CN206621594U - Physics artificial liver adsorptive reactor based on hollow fiber conduit - Google Patents

Physics artificial liver adsorptive reactor based on hollow fiber conduit Download PDF

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Publication number
CN206621594U
CN206621594U CN201621017118.6U CN201621017118U CN206621594U CN 206621594 U CN206621594 U CN 206621594U CN 201621017118 U CN201621017118 U CN 201621017118U CN 206621594 U CN206621594 U CN 206621594U
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hollow fiber
fiber conduit
reactor
blood plasma
shell
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周平
刘路
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Zhejiang Tonggan Medical Technology Co.,Ltd.
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Wuhan Tong Stem Medical Polytron Technologies Inc
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Abstract

The utility model discloses the physics artificial liver adsorptive reactor based on hollow fiber conduit, including shell of reactor and more hollow fiber conduits in shell of reactor inner chamber and the sorbing material for being capable of adsorbing bilirubin;Shell of reactor one end offers blood plasma/pre- fliud flushing entrance, and the other end offers blood plasma/pre- fliud flushing outlet;The both ends of hollow fiber conduit respectively with the blood plasma/pre- fliud flushing entrance and the blood plasma/pre- fliud flushing outlet;The sorbing material bag is located at the hollow fiber conduit periphery.The beneficial effects of the utility model are:By setting hollow fiber conduit and sorbing material in shell of reactor inner chamber, when the blood plasma is flowed through hollow fiber conduit, various albumen, such as albumin, fibrinogen, clotting factor macromolecular directly flow through, and the small-molecule substance such as unconjugated bilirubin, bile acid can pass freely through hollow fiber conduit and be adsorbed material absorption, the purpose of selective absorption toxin is realized.

Description

Physics artificial liver adsorptive reactor based on hollow fiber conduit
Technical field
The utility model belongs to physics artificial liver technical field, more particularly to a kind of physics based on hollow fiber conduit is artificial Liver adsorptive reactor.
Background technology
Hepatic failure is to cause liver cell seriously to damage by many factors, causes the functions such as its synthesis, removing toxic substances and bioconversion Generation serious hindrance, occur with jaundice, coagulation disorders, hepatic encephalopathy and ascites etc. for a kind of Comprehensive Clinical for mainly showing Sign.Liver transfer operation is the maximally effective treatment method of hepatic failure, but because the shortage in liver source, most of patient cannot be effective Treatment, it is dead during liver source is waited.Artificial liver is effective alternative means of liver metabolism, and artificial liver is divided into bio-artificial Liver and non-ecology phenomena.What it is currently used for clinic is mainly non-ecology phenomena, both physics artificial liver.
Traditional physical artificial liver is mainly recycled for blood purification using Molecular Adsorption, and its process is blood stream Through sorbing material, toxin is adsorbed material attachment;But during toxin is absorbed, substantial amounts of albumen, clotting factor etc. are effective Material is also adsorbed simultaneously, is existed compared with multi-risk System.
Utility model content
The purpose of this utility model is to overcome existing physics artificial liver adsorptive reactor during toxin is absorbed, greatly The benefit materials such as the albumen of amount, clotting factor are also adsorbed simultaneously, the defects of compared with multi-risk System be present, there is provided one kind can be selected effectively The physics artificial liver adsorptive reactor based on hollow fiber conduit of property absorbing toxin.
To achieve the above object, the physics artificial liver adsorption reaction based on hollow fiber conduit designed by the utility model Device, including shell of reactor and more hollow fiber conduits in the shell of reactor inner chamber and it is capable of adsorbing bilirubin Sorbing material;Described shell of reactor one end offers blood plasma/pre- fliud flushing entrance, and the other end offers blood plasma/pre- fliud flushing outlet; The both ends of the hollow fiber conduit respectively with the blood plasma/pre- fliud flushing entrance and the blood plasma/pre- fliud flushing outlet;The suction Enclosure material bag is located at the hollow fiber conduit periphery.
Further, the sorbing material be macroporous absorbent resin microballoon, cellulose, chitosan, carragheen, glucan, Sodium alginate, anion exchange resin, politef, polyamide, poly-hydroxyethyl methacrylate, polyacrylamide In one or more.
Further, the sorbing material is macroporous absorbent resin microballoon of the particle diameter between 0.1~1.1mm, thereon Aperture is 6~49nm.
Yet further, the shell of reactor both ends are provided with the polyurethane resin support for being used for fixing hollow fiber conduit; The polyurethane resin support keeps gap with shell of reactor both ends inner chamber;The hollow fiber conduit both ends penetrate described Polyurethane resin support.
Further, the physics artificial liver also includes standby inlet and outlet;The shell of reactor is tubular, its both ends Provided with end cap;The blood plasma/pre- fliud flushing entrance is opened on one of them described end cap, and the blood plasma/pre- fliud flushing outlet opens up In on another described end cap;The standby inlet and outlet be opened in described in any of which on end cap and with the shell of reactor Inner chamber connects.
Preferably, the micro-pore diameter on the hollow fiber conduit membranous wall is 0.001~0.3 μm.
The beneficial effects of the utility model are:By setting hollow fiber conduit and adsorption material in shell of reactor inner chamber Material, when the blood plasma is flowed through hollow fiber conduit, various albumen, such as albumin, fibrinogen, clotting factor macromolecular directly flow Cross, and the slightly smaller material of bilirubin, bile acid equimolecular can more pass freely through doughnut tube wall and be adsorbed material absorption, Realize the purpose of selective absorption toxin.
Brief description of the drawings
Fig. 1 is the structural representation of physics artificial liver adsorptive reactor of the utility model based on hollow fiber conduit.
Fig. 2 is Fig. 1 main view schematic cross-sectional view.
Fig. 3 is A-A section view enlarged diagrams in Fig. 1.
In figure, shell of reactor 1, end cap 2, sorbing material 3, hollow fiber conduit 4, blood plasma/pre- fliud flushing entrance 5, it is standby enter Outlet 6, blood plasma/pre- fliud flushing outlet 7, polyurethane resin support 8.
Embodiment
The utility model is described in further detail below in conjunction with the drawings and specific embodiments.
The physics artificial liver adsorptive reactor based on hollow fiber conduit as shown in Figure 1, Figure 2, Figure 3 shows, including outside reactor Shell 1 and more hollow fiber conduits 4 in the inner chamber of shell of reactor 1 and the sorbing material 3 for being capable of adsorbing bilirubin;Reactor The one end of shell 1 offers blood plasma/pre- fliud flushing entrance 5, and the other end offers blood plasma/pre- fliud flushing outlet 7;The two of hollow fiber conduit 4 End connects with blood plasma/pre- fliud flushing entrance 5 and blood plasma/pre- fliud flushing outlet 7 respectively;The bag of sorbing material 3 is outside hollow fiber conduit 4 Week.
Sorbing material 3 be macroporous absorbent resin microballoon, cellulose, chitosan, carragheen, glucan, sodium alginate, it is cloudy from One kind or several in sub-exchange resin, politef, polyamide, poly-hydroxyethyl methacrylate, polyacrylamide Kind.
If sorbing material 3 is macroporous absorbent resin microballoon, carried using crosslinked polystyrene-divinylbenzene microspheres to be basic Body, with oligomeric macromolecule (low polystyrene of the degree of polymerization 200~900, the oligomeric methacrylate of the degree of polymerization 200~900 The polyvinyl acetate etc. of class, the degree of polymerization 200~700), toluene, liquid wax, solid wax and their scalemic thereof be pore Agent, the macroporous absorbent resin microballoon prepared by free radical suspensioning polymerization method;Macroporous absorbent resin microballoon is spherical, and swellbility is low, Mechanical strength is good, and particle diameter is between 0.1~1.1mm, 6~49nm of aperture, and there is good biological biocompatibility and absorption to select Selecting property.
Through experiment, sorbing material 3 of the present utility model reaches more than 80% to the adsorption rate of bilirubin.
The both ends of shell of reactor 1 are provided with the polyurethane resin support 8 for being used for fixing hollow fiber conduit 4;Polyurethane resin branch Frame 8 keeps gap with the both ends inner chamber of shell of reactor 1;The both ends of hollow fiber conduit 4 penetrate polyurethane resin support 8.
Physics artificial liver also includes standby inlet and outlet 6;Shell of reactor 1 is tubular, and its both ends is provided with end cap 2;Blood plasma/pre- Fliud flushing entrance 5 is opened on one of end cap 2, and blood plasma/pre- fliud flushing outlet 7 is opened on another end cap 2;Standby inlet and outlet 6 are opened on any of which end cap 2 and are connected with the inner chamber of shell of reactor 1.
Micro-pore diameter on the membranous wall of hollow fiber conduit 4 is 0.001~0.3 μm.
In use, being first turned on blood plasma/pre- fliud flushing entrance 5 and blood plasma/pre- fliud flushing outlet 7, then pass through blood plasma/pre- fliud flushing Entrance 5 into the inner chamber of shell of reactor 1 saline injection with the inner chamber of pre-flush shell of reactor 1;By blood plasma from blood plasma/pre- punching Liquid entrance 5 injects, and because the micro-pore diameter on the membranous wall of hollow fiber conduit 4 is 0.001~0.3 μm, only allows small-molecule substance to wear Cross, and macromolecular can not pass through the membranous wall of hollow fiber conduit 4;Therefore various albumen, such as albumin, fibrinogen, clotting factor Directly discharged etc. macromolecular after hollow fiber conduit from blood plasma/pre- fliud flushing outlet 7, and unconjugated bilirubin, bile acid in blood plasma Hollow fiber conduit 4 is penetrated in flow process Deng small-molecule substance, the sorbing material 3 being filled in the inner chamber of shell of reactor 1 Absorption, realize the purpose of absorbing toxin.

Claims (5)

  1. A kind of 1. physics artificial liver adsorptive reactor based on hollow fiber conduit, it is characterised in that:Including shell of reactor (1) and More hollow fiber conduits (4) in the shell of reactor (1) inner chamber and the sorbing material (3) for being capable of adsorbing bilirubin; Described shell of reactor (1) one end offers blood plasma/pre- fliud flushing entrance (5), and the other end offers blood plasma/pre- fliud flushing outlet (7); The both ends of the hollow fiber conduit (4) connect with the blood plasma/pre- fliud flushing entrance (5) and the blood plasma/pre- fliud flushing outlet (7) respectively It is logical;Sorbing material (3) bag is located at the hollow fiber conduit (4) periphery.
  2. 2. the physics artificial liver adsorptive reactor according to claim 1 based on hollow fiber conduit, it is characterised in that:It is described Sorbing material (3) is macroporous absorbent resin microballoon of the particle diameter between 0.1~1.1mm, and aperture thereon is 6~49nm.
  3. 3. the physics artificial liver adsorptive reactor according to claim 1 based on hollow fiber conduit, it is characterised in that:It is described Shell of reactor (1) both ends are provided with the polyurethane resin support (8) for being used for fixing hollow fiber conduit (4);The polyurethane resin Support (8) keeps gap with the shell of reactor (1) both ends inner chamber;Hollow fiber conduit (4) both ends penetrate the poly- ammonia Ester resin scaffold (8).
  4. 4. the physics artificial liver adsorptive reactor according to claim 1 based on hollow fiber conduit, it is characterised in that:It is described Physics artificial liver also includes standby inlet and outlet (6);The shell of reactor (1) is tubular, and its both ends is provided with end cap (2);It is described Blood plasma/pre- fliud flushing entrance (5) is opened on one of them described end cap (2), and the blood plasma/pre- fliud flushing outlet (7) is opened in separately On one end cap (2);It is described it is standby inlet and outlet (6) be opened on end cap described in any of which (2) and with the reaction Device shell (1) inner chamber connects.
  5. 5. the physics artificial liver adsorptive reactor based on hollow fiber conduit according to any one of claims 1 to 3, its feature It is:Micro-pore diameter on hollow fiber conduit (4) membranous wall is 0.001~0.3 μm.
CN201621017118.6U 2016-08-31 2016-08-31 Physics artificial liver adsorptive reactor based on hollow fiber conduit Active CN206621594U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201621017118.6U CN206621594U (en) 2016-08-31 2016-08-31 Physics artificial liver adsorptive reactor based on hollow fiber conduit

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201621017118.6U CN206621594U (en) 2016-08-31 2016-08-31 Physics artificial liver adsorptive reactor based on hollow fiber conduit

Publications (1)

Publication Number Publication Date
CN206621594U true CN206621594U (en) 2017-11-10

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CN (1) CN206621594U (en)

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