CN206651888U - Animal cold stress experimental provision - Google Patents
Animal cold stress experimental provision Download PDFInfo
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- CN206651888U CN206651888U CN201621434003.7U CN201621434003U CN206651888U CN 206651888 U CN206651888 U CN 206651888U CN 201621434003 U CN201621434003 U CN 201621434003U CN 206651888 U CN206651888 U CN 206651888U
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- China
- Prior art keywords
- animal
- reservoir chamber
- cold stress
- experimental provision
- hygrosensor
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Abstract
The utility model provides animal cold stress experimental provision, including testing stand, several mutually isolated reservoir chambers, the compressor connected with reservoir chamber；Testing stand is provided with the fixing device of fixed animal trunk, and reservoir chamber is provided with the resettlement section for housing animal supporting leg, hygrosensor is provided with reservoir chamber；Also include the controller being electrically connected with respectively with compressor and hygrosensor, the temperature detected is delivered to controller by hygrosensor, and the temperature and predetermined temperature that controller receives by comparing control whether compressor works.By setting several mutually isolated reservoir chambers, the resettlement section for housing animal supporting leg is provided with reservoir chamber, the fixing device of fixed animal trunk is provided with testing stand, the different supporting legs that same mouse can be tested in same time are reacted the cold stress of extraneous different temperatures, the flexibility for improving the adaptability of animal cold stress experimental provision and using, experimental period has been saved, has improved conventional efficient.
Description
Technical field
It the utility model is related to cold stress experimental provision technical field, more particularly to animal cold stress experimental provision.
Background technology
Rheumatoid arthritis (Rheumatoid Arthritis, RA) be it is a kind of characterized by arthrosynovitis it is chronic from
Body immunological diseases, it is often accompanied by inflammatory cell (T cell, neutrophil leucocyte, macrophage etc.) invasion and attack, capillary proliferation, joint cunning
Theca cell hyperplasia, synovial membrane lower floor synovial membrane thicken to form the pathological changes such as villiform projection and cartilage damage.This inflammation can be made
It is into dysarthrasis until maimed.RA worldwide generally existings, whole world illness rate is about 1~2% according to statistics, and China suffers from
Sick rate is about 0.5%.
Temperature is an important factor for inducing rheumatoid arthritis, therefore, probes into ambient temperature height and human body rheumatoid is closed
Save the only way which must be passed that scorching induction situation is the generation for effectively preventing rheumatoid arthritis.Human body brothers articulation structure and other animals
Such as mouse is similar, thus the cold stress of ambient temperature can be reacted to judge ambient temperature to people by studying other animals
The influence in body joint.
In view of this, it is necessary to animal cold stress experimental provision of the prior art is improved, to solve above-mentioned ask
Topic.
Utility model content
The purpose of this utility model is open animal cold stress experimental provision, same old to be tested in same time
The different supporting legs of mouse are reacted the cold stress of extraneous different temperatures, are improved the adaptability of animal cold stress experimental provision and are used
Flexibility, experimental period is saved, improve conventional efficient.
To achieve the above object, the utility model provides animal cold stress experimental provision, including testing stand, several phases
The reservoir chamber mutually isolated, the compressor connected with reservoir chamber；The testing stand is provided with the fixing device of fixed animal trunk, institute
State reservoir chamber and be provided with the resettlement section for housing animal supporting leg, hygrosensor is provided with the reservoir chamber；Also include respectively with compression
The controller that machine and hygrosensor are electrically connected with, the temperature detected is delivered to controller by the hygrosensor, described
Temperature and predetermined temperature that controller is received by comparing controls whether compressor works.
In some embodiments, the fixing device includes elastic body, and the first free end of elastic body is provided with card
Gripping member, the second free end of elastic body be provided with several be located at different vertical heights by holding part.
In some embodiments, the resettlement section is in gradually wide along animal supporting leg direction of insertion.
In some embodiments, the hygrosensor is fixedly mounted in resettlement section.
In some embodiments, circulating pump is also associated with the loop that the reservoir chamber connects with compressor.
In some embodiments, the reservoir chamber includes room body and covers the lid on the body of room.
In some embodiments, the number of the reservoir chamber is four, and adjacent reservoir chamber is isolated by division board.
Compared with prior art, the beneficial effects of the utility model are：By setting several mutually isolated reservoir chambers,
The resettlement section for housing animal supporting leg is provided with reservoir chamber, the fixing device of fixed animal trunk is provided with testing stand, can be with
The different supporting legs that same mouse is tested in same time are reacted the cold stress of extraneous different temperatures, improve animal cold stress
The adaptability of experimental provision and the flexibility used, have saved experimental period, have improved conventional efficient.
Brief description of the drawings
Fig. 1 is the structural representation of the animal cold stress experimental provision shown in the utility model；
Fig. 2 is the sectional drawing of the line A-A along Fig. 1 (not comprising animal)；
Fig. 3 is the structural representation of the fixing device shown in Fig. 1；
Fig. 4 is the electric operation control circuit figure shown in the utility model.
Embodiment
The utility model is described in detail shown each embodiment below in conjunction with the accompanying drawings, but it should explanation,
These embodiments are not limitation of the utility model, and those of ordinary skill in the art are according to these embodiment institute works
Energy, method or equivalent transformation or replacement in structure, are belonged within the scope of protection of the utility model.
Animal cold stress experimental provision as Figure 1-4, including controller 8, testing stand 7, reservoir chamber a, reservoir chamber b,
Reservoir chamber c and reservoir chamber d, it is isolated between reservoir chamber a, reservoir chamber b, reservoir chamber c and reservoir chamber d by division board 10.At this
In embodiment, animal is preferably mouse.
Water or other medical products can be filled in reservoir chamber a, reservoir chamber b, reservoir chamber c and reservoir chamber d, by making mouse
Supporting leg is immersed in water or in medical product, so as to study the influence of the medical product or water to mouse supporting leg.In this reality
Apply in example, be preferably filling water in reservoir chamber a, reservoir chamber b, reservoir chamber c and reservoir chamber d.
Reservoir chamber a includes room body 310 and covers the lid 31a on room body 310.Reservoir chamber b includes room body
320 and cover the lid 32a on room body 320.Reservoir chamber c includes room body 330 and covered on room body 330
Lid 33a.Reservoir chamber d includes room body 340 and covers the lid 34a on room body 340.
Room body 310 connects with compressor 51 and circulating pump 61, and room body 320 connects with compressor 52 and circulating pump 62,
Room body 330 connects with compressor 53 and circulating pump 63, and room body 340 connects with compressor 54 and circulating pump 64.
Testing stand 7 is provided with the fixing device 4 of fixed mouse trunk 1, and the fixing device 4 includes elastic body 40, bullet
Property body 40 is bonded and fixed on testing stand 7.The first free end of elastic body 40 is provided with holding part 41, the holding part 41
Preferably circular projection；The second free end of elastic body 40 is provided with three positioned at different vertical heights by holding part 42, institute
It is preferably circular hole to state by holding part 42, and circular protrusions closely can be held in circular hole.By setting positioned at different vertical heights
, can fixed volume mouse of different sizes, the adaptability of raising animal cold stress experimental provision and the spirit used by holding part 42
Activity.
Room body 310 is provided with the resettlement section 31 for housing mouse supporting leg 11, and room body 320 is provided with the receipts for housing mouse supporting leg 12
Appearance portion 32, room body 330 are provided with the resettlement section 33 for housing mouse supporting leg 13, and room body 340 is provided with the receipts for housing mouse supporting leg 14
Appearance portion 34.
Resettlement section 31 is in gradually wide along the direction of insertion of mouse supporting leg 11, on the one hand makes mouse supporting leg 11 by room body 310
Water preferably coats, and mouse supporting leg 11 is more securely fixed in resettlement section 31；Resettlement section 32 is along mouse
The direction of insertion of supporting leg 12 is in gradually wide, mouse supporting leg 12 is preferably coated by the water in room body 320, on the other hand makes
Mouse supporting leg 12 is more securely fixed in resettlement section 32；Resettlement section 33 along the direction of insertion of mouse supporting leg 13 in gradually wide, one
Aspect makes mouse supporting leg 13 preferably be coated by the water in room body 330, on the other hand makes mouse supporting leg 13 by more securely
It is fixed in resettlement section 33；Resettlement section 34 is in gradually wide along the direction of insertion of mouse supporting leg 14, on the one hand makes mouse supporting leg 14 by room sheet
Water in body 340 preferably coats, and mouse supporting leg 14 is more securely fixed in resettlement section 34.
Hygrosensor 21 is provided with reservoir chamber a, hygrosensor 21 is fixedly mounted in resettlement section 31, to Detecting Old
The water temperature height that mouse supporting leg 11 is contacted.Hygrosensor 22 is provided with reservoir chamber b, hygrosensor 22 is fixedly mounted on collecting
In portion 32, to detect the water temperature height that mouse supporting leg 12 is contacted.Hygrosensor 23, temperature sensing are provided with reservoir chamber c
Device 23 is fixedly mounted in resettlement section 33, to detect the water temperature height that mouse supporting leg 13 is contacted.Temperature is provided with reservoir chamber d
Detector 24, hygrosensor 24 are fixedly mounted in resettlement section 34, to detect the water temperature height that mouse supporting leg 14 is contacted.
Compressor 51, compressor 52, compressor 53, compressor 54, hygrosensor 21, hygrosensor 22, temperature are visited
Survey device 23 and hygrosensor 24 is electrically connected with controller 8.
The temperature that hygrosensor 21, hygrosensor 22, hygrosensor 23 and hygrosensor 24 will detect
Controller 8 is delivered to respectively, contains A/D modular converters in controller 8, so as to which the analog signal received is changed into digital letter
Number handled again.
The water temperature in reservoir chamber a is set in advance as 0 DEG C -1 DEG C by controller 8, the water temperature in reservoir chamber b is set in advance
2 DEG C -3 DEG C are set to, the water temperature in reservoir chamber c is set in advance as 4 DEG C -5 DEG C, the water temperature in reservoir chamber d is set in advance as 6
DEG C -7 DEG C, so that mouse supporting leg 11, mouse supporting leg 12, mouse supporting leg 13 and mouse supporting leg 14 are individually positioned in different water temperatures
Under, have the function that the different supporting legs that same mouse is tested in same time are reacted the cold stress of extraneous different temperatures,
Experimental period has been saved, has improved conventional efficient.
When the temperature that controller 8 receives the transmission of hygrosensor 21 is higher than 1 DEG C, controller 8 controls compressor 51 to open
Beginning work, the water temperature in reservoir chamber a is reduced to 0 DEG C -1 DEG C；When controller 8 receive hygrosensor 21 transmission temperature be
0 DEG C -1 DEG C, controller 8 controls compressor 51 to be stopped.
When the temperature that controller 8 receives the transmission of hygrosensor 22 is higher than 3 DEG C, controller 8 controls compressor 52 to open
Beginning work, the water temperature in reservoir chamber b is reduced to 2 DEG C -3 DEG C；When controller 8 receive hygrosensor 22 transmission temperature be
2 DEG C -3 DEG C, controller 8 controls compressor 52 to be stopped.
When the temperature that controller 8 receives the transmission of hygrosensor 23 is higher than 5 DEG C, controller 8 controls compressor 53 to open
Beginning work, the water temperature in reservoir chamber c is reduced to 4 DEG C -5 DEG C；When controller 8 receive hygrosensor 23 transmission temperature be
4 DEG C -5 DEG C, controller 8 controls compressor 53 to be stopped.
When the temperature that controller 8 receives the transmission of hygrosensor 24 is higher than 7 DEG C, controller 8 controls compressor 54 to open
Beginning work, the water temperature in reservoir chamber d is reduced to 6 DEG C -7 DEG C；When controller 8 receive hygrosensor 24 transmission temperature be
6 DEG C -7 DEG C, controller 8 controls compressor 54 to be stopped.
By setting different water temperatures respectively in reservoir chamber a, reservoir chamber b, reservoir chamber c and reservoir chamber d, can test in phase
The cold stress of extraneous different temperatures is reacted with mouse supporting leg in the time, it is external that the mouse supporting leg in different time can also be tested
The cold stress reaction of boundary's different temperatures, it is not necessary to one by one to mouse supporting leg 11, mouse supporting leg 12, mouse supporting leg 13, mouse supporting leg
14 are tested, and have saved experimental period, improve conventional efficient.Finally, dissection and analysis mouse supporting leg 11, mouse supporting leg 12,
The sclerotin situation of mouse supporting leg 13 and mouse supporting leg 14, arthritic influence of the analysis ambient temperature on mouse supporting leg.Due to old
Mouse sclerotin is similar to human body bone structure, so as to analyze arthritic influence of the ambient temperature on human body indirectly.
The a series of tool described in detail only for feasibility embodiment of the present utility model of those listed above
Body illustrates that they are simultaneously not used to limit the scope of protection of the utility model, all to be made without departing from the utility model skill spirit
Equivalent implementations or change should be included within the scope of protection of the utility model.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that those skilled in the art should for clarity
Using specification as an entirety, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
It is appreciated that other embodiment.
Claims (7)
1. animal cold stress experimental provision, it is characterised in that including testing stand, several mutually isolated reservoir chambers and water storage
The compressor of room connection；
The testing stand is provided with the fixing device of fixed animal trunk, and the reservoir chamber is provided with the collecting for housing animal supporting leg
Portion, the reservoir chamber is interior to be provided with hygrosensor；
Also include the controller being electrically connected with respectively with compressor and hygrosensor, the temperature that the hygrosensor will detect
Degree is delivered to controller, and whether temperature and predetermined temperature that the controller is received by comparing controls compressor
Work.
2. animal cold stress experimental provision according to claim 1, it is characterised in that the fixing device includes elasticity originally
Body, the first free end of elastic body are provided with holding part, and the second free end of elastic body is provided with several positioned at different vertical
Height by holding part.
3. animal cold stress experimental provision according to claim 1 or 2, it is characterised in that the resettlement section is along animal branch
Leg direction of insertion is in gradually wide.
4. animal cold stress experimental provision according to claim 3, it is characterised in that the hygrosensor is fixedly mounted
In resettlement section.
5. animal cold stress experimental provision according to claim 1, it is characterised in that the reservoir chamber connects with compressor
Loop in be also associated with circulating pump.
6. animal cold stress experimental provision according to claim 1, it is characterised in that the reservoir chamber include room body with
And cover the lid on the body of room.
7. animal cold stress experimental provision according to claim 6, it is characterised in that the number of the reservoir chamber is four
Individual, adjacent reservoir chamber is isolated by division board.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621434003.7U CN206651888U (en) | 2016-12-23 | 2016-12-23 | Animal cold stress experimental provision |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621434003.7U CN206651888U (en) | 2016-12-23 | 2016-12-23 | Animal cold stress experimental provision |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206651888U true CN206651888U (en) | 2017-11-21 |
Family
ID=60313967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621434003.7U Expired - Fee Related CN206651888U (en) | 2016-12-23 | 2016-12-23 | Animal cold stress experimental provision |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206651888U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107334558A (en) * | 2016-12-23 | 2017-11-10 | 无锡市中医医院 | Animal cold stress experimental provision |
| CN114208713A (en) * | 2021-11-17 | 2022-03-22 | 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） | Adjustable constant-temperature experimental mouse acute stress model establishing device |
-
2016
- 2016-12-23 CN CN201621434003.7U patent/CN206651888U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107334558A (en) * | 2016-12-23 | 2017-11-10 | 无锡市中医医院 | Animal cold stress experimental provision |
| CN114208713A (en) * | 2021-11-17 | 2022-03-22 | 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） | Adjustable constant-temperature experimental mouse acute stress model establishing device |
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171121 Termination date: 20181223 |
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| CF01 | Termination of patent right due to non-payment of annual fee |