CN206731154U - A kind of constant temperature water bath apparatus of controlling magnetic field - Google Patents
A kind of constant temperature water bath apparatus of controlling magnetic field Download PDFInfo
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- CN206731154U CN206731154U CN201720236777.7U CN201720236777U CN206731154U CN 206731154 U CN206731154 U CN 206731154U CN 201720236777 U CN201720236777 U CN 201720236777U CN 206731154 U CN206731154 U CN 206731154U
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Abstract
The utility model discloses a kind of constant temperature water bath apparatus of controlling magnetic field, and it includes heating container and heat-conducting cylinder, and the heat-conducting cylinder is arranged at the center of heating container, heating plate is provided with around the heat-conducting cylinder；Sample tube can be placed in the heat-conducting cylinder；The electromagnetic device of the magnetic force for being provided with the electromagnetic device for producing horizontal direction magnetic force and producing vertical direction of the heat-conducting cylinder；Controller and thermistor are provided with the heating container, the output end of the controller is connected with electromagnetic device and heating plate respectively, and the input of the controller and the output end of thermistor connect.The present apparatus passes through electrical heating fluid sample, realize that constant temperature automatically controls by controller and thermistor, changing the polarity of electromagnetic device and intensity by controller makes the magnetic bead in sample tube translate and move up and down in a liquid, magnetic micro-beads and fluid sample is set to be sufficiently stirred mixing, abundant adsorbed target compound, realizes the purpose for being sufficiently mixed with sample liquids and being separated with liquid.
Description
Technical field
It the utility model is related to liquid mixture purifies and separates technical field, a kind of constant temperature water bath apparatus of controlling magnetic field.
Background technology
, generally need to be by magnetic micro-beads during some compounds are isolated and purified from fluid sample using magnetic micro-beads
Mixed with fluid sample and be placed in being sufficiently stirred mixing under certain temperature, in favor of abundant absorption of the magnetic bead to target compound.
After the completion of magnetic strain is adsorbed to object, the magnetic bead of adsorbed target thing is separated with liquid by the method for centrifugation or externally-applied magnetic field.
Therefore, it is generally necessary to use a variety of devices such as vortex vortex mixer, water-bath, centrifuge or electromagnetic device or magnet.In addition, generally only
Apply magnetic force on an in-plane of fluid sample, magnetic bead is moved in a plane, it is impossible to put down simultaneously in a liquid
Move and move up and down, be unfavorable for magnetic micro-beads and fluid sample is sufficiently stirred mixing, cause absorption of the magnetic bead to target compound
It is not abundant enough.In above-mentioned whole process, manual operation is all needed, time length, labor intensive is more, and different links all have system
System error, the accuracy and reappearance of impact analysis result.
Utility model content
In order to solve the above-mentioned technical problem, the purpose of this utility model, which is to provide one kind, can automatically control magnetic bead in a liquid
Translation and up and down motion（Such as translational speed, distance）, allow magnetic bead fully to be contacted with liquid but together with not mutual magnetic, and not
With the highly consistent controlling magnetic field constant temperature water bath apparatus of the processing procedure of sample.
Technical scheme is used by the utility model：A kind of constant temperature water bath apparatus of controlling magnetic field, it includes heating and held
Device and heat-conducting cylinder；The heat-conducting cylinder is arranged at the center of heating container, and heating plate, the heat conduction are provided with around the heat-conducting cylinder
Sample tube can be placed in cylinder；The heat-conducting cylinder is provided with the electromagnetic device for producing horizontal direction magnetic force and produces vertical direction magnetic force
Electromagnetic device；Be provided with controller and thermistor in the heating container, the output end of the controller respectively with electromagnetic device
Connected with heating plate, the input of the controller and the output end of thermistor connect.
Further, the heating plate includes 2 pieces of curved surface semiconductor heating plates and 1 piece of circular semiconductor heating plate, and 3 piece half is led
Heating body plate is placed in heating container center in garden tubular.
Further, the electromagnetic device for producing horizontal direction magnetic force includes 4 magnet coils for being respectively in heat-conducting cylinder surrounding.
Further, the electromagnetic device of the magnetic force for producing vertical direction includes 2 electromagnetism for being respectively in heat-conducting cylinder upper and lower side
Coil.
Further, heat transmission medium, heat conductive insulating oil, high thermal stability paraffin matrix are provided with the heating container to pass
One or more in deep fat or silicone oil.
Further, the material of the heating container and heat-conducting cylinder is Teflon material container.
The beneficial effects of the utility model are：The present apparatus passes through controller and thermistor by electrical heating fluid sample
Realize that constant temperature automatically controls, changing the polarity of electromagnetic device and intensity by controller makes the magnetic bead in sample tube put down in a liquid
Move and move up and down, magnetic micro-beads and fluid sample is sufficiently stirred mixing, abundant adsorbed target compound, realization and sample liquid
The purpose that body is sufficiently mixed and separated with liquid.
Brief description of the drawings
Specific embodiment of the present utility model is described further below in conjunction with the accompanying drawings：
Fig. 1 is the structure chart of the specific embodiment of the utility model one.
Embodiment
It should be noted that in the case where not conflicting, the feature in embodiment and embodiment in the application can phase
Mutually combination.
As shown in figure 1, a kind of constant temperature water bath apparatus of controlling magnetic field, it includes heating container 1 and heat-conducting cylinder 2, described to lead
Hot 2, cylinder sets the center with heating container 1, and 2 pieces of curved surface semiconductor heating plates 31,32 and 1 are provided with around the heat-conducting cylinder 2
The block semiconductor heating plate of block circular semiconductor 4,3 is placed in the center of heating container 1 in garden tubular, around heat-conducting cylinder 2, the heat-conducting cylinder
Sample tube 7 is additionally provided among 2, the sample tube 7 is used to place magnetic bead and sample to be separated.
The heat-conducting cylinder is provided with 4 magnet coils for being respectively in the surrounding of heat-conducting cylinder 2 for producing horizontal direction magnetic force
51st, 52,53,54, the central shaft of 4 magnet coils 51,52,53,54 and the central axis of the heat-conducting cylinder 2 are described
The setting of heat-conducting cylinder 2 is additionally provided with the magnet coil 61,62 for the magnetic force for producing vertical direction, the central shaft of magnet coil 61,62
It is parallel with the central shaft of the heat-conducting cylinder 2；Controller and thermistor are provided with the heating container 1, the controller
Output end is connected with magnet coil and heating plate respectively, and the input of the controller and the output end of thermistor connect.Its
Middle controller can use single-chip microcomputer, ARM etc., the salable bottom for being arranged on heating container 1 of controller.
Realize that constant temperature automatically controls by controller and thermistor, the polarity of magnet coil and strong is changed by controller
Degree makes magnetic bead translate and move up and down in a liquid, magnetic micro-beads and fluid sample is sufficiently stirred mixing, abundant adsorbed target
Compound, realize the purpose for being sufficiently mixed with sample liquids and being separated with liquid.
Preferred embodiment, the heating container is interior to be provided with heat transmission medium, heat conductive insulating oil, high thermal stability stone
One or more in wax-matrix heat-transfer oil or silicone oil.
Preferred embodiment, the material of the heating container and heat-conducting cylinder is Teflon material container.
It is below a specific embodiment of sample separation.
The filling heat-conductive oil in heating container（It about the 95% of volume, must not completely fill, prevent oil from heating the swollen spilling that rises）,
A certain amount of pure water of injection in heat-conducting cylinder（It is optimal higher than intraluminal fluid face to insert the water surface after sample cell）, it is heated to by controller
The steady temperature of setting（The boiling point of water body must not be higher than）；By a certain amount of Magnetism granule（Such as nano-magnetic chitin particle, receive
Rice magnetic polyphosphoric acids aluminium etc.）Insert in glass or plastic test tube, add certain volume liquid to be separated, rock it is several under, make magnetic
Property particulate matter is suspended in liquid, and test tube is placed in heat-conducting cylinder in water body；Set horizontal magnetic intensity and action time.Magnetic field
Intensity must be moderate, and Magnetism granule horizontal direction or so is slowly mobile, and one direction action time also needs moderate, magnetic bead can not be allowed to exist
Test tube wall is attached together.When the lateral coil of test tube one produces magnetic field, another lateral coil and upper lower coil are stopped, and prevent magnetic
Field interferes, and vice versa；Left and right coil alternation, move magnetic-particle reciprocal horizontal；Set above-below direction magnetic field
Intensity and action time, make to vertically move up and down after making magnetic-particle reciprocal horizontal movement certain time；Now horizontal coil stops
Only work；After Magnetism granule moves certain time in the solution, increase make the magnetic field intensity that particulate matter vertically moves down and when
Between, magnetic-particle is all deposited on test tube bottom；Test tube is taken out, after removing liquid with liquid-transfering gun, adds a certain amount of desorption
Attached solution shaking test tube, makes Magnetism granule suspend again in test tube；Reset constant temperature（According to most suitable desorption
Condition is reset）, repeat above-mentioned particulate matter moving process.Finally by desorption solution, the target after being isolated and purified
Compound.
Above is illustrating to the preferred embodiment of the utility model device, but the invention is not limited to institute
Embodiment is stated, those skilled in the art can also carry out a variety of be equal on the premise of without prejudice to the utility model spirit
Deformation is replaced, and these equivalent deformations or replacement are all contained in the application claim limited range.
Claims (6)
- A kind of 1. constant temperature water bath apparatus of controlling magnetic field, it is characterised in that：It includes heating container and heat-conducting cylinder；The heat-conducting cylinder is arranged at the center of heating container, and heating plate is provided with around the heat-conducting cylinder, can in the heat-conducting cylinder Place sample tube；The heat-conducting cylinder is provided with the electromagnetic device for producing horizontal direction magnetic force and the electromagnetic device for producing vertical direction magnetic force；Controller and thermistor, the output end input with electromagnetic device respectively of the controller are provided with the heating container End connects with the input of heating plate, and the input of the controller and the output end of thermistor connect.
- 2. the constant temperature water bath apparatus of controlling magnetic field according to claim 1, it is characterised in that：The heating plate includes 2 pieces Curved surface semiconductor heating plate and 1 piece of circular semiconductor heating plate, 3 block semiconductor heating plates are placed in device center in garden tubular.
- 3. the constant temperature water bath apparatus of controlling magnetic field according to claim 2, it is characterised in that：The generation horizontal direction magnetic The electromagnetic device of power includes 4 magnet coils for being respectively in heat-conducting cylinder surrounding.
- 4. the constant temperature water bath apparatus of controlling magnetic field according to claim 3, it is characterised in that：The generation vertical direction The electromagnetic device of magnetic force includes 2 magnet coils for being respectively in heat-conducting cylinder upper and lower ends.
- 5. the constant temperature water bath apparatus of controlling magnetic field according to claim 4, it is characterised in that：It is provided with the heating container One or more in heat transmission medium, heat conductive insulating oil, high thermal stability paraffin matrix heat-transfer oil or silicone oil, in heat conduction letter For the aqueous solution.
- 6. the constant temperature water bath apparatus of controlling magnetic field according to claim 5, it is characterised in that：The heating container and heat conduction The material of cylinder is Teflon material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720236777.7U CN206731154U (en) | 2017-03-10 | 2017-03-10 | A kind of constant temperature water bath apparatus of controlling magnetic field |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720236777.7U CN206731154U (en) | 2017-03-10 | 2017-03-10 | A kind of constant temperature water bath apparatus of controlling magnetic field |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206731154U true CN206731154U (en) | 2017-12-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720236777.7U Active CN206731154U (en) | 2017-03-10 | 2017-03-10 | A kind of constant temperature water bath apparatus of controlling magnetic field |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206731154U (en) |
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2017
- 2017-03-10 CN CN201720236777.7U patent/CN206731154U/en active Active
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| CP01 | Change in the name or title of a patent holder |
Address after: 518110 Guangdong province Shenzhen city Longhua District Guanlan street view Hunan Dafu community tiger ranked No. 119 Jinxiudadi No. 9 Building 5 layer Co-patentee after: Jinan University Patentee after: Shenzhen sanfangyuan Biotechnology Co.,Ltd. Address before: 518110 Guangdong province Shenzhen city Longhua District Guanlan street view Hunan Dafu community tiger ranked No. 119 Jinxiudadi No. 9 Building 5 layer Co-patentee before: Jinan University Patentee before: SHENZHEN CITY TRIPHIL BIO-TECH Co.,Ltd. |
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| CP01 | Change in the name or title of a patent holder |