sectional view of box body of the present utility model；
Fig. 5 shows the three-dimensional structure diagram of the utility model magnetic frame；
Fig. 6 shows the cross-sectional view of the utility model magnetic frame.
Embodiment
The utility model is described below based on embodiment, but the utility model is not restricted to these implementations
Example.
The directional terminology "front", "rear" being previously mentioned in the utility model is the position relationship shown in based on accompanying drawing 1, and top is
Afterwards, before lower section is.
The utility model provides a kind of kit for being used for tumour cell detection in body fluid, as shown in figure 1, it includes：Box
Body 1, reagent bottle 2 and magnetic frame 7, the reagent bottle 2 and magnetic frame 7 are positioned in box body 1；As shown in Figure 5,6, the magnetic frame
7 include detection pipe 8, the horizontal fixed mount 73 for the top of fixed test pipe 8, the horizontal support for supporting the bottom of detection pipe 8
Frame 74, vertical plate 75 and bar magnet 71, the vertical plate 75 are two, the horizontal fixed mount 73 and horizontal shore 74
Both ends are fixedly connected with vertical plate 75；The bar magnet 71 between horizontal fixed mount 73 and horizontal shore 74 and its
Bottom is hanging, and the both ends of the bar magnet 71 are fixedly connected with vertical plate 75.The detection pipe 8 can be EP pipes or centrifugation
Pipe.
Further, offer the first hole 70 on the horizontal fixed mount 73, the detection pipe 8 passed through from the first hole 70 and
Its underpart is in contact with horizontal shore 74, and the top of detection pipe 8 is stretched out from the first hole 70.Have on preferred levels support frame
With the second hole 72 of the position correspondence of the first hole 70, the diameter of the second hole 72 is less than the lower end of detection pipe 8, for putting detection pipe 8
Put more stable.
Further, the bar magnet 71 is located at the medium position under 8 vertical laying state of detection pipe, and bar shaped magnetic
There is interval between the top of iron 71 and horizontal fixed mount 73.In this way, when placing testing liquid in detection pipe 8, adsorbed by magnetic bead
Tumour cell can concentrate the middle part for being affixed on detection pipe 8, reduce suction and swollen by the volume that magnetic bead adsorbs in bottom and top when abandoning liquid
The loss of oncocyte.It is preferred that bar magnet 71 is cuboid, it is provided with what is placed for making the both ends of bar magnet 71 on vertical plate 75
Magnet places mouth, and the bottom of bar magnet 71 can be made hanging and interval between top and horizontal fixed mount 73 be present.Magnetic frame 7 can be put
It is placed in framework 9, framework 9 is positioned in box body 1, is placed so that magnetic frame 7 is stable in kit, magnetic frame 7 and framework 9
Between space in can fill elastomeric cushion material.
Preferably, the reagent bottle 2 includes magnetic bead dispersion liquid bottle and magnetic bead bottle.Reagent bottle 2 is two, respectively magnetic bead point
Dispersion liquid bottle and magnetic bead bottle.
As shown in Figures 1 to 3, for the damping effect of Contrast agent box, the kit detected for tumour cell in body fluid
Also include support, the support is fixedly connected with box body 1, and the support surrounds the U-shaped space that can place reagent bottle 2；It is described
Support includes being used to push down the upper cover plate 3 of reagent bottle body 21, the side block 4 for surrounding reagent bottle body 21 and trying for supporting
The supporting plate 5 of agent bottle 2, the upper cover plate 3 are located at the top of support, and the upper cover plate 3 surrounds U-shaped region, the supporting plate 5
In the bottom of support, the side block 4 is between upper cover plate 3 and supporting plate 5, between the upper cover plate 3, side block 4 and supporting plate 5
It is fixedly connected, the support is spliced by the carrier unit of two speculars.
As shown in figure 4, the box body 1 includes foreboard 10, top plate 11, side plate, back plate 14, buckling plate 12 and bottom plate 13, institute
State top plate 11 to be rotatablely connected with foreboard 10, foreboard 10 is rotatablely connected with buckling plate 12, and the bottom plate 13 is provided with to be inserted for buckling plate 12
The caulking groove entered, the foreboard 10 are provided with for limiting reagent bottle 2 to the spacing of the anterior movement of support close to the side of reagent bottle 2
Mechanism 6.The side plate is fixedly connected with back plate 14, bottom plate 13, and back plate 14 is fixedly connected with bottom plate 13.
Reagent bottle 2 is positioned in the U-bend in U-shaped space, and upper cover plate 3 can push down the body 21 of reagent bottle 2, limits reagent bottle
2 to ionized motion, and supporting plate 5 is used to support reagent bottle 2 from the bottom of reagent bottle 2.Support by two speculars carrier unit
Connect and form U-shaped space, two carrier units can connect (not shown) at rear portion by spring, on the one hand in reagent bottle 2
When running into shock, spring between two carrier units can buffer portion active force, on the other hand, support is adapted to difference
The reagent bottle 2 of size, if reagent bottle 2 is bigger than normal, the pulling force of spring can make support tightly surround reagent bottle 2, therefore use support
The mode of unit spliced forms support.The top plate 11 of box body 1 is to be rotatablely connected with buckling plate 12 with foreboard 10, foreboard 10, box
Body 1 is closed by the way of fastening, and foreboard 10 is rotated downwards relative to top plate 11, and by buckling plate 12 with respect to 10 turns of foreboard
It is dynamic, buckled into when buckling plate 12 turns to proper angle into caulking groove.The depth of caulking groove may extend to the half of bottom plate 13
Place, the stability when fastness of bottom plate 13, box body 1 are placed naturally if caulking groove is too deep decline, if caulking groove is excessively shallow, fastened
Plate 12 fastens insecure, causes foreboard 10 to be easily opened, in addition, the caulking groove of bottom plate 13 and buckling plate 12 form multilayer knot after coordinating
Structure, there is part damping effect.When box body 1 is opened, first buckling plate 12 is extracted out from caulking groove, then foreboard 10 is relative to top plate
11 are rotated upward, and reagent bottle 2 is pulled out forwards, depart from support.When closing box body 1, the position-limit mechanism 6 on foreboard 10 is inserted
Enter U-shaped space, position-limiting action is risen to reagent bottle 2.
Further, the reagent bottle 2 includes precipitation lysate bottle, magnetic bead dispersion liquid bottle, lavation buffer solution bottle and magnetic bead
Bottle.Precipitation lysate bottle is used to dissolve caused precipitation after body fluid centrifuges, and magnetic bead dispersion liquid bottle is used to disperse magnetic bead, washing buffer
Liquid bottle is used for the pH value for adjusting mixed solution.The size of kit, the quantity of support according to the quantity of reagent bottle 2 held and
Fixed, the box body 1 being capable of coated stent.
Preferably, as shown in Figure 1, 2, the position-limit mechanism 6 has stopper section 60 and a connecting portion 61, the stopper section 60 to
The curving of reagent bottle 2 forms the radian to be matched with the body 21 of reagent bottle 2, and the stopper section 60 passes through connecting portion 61 and foreboard
10 are fixedly connected.After box body 1 fastens, stopper section 60 prevents reagent bottle 2 from being slid in and out from U-shaped space.
In order to further enhance the buffering and damping effect of box body 1, the stopper section 60 is elastomeric material, is had while backstop
Standby certain buffering effect.
In order to strengthen shock-absorbing capacity, as shown in Figure 1,3, the support rear portion can surround reagent bottle body 21, the side
The receiving space of padded coaming 41 can be placed by keeping off 4 rear portions and having, the receiving space towards the side of reagent bottle 2 be opening,
Accommodating padded coaming 41 can be in contact with reagent bottle 2 in it, and padded coaming 41 can be flexible material, such as sea
Continuous, rubber, it can have the convex stupefied of multiple parallel distributions close to the side of reagent bottle 2.
In order to prevent position-limit mechanism 6 from being skidded off from U-shaped space, as shown in figure 3, the side wall of the front portion of the side block 4 is provided with and used
In the card article 40 for blocking position-limit mechanism 6.
Further, the foreboard 10 is more than the company to stopper section 60 and the distance of the contact surface of 2 body of reagent bottle 21
The length of socket part 61, it so, it is possible to reduce the possibility that stopper section 60 slips by bending diminution from card article 40.
As shown in figure 4, position-limit mechanism 6 fastens into support when being closed for the ease of box body 1, the position-limit mechanism 6 is perpendicular
Nogata to length gradually increased by the side close to reagent bottle 2 one laterally closer foreboard 10.
As shown in Fig. 2 further, the diameter in the U-shaped region that the upper cover plate 3 surrounds is less than the straight of reagent bottle body 21
Footpath and the diameter for being more than the bottle cap 20 of reagent bottle 2.Moved upward in this way, reagent bottle body 21 can be limited.
Further, the supporting plate 5 is provided with damping 50.
On the basis of such scheme, the damping 50 is raised line.
For those skilled in the art it is easily understood that on the premise of not conflicting, above-mentioned each preferred scheme can be free
Ground combination, superposition.
Preferred embodiment of the present utility model is the foregoing is only, is not limited to the utility model, for this area
For technical staff, the utility model can have various changes and change.All institutes within spirit of the present utility model and principle
Any modification, equivalent substitution and improvements of work etc., should be included within the scope of protection of the utility model.
Claims (10)
1. a kind of be used for the kit that tumour cell detects in body fluid, it is characterised in that including：Magnetic frame, the magnetic frame bag
Include detection pipe, the horizontal fixed mount for fixed test pipe top, horizontal shore, vertical plate for supporting detection bottom of the tube
And bar magnet, the vertical plate are two, the both ends of the horizontal fixed mount and horizontal shore are fixed with vertical plate to be connected
Connect；The bar magnet is between horizontal fixed mount and horizontal shore and its underpart is hanging, the both ends of the bar magnet
It is fixedly connected with vertical plate.
A kind of 2. kit for being used for tumour cell detection in body fluid according to claim 1, it is characterised in that the water
The first hole is offered on flat fixed mount, the detection pipe is passed through from the first hole and its underpart is in contact with horizontal shore, described
Detection pipe top is stretched out from the first hole.
A kind of 3. kit for being used for tumour cell detection in body fluid according to claim 2, it is characterised in that the bar
Shape magnet is located at the medium position under the vertical laying state of detection pipe, and between having between bar magnet top and horizontal fixed mount
Every.
4. a kind of kit for being used for tumour cell detection in body fluid according to any one of claims 1 to 3, it is special
Sign is, in addition to box body and reagent bottle, and the reagent bottle includes magnetic bead dispersion liquid bottle and magnetic bead bottle.
5. a kind of kit for being used for tumour cell detection in body fluid according to claim 4, it is characterised in that also include
Support, the support are fixedly connected with box body, and the support surrounds the U-shaped space that can place reagent bottle, and the support includes
For pushing down the upper cover plate of reagent bottle body, the side block for surrounding reagent bottle body and the supporting plate for supporting reagent bottle,
The upper cover plate is located at the top of support, and the upper cover plate surrounds U-shaped region, and the supporting plate is located at the bottom of support, described
Side block is fixedly connected between upper cover plate and supporting plate between the upper cover plate, side block and supporting plate, and the support is by two
The carrier unit composition of specular；
The box body includes foreboard, top plate, side plate, buckling plate and bottom plate, and the top plate is rotatablely connected with foreboard, and foreboard is with fastening
Plate is rotatablely connected, and the bottom plate is provided with the caulking groove for buckling plate insertion, and the foreboard is provided with the side of close reagent bottle to be used for
Reagent bottle is limited to the anterior mobile position-limit mechanism of support.
A kind of 6. kit for being used for tumour cell detection in body fluid according to claim 5, it is characterised in that the limit
Position mechanism has stopper section and connecting portion, and the stopper section forms the arc to be matched with reagent bottle body to reagent bottle curving
Degree, the stopper section is fixedly connected by connecting portion with foreboard.
A kind of 7. kit for being used for tumour cell detection in body fluid according to claim 6, it is characterised in that the branch
Frame rear portion surrounds reagent bottle body, and the side block rear portion has the receiving space that can place padded coaming, the side block front portion
Side wall be provided with and be used to block the card article of position-limit mechanism.
8. a kind of kit for being used for tumour cell detection in body fluid according to claim 6, it is characterised in that described to stop
Stopper and the distance of contact surface to the foreboard of reagent bottle body are more than the length of the connecting portion.
A kind of 9. kit for being used for tumour cell detection in body fluid according to claim 6, it is characterised in that the limit
Position mechanism is gradually increased in the length of vertical direction by the side of one laterally closer foreboard of close reagent bottle.
10. a kind of kit for being used for tumour cell detection in body fluid according to claim 5, it is characterised in that described
The diameter in the U-shaped region that upper cover plate surrounds is less than the diameter of reagent bottle body and more than the diameter of reagent bottle cap.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720903826.8U CN207198164U (en) | 2017-07-25 | 2017-07-25 | It is a kind of to be used for the kit that tumour cell detects in body fluid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720903826.8U CN207198164U (en) | 2017-07-25 | 2017-07-25 | It is a kind of to be used for the kit that tumour cell detects in body fluid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207198164U true CN207198164U (en) | 2018-04-06 |
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ID=61798358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720903826.8U Active CN207198164U (en) | 2017-07-25 | 2017-07-25 | It is a kind of to be used for the kit that tumour cell detects in body fluid |
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| Country | Link |
|---|---|
| CN (1) | CN207198164U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111678752A (en) * | 2020-06-21 | 2020-09-18 | 赵洪楠 | Apoptosis detection kit capable of rapidly outputting result |
| CN113368921A (en) * | 2021-01-15 | 2021-09-10 | 重庆赛铃科技有限公司 | Reagent bottle fixing assembly and reagent kit thereof |
-
2017
- 2017-07-25 CN CN201720903826.8U patent/CN207198164U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111678752A (en) * | 2020-06-21 | 2020-09-18 | 赵洪楠 | Apoptosis detection kit capable of rapidly outputting result |
| CN113368921A (en) * | 2021-01-15 | 2021-09-10 | 重庆赛铃科技有限公司 | Reagent bottle fixing assembly and reagent kit thereof |
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