CN206787189U - Liquaemin low-temperature vacuum drying case - Google Patents
Liquaemin low-temperature vacuum drying case Download PDFInfo
- Publication number
- CN206787189U CN206787189U CN201720459138.7U CN201720459138U CN206787189U CN 206787189 U CN206787189 U CN 206787189U CN 201720459138 U CN201720459138 U CN 201720459138U CN 206787189 U CN206787189 U CN 206787189U
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- Prior art keywords
- water
- hot
- liquaemin
- low
- low temperature
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- 229920000669 heparin Polymers 0.000 title claims abstract description 36
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 238000001291 vacuum drying Methods 0.000 title claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 86
- 238000001035 drying Methods 0.000 claims abstract description 45
- 238000010438 heat treatment Methods 0.000 claims abstract description 35
- 230000000740 bleeding effect Effects 0.000 claims abstract description 12
- 238000010079 rubber tapping Methods 0.000 claims abstract description 7
- 238000007789 sealing Methods 0.000 claims description 5
- 238000010276 construction Methods 0.000 abstract description 2
- 239000000463 material Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 4
- 229960001008 heparin sodium Drugs 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000010828 elution Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000002028 Biomass Substances 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Abstract
The utility model provides a kind of liquaemin low-temperature vacuum drying case, including hot-water cylinder, low temperature drying room and vacuum buffer room, the vacuum buffer room and the low temperature drying room are isolated by a division board, interior bleeding point and cool Condensed water collection groove are offered on the division board, outer bleeding point and tapping valve are provided with outside the side wall of the vacuum buffer room, vavuum pump is sealedly connected with the outer bleeding point；The low temperature drying ceiling portion is provided with inverted V-shaped top cover, and the low temperature drying chamber interior is evenly arranged with the pallet heating plate that multiple inside include hot-water coil pipe, and the hot-water coil pipe is connected by water circulating pump with hot-water cylinder.The liquaemin low-temperature vacuum drying case can carry out uniform low-temperature heating to liquaemin and be avoided that pollution of the cool condensate to dried liquaemin, simple in construction, easy to use.
Description
Technical field
A kind of liquaemin production equipment is the utility model is related to, specifically, a kind of liquaemin cryogenic vacuum is relate to and does
Dry case.
Background technology
Liquaemin is current clinically wide variety of anticoagulant, with the horizontal raising of social life and medical thing
The development of industry, the demand of liquaemin is growing, and each pharmaceutical equipment manufacturing enterprise is also updating properties of product, to meet
Requirement of the market to liquaemin yield and quality.Existing liquaemin production process typically can pass through postcibal diarrhea, enzymolysis, absorption, elution,
The process such as precipitation and drying.The process wherein digested refer to by casing process the remaining salt solution raw material of dehydration,
Enzymolysis agent is added medicinal effects therein to be decomposited from biomass state carry out step.Enzymolysis operation is typically digesting
Carried out in tank.Need enzymolysis liquid placing into adsorption tanks after filter tank filters after enzymolysis, liquaemin is added in adsorption tanks
Polymeric adsorbent, medicinal ingredient is absorbed into after stirring after resin is isolated again in resin and enters elution processes and handle.After elution
Eluent filter by alcohol precipitation, dry after obtain heparin sodium crude, because liquaemin performance can be affected by temperature,
Therefore drying steps are extremely crucial.
In the prior art, traditional vacuum drying chamber heating component is typically placed in outside surrounding and the bottom of drying chamber
Portion, and using heater plate.Heating inside drying chamber is entirely to be heated by heating component, by heating component handle
Heat is transmitted to drying chamber outer wall and drying chamber inwall until material tray, so in temperature-rise period, due to heating group
Part needs to be transmitted to pallet from drying chamber outer wall, so causing operating efficiency low, heating component produces heat losses, and
The inequality of drying chamber internal temperature can be caused, on the other hand, the moisture contained during to drying material in vacuum by material
Evaporation cool condensate, the phenomenon for causing condensing drip to fall on material can be produced at the top of drying box.
In order to solve the problem present on, people are seeking a kind of preferable technical solution always.
The content of the invention
The purpose of this utility model is that in view of the shortcomings of the prior art, so as to provide, one kind is practical, drying effect is good
Liquaemin low-temperature vacuum drying case.
To achieve these goals, technical scheme is used by the utility model：A kind of liquaemin low-temperature vacuum drying
Case, it includes hot-water cylinder, low temperature drying room and the vacuum buffer room for being arranged on low temperature drying room bottom, the vacuum buffer
Room and the low temperature drying room are isolated by a division board, and the side wall of low temperature drying room one is sealing door,
Interior bleeding point and cool Condensed water collection groove are offered on the division board, is provided with outside the side wall of the vacuum buffer room
Outer bleeding point and tapping valve, vavuum pump is sealedly connected with the outer bleeding point；
The low temperature drying ceiling portion is provided with inverted V-shaped top cover, and the low temperature drying chamber interior is also evenly arranged with multiple
Pallet heating plate, slide respectively in multiple pallet heating plates and be provided with pallet, set respectively inside each pallet heating plate
Hot-water coil pipe is equipped with, the hot-water coil pipe delivery port and hot-water coil pipe water inlet of the hot-water coil pipe stretch out the pallet heating respectively
Plate is set,
The hot-water coil pipe delivery port and hot-water coil pipe water inlet of each hot-water coil pipe are connected to water branch pipe and returned
Water branch pipe；The upper water branch pipe and the return branch are also connected by upper hose and return pipe with the hot-water cylinder respectively,
Water circulating pump is additionally provided between the upper hose and the hot-water cylinder.
Based on above-mentioned, the pallet heating plate edge is additionally provided with pallet clamping slot.
Based on above-mentioned, the upper water branch pipe and the return branch are arranged on the squab panel of the low temperature drying room.
Based on above-mentioned, the hot-water cylinder includes tank body and the electrical heating wire being arranged on inside tank body die cavity and temperature control
Device, the temperature controller control the electrical heating wire to be powered and power off, water compensating valve are additionally provided with the tank body.
The utility model has substantive distinguishing features and progress compared with the prior art, specifically, the utility model pass through by
Liquaemin low-temperature vacuum drying case is divided into low temperature drying room and vacuum buffer room by division board, can avoid thing in vacuum
Material is pumped, while low temperature drying ceiling lid is designed as into inverted V-shaped top cover, can by caused cool condensate in drying process along
Low temperature drying room side wall is trickled downwards, avoids pollution of the cool condensate to dried liquaemin.Further, by the support
Hot-water coil pipe is set inside disk heating plate, it is achieved thereby that carry out low-temperature vacuum drying uniform to heparin sodium crude, is reduced dry
Influence of the temperature fluctuation to liquaemin performance during dry, and the device also has the advantages that simple in construction, convenient to use.
Brief description of the drawings
Fig. 1 is liquaemin low-temperature vacuum drying case overall structure diagram provided by the utility model.
Fig. 2 is low temperature drying outdoor structural representation in liquaemin low-temperature vacuum drying case provided by the utility model.
Fig. 3 is liquaemin low-temperature vacuum drying case internal structure schematic diagram provided by the utility model.
Fig. 4 is the vacuum buffer cell structure schematic diagram in liquaemin low-temperature vacuum drying case provided by the utility model.
Fig. 5 is the pallet heating board structure schematic diagram in liquaemin low-temperature vacuum drying case provided by the utility model.
Fig. 6 is the hot-water coil pipe structural representation in liquaemin low-temperature vacuum drying case provided by the utility model.
In figure：1st, low temperature drying room；101st, inverted V-shaped top cover；102nd, squab panel；103rd, door is sealed；2nd, vacuum buffer room；
21st, cool Condensed water collection groove；22nd, interior bleeding point；3rd, vavuum pump；4th, tapping valve；5th, return branch；6th, upper water branch pipe；7th, pallet adds
Hot plate；71st, pallet clamping slot；72nd, hot-water coil pipe；73rd, hot-water coil pipe delivery port；74th, hot-water coil pipe water inlet；8th, water compensating valve；
9th, electrical heating wire；10th, temperature controller；11st, upper hose；12nd, water circulating pump；13rd, return pipe；14th, hot-water cylinder.
Embodiment
Below by embodiment, the technical solution of the utility model is described in further detail.
Embodiment 1
As shown in Figure 1, Figure 2 and Figure 3, the present embodiment provides a kind of liquaemin low-temperature vacuum drying case, and it includes hot-water cylinder
14th, low temperature drying room 1 and the vacuum buffer room 2 of the bottom of low temperature drying room 1 is arranged on, the vacuum buffer room 2 and described
Low temperature drying room 1 is isolated by a division board, wherein the side wall of low temperature drying room 1 one is sealing door 103.
The top of low temperature drying room 1 is provided with inverted V-shaped top cover 101, is also evenly arranged with inside the low temperature drying room 1
Three pallet heating plates 7, pallet is provided with by roller-coaster respectively in three pallet heating plates 7.Three pallets
Hot-water coil pipe 72 is respectively arranged with inside heating plate 7.The hot-water coil pipe 72 is connected by upper hose 11 with return pipe 13 respectively
Connect, water circulating pump 12 is additionally provided between the upper hose 11 and the hot-water cylinder 14.
The hot-water cylinder 14 includes tank body and the electrical heating wire 9 and temperature controller 10 that are arranged on inside tank body die cavity, institute
Stating temperature controller 10 controls the electrical heating wire 9 to be powered and power off, and water compensating valve 8 is additionally provided with the tank body.
As shown in figure 4, interior bleeding point 22 and cool Condensed water collection groove 21 are offered on the division board, the vacuum buffer room
Outer bleeding point and tapping valve 4 are provided with 2 side walls, vavuum pump 3 is sealedly connected with the outer bleeding point.
As shown in Figure 5 and Figure 6, the hot-water coil pipe delivery port 73 of the hot-water coil pipe 72 and hot-water coil pipe water inlet 74 are distinguished
The pallet heating plate 7 is stretched out to set.Each hot-water coil pipe delivery port 73 and the hot-water coil pipe water inlet 74 connect respectively
There are upper water branch pipe 6 and return branch 5；After the upper water branch pipe 6 and the return branch 5 are arranged on the low temperature drying room 1
On wallboard 102.The upper water branch pipe 6 and the return branch 5 also pass through upper hose 11 and return pipe 13 and the hot water respectively
Tank 14 is connected, and the water circulating pump 12 is set between the upper hose 11 and the hot-water cylinder.Wherein in order to preferably to putting
The pallet put in the pallet heating plate 7 is positioned, and the edge of pallet heating plate 7 is additionally provided with pallet clamping slot 71.
Specifically, when carrying out vacuum drying treatment to liquaemin using the device, concrete operation step is as follows：
The first step：The pallet for being placed with heparin sodium crude is respectively placed in pallet heating plate 7, then closes discharge opeing respectively
Valve 4 and sealing door 103, and open vavuum pump 3 and low temperature drying room 1 and vacuum buffer room 2 are subjected to vacuumize process；
Second step, water is added into hot-water cylinder 14 by water compensating valve 8 and heated water by electrical heating wire 9, when water temperature reaches
To temperature controller 10 set temperature when, open the water circulating pump 12 to hot-water coil pipe 72 carry out circulation supply hot water, from
And vacuum dehydrating at lower temperature is carried out to heparin sodium crude.
3rd step, after low temperature drying terminates, the tapping valve 4 is slowly opened to the low temperature drying room 1 and vacuum buffer
Room 2 imports air, and cool condensate is discharged from the tapping valve 4；Finally open sealing door 103 and take out the pallet, from
And obtain dry liquaemin.
Finally it should be noted that:Above example is only illustrating the technical solution of the utility model rather than it is limited
System；Although the utility model is described in detail with reference to preferred embodiment, those of ordinary skill in the art should
Understand：Specific embodiment of the present utility model can still be modified or some technical characteristics are equally replaced
Change；Without departing from the spirit of technical solutions of the utility model, it all should cover in the claimed technical scheme of the utility model
Among scope.
Claims (4)
- A kind of 1. liquaemin low-temperature vacuum drying case, it is characterised in that：It includes hot-water cylinder, low temperature drying room and is arranged on described The vacuum buffer room of low temperature drying room bottom, the vacuum buffer room and the low temperature drying room are isolated by a division board, The side wall of low temperature drying room one is sealing door,Interior bleeding point and cool Condensed water collection groove are offered on the division board, outer take out is provided with outside the side wall of the vacuum buffer room Gas port and tapping valve, vavuum pump is sealedly connected with the outer bleeding point；The low temperature drying ceiling portion is provided with inverted V-shaped top cover, and the low temperature drying chamber interior is also evenly arranged with multiple pallets Heating plate, slide respectively in multiple pallet heating plates and be provided with pallet, be respectively arranged with inside each pallet heating plate Hot-water coil pipe, the hot-water coil pipe delivery port and hot-water coil pipe water inlet of the hot-water coil pipe stretch out the pallet heating plate and set respectively Put,The hot-water coil pipe delivery port and hot-water coil pipe water inlet of each hot-water coil pipe are connected to water branch pipe and backwater branch Pipe；The upper water branch pipe and the return branch are also connected by upper hose and return pipe with the hot-water cylinder respectively, described Water circulating pump is additionally provided between upper hose and the hot-water cylinder.
- 2. liquaemin low-temperature vacuum drying case according to claim 1, it is characterised in that：The pallet heating plate edge is also It is provided with pallet clamping slot.
- 3. liquaemin low-temperature vacuum drying case according to claim 2, it is characterised in that：The upper water branch pipe and described time Water branch pipe is arranged on the squab panel of the low temperature drying room.
- 4. liquaemin low-temperature vacuum drying case according to claim 3, it is characterised in that：The hot-water cylinder include tank body and The electrical heating wire and temperature controller being arranged on inside tank body die cavity, the temperature controller control the electrical heating wire be powered and Power off, water compensating valve is additionally provided with the tank body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720459138.7U CN206787189U (en) | 2017-04-28 | 2017-04-28 | Liquaemin low-temperature vacuum drying case |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720459138.7U CN206787189U (en) | 2017-04-28 | 2017-04-28 | Liquaemin low-temperature vacuum drying case |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206787189U true CN206787189U (en) | 2017-12-22 |
Family
ID=60708005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720459138.7U Active CN206787189U (en) | 2017-04-28 | 2017-04-28 | Liquaemin low-temperature vacuum drying case |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206787189U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108931114A (en) * | 2018-08-17 | 2018-12-04 | 宁夏百乐杞智汇科技有限公司 | A kind of alkali-free fructus lycii drying machine circulatory system |
-
2017
- 2017-04-28 CN CN201720459138.7U patent/CN206787189U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108931114A (en) * | 2018-08-17 | 2018-12-04 | 宁夏百乐杞智汇科技有限公司 | A kind of alkali-free fructus lycii drying machine circulatory system |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Heparin sodium low temperature vacuum drying oven Effective date of registration: 20211221 Granted publication date: 20171222 Pledgee: Bank of China Limited Xinyang branch Pledgor: HUANGCHUAN PENGSHENG LIVESTOCK PRODUCTS CO.,LTD. Registration number: Y2021980015690 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20231130 Granted publication date: 20171222 Pledgee: Bank of China Limited Xinyang branch Pledgor: HUANGCHUAN PENGSHENG LIVESTOCK PRODUCTS CO.,LTD. Registration number: Y2021980015690 |