CN206621594U - Physics artificial liver adsorptive reactor based on hollow fiber conduit - Google Patents
Physics artificial liver adsorptive reactor based on hollow fiber conduit Download PDFInfo
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- CN206621594U CN206621594U CN201621017118.6U CN201621017118U CN206621594U CN 206621594 U CN206621594 U CN 206621594U CN 201621017118 U CN201621017118 U CN 201621017118U CN 206621594 U CN206621594 U CN 206621594U
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- hollow fiber
- fiber conduit
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- blood plasma
- shell
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- 239000012510 hollow fiber Substances 0.000 title claims abstract description 44
- 210000004185 liver Anatomy 0.000 title claims abstract description 26
- 230000000274 adsorptive effect Effects 0.000 title claims abstract description 13
- 210000002381 plasma Anatomy 0.000 claims abstract description 33
- 238000011010 flushing procedure Methods 0.000 claims abstract description 28
- 239000000463 material Substances 0.000 claims abstract description 26
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims abstract description 12
- 229920005749 polyurethane resin Polymers 0.000 claims description 9
- 229920005989 resin Polymers 0.000 claims description 9
- 239000011347 resin Substances 0.000 claims description 9
- 230000002745 absorbent Effects 0.000 claims description 7
- 239000002250 absorbent Substances 0.000 claims description 7
- 239000011148 porous material Substances 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 3
- -1 poly- ammonia Ester Chemical class 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 1
- 239000003053 toxin Substances 0.000 abstract description 7
- 231100000765 toxin Toxicity 0.000 abstract description 7
- 238000010521 absorption reaction Methods 0.000 abstract description 6
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract description 5
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract description 5
- 239000003114 blood coagulation factor Substances 0.000 abstract description 5
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 abstract description 3
- 108010088751 Albumins Proteins 0.000 abstract description 3
- 102000009027 Albumins Human genes 0.000 abstract description 3
- 102000008946 Fibrinogen Human genes 0.000 abstract description 3
- 108010049003 Fibrinogen Proteins 0.000 abstract description 3
- 239000003613 bile acid Substances 0.000 abstract description 3
- 229940012952 fibrinogen Drugs 0.000 abstract description 3
- 150000003384 small molecules Chemical class 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- BPYKTIZUTYGOLE-UHFFFAOYSA-N billirubin-IXalpha Natural products N1C(=O)C(C)=C(C=C)C1=CC1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(C=C3C(=C(C=C)C(=O)N3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-UHFFFAOYSA-N 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 4
- 238000006116 polymerization reaction Methods 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- 229920001661 Chitosan Polymers 0.000 description 2
- 241000206575 Chondrus crispus Species 0.000 description 2
- 229920001503 Glucan Polymers 0.000 description 2
- 206010019663 Hepatic failure Diseases 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 208000007903 liver failure Diseases 0.000 description 2
- 231100000835 liver failure Toxicity 0.000 description 2
- 229950000845 politef Drugs 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 235000010413 sodium alginate Nutrition 0.000 description 2
- 239000000661 sodium alginate Substances 0.000 description 2
- 229940005550 sodium alginate Drugs 0.000 description 2
- 206010003445 Ascites Diseases 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 208000015294 blood coagulation disease Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000009852 coagulant defect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000012489 doughnuts Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000007386 hepatic encephalopathy Diseases 0.000 description 1
- 230000010224 hepatic metabolism Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920003053 polystyrene-divinylbenzene Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
Abstract
The utility model discloses the physics artificial liver adsorptive reactor based on hollow fiber conduit, including shell of reactor and more hollow fiber conduits in shell of reactor inner chamber and the sorbing material for being capable of adsorbing bilirubin；Shell of reactor one end offers blood plasma/pre- fliud flushing entrance, and the other end offers blood plasma/pre- fliud flushing outlet；The both ends of hollow fiber conduit respectively with the blood plasma/pre- fliud flushing entrance and the blood plasma/pre- fliud flushing outlet；The sorbing material bag is located at the hollow fiber conduit periphery.The beneficial effects of the utility model are：By setting hollow fiber conduit and sorbing material in shell of reactor inner chamber, when the blood plasma is flowed through hollow fiber conduit, various albumen, such as albumin, fibrinogen, clotting factor macromolecular directly flow through, and the small-molecule substance such as unconjugated bilirubin, bile acid can pass freely through hollow fiber conduit and be adsorbed material absorption, the purpose of selective absorption toxin is realized.
Description
Technical field
The utility model belongs to physics artificial liver technical field, more particularly to a kind of physics based on hollow fiber conduit is artificial
Liver adsorptive reactor.
Background technology
Hepatic failure is to cause liver cell seriously to damage by many factors, causes the functions such as its synthesis, removing toxic substances and bioconversion
Generation serious hindrance, occur with jaundice, coagulation disorders, hepatic encephalopathy and ascites etc. for a kind of Comprehensive Clinical for mainly showing
Sign.Liver transfer operation is the maximally effective treatment method of hepatic failure, but because the shortage in liver source, most of patient cannot be effective
Treatment, it is dead during liver source is waited.Artificial liver is effective alternative means of liver metabolism, and artificial liver is divided into bio-artificial
Liver and non-ecology phenomena.What it is currently used for clinic is mainly non-ecology phenomena, both physics artificial liver.
Traditional physical artificial liver is mainly recycled for blood purification using Molecular Adsorption, and its process is blood stream
Through sorbing material, toxin is adsorbed material attachment；But during toxin is absorbed, substantial amounts of albumen, clotting factor etc. are effective
Material is also adsorbed simultaneously, is existed compared with multi-risk System.
Utility model content
The purpose of this utility model is to overcome existing physics artificial liver adsorptive reactor during toxin is absorbed, greatly
The benefit materials such as the albumen of amount, clotting factor are also adsorbed simultaneously, the defects of compared with multi-risk System be present, there is provided one kind can be selected effectively
The physics artificial liver adsorptive reactor based on hollow fiber conduit of property absorbing toxin.
To achieve the above object, the physics artificial liver adsorption reaction based on hollow fiber conduit designed by the utility model
Device, including shell of reactor and more hollow fiber conduits in the shell of reactor inner chamber and it is capable of adsorbing bilirubin
Sorbing material；Described shell of reactor one end offers blood plasma/pre- fliud flushing entrance, and the other end offers blood plasma/pre- fliud flushing outlet；
The both ends of the hollow fiber conduit respectively with the blood plasma/pre- fliud flushing entrance and the blood plasma/pre- fliud flushing outlet；The suction
Enclosure material bag is located at the hollow fiber conduit periphery.
Further, the sorbing material be macroporous absorbent resin microballoon, cellulose, chitosan, carragheen, glucan,
Sodium alginate, anion exchange resin, politef, polyamide, poly-hydroxyethyl methacrylate, polyacrylamide
In one or more.
Further, the sorbing material is macroporous absorbent resin microballoon of the particle diameter between 0.1~1.1mm, thereon
Aperture is 6~49nm.
Yet further, the shell of reactor both ends are provided with the polyurethane resin support for being used for fixing hollow fiber conduit；
The polyurethane resin support keeps gap with shell of reactor both ends inner chamber；The hollow fiber conduit both ends penetrate described
Polyurethane resin support.
Further, the physics artificial liver also includes standby inlet and outlet；The shell of reactor is tubular, its both ends
Provided with end cap；The blood plasma/pre- fliud flushing entrance is opened on one of them described end cap, and the blood plasma/pre- fliud flushing outlet opens up
In on another described end cap；The standby inlet and outlet be opened in described in any of which on end cap and with the shell of reactor
Inner chamber connects.
Preferably, the micro-pore diameter on the hollow fiber conduit membranous wall is 0.001~0.3 μm.
The beneficial effects of the utility model are：By setting hollow fiber conduit and adsorption material in shell of reactor inner chamber
Material, when the blood plasma is flowed through hollow fiber conduit, various albumen, such as albumin, fibrinogen, clotting factor macromolecular directly flow
Cross, and the slightly smaller material of bilirubin, bile acid equimolecular can more pass freely through doughnut tube wall and be adsorbed material absorption,
Realize the purpose of selective absorption toxin.
Brief description of the drawings
Fig. 1 is the structural representation of physics artificial liver adsorptive reactor of the utility model based on hollow fiber conduit.
Fig. 2 is Fig. 1 main view schematic cross-sectional view.
Fig. 3 is A-A section view enlarged diagrams in Fig. 1.
In figure, shell of reactor 1, end cap 2, sorbing material 3, hollow fiber conduit 4, blood plasma/pre- fliud flushing entrance 5, it is standby enter
Outlet 6, blood plasma/pre- fliud flushing outlet 7, polyurethane resin support 8.
Embodiment
The utility model is described in further detail below in conjunction with the drawings and specific embodiments.
The physics artificial liver adsorptive reactor based on hollow fiber conduit as shown in Figure 1, Figure 2, Figure 3 shows, including outside reactor
Shell 1 and more hollow fiber conduits 4 in the inner chamber of shell of reactor 1 and the sorbing material 3 for being capable of adsorbing bilirubin；Reactor
The one end of shell 1 offers blood plasma/pre- fliud flushing entrance 5, and the other end offers blood plasma/pre- fliud flushing outlet 7；The two of hollow fiber conduit 4
End connects with blood plasma/pre- fliud flushing entrance 5 and blood plasma/pre- fliud flushing outlet 7 respectively；The bag of sorbing material 3 is outside hollow fiber conduit 4
Week.
Sorbing material 3 be macroporous absorbent resin microballoon, cellulose, chitosan, carragheen, glucan, sodium alginate, it is cloudy from
One kind or several in sub-exchange resin, politef, polyamide, poly-hydroxyethyl methacrylate, polyacrylamide
Kind.
If sorbing material 3 is macroporous absorbent resin microballoon, carried using crosslinked polystyrene-divinylbenzene microspheres to be basic
Body, with oligomeric macromolecule (low polystyrene of the degree of polymerization 200~900, the oligomeric methacrylate of the degree of polymerization 200~900
The polyvinyl acetate etc. of class, the degree of polymerization 200~700), toluene, liquid wax, solid wax and their scalemic thereof be pore
Agent, the macroporous absorbent resin microballoon prepared by free radical suspensioning polymerization method；Macroporous absorbent resin microballoon is spherical, and swellbility is low,
Mechanical strength is good, and particle diameter is between 0.1~1.1mm, 6~49nm of aperture, and there is good biological biocompatibility and absorption to select
Selecting property.
Through experiment, sorbing material 3 of the present utility model reaches more than 80% to the adsorption rate of bilirubin.
The both ends of shell of reactor 1 are provided with the polyurethane resin support 8 for being used for fixing hollow fiber conduit 4；Polyurethane resin branch
Frame 8 keeps gap with the both ends inner chamber of shell of reactor 1；The both ends of hollow fiber conduit 4 penetrate polyurethane resin support 8.
Physics artificial liver also includes standby inlet and outlet 6；Shell of reactor 1 is tubular, and its both ends is provided with end cap 2；Blood plasma/pre-
Fliud flushing entrance 5 is opened on one of end cap 2, and blood plasma/pre- fliud flushing outlet 7 is opened on another end cap 2；Standby inlet and outlet
6 are opened on any of which end cap 2 and are connected with the inner chamber of shell of reactor 1.
Micro-pore diameter on the membranous wall of hollow fiber conduit 4 is 0.001~0.3 μm.
In use, being first turned on blood plasma/pre- fliud flushing entrance 5 and blood plasma/pre- fliud flushing outlet 7, then pass through blood plasma/pre- fliud flushing
Entrance 5 into the inner chamber of shell of reactor 1 saline injection with the inner chamber of pre-flush shell of reactor 1；By blood plasma from blood plasma/pre- punching
Liquid entrance 5 injects, and because the micro-pore diameter on the membranous wall of hollow fiber conduit 4 is 0.001~0.3 μm, only allows small-molecule substance to wear
Cross, and macromolecular can not pass through the membranous wall of hollow fiber conduit 4；Therefore various albumen, such as albumin, fibrinogen, clotting factor
Directly discharged etc. macromolecular after hollow fiber conduit from blood plasma/pre- fliud flushing outlet 7, and unconjugated bilirubin, bile acid in blood plasma
Hollow fiber conduit 4 is penetrated in flow process Deng small-molecule substance, the sorbing material 3 being filled in the inner chamber of shell of reactor 1
Absorption, realize the purpose of absorbing toxin.
Claims (5)
- A kind of 1. physics artificial liver adsorptive reactor based on hollow fiber conduit, it is characterised in that：Including shell of reactor (1) and More hollow fiber conduits (4) in the shell of reactor (1) inner chamber and the sorbing material (3) for being capable of adsorbing bilirubin； Described shell of reactor (1) one end offers blood plasma/pre- fliud flushing entrance (5), and the other end offers blood plasma/pre- fliud flushing outlet (7)； The both ends of the hollow fiber conduit (4) connect with the blood plasma/pre- fliud flushing entrance (5) and the blood plasma/pre- fliud flushing outlet (7) respectively It is logical；Sorbing material (3) bag is located at the hollow fiber conduit (4) periphery.
- 2. the physics artificial liver adsorptive reactor according to claim 1 based on hollow fiber conduit, it is characterised in that：It is described Sorbing material (3) is macroporous absorbent resin microballoon of the particle diameter between 0.1~1.1mm, and aperture thereon is 6~49nm.
- 3. the physics artificial liver adsorptive reactor according to claim 1 based on hollow fiber conduit, it is characterised in that：It is described Shell of reactor (1) both ends are provided with the polyurethane resin support (8) for being used for fixing hollow fiber conduit (4)；The polyurethane resin Support (8) keeps gap with the shell of reactor (1) both ends inner chamber；Hollow fiber conduit (4) both ends penetrate the poly- ammonia Ester resin scaffold (8).
- 4. the physics artificial liver adsorptive reactor according to claim 1 based on hollow fiber conduit, it is characterised in that：It is described Physics artificial liver also includes standby inlet and outlet (6)；The shell of reactor (1) is tubular, and its both ends is provided with end cap (2)；It is described Blood plasma/pre- fliud flushing entrance (5) is opened on one of them described end cap (2), and the blood plasma/pre- fliud flushing outlet (7) is opened in separately On one end cap (2)；It is described it is standby inlet and outlet (6) be opened on end cap described in any of which (2) and with the reaction Device shell (1) inner chamber connects.
- 5. the physics artificial liver adsorptive reactor based on hollow fiber conduit according to any one of claims 1 to 3, its feature It is：Micro-pore diameter on hollow fiber conduit (4) membranous wall is 0.001~0.3 μm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621017118.6U CN206621594U (en) | 2016-08-31 | 2016-08-31 | Physics artificial liver adsorptive reactor based on hollow fiber conduit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621017118.6U CN206621594U (en) | 2016-08-31 | 2016-08-31 | Physics artificial liver adsorptive reactor based on hollow fiber conduit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206621594U true CN206621594U (en) | 2017-11-10 |
Family
ID=60212006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621017118.6U Active CN206621594U (en) | 2016-08-31 | 2016-08-31 | Physics artificial liver adsorptive reactor based on hollow fiber conduit |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206621594U (en) |
-
2016
- 2016-08-31 CN CN201621017118.6U patent/CN206621594U/en active Active
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 4th floor, podium building, Gongtou Building, No. 433-505 Chunhui Road, Lingxi Town, Cangnan County, Wenzhou City, Zhejiang Province, 325000 Patentee after: Zhejiang Tonggan Medical Technology Co.,Ltd. Country or region after: China Address before: No. 818, Gaoxin Avenue, Donghu high tech Development Zone, Wuhan, Hubei 430206 Patentee before: WUHAN TOGO MEDITECH Co.,Ltd. Country or region before: China |
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