CN207103036U - Spot printing sealing device - Google Patents
Spot printing sealing device Download PDFInfo
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- CN207103036U CN207103036U CN201720352475.6U CN201720352475U CN207103036U CN 207103036 U CN207103036 U CN 207103036U CN 201720352475 U CN201720352475 U CN 201720352475U CN 207103036 U CN207103036 U CN 207103036U
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- peristoma
- sleeve
- spot printing
- crystallizing pond
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Abstract
The utility model provides a kind of spot printing sealing device, for the peristoma spot printing binding agent of crystallizing pond, being related to the technical field of Bioexperiment equipment, including sleeve and pushing part；The cavity for placing binding agent is provided with sleeve；One end of pushing part is arranged in cavity, and with sleeve slidable connection；One end of sleeve is provided with the multiple through holes connected with the cavity, and the arrangement position of through hole is corresponding with the shape of the peristoma on the crystallizing pond, promotes the pushing part, so that the binding agent is extruded from through hole.Because the arrangement position of through hole and the peristoma of crystallizing pond are corresponding, when the peristoma of crystallizing pond is staggered relatively with through hole, after binding agent is extruded from through hole, portion of binder is bonded in the peristoma of crystallizing pond, so far, the convenient and swift completion of spot printing work in the peristoma of crystallizing pond.Meanwhile when spot printing works, the position of spot printing binding agent, quantity be affected by human factors it is smaller, so as to reduce probabilistic technical problem of experiment.
Description
Technical field
The technical field of Bioexperiment equipment is the utility model is related to, more particularly, to a kind of spot printing sealing device.
Background technology
In structure biology research, it is usually directed to screening protein solution crystallization condition and high throughput protein crystallizes this
Two infrastests.The sessile drop method that above-mentioned experiment generally use is developed according to gas phase diffusion equilibrium principle.In experimentation, it is necessary to
A confined space isolation and extraneous mass exchange are established, maintains gas-liquid equilibrium condition steady in a long-term in crystallizing pond, for
Protein crystal growth.
Do optimization protein solution crystallization condition and produce in the experiment such as protein monocrystalline, need crystallizing pond and cover glass.
As shown in figure 1, placing high concentration crystallization solution 13 in crystallizing pond 10, hanging-drop solution 21 is placed on cover glass 20, crystallizing pond 10
Sealed between peristoma and cover glass 20 by vacuum grease.In the prior art, it is with the specific practice of vacuum grease sealing：To syringe
Middle filling vacuum grease, by way of injecting by hand by vacuum grease extrusion in the peristoma of crystallizing pond 10.The knot commonly used in experiment
Brilliant plate has 16 independent crystallizing ponds 10, to establish confined space, it is necessary to be coated in each independent crystallizing pond with vacuum grease
10 peristoma, usual single protein crystallization condition screening experiment need the crystallization plates in 6 16 ponds, therefore need spot printing 6x16=96
Individual crystallizing pond, each crystallizing pond 10 18 points of average spot printing, need to repeat 1728 spot printing actions altogether.For the skilled of laboratory
Operator, paint point operation need more than 6 minutes.
Spot printing sealing operation is less efficient on above-mentioned completion crystallizing pond.Meanwhile the operation that simple machinery repeats is easily
Make one burnout and agitation, and the position of the peristoma spot printing vacuum grease of crystallizing pond, quantity be affected by human factors it is larger, therefore to real
Test and bring uncertainty.
Utility model content
The purpose of this utility model is to provide a kind of spot printing sealing device, completed in the prior art on crystallizing pond with alleviating
Spot printing sealing operation it is less efficient, simultaneously as the operation that simple machinery repeats easily makes one burnout and agitation, and crystallize
The position of the peristoma spot printing vacuum grease in pond, quantity are affected by human factors larger, therefore bring probabilistic technology to experiment
Problem.
Spot printing sealing device provided by the utility model, for close to the peristoma spot printing binding agent of crystallizing pond, the spot printing
Seal apparatus includes sleeve and pushing part；The cavity for placing the binding agent is provided with the sleeve；The pushing part
One end is arranged in the cavity, and with the sleeve slidable connection；One end of the sleeve is provided with to be connected with the cavity
Logical multiple through holes, the arrangement position of the through hole is corresponding with the shape of the peristoma on the crystallizing pond, promotes the promotion
Portion, so that the binding agent is extruded from the through hole.
Further, the peristoma of the crystallizing pond is circle；Multiple through holes surround and the peristoma of the crystallizing pond
It is circular corresponding to shape.
Further, the shape internal diameter of the peristoma of the crystallizing pond is 16mm, a width of 2mm, the through hole it is a diameter of
1.5mm, the quantity for surrounding the circular through hole are 18.
Further, the circular quantity that multiple through holes surround is multiple；There is phase on one end of the sleeve
Mutually vertical first direction and second direction, multiple circles are provided with the first direction and second direction.
Further, limiting section is provided with the sleeve, so that circular position that multiple through holes surround and institute
The position for stating the peristoma on crystallizing pond is corresponding.
Further, the limiting section is the protuberance being arranged on the face where the through hole；The protuberance and knot
The recesses fit on crystallization plates where brilliant pond, make the circular position that multiple through holes surround and the mouth on the crystallizing pond
The position of edge is corresponding.
Further, the cross section of the protuberance is trapezoidal.
Further, seal is provided with the pushing part, to avoid the pushing part from promoting the binding agent
During, the binding agent overflows between the sleeve and pushing part.
Further, the cross section of the sleeve is circle；Internal thread is provided with the aperture surface of the sleeve；It is described to push away
It is provided with external screw thread in dynamic portion, the external screw thread set on the internal thread and pushing part on the sleeve matches.
Further, it is provided with ribs on the outside of the sleeve.
Spot printing sealing device provided by the utility model is used for the peristoma spot printing binding agent to crystallizing pond.The spot printing sealing
Device includes sleeve and pushing part；The cavity for placing the binding agent is provided with the sleeve；The one of the pushing part
End be arranged in the cavity, and with the sleeve slidable connection；One end of the sleeve is provided with to be connected with the cavity
Multiple through holes, the arrangement position of the through hole is corresponding with the shape of the peristoma on the crystallizing pond, promotes the pushing part,
So that the binding agent is extruded from the through hole.When using spot printing sealing device provided by the utility model, by binding agent
(such as vacuum grease) is placed in the cavities, is promoted binding agent with pushing part, binding agent is extruded from multiple through holes of sleeve one end.
Because the arrangement position of through hole and the peristoma of crystallizing pond are corresponding, when the peristoma of crystallizing pond is staggered relatively with through hole, binding agent
After being extruded from through hole, portion of binder is bonded in the peristoma of crystallizing pond, so far, the spot printing work in the peristoma of crystallizing pond
Convenient and swift completion.More show convenience of the present utility model, quick in the case of multiple crystallizing ponds are provided with crystallization plates
Property, thus improve the efficiency for completing spot printing sealing operation on crystallizing pond.Simultaneously as it is provided with sleeve multiple and crystallizing pond
Peristoma is to corresponding through hole, when spot printing works, the position of spot printing binding agent, quantity be affected by human factors it is smaller, so as to subtract
The uncertainty of experiment is lacked.
Brief description of the drawings
, below will be right in order to illustrate more clearly of the utility model embodiment or technical scheme of the prior art
The required accompanying drawing used is briefly described in embodiment or description of the prior art, it should be apparent that, describe below
In accompanying drawing be some embodiments of the present utility model, for those of ordinary skill in the art, do not paying creativeness
On the premise of work, other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is crystallizing pond of the prior art and the schematic diagram of cover glass relative position；
Fig. 2 is the perspective view of crystallization plates of the prior art；
Fig. 3 is the stereogram of spot printing sealing device provided by the utility model；
Fig. 4 is the perspective view of spot printing sealing device provided by the utility model；
Fig. 5 is the top view of spot printing sealing device provided by the utility model；
Fig. 6 is sleeve and the half sectional view of crystallization plates positioning in spot printing sealing device provided by the utility model.
Icon：1- crystallization plates；10- crystallizing ponds；11- peristomas；12- recesses；13- crystallization solutions；20- cover glasses；21- hanging drops
Solution；30- sleeves；31- bottom plates；311- through holes；312- positive stop strips；32- cavitys；33- ribs；40- pushing parts；41- is sealed
Circle.
Embodiment
The technical solution of the utility model is clearly and completely described below in conjunction with accompanying drawing, it is clear that described
Embodiment is the utility model part of the embodiment, rather than whole embodiments.Based on the embodiment in the utility model, sheet
The every other embodiment that field those of ordinary skill is obtained under the premise of creative work is not made, belongs to this practicality
Novel protected scope.
, it is necessary to explanation in description of the present utility model, such as occur term " " center ", " on ", " under ", " left side ",
" right side ", " vertical ", " level ", " interior ", " outer " etc., orientation or position relationship indicated by it be based on orientation shown in the drawings or
Position relationship, it is for only for ease of description the utility model and simplifies description, rather than indicates or imply signified device or member
Part must have specific orientation, with specific azimuth configuration and operation, therefore it is not intended that to limitation of the present utility model.
In addition, such as there is term " first ", " second ", " the 3rd " are only used for describing purpose, and it is not intended that instruction or implying relative
Importance.
, it is necessary to which explanation, unless otherwise clearly defined and limited, term such as occurs in description of the present utility model
" installation ", " connected ", " connection " should be interpreted broadly, for example, it may be fixedly connected or be detachably connected, or one
Connect body；Can be mechanical connection or electrical connection；Can be joined directly together, can also be indirect by intermediary
It is connected, can is the connection of two element internals.For the ordinary skill in the art, on being understood with concrete condition
State concrete meaning of the term in the utility model.
Spot printing sealing device provided by the utility model, as shown in Figure 3,4, the spot printing in the peristoma 11 to crystallizing pond 10
Binding agent.Spot printing sealing device includes sleeve 30 and pushing part 40；The cavity 32 for placing binding agent is provided with sleeve 30；
One end of pushing part 40 is arranged in cavity 32, and with the slidable connection of sleeve 30；One end of sleeve 30 is provided with and cavity 32
Multiple through holes 311 of connection, the arrangement position of through hole 311 is corresponding with the shape of the peristoma 11 of crystallizing pond 10, promotes pushing part
40, so that binding agent is extruded from through hole 311.When using spot printing sealing device provided by the utility model, by binding agent (such as
Vacuum grease) it is placed in cavity 32, binding agent is promoted with pushing part 40, makes binding agent from multiple through holes 311 of the one end of sleeve 30
Middle extrusion.Because the arrangement position of through hole 311 is corresponding with the shape of the peristoma 11 of crystallizing pond 10, when the peristoma 11 of crystallizing pond 10
With through hole 311 it is staggered relatively when, after binding agent is extruded from through hole 311, portion of binder is bonded in the peristoma 11 of crystallizing pond 10
On, so far, the convenient and swift completion of spot printing work in the peristoma 11 of crystallizing pond 10.After covered 20, overstock and crystallizing
Binding agent flowing in the peristoma 11 in pond 10, so that the peristoma 11 of cover glass 20 and crystallizing pond 10 is bonded in one by binding agent
Rise, to ensure to cover when in the peristoma 11 of crystallizing pond 10 when cover glass 20, the sealing of crystallizing pond 10 and cover glass 20.For knot
The situation that multiple crystallizing ponds 10 are provided with brilliant plate 1 more shows convenient, fast property of the present utility model, thus improves and complete crystallization
The efficiency of spot printing sealing operation on pond 10.Simultaneously as be provided with sleeve 30 it is multiple with the peristoma of crystallizing pond 10 11 to corresponding
Through hole 311, when spot printing works, the position of spot printing binding agent, quantity be affected by human factors it is smaller, so as to reduce experiment
Uncertainty.Below so that binding agent is vacuum grease as an example, to illustrate the structure of spot printing sealing device provided by the utility model
And application method.
If the peristoma 11 of crystallizing pond 10 is circle, multiple through holes 311 surround corresponding with the shape of the peristoma of crystallizing pond 10 11
Circle.If crystallizing pond 10 is arranged on crystallization plates 1, and the quantity of crystallizing pond 10 is multiple, multiple through holes 311 surround with it is multiple
The corresponding multiple circles of the shape of the peristoma 11 of crystallizing pond 10.When carrying out the spot printing work of crystallizing pond 10, by crystallizing pond 10
Peristoma 11 is oppositely arranged with the through hole on sleeve 30 about 311, is promoted pushing part 40 to extrude vacuum grease, is made vacuum grease from through hole
Extrude, and be bonded in the peristoma 11 of crystallizing pond 10 in 311.It should be noted that the peristoma 11 of crystallizing pond 10 can also be it
His shape, such as rectangle, the multiple through holes 311 set on sleeve 30 also enclose corresponding shape.
Existing crystallizing pond 10 is arranged on crystallization plates 1 mostly, as shown in Fig. 2 multiple crystallizing ponds 10 are on crystallization plates 1
Matrix arrangement.It is about 1.00mm that the peristoma 11 of crystallizing pond 10 protrudes from crystallization plates 1 mostly.The raised external diameter of peristoma 11 is
20.00mm, internal diameter 16.00mm.Therefore 11 a width of 2.00mm of peristoma.So that 4 × 4=16 independent knots to be distributed with crystallization plates 1
Exemplified by brilliant pond 10, the length of side on the inside of the rectangular outer of crystallization plates 1 is 90.00mm, a height of 2.00mm of outer rim.Above-mentioned crystallization plates 1 are
The specification crystallization plates 1 commonly used in Bioexperiment, therefore below by taking the crystallization plates 1 of above-mentioned specification as an example, to illustrate spot printing sealing device
The situation of the peristoma 11 of spot printing crystallizing pond 10.For convenience of description, one end of the sleeve 30 where through hole 311 is properly termed as sleeve 30
Bottom plate 31.Bottom plate 31 be able to can be integrally formed with sleeve 30, can also be provided separately with sleeve 30.Bottom plate 31 and sleeve 30
When being provided separately, it is ensured that the sealing between bottom plate 31 and sleeve 30.
The material of spot printing sealing device can be selected as lucite.Lucite has heigh clarity, can facilitate
Observe the volume of the vacuum resin in sleeve 30.Meanwhile the mechanical strength of lucite is higher and in light weight, resistance to combustion is corrosion-resistant,
With lucite make spot printing sealing device using when be hardly damaged, make more convenient.The price of lucite is relatively low, with having
It is cheap that machine glass makes spot printing sealing device.It is existing when making through hole 311 on sleeve 30 made of lucite
The specification of drill bit is：Diameter 1.00mm, 1.50mm, 2.00mm, that is, the diameter of the through hole 311 produced be about 1.00mm,
1.50mm、2.00mm。
Draw by experiment, sent out when the vacuum grease of extrusion forms vacuum grease post, and touches the peristoma 11 of crystallizing pond 10
Raw flow deformation, and be adhered to each other with the peristoma 11 of crystallizing pond 10.If vacuum grease post can keep plumbness, vacuum grease post
Height when within 2 times of diameters can keep plumbness, therefore, on the premise of highly constant, the vacuum grease post that is relatively large in diameter
It is more beneficial for keeping vertical stability.Meanwhile after vacuum grease touches the peristoma 11 of crystallizing pond 10, the two process slowly separated
In, vacuum grease post will be broken, and a part of vacuum grease is adhered to the surface of peristoma 11 of crystallizing pond 10.Many experiments and theory
Analysis shows, after vacuum grease touches the peristoma 11 of crystallizing pond 10, during the two is slowly separated, it is adhered to crystallizing pond 10
The volume approximately equal of the volume of vacuum grease on the surface of peristoma 11 and the vacuum grease stayed at extrusion, about original vacuum grease
The half of column volume.According to the size of above-mentioned crystallizing pond 10, the area of peristoma 11 for drawing each crystallizing pond 10 is：
Wherein D is the external diameter of crystallizing pond 10, and d is the internal diameter of crystallizing pond 10.Try to achieve the area of peristoma 11 of each crystallizing pond 10
For 113.04mm2.To reach excellent sealing effect, the thickness for the vacuum grease being bonded in the peristoma 11 of crystallizing pond 10 is at least
0.20mm.Then in the ideal situation, it is 22.61mm that the peristoma 11 of each crystallizing pond 10, which needs the volume of spot printing vacuum grease,3。
According to design, the through hole 311 on bottom plate 31 surrounds circle, and multiple through holes 311 are evenly distributed on diameter 18mm
On circumference.In theory, through hole 311 is closeer, and the vacuum grease of extrusion is easier to be linked to be ring after compression.The through hole 311 continuously arranged
Center spacing be no less than 2 times of the diameter of through hole 311, otherwise have the risk being broken along extrusion after pressure-bearing.Due to through hole 311
Quantity is more, and 2 center spacing of through hole 311 are approximately equal to the arc length between center.Therefore the calculating of the maximum quantity of opened hole 311
Formula is as follows：
Wherein, outer diameter D=20.00mm of crystallizing pond 10；The internal diameter d=16.00mm of crystallizing pond 10；Hole diameter Φ=
1.00th, 1.50 or 2.00mm；Small hole number n waits to ask.
Diameter of phi=1.00mm, 1.50mm or 2.00mm of through hole 311.
Small hole number n is：
During Φ=1.00mm, n≤28；
During Φ=1.50mm, n≤18；
During Φ=2.00mm, n≤14.
The vacuum grease post extruded from the through hole 311 of spot printing sealing device should keep state vertically upward.After separation, glue
Being attached to the vacuum grease volume on the surface of peristoma 11 of crystallizing pond 10 can be estimated by the half of vacuum grease column volume.Therefore, stay in
The volume calculation formula of vacuum grease in the peristoma 11 of crystallizing pond 10 is：
Diameter of phi=1.00mm, 1.50mm or 2.00mm of aperture, accordingly, the quantity n=28,18 or 14 of through hole 311.
According to experimental data, the vacuum grease pillar height degree of extrusion within 2 times of its diameter by that can keep vertical, by 1.5 times of calculating.Vacuum grease post
Vertical height H=1.5 Φ.The vacuum grease volume V of the surface adhesion of peristoma 11 of crystallizing pond 10 waits to ask.
During due to Φ=1.00mm, V=16.48mm3；
During Φ=1.50mm, V=35.76mm3；
During Φ=2.00mm, V=65.94mm3。
Because the sealing of peristoma 11 of single crystallizing pond 10 needs vacuum grease volume 22.61mm3, diameter 1mm apertures extrusion is very
Empty fat volume deficiency；Diameter 1.5mm, 2mm aperture extrusion vacuum grease volume exceed seal request.To sum up, spot printing sealing device
The small hole number of annular spread on each extrusion is 18, a diameter of 1.5mm, is optimal design parameters.Spot printing sealing device
The key parameter of model presses this design data.
It can be learnt from above, as shown in figure 5, the internal diameter of the peristoma 11 of crystallizing pond 10 is 16mm, during a width of 2mm, through hole 311
A diameter of 1.5mm, the quantity for surrounding the through hole 311 of circle are 18.
Limiting section can be provided with sleeve 30, so that the circle that the peristoma 11 on crystallizing pond 10 surrounds with multiple through holes 311
The position of shape is corresponding, to ensure the precise positioning of the peristoma 11 of crystallizing pond 10 and through hole 311.
The circular quantity that above-mentioned multiple through holes 311 surround is multiple；Have on one end of sleeve 30 orthogonal
Multiple circles, i.e., the circle that multiple through holes 311 surround are provided with first direction and second direction, first direction and second direction
Shape can be distributed on bottom plate 31 in the matrix form.As can be distributed with bottom plate 31 4 × 4 totally 16 surrounded by multiple through holes 311
Circle
Specifically, limiting section can be the protuberance set on the face at the place of through hole 311；Crystallizing pond 10 is arranged on crystallization plates
On 1；Recess 12 is provided with crystallization plates 1, protuberance coordinates with the recess 12 on crystallization plates 1, makes the peristoma 11 on crystallizing pond 10
Position it is corresponding with the circular position that multiple through holes 311 surround.
The side protruded due to crystallization plates 1 and the distance of the peristoma 11 of crystallizing pond 10 are about 2 ㎜, and said structure, which is formed, to be finished
Recess 12 on brilliant plate 1, as shown in Figure 6.Protuberance is provided with bottom plate 31, protuberance can be the limit being engaged with recess 12
Position bar 312, so that when the peristoma 11 of crystallizing pond 10 and the bottom plate 31 of sleeve 30 are relatively setting up and down, relative movement crystallization plates 1, make
The peristoma 11 of multiple crystallizing ponds 10 on crystallization plates 1 is relative with multiple circles that multiple through holes 311 on floor surround, and works as vacuum
When fat is extruded, vacuum grease is bonded in the peristoma 11 of crystallizing pond 10.
Further, the cross section of positive stop strip 312 can be trapezoidal.Trapezoidal bottom is 2 ㎜.Upper bottom edge is 1.5~1
㎜.Above-mentioned setting can have small adjustment effect to crystallization plates 1 in position fixing process.
Meanwhile the height of positive stop strip 312 can be 3.5~3 ㎜, so that after crystallization plates 1 position with bottom plate 31, crystallizing pond 10
Peristoma 11 and bottom plate 31 have 1.5~1 ㎜ gap so that the vacuum grease post extruded from through hole 311 is vertically bonded in crystallization
In the peristoma 11 in pond 10.Now, the height of the vacuum grease post of the High definition extrusion of positioning strip.Certainly, the height of positive stop strip 312
The amount of vacuum grease that can also be as needed is set, to limit after crystallization plates 1 position with bottom plate 31, bottom plate 31 and crystallizing pond 10
Peristoma 11 distance.
Above-mentioned positive stop strip 312 can be bonded on bottom plate 31, or in manufacturing process, is processed on present bottom plate 31 for putting
The groove of positioning strip is put, to carry out precise positioning to the position of positioning strip.Certainly, positioning strip can also be integrally formed with sleeve 30.
Certainly, limiting section can also be other shapes and structure.For example, limiting section can be the protrusion on bottom plate 31
Cylinder, for positioning action.Limiting section is alternatively the structures such as the bearing for playing position-limiting action stretched out on sleeve 30.
Further, seal is provided with pushing part 40, to avoid pushing part 40 during binding agent is promoted, glued
Knot agent is overflowed between sleeve 30 and pushing part 40.Above-mentioned seal can be sealing ring 41.
The cross section of above-mentioned sleeve 30 can design squarely, so that the end face for being provided with through hole 311 of sleeve 30 and knot
Brilliant plate 1 is corresponding.The cross section of pushing part 40 can be corresponding square.
Alternately, the cross section of sleeve 30 can be circle；Internal thread is provided with the aperture surface of sleeve 30；Pushing part
It is provided with external screw thread on 40, the external screw thread set on the internal thread and pushing part 40 on sleeve 30 matches.Using above-mentioned point
When applying sealing device, by screw propulsion pushing part 40, vacuum grease can be extruded from through hole 311.
The outside of sleeve 30 can be provided with ribs 33.When pushing part 40 is during vacuum grease is extruded, vacuum grease
Easily cause the extruding to the side wall of sleeve 30 and deform.Therefore ribs 33 is set in the outside of sleeve 30, can be with protective case
The side wall of cylinder 30 is not damaged.
When carrying out spot printing operation, sleeve 30 is setting up and down with crystallization plates 1.The first situation：By the peristoma of crystallizing pond 10
11 upwards, and bottom plate 31 is downward, after bottom plate 31 positions with crystallization plates 1, pushes down on pushing part 40, makes the relative sleeve 30 of pushing part 40
Move down, vacuum grease is flowed out from through hole 311.Second of situation：The bottom of pushing part 40 can be provided with base, bottom
The seat room of being placed on is tested on platform or desktop, and during spot printing operation, crystallization plates 1 are overturn, after bottom plate 31 and crystallization plates 1 position, downwards
Crystallization plates 1 are pressed, now, pushing part 40 and sleeve 30 have relative displacement, and vacuum grease extrudes certain height from through hole 311
It is bonded in afterwards in the peristoma 11 of crystallizing pond 10.Certainly, during spot printing operation, crystallization plates 1 and spot printing sealing device can also level set
Put.
Preferably, when carrying out spot printing operation, second of fashion of extrusion is selected.Because spot printing sealing device has certain weight
Amount, aforesaid way spot printing is more convenient, in position fixing process, it is only necessary to overturn crystallization plates 1, to be positioned.It is meanwhile above-mentioned
Mode, vacuum grease easily form vacuum grease post during extruding.
It should be noted that when produce in enormous quantities above-mentioned spot printing sealing device, the diameter and quantity of through hole 311 can
To be set according to actual conditions.Such as when producing above-mentioned spot printing sealing device using Shooting Technique, the size of above-mentioned through hole 311 is not
It is limited to use 1.5mm, but ensures the volume of vacuum grease being a little coated in the peristoma 11 of crystallizing pond 10, that is, through hole 311 is set
Diameter and quantity, it is close between crystallizing pond 10 and cover glass 20 to ensure that cover glass 20 is covered when in the peristoma 11 of crystallizing pond 10
Feng Xing.
Above-mentioned spot printing sealing device can also be made in addition to being made using lucite using alloy material.Example
Aluminium alloy is such as used, steel alloy has higher plasticity and toughness, while easily shaping.
It should also be noted that, the vacuum grease in the utility model may be replaced by other binding agents, such as asphalt mixtures modified by epoxy resin
The material such as fat or colloid.Crystallizing pond 10 can also be other specifications, the shape and institute that now the through hole 311 on sleeve 30 surrounds
Position it is corresponding with the shape of the peristoma 11 of crystallizing pond 10 and position.
In summary, spot printing sealing device provided by the utility model, binding agent are placed in the cavity 32 in sleeve 30；
One end of pushing part 40 is arranged in cavity 32, and with the slidable connection of sleeve 30；One end of sleeve 30 is provided with multiple through holes
311, the arrangement position of through hole 311 is corresponding with the peristoma 11 of crystallizing pond 10.Pushing part 40 is promoted, so that from the one end of sleeve 30
Extruded in multiple through holes 311.Binding agent can be vacuum grease.Arrangement position due to through hole 311 and the peristoma on crystallizing pond 10
11 is corresponding, and when the peristoma 11 of crystallizing pond 10 is staggered relatively with through hole 311, after binding agent is extruded from through hole 311, part is viscous
Knot agent is bonded in the peristoma 11 of crystallizing pond 10, so far, the convenient and swift completion of spot printing work in the peristoma 11 of crystallizing pond 10.
Usual single protein crystallization condition screening experiment needs 6 16 pond crystallization plates 1, therefore needs 6 × 16=96 crystallizing pond of spot printing
10, each crystallizing pond 10 18 points of average spot printing, need to repeat 1728 spot printing actions altogether, use point provided by the utility model
Sealing device is applied, spot printing operation is once completed, and can more highlight the convenient, fast of spot printing sealing device provided by the utility model
Property, to alleviate the less efficient of spot printing sealing operation on crystallizing pond 10 is completed in the prior art, while simple machinery repeats
Operation easily make one burnout and it is irritated the problem of, thus spot printing sealing device provided by the utility model improve complete crystallizing pond 10
The efficiency of upper spot printing sealing operation.Simultaneously as be provided with sleeve 30 it is multiple with the peristoma of crystallizing pond 10 11 to corresponding logical
Hole 311, when spot printing works, the position of spot printing binding agent, quantity be affected by human factors it is smaller, so as to reduce the not true of experiment
It is qualitative.Multiple through holes 311 on sleeve 30 surround in the peristoma 11 with crystallizing pond 10 shape and the shape of position correspondence and
Position, while the diameter of through hole 311 and the quantity of through hole 311 pass through reasonable computation, it can be ensured that point is coated in the peristoma of crystallizing pond 10
The volume of binding agent on 11 and position, to ensure that cover glass 20 is covered when on crystallizing pond 10, crystallizing pond 10 and cover glass 20
Sealing.Meanwhile positioning strip is provided with bottom plate 31, to realize being accurately positioned for crystallization plates 1 and bottom plate 31, make crystallization plates 1
Quickly cover on bottom plate 31, it is more convenient during use.
Finally it should be noted that：Various embodiments above is only to illustrate the technical solution of the utility model, rather than it is limited
System；Although the utility model is described in detail with reference to foregoing embodiments, one of ordinary skill in the art should
Understand：It can still modify to the technical scheme described in foregoing embodiments, either to which part or whole
Technical characteristic carries out equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from this practicality newly
The scope of each embodiment technical scheme of type.
Claims (10)
1. a kind of spot printing sealing device, for the peristoma spot printing binding agent of crystallizing pond, it is characterised in that the spot printing sealing dress
Put including sleeve and pushing part；The cavity for placing the binding agent is provided with the sleeve；One end of the pushing part
Be arranged in the cavity, and with the sleeve slidable connection；One end of the sleeve is provided with what is connected with the cavity
Multiple through holes, the arrangement position of the through hole is corresponding with the shape of the peristoma on the crystallizing pond, promotes the pushing part, with
The binding agent is set to be extruded from the through hole.
2. spot printing sealing device according to claim 1, it is characterised in that the peristoma of the crystallizing pond is circle；It is multiple
The through hole surrounds circle corresponding with the shape of the peristoma of the crystallizing pond.
3. spot printing sealing device according to claim 2, it is characterised in that the shape internal diameter of the peristoma of the crystallizing pond is
16mm, a width of 2mm, a diameter of 1.5mm of the through hole, the quantity for surrounding the circular through hole are 18.
4. the spot printing sealing device according to Claims 2 or 3, it is characterised in that multiple through holes surround circular
Quantity is multiple；
There is orthogonal first direction and second direction, the first direction and second direction on one end of the sleeve
On be provided with multiple circles.
5. spot printing sealing device according to claim 1, it is characterised in that limiting section is provided with the sleeve, so that
The circular position that multiple through holes surround is corresponding with the position of the peristoma on the crystallizing pond.
6. spot printing sealing device according to claim 5, it is characterised in that the limiting section is is arranged on the through hole institute
Face on protuberance；
The protuberance is with the recesses fit on the crystallization plates where crystallizing pond, the circular position for surrounding multiple through holes
It is corresponding with the position of the peristoma on the crystallizing pond.
7. spot printing sealing device according to claim 6, it is characterised in that the cross section of the protuberance is trapezoidal.
8. spot printing sealing device according to claim 1, it is characterised in that seal is provided with the pushing part, with
Avoiding the pushing part, the binding agent overflows between the sleeve and pushing part during the binding agent is promoted.
9. spot printing sealing device according to claim 1, it is characterised in that the cross section of the sleeve is circle；It is described
Internal thread is provided with the aperture surface of sleeve；It is provided with external screw thread on the pushing part, internal thread and promotion on the sleeve
The external screw thread set in portion matches.
10. spot printing sealing device according to claim 1, it is characterised in that be provided with ribs on the outside of the sleeve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720352475.6U CN207103036U (en) | 2017-04-06 | 2017-04-06 | Spot printing sealing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720352475.6U CN207103036U (en) | 2017-04-06 | 2017-04-06 | Spot printing sealing device |
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| Publication Number | Publication Date |
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| CN207103036U true CN207103036U (en) | 2018-03-16 |
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| CN201720352475.6U Expired - Fee Related CN207103036U (en) | 2017-04-06 | 2017-04-06 | Spot printing sealing device |
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| CN (1) | CN207103036U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110641963A (en) * | 2019-09-26 | 2020-01-03 | 长兴柏成电子有限公司 | Turning device is used in magnetic core production |
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2017
- 2017-04-06 CN CN201720352475.6U patent/CN207103036U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110641963A (en) * | 2019-09-26 | 2020-01-03 | 长兴柏成电子有限公司 | Turning device is used in magnetic core production |
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