CN206793433U - Buffer solution configuration system based on quaternary pumping system - Google Patents
Buffer solution configuration system based on quaternary pumping system Download PDFInfo
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- CN206793433U CN206793433U CN201720659451.5U CN201720659451U CN206793433U CN 206793433 U CN206793433 U CN 206793433U CN 201720659451 U CN201720659451 U CN 201720659451U CN 206793433 U CN206793433 U CN 206793433U
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Abstract
This application discloses a kind of buffer solution based on quaternary pumping system to configure system, and the system mainly includes：A pumps for the dense cushioning liquid of pumping, for the B pumps of pumping acid-base value adjustment solution, for the C pumps of pumping conductance adjustment solution, the D pumps for pumping purified water, A pumps out liquid pipe, B pumps out liquid pipe, and C pumps out liquid pipe, and D pumps out liquid pipe, main drain pipe, acid-base value detector and electric conductivity detector, qualified solution discharge tube, waste liquid discharge pipe control system.The system conveys four kinds of different mother liquors using four pumps, can control control PH and conductance, can make required solution online rapidly, and indices are attained by the accuracy of production requirement.
Description
Technical field
The application is related to a kind of buffer solution configuration system, and in particular to a kind of buffer solution configuration system based on quaternary pumping system
System.
Background technology
Chromatographing with ultra-filtration process, a variety of buffer solutions can be used, especially in industrialized production, the use of every kind of solution
Amount is all very big.It was to be prepared inside a collection of very big tank in the past, and adjusted required concentration, then pass through pump or air pressure
Conveying, used for tomographic system or ultrafiltration apparatus, it is very inconvenient.
The content of the invention
The purpose of the application is：In view of the above-mentioned problems, proposing a kind of buffer solution configuration system based on quaternary pumping system, it is adopted
Four kinds of different mother liquors are conveyed with four pumps, control PH and conductance can be controlled, required solution can be made online rapidly,
And indices are attained by the accuracy of production requirement.
The technical scheme of the application is：
A kind of buffer solution configuration system based on quaternary pumping system, including：
A pumps for the dense cushioning liquid of pumping；
B pumps for pumping acid-base value adjustment solution；
C pumps for pumping conductance adjustment solution；
D pumps for pumping purified water；
A pumps out liquid pipe, and its liquid feeding end is connected with the outlet end of the A pumps；
B pumps out liquid pipe, and its liquid feeding end is connected with the outlet end of the B pumps；
C pumps out liquid pipe, and its liquid feeding end is connected with the outlet end of the C pumps；
D pumps out liquid pipe, and its liquid feeding end is connected with the outlet end of the D pumps；
Main drain pipe, its liquid feeding end with the A pumps out liquid pipe, B pumps out liquid pipe, C pumps out liquid pipe and what D pumped out liquid pipe goes out liquid
End is connected；
Acid-base value detector and the electric conductivity detector being connected on the main drain pipe；
Qualified solution discharge tube and the waste liquid discharge pipe being respectively connected with the main drain pipe outlet end；And
The control system being connected with the A pumps, B pumps, C pumps, D pumps, acid-base value detector and electric conductivity detector.
The application is on the basis of above-mentioned technical proposal, in addition to following preferred scheme：
Also include：
First automatic valve, it is connected to the A and pumped out in liquid pipe；
Second automatic valve, it is connected to the B and pumped out in liquid pipe；
3rd automatic valve, it is connected to the C and pumped out in liquid pipe；And
4th automatic valve, it is connected to the D and pumped out in liquid pipe；
First automatic valve, the second automatic valve, the 3rd automatic valve and the 4th automatic valve with the control
System is connected.
Also include：
5th automatic valve, it is connected on the qualified solution discharge tube；And
6th automatic valve, it is connected on the waste liquid discharge pipe；
5th automatic valve and the 6th automatic valve are connected with the control system.
Also include the 7th automatic valve being connected on the main drain pipe, the 7th automatic valve is also with the control
System is connected.
Also include the blender being connected on the main drain pipe, the blender is also connected with the control system.
Also include：
A pump discharge meters, it is connected to the A and pumped out in liquid pipe；
B pump discharge meters, it is connected to the B and pumped out in liquid pipe；
C pump discharge meters, it is connected to the C and pumped out in liquid pipe；And
D pump discharge meters, it is connected to the D and pumped out in liquid pipe；
The A pump discharges meter, B pump discharges meter, C pump discharges meter and D pump discharges meter are connected with the control system.
The control system is PLC or industrial computer.
The advantages of the application is：
1st, because in chromatography, the absorption of many albumen, there are much relations with pH value and electric conductivity value, only to pH and conductance
It is monitored not enough, many times also need to be adjusted, and the application can make rapidly required solution online, and
Indices are attained by the accuracy of production requirement.
2nd, the pH value of solution is configured, if pH is higher than desired value, is added by infusion pump using pH detectors, measure
Acid, to reduce pH value；If pH value is less than desired value, alkali is mended by infusion pump, so as to improve pH value.
3rd, the electric conductivity value of solution is configured, if conductance is higher than desired value, passes through infusion pump using electric conductivity detector, measure
Highly concentrated solution is added, to reduce electric conductivity value；If conductance is less than desired value, low concentration solution is mended by infusion pump, so as to improve
Electric conductivity value.
4th, real-time feedback control, may be up to online with liquid precision：PH ± 0.01, conductance ± 0.01mS/cm；
5th, system automatic detection configuration pH of buffer and electric conductivity value, the satisfactory equipment that enters uses, not up to standard by giving up
Liquid valve is discharged.
Brief description of the drawings
The above-mentioned and/or additional aspect and advantage of the application will become in the description from combination accompanying drawings below to embodiment
Substantially and it is readily appreciated that, wherein：
Fig. 1 is the structural representation that the buffer solution based on quaternary pumping system configures system in the embodiment of the present application；
Wherein：1-A pumps, 2-B pumps, 3-C pumps, 4-D pumps, 5-A pump out liquid pipe, and 6-B pumps out liquid pipe, and 7-C pumps out liquid pipe, 8-D
Pump out liquid pipe, 9- main drain pipes, 10- acid-base value detectors, 11- electric conductivity detectors, the qualified solution discharge tubes of 12-, 13- waste liquids row
Outlet pipe, the automatic valves of 14- first, the automatic valves of 15- second, the automatic valves of 16- the 3rd, the automatic valves of 17- the 4th, 18- the 5th
Automatic valve, the automatic valves of 19- the 6th, the automatic valves of 20- the 7th, 21- blenders, 22-A pump discharge meters, 23-B pump discharge meters,
24-C pump discharge meters, 25-D pump discharge meters.
Embodiment
It is below in conjunction with the accompanying drawings and specific real in order to be more clearly understood that the above-mentioned purpose of the application, feature and advantage
Mode is applied the application is further described in detail.It should be understood that these embodiments are to be used to illustrate the application and be not limited to
Limit scope of the present application.The implementation condition used in embodiment can do further adjustment according to the condition of specific producer, not
Dated implementation condition is usually the condition in normal experiment.Many details are elaborated in the following description in order to fill
Sub-argument solution the application, still, the application can also be different from other modes described here to implement using other, therefore, this
The protection domain of application is not limited by following public specific embodiment.
In the description of this specification, term " connection ", " installation ", " fixation " etc. all should be interpreted broadly.For example, " even
Connect " it can make to be fixedly connected or be detachably connected, or be integrally connected；It can make to be joined directly together or pass through
Intermediate media are indirectly connected.For the ordinary skill in the art, it can understand that above-mentioned term exists as the case may be
Concrete meaning in the application.
In the description of this specification, the orientation or position relationship of the instruction such as term " on ", " under " are based on shown in accompanying drawing
Orientation or position relationship, be for only for ease of description the application and simplify and describe, rather than instruction or imply signified device
Or unit must have specific direction, with specific azimuth configuration and operation, it is thus impossible to be interpreted as the limit to the application
System.
It is herein part institute serialization number itself, such as " first ", " second " etc., is only used for distinguishing described object,
Without any order or art-recognized meanings.
Fig. 1 shows a preferred embodiment of this buffer solution configuration system based on quaternary pumping system of the application, should
Buffer solution configuration system includes：
A pumps 1, it is used for the dense cushioning liquid of pumping, or referred to as dense cushioning liquid pump." dense " mentioned here, is relative
For the Target buffer liquid finally obtained.
B pumps 2, it is used for pumping acid-base value adjustment solution, or referred to as basicity adjustment solution pump.
C pumps 3, it is used for pumping conductance adjustment solution, or referred to as conductance adjustment solution pump.
D pumps 4, it is used for pumping purified water, or is referred to as purifying water pump.
A pumps out liquid pipe 5, and its liquid feeding end is connected with the outlet end of A pumps 1.
B pumps out liquid pipe 6, and its liquid feeding end is connected with the outlet end of B pumps 2.
C pumps out liquid pipe 7, and its liquid feeding end is connected with the outlet end of C pumps 3.
D pumps out liquid pipe 8, and its liquid feeding end is connected with the outlet end of D pumps 4；
Main drain pipe 9, its liquid feeding end pumps out liquid pipe 5 with A, B pumps out liquid pipe 6, C pumps out liquid pipe 7 and D pumps out going out for liquid pipe 8
Liquid end is connected.
Blender 21, acid-base value detector 10 and electric conductivity detector 11, three are both connected on main drain pipe 9, Er Qieyan
Solution flow direction to be sequentially arranged.
Qualified solution discharge tube 12, it is connected with the outlet end of main drain pipe 9.
Waste liquid discharge pipe 13, its outlet end also with main drain pipe 9 are connected.
First automatic valve 14, it is connected to A and pumped out in liquid pipe 5, and dense cushioning liquid in liquid pipe 5 is pumped out directly to adjust A
Flow.
Second automatic valve 15, it is connected to B and pumped out in liquid pipe 6, and acid-base value adjustment in liquid pipe 6 is pumped out directly to adjust B
The flow of solution.
3rd automatic valve 16, it is connected to C and pumped out in liquid pipe 7, with directly adjust C pump out the internal conductance of liquid pipe 7 adjustment it is molten
The flow of liquid.
4th automatic valve 17, it is connected to the D and pumped out in liquid pipe 8, and purified water in liquid pipe 8 is pumped out directly to adjust D
Flow.
5th automatic valve 18, it is connected on qualified solution discharge tube 12, directly to adjust qualified solution discharge tube 12
The flow of interior qualified solution.
6th automatic valve 19, it is connected on waste liquid discharge pipe 13, directly to adjust the waste liquid in waste liquid discharge pipe 13
Flow.
7th automatic valve 20, it is connected on main drain pipe 9, directly to adjust the fluid flow in main drain pipe 9.
A pump discharges meter 22, it is connected to A and pumped out in liquid pipe 5, and fluid flow in liquid pipe 5 is pumped out to detect A.
B pump discharges meter 23, it is connected to B and pumped out in liquid pipe 6, and fluid flow in liquid pipe 6 is pumped out to detect B.
C pump discharges meter 24, it is connected to C and pumped out in liquid pipe 7, and fluid flow in liquid pipe 7 is pumped out to detect C.
D pump discharges meter 25, it is connected to D and pumped out in liquid pipe 8, and fluid flow in liquid pipe 8 is pumped out to detect D.
Control system, it is with A pumps 1, B pumps 2, C pumps 3, D pumps 4, the first automatic valve 14, the second automatic valve the 15, the 3rd from
Movable valve 16, the 4th automatic valve 17, the 5th automatic valve 18, the 6th automatic valve 19, A pump discharges meter 22, B pump discharge meters
23rd, C pump discharges meter 24, D pump discharges meter 25, blender 21, acid-base value detector 10 are connected with electric conductivity detector 11, with to each
The operation of individual part is monitored, controlled.In the present embodiment, the control system is industrial computer, and it can also use PLC certainly
Etc. other forms.
During practical application, above-mentioned A pumps 1, B pumps 2, C pumps 3 and D pumps 4 connect four equipped with dense cushioning liquid, acid-base value respectively
Adjust four mother liquor tanks of solution, conductance adjustment solution and purified water.
A pumps out liquid pipe 5, and its liquid feeding end is connected with the outlet end of A pumps 1.
B pumps out liquid pipe 6, and its liquid feeding end is connected with the outlet end of B pumps 2.
C pumps out liquid pipe 7, and its liquid feeding end is connected with the outlet end of C pumps 3.
D pumps out liquid pipe 8, and its liquid feeding end is connected with the outlet end of D pumps 4；
User (is inputted in control system and is formulated, matched somebody with somebody by control system according to the proportioning and concentration of Target buffer liquid
The ratio and flow velocity that side includes each composition solution) come control the open/close states of each automatic valve and keying degree and A pumps,
The speed of service of B pumps, C pumps and D pumps.In running, A pump discharges meter 22, B pump discharges meter 23, C pump discharges meter 24, D pump discharges
The flow velocity of the corresponding fluid of the detection in real time of meter 25, blender 21 are sufficiently mixed to the solution in main drain pipe 9, acid-base value detection
The acid-base value (pH) of solution is prepared in the detection in real time of device 10, and electric conductivity detector 11 detects electric conductivity value in real time, and by the fluid stream of detection
Speed, pH and electric conductivity value are transmitted to control system.When pH and electric conductivity value deviate target zone, the stable premise of overall flow rate is being kept
Under, each pump adjustment flow velocity is fed back, makes pH and conductance value stabilization in target zone.
During liquid, when the acid-base value detected and electric conductivity value of acid-base value detector and electric conductivity detector are in target model
When enclosing interior, control system automatically controls the 5th automatic valve 18 and opened, and the 6th automatic valve 19 is closed, and makes the solution of preparation (slow
Fliud flushing) it is collected by the liquid outlet of qualified solution discharge tube 16.When detecting for acid-base value detector and electric conductivity detector
Acid-base value and electric conductivity value when exceeding target zone, control system automatically controls the 5th automatic valve 18 and closed, the 6th automatic valve
Door 19 is opened, and underproof preparation solution is discharged by the liquid outlet of waste liquid discharge pipe 17, until control system passes through change
The operational factor of each pump and acid-base value and electric conductivity value is adjusted to target zone.When preparation solution reaches demand volume, it is
Unite out of service, automatic liquid matching terminates.
It should be noted that in extreme circumstances, above-mentioned each automatic valve (totally seven) especially the 7th automatic valve
20 may not necessarily be set.Above-mentioned blender 12 is used for the mixing of reinforced solution, also not necessarily part.Above-mentioned A pump discharges meter 22,
B pump discharges meter 23, C pump discharges meter 24, D pump discharges meter 25 are the also not necessarily parts in order to preferably monitor flow rate of liquid.
Certainly, above-described embodiment is only the technical concepts and features for illustrating the application, and its object is to make people much of that
Solution present context is simultaneously implemented according to this, and the protection domain of the application can not be limited with this.It is all according to the application major technique
The equivalent transformation or modification that the Spirit Essence of scheme is done, should all cover within the protection domain of the application.
Claims (7)
- A kind of 1. buffer solution configuration system based on quaternary pumping system, it is characterised in that including：A pumps (1) for the dense cushioning liquid of pumping；B pumps (2) for pumping acid-base value adjustment solution；C pumps (3) for pumping conductance adjustment solution；D pumps (4) for pumping purified water；A pumps out liquid pipe (5), and its liquid feeding end is connected with the outlet end of the A pumps (1)；B pumps out liquid pipe (6), and its liquid feeding end is connected with the outlet end of the B pumps (2)；C pumps out liquid pipe (7), and its liquid feeding end is connected with the outlet end of the C pumps (3)；D pumps out liquid pipe (8), and its liquid feeding end is connected with the outlet end of the D pumps (4)；Main drain pipe (9), its liquid feeding end with the A pumps out liquid pipe (5), B pumps out liquid pipe (6), C pumps out liquid pipe (7) and D pumps out liquid The outlet end for managing (8) is connected；The acid-base value detector (10) and electric conductivity detector (11) being connected on the main drain pipe (9)；The qualified solution discharge tube (12) and waste liquid discharge pipe (13) being respectively connected with the main drain pipe (9) outlet end；AndIt is connected with the A pumps (1), B pumps (2), C pumps (3), D pumps (4), acid-base value detector (10) and electric conductivity detector (11) Control system.
- 2. the buffer solution configuration system based on quaternary pumping system as claimed in claim 1, it is characterised in that also include：First automatic valve (14), it is connected to the A and pumped out in liquid pipe (5)；Second automatic valve (15), it is connected to the B and pumped out in liquid pipe (6)；3rd automatic valve (16), it is connected to the C and pumped out in liquid pipe (7)；And4th automatic valve (17), it is connected to the D and pumped out in liquid pipe (8)；First automatic valve (14), the second automatic valve (15), the 3rd automatic valve (16) and the 4th automatic valve (17) It is connected with the control system.
- 3. the buffer solution configuration system based on quaternary pumping system as claimed in claim 2, it is characterised in that also include：5th automatic valve (18), it is connected on the qualified solution discharge tube (12)；And6th automatic valve (19), it is connected on the waste liquid discharge pipe (13)；5th automatic valve (18) and the 6th automatic valve (19) are connected with the control system.
- 4. the buffer solution configuration system based on quaternary pumping system as claimed in claim 3, it is characterised in that also include being connected to The 7th automatic valve (20) on the main drain pipe (9), the 7th automatic valve (20) are also connected with the control system.
- 5. the buffer solution configuration system based on quaternary pumping system as claimed in claim 4, it is characterised in that also include being connected to Blender (21) on the main drain pipe (9), the blender (21) are also connected with the control system.
- 6. the buffer solution configuration system based on quaternary pumping system as claimed in claim 1, it is characterised in that also include：A pump discharges meter (22), it is connected to the A and pumped out in liquid pipe (5)；B pump discharges meter (23), it is connected to the B and pumped out in liquid pipe (6)；C pump discharges meter (24), it is connected to the C and pumped out in liquid pipe (7)；AndD pump discharges meter (25), it is connected to the D and pumped out in liquid pipe (8)；The A pump discharges meter (22), B pump discharges meter (23), C pump discharges meter (24) and D pump discharges meter (25) with the control System is connected.
- 7. the configuration system of the buffer solution based on quaternary pumping system as described in any in claim 1-6, it is characterised in that described Control system is PLC or industrial computer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720659451.5U CN206793433U (en) | 2017-06-08 | 2017-06-08 | Buffer solution configuration system based on quaternary pumping system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720659451.5U CN206793433U (en) | 2017-06-08 | 2017-06-08 | Buffer solution configuration system based on quaternary pumping system |
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| CN206793433U true CN206793433U (en) | 2017-12-26 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107413214A (en) * | 2017-06-08 | 2017-12-01 | 利穗科技(苏州)有限公司 | Buffer solution configuration system based on quaternary pumping system |
| CN108745022A (en) * | 2018-05-31 | 2018-11-06 | 上海药明生物技术有限公司 | A kind of buffer system based on AKTA avant |
-
2017
- 2017-06-08 CN CN201720659451.5U patent/CN206793433U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107413214A (en) * | 2017-06-08 | 2017-12-01 | 利穗科技(苏州)有限公司 | Buffer solution configuration system based on quaternary pumping system |
| CN108745022A (en) * | 2018-05-31 | 2018-11-06 | 上海药明生物技术有限公司 | A kind of buffer system based on AKTA avant |
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