CN207085955U - Flow channel type heater and reagent biochemical reaction device - Google Patents
Flow channel type heater and reagent biochemical reaction device Download PDFInfo
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- CN207085955U CN207085955U CN201720986202.7U CN201720986202U CN207085955U CN 207085955 U CN207085955 U CN 207085955U CN 201720986202 U CN201720986202 U CN 201720986202U CN 207085955 U CN207085955 U CN 207085955U
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Abstract
The utility model discloses a kind of flow channel type heater and reagent biochemical reaction device, flow channel type heater, including：Reagent trough, it is provided with reagent runner close to each other and independent mutually and heating liquid recycle stream road；Insulating box, it has heating liquid inlet and heating liquid liquid outlet, and the heating liquid liquid outlet and heating liquid inlet of insulating box are connected by pipeline with the heating liquid inlet and heating liquid liquid outlet in heating liquid recycle stream road respectively；And circulating pump, it is arranged on the pipeline between the heating liquid liquid outlet of insulating box and the heating liquid inlet for heating liquid recycle stream road.The heating liquid recycle stream road for importing heated at constant temperature liquid is circulated because reagent trough is provided with, heating liquid recycle stream road is set close to reagent runner so that heating liquid energy is enough to the heating of reagent uniform flow passage and fast cooling, and the small volume of whole heater, it is easy to safeguard, easy for installation, cost is low.
Description
Technical field
A kind of equipment that the utility model is related to chip and reagent biochemical reaction, and in particular to runner for reagent heating
Formula heater and reagent biochemical reaction device.
Background technology
Chip needs a variety of independent reagents when carrying out biochemical reaction with reagent, different reagents and chip need difference when reacting
Steady temperature.
Prior art be using water-bath to reagent trough immersion type heat, reagent trough correspondence position put one it is special
Water-bath, reagent trough is fixed bubble inside water-bath, exposes reagent notch, water-bath has heating module, can be to water
Bath water heat and constant temperature, and reagent trough is heated by the water of heating, and heating reagent trough is again to the reagent and core inside groove
Piece heating and constant temperature.
Existing heating constant-temperature equipment heat time length, volume cause greatly machine volume excessive, and cost is high, and installation site is not
Variable, bad maintenance is uneven to reagent trough transient heating, cools after heating difficult, it is impossible to provide the temperature less than environment temperature
Degree demand.
The content of the invention
The application provides a kind of reagent trough that biochemical reaction can be carried out to chip and reagent and provides corresponding steady temperature
Flow channel type heating constant-temperature equipment and reagent biochemical reaction device.
According in a first aspect, provide a kind of flow channel type heater in a kind of embodiment, including：
Reagent trough, it is provided with reagent runner close to each other and independent mutually and heating liquid recycle stream road, reagent runner edge
Vertical direction setting, the upper end of reagent runner has reagent inlet, and lower end has waste liquid liquid outlet, heating liquid recycle stream road
With heating liquid inlet and heating liquid liquid outlet；
For providing the insulating box of heated at constant temperature liquid, it has heating liquid inlet and heating liquid liquid outlet, insulating box
Heat liquid liquid outlet and heat liquid inlet respectively by the heating liquid inlet and heating liquid of pipeline and heating liquid recycle stream road
Liquid outlet connects；
And circulating pump, its heating liquid inlet for being arranged on the heating liquid liquid outlet of insulating box and heating liquid recycle stream road
Between pipeline on.
Further, flow channel type heater also includes heating liquid branching block and heating liquid confluxes block, heats liquid branching block
With an inlet and several liquid outlets, the heating liquid block that confluxes has several inlets and a liquid outlet；Heat liquid
The inlet of branching block is connected by the heating liquid liquid outlet of pipeline and inlet, and the liquid outlet of heating liquid branching block passes through respectively
Pipeline is connected with the heating liquid inlet of several reagent troughs, and each reagent trough heating liquid inlet and heating liquid branching block
Liquid outlet between pipeline on a circulating pump is installed；Heating liquid conflux block inlet by pipeline respectively with several
Reagent trough heating liquid liquid outlet connection, heating liquid conflux block liquid outlet pass through the inlet of pipeline and insulating box connect.
Further, reagent runner and heating liquid recycle stream road are arranged side by side vertically.
In other embodiments, liquid recycle stream road structure in a ring is heated, heating liquid recycle stream road is enclosed on reagent runner
Outside.
In other embodiments, liquid recycle stream road helically structure is heated, heating liquid recycle stream road is spirally wound on reagent
Around runner.
Further, heating system and semiconductor refrigeration system are set in insulating box.
Further, liquid-level switch and temperature sensor are additionally provided with insulating box.
Further, it is water to heat liquid.
According to second aspect, a kind of reagent biochemical reaction device is provided in a kind of embodiment, including：
Above-mentioned flow channel type heater；
Depositing has the refrigerator of some reagent bottles, and the reagent bottle in refrigerator passes through pipeline and the reagent inlet of reagent runner connects
Connect；
Reagent confluxes block, its several inlet and liquid outlet, several reagent bottles in refrigerator respectively by pipeline with
Reagent conflux block import connection, reagent conflux block liquid outlet pass through the reagent inlet of pipeline and reagent trough connect；
And reagent topping-up pump, it is arranged on the pipeline between reagent bottle and the reagent inlet of reagent runner.
Further, reagent biochemical reaction device also includes waste collection tank, waste drains pump and magnetic valve, and waste collection tank leads to
The conflux liquid outlet of block of piping and reagent is connected, and the waste liquid liquid outlet of reagent trough is confluxed the inlet of block by pipeline and reagent
Connection, waste drains pump be arranged on reagent trough waste liquid liquid outlet and reagent conflux block inlet between pipeline on, magnetic valve peace
On two pipelines being connected mounted in the reagent inlet and waste liquid liquid outlet with reagent runner, and reagent topping-up pump and waste drains pump
Be respectively positioned on magnetic valve and pipeline that reagent confluxes between block on.
According to the flow channel type heater and reagent biochemical reaction device of above-described embodiment, because reagent trough is provided with circulation
The heating liquid recycle stream road of heated at constant temperature liquid is imported, heating liquid recycle stream road is set close to reagent runner so that heating liquid energy reaches
To the heating of reagent uniform flow passage and fast cooling, and the entirely small volume of heater, it is easy to safeguard, easy for installation, cost
It is low.
Brief description of the drawings
Fig. 1 is a kind of structural representation of flow channel type heater in embodiment；
Fig. 2 is the structural representation of flow channel type heater in another embodiment；
Fig. 3 is a kind of structural representation of reagent biochemical reaction device in embodiment.
Embodiment
The present invention is described in further detail below by embodiment combination accompanying drawing.
Embodiment one：
The present embodiment provides a kind of flow channel type heater, and this flow channel type heater is mainly used in reagent and chip life
Change the heating of reaction, it can also be used to which other liquid are heated.
As shown in figure 1, the flow channel type heater of the present embodiment mainly includes reagent trough 1, insulating box 2 and circulating pump 3.
Reagent trough 1 is provided with reagent runner 101 and heating liquid recycle stream road 102, and reagent runner 101 is placed in the vertical direction
In the centre position of reagent trough 1, and upper end is provided with opening, is open and is placed into for chip 12 in reagent runner 101, reagent flow
(direction shown in Fig. 1) is extended with reagent inlet to the right for the upper end in road 101, and the lower end of reagent runner 101 is extended with to the right
Waste liquid liquid outlet.
Heating liquid recycle stream road 102 reclines vertically is arranged on the right side of reagent runner 101, heating liquid recycle stream road 102
Lower end is provided with heating liquid inlet, and upper end is provided with heating liquid liquid outlet.In other embodiments, liquid recycle stream road 102 is heated to set
Loop configuration is set to, heating liquid recycle stream road 102 is enclosed on the outside of reagent runner 101, reagent runner 101 is wrapped, improves
Heating effect；Or heating liquid recycle stream road 102 is arranged to helical structure, heating liquid recycle stream road 102 is spirally wound on reagent
Around runner 101.
In the present embodiment, insulating box 2 heats liquid for storing, and the heating liquid in the present embodiment is water, in other embodiment
In, it can also use other heating media, such as oil.Heating system (not shown in figure 1) and semiconductor refrigerating are provided with insulating box 2
System 201, heating system can heat water to preset temperature, and semiconductor refrigeration system 201 is used to water temperature being reduced to default temperature
Degree.Insulating box 2 has heating liquid liquid outlet and heating liquid inlet, the heating liquid liquid outlet and heating liquid inlet of insulating box 2
It is connected respectively by pipeline with the heating liquid inlet and heating liquid liquid outlet in heating liquid recycle stream road 102, forms circulation loop
System.
Circulating pump 3 be arranged on the heating liquid liquid outlet of insulating box 2 and heat liquid recycle stream road 102 heating liquid inlet it
Between pipeline on, circulating pump 3 is used to drive heating liquid in insulating box 2 to heating liquid recycle stream road 102, is formed to reagent flow
The heating in road 101.
In order to adjust water level and control water temperature, liquid-level switch 202 is installed in the upper end of insulating box 2, centre is provided with temperature
Sensor 203 is spent, lower end is provided with drainage switch 204.
The thermostat principle of the present embodiment is：When cold reagent is added in reagent runner 101, the temperature potential of reagent runner 101 must
Reducing, coolant-temperature gage can also reduce in heating liquid recycle stream road 102, but because heating liquid recycle stream road 102 is that water circulation heats work(
Can, the water at low temperature drained in heating liquid recycle stream road 102 can be constantly circulated, hot water is changed and reagent is heated, so as to quickly make
Reagent is heated to need temperature and keeps constant temperature.
The flow channel type heater that the present embodiment provides, adding for heated at constant temperature liquid is imported because reagent trough 1 is provided with circulation
Hydrothermal circulation runner 102, heating liquid recycle stream road 102 are set close to reagent runner 101 so that heating liquid energy is enough to reagent runner
101 uniformly heating and fast coolings, and the small volume of whole heater, are easy to safeguard, easy for installation, cost is low.
Embodiment two：
Another flow channel type heater is present embodiments provided, the insulating box 2 of this flow channel type heater can be simultaneously real
Heated at constant temperature now is carried out to multiple reagent troughs 1.
Specifically, as shown in Fig. 2 the flow channel type heater of the present embodiment include multiple 1, insulating box 2 of reagent trough,
Multiple circulating pumps 3, heating liquid branching block 4 and heating liquid conflux block 5, and reagent trough 1 and circulating pump 3 only show one in Fig. 2, other
Omit.Reagent trough 1, insulating box 2 and circulating pump 3 are identical with above-described embodiment one.Difference is, adds heating liquid point
Stream block 4 and heating liquid conflux block 5.
Heating liquid branching block 4 has an inlet and a multiple liquid outlets, heating liquid conflux block 5 with multiple inlets with
One liquid outlet.The heating liquid liquid outlet of insulating box 2 is connected by pipeline with heating the inlet of liquid branching block 4, heating liquid point
Multiple liquid outlets of stream block 4 are connected by pipeline with the heating liquid inlet of multiple reagent troughs 1 respectively, and each reagent trough 1
A circulating pump 3 is correspondingly arranged on, circulating pump 3 is arranged on the heating liquid feed liquor of the liquid outlet and reagent trough 1 of heating liquid branching block 4
On pipeline between mouthful, circulating pump 3 drives the heating liquid stream in the circulation loop of corresponding reagent trough 1 to lead to respectively.Heating liquid confluxes
Multiple inlets of block 5 are connected by pipeline with the heating liquid liquid outlet of multiple reagent troughs 1 respectively, and heating liquid confluxes the going out of block 5
Liquid mouth is connected by pipeline with the heating liquid inlet of insulating box 2.
The flow channel type heater of the present embodiment, due to setting heating liquid branching block 4 and heating liquid confluxes block 5, insulating box 2
Heating liquid can be imported into multiple different reagent troughs 1, heating liquid confluxes block 5 can be by multiple different reagent troughs 1
Desuperheated heating liquid, which collects, to be imported into insulating box 2 so that insulating box 2 can meet that the circulation of multiple reagent troughs 1 adds simultaneously
The supply of hot water, conventional efficient is improved, while saved cost.
Embodiment three：
A kind of reagent biochemical reaction device is present embodiments provided, reagent biochemical reaction device is mainly used in reagent and core
Piece carries out biochemical reaction under default isoperibol, and can realize biochemical reaction of the different reagents under different constant temperature.
As shown in figure 3, the reagent biochemical reaction device of the present embodiment is on the basis of the flow channel type heater of embodiment two
On add refrigerator 6, reagent confluxes block 7, reagent topping-up pump 8, waste collection tank 9, waste drains pump 10 and magnetic valve 11.
Multiple different reagent bottles 61 are placed with refrigerator 6, refrigerator 6 is used to carry out cryopreservation to reagent bottle 61.
The reagent block 7 that confluxes has several liquid outlets and an inlet, and liquid outlet and inlet are corresponded and set.It is cold
Multiple reagent bottles 61 of cabinet 6 are connected by the conflux inlet of block 7 of pipeline and reagent respectively, and a liquid outlet of refrigerator 6 passes through
Pipeline is connected with the reagent inlet of reagent runner 101, and reagent confluxes the changeable different liquid outlets of block 7 and reagent runner 101
Reagent inlet is connected, and biochemical reaction is carried out to importing different reagents so as to realize.
Reagent topping-up pump 8 is arranged on the pipeline between the liquid outlet of refrigerator 6 and the reagent inlet of reagent runner 101,
Reagent topping-up pump 8 is used to introduce an agent into the progress biochemical reaction of reagent runner 101.
Waste collection tank 9 is connected by pipeline with the waste liquid liquid outlet of reagent runner 101, after reclaiming biochemical reaction
Waste liquid.
Waste drains pump 10 is arranged on the pipeline between waste collection tank 9 and the waste liquid liquid outlet of reagent runner 101, for inciting somebody to action
Devil liquor recovery in reagent runner 101 is in waste collection tank 9.
Magnetic valve 11 is arranged on two pipelines being connected with the reagent inlet and waste liquid liquid outlet of reagent runner 101,
And on the pipeline between reagent topping-up pump 8 and waste drains pump 10 are respectively positioned on magnetic valve 11 and reagent confluxes block 7.Magnetic valve 11 is realized
To the open and close controlling of pipeline.
The injection reagent operation principle step of the reagent biochemical reaction device of the present embodiment is：When being connected to fluid injection order reagent
Topping-up pump 8 and magnetic valve 11 are opened, and quantitative drawing liquid are carried out from the reagent bottle 61 of refrigerator 6 by the reagent block 7 that confluxes, by magnetic valve
11 are injected into reagent runner 101 and carry out biochemical reaction with chip 12, waste drains pump 10 and correspond to magnetic valve 11 after react and open,
Spent reagent in reagent runner 101 is taken away, after waste drains pump 10 and the corresponding closing of magnetic valve 11, carried out from other reagents are newly injected
Biochemical reaction.
The reagent biochemical reaction device that the present embodiment provides can carry out constant temperature biochemical reaction to different reagents, improve
Conventional efficient, while saved cost.
Use above specific case is illustrated to the present invention, is only intended to help and is understood the present invention, not limiting
The system present invention.For those skilled in the art, according to the thought of the present invention, can also make some simple
Deduce, deform or replace.
Claims (10)
- A kind of 1. flow channel type heater, it is characterised in that including：Reagent trough, it is provided with reagent runner close to each other and independent mutually and heating liquid recycle stream road, the reagent runner edge Vertical direction setting, the upper end of the reagent runner has reagent inlet, and lower end has waste liquid liquid outlet, the heating liquid Circulatory flow has heating liquid inlet and heating liquid liquid outlet；For providing the insulating box of heated at constant temperature liquid, it has heating liquid inlet and heating liquid liquid outlet, the insulating box Heating liquid liquid outlet and heating liquid inlet by pipeline and the heating liquid inlet for heating liquid recycle stream road and add respectively Hydrothermal solution liquid outlet connects；And circulating pump, its heating liquid inlet for being arranged on the heating liquid liquid outlet of the insulating box and heating liquid recycle stream road Between pipeline on.
- 2. flow channel type heater as claimed in claim 1, it is characterised in that also include heating liquid branching block and heating liquid converges Flow block, the heating liquid branching block has an inlet and several liquid outlets, and the heating liquid block that confluxes has several Inlet and a liquid outlet；The inlet of the heating liquid branching block passes through pipeline and the heating liquid liquid outlet of the inlet Connection, the liquid outlet of the heating liquid branching block are connected by the heating liquid inlet of pipeline and several reagent troughs respectively Connect, and be provided with the pipeline between each reagent trough heating liquid inlet and the liquid outlet of heating liquid branching block described in one Circulating pump；It is described heating liquid conflux block inlet by pipeline respectively with several described reagent trough heating liquid liquid outlet connect Connect, the conflux liquid outlet of block of the heating liquid is connected by pipeline with the inlet of the insulating box.
- 3. flow channel type heater as claimed in claim 1 or 2, it is characterised in that the reagent runner and plus hydrothermal circulation Runner is arranged side by side vertically.
- 4. flow channel type heater as claimed in claim 1 or 2, it is characterised in that the heating liquid recycle stream road is in a ring Structure, the heating liquid recycle stream road are enclosed on the outside of the reagent runner.
- 5. flow channel type heater as claimed in claim 1 or 2, it is characterised in that the heating liquid recycle stream road is helically Structure, the heating liquid recycle stream road are spirally wound on around the reagent runner.
- 6. flow channel type heater as claimed in claim 1 or 2, it is characterised in that set in the insulating box heating system and Semiconductor refrigeration system.
- 7. flow channel type heater as claimed in claim 6, it is characterised in that be additionally provided with the insulating box liquid-level switch and Temperature sensor.
- 8. flow channel type heater as claimed in claim 1 or 2, it is characterised in that the heating liquid is water.
- A kind of 9. reagent biochemical reaction device, it is characterised in that including：Flow channel type heater described in any one of claim 1 to 8；Depositing has the refrigerator of some reagent bottles, and the reagent bottle in the refrigerator passes through the reagent feed liquor of pipeline and the reagent runner Mouth connection；Reagent confluxes block, its several inlet and liquid outlet, several reagent bottles in the refrigerator respectively by pipeline with The reagent confluxes the inlet connection of block, and the conflux liquid outlet of block of the reagent is entered by the reagent of pipeline and the reagent trough Liquid mouth connects；And reagent topping-up pump, it is arranged on the pipeline between the reagent bottle and the reagent inlet of reagent runner.
- 10. reagent biochemical reaction device as claimed in claim 9, it is characterised in that also including waste collection tank, waste drains pump and Magnetic valve, the waste collection tank are connected by the conflux liquid outlet of block of pipeline and the reagent, and the waste liquid of the reagent trough goes out Liquid mouth is connected by the conflux inlet of block of pipeline and the reagent, and the waste liquid that the waste drains pump is arranged on the reagent trough goes out liquid Mouthful and the reagent conflux block inlet between pipeline on, the magnetic valve is arranged on to be entered with the reagent of the reagent runner On two pipelines that liquid mouth connects with waste liquid liquid outlet, and the reagent topping-up pump and waste drains pump be respectively positioned on the magnetic valve and On the pipeline that reagent confluxes between block.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720986202.7U CN207085955U (en) | 2017-08-08 | 2017-08-08 | Flow channel type heater and reagent biochemical reaction device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720986202.7U CN207085955U (en) | 2017-08-08 | 2017-08-08 | Flow channel type heater and reagent biochemical reaction device |
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| Publication Number | Publication Date |
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| CN207085955U true CN207085955U (en) | 2018-03-13 |
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| CN201720986202.7U Active CN207085955U (en) | 2017-08-08 | 2017-08-08 | Flow channel type heater and reagent biochemical reaction device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111841680A (en) * | 2020-07-01 | 2020-10-30 | 泰安磐然测控科技有限公司 | Thermostatic bath and control method thereof |
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2017
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111841680A (en) * | 2020-07-01 | 2020-10-30 | 泰安磐然测控科技有限公司 | Thermostatic bath and control method thereof |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 518083 comprehensive building, Beishan Industrial Zone, Yantian District, Shenzhen, Guangdong Patentee after: BGI SHENZHEN Address before: 518083 comprehensive building, Beishan Industrial Zone, Yantian District, Shenzhen, Guangdong Patentee before: BGI SHENZHEN |
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| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180607 Address after: 518083 the comprehensive building of Beishan industrial zone and 11 2 buildings in Yantian District, Shenzhen, Guangdong. Patentee after: MGI TECH Co.,Ltd. Address before: 518083 comprehensive building, Beishan Industrial Zone, Yantian District, Shenzhen, Guangdong Patentee before: BGI SHENZHEN |
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| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 518083 comprehensive building of Beishan industrial zone and 11 Building 2, Yantian District, Guangdong, Shenzhen Patentee after: Shenzhen Huada Zhizao Technology Co.,Ltd. Address before: 518083 comprehensive building of Beishan industrial zone and 11 Building 2, Yantian District, Guangdong, Shenzhen Patentee before: MGI TECH Co.,Ltd. |