CN206616169U - A kind of albumen sample fast purifying frame - Google Patents
A kind of albumen sample fast purifying frame Download PDFInfo
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- CN206616169U CN206616169U CN201720235364.7U CN201720235364U CN206616169U CN 206616169 U CN206616169 U CN 206616169U CN 201720235364 U CN201720235364 U CN 201720235364U CN 206616169 U CN206616169 U CN 206616169U
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- column
- shell
- laminate
- guide pillar
- albumen sample
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Abstract
The utility model discloses a kind of albumen sample fast purifying frame, wherein, including：Bottom plate；Guide pillar, is arranged at the predetermined position of bottom plate and on bottom plate；First laminate, along guide pillar activity and is fixedly installed on the first pre-position of bottom plate upper end；Second laminate, is active between guide pillar top and the first precalculated position along guide pillar；Wherein, guide pillar includes the first shell of column, the 3rd shell of column and the second shell of column being arranged between the first shell of column and the 3rd shell of column, and the first shell of column, the sectional view of the 3rd shell of column are taper.When second laminate is constantly pushed close to the first precalculated position, the push rod inside syringe does downward motion, now does Image processing to the material in syringe.Because frictional force is smaller so that the second laminate is declined by gravity completely, it is ensured that the second laminate is in horizontality, while the gravity of weight thing is carried on push rod, then uniform-compression at the top of the push rod of syringe, improves chromatographic effect.
Description
Technical field
The utility model is related to biologically pure technical field, relates in particular to a kind of albumen sample fast purifying frame.
Background technology
With the fast development of biochemistry science and technology, current diversified biological, medical purification production technique is increasingly
Maturation, is integrally improved application level of the molecular engineering in medicine, biological, chemical field.Wherein, protein is used as composition human body
Essential component, for how to realize protein purification, has become the main flow side that biochemical field produces protein
Method.
In the prior art, the purifying of albumen sample need to be by chromatography instrument.Specifically, in traditional sample preparation process,
Longer pipeline is provided between syringe and chromatographic column, material to be purified is carried in syringe, usual electric energy drives instrument
Piston pump built in device is pressed to chromatographic column to realize the feed liquor and sample introduction of chromatographic column, therefore such a mode needs multiple pump heads to hand over
Interaction is to reduce influence of the pulse to sampling.But longer pipeline is provided between syringe and chromatographic column, chromatographic column is caused
Feed liquor sample introduction it is less efficient, while it is existing chromatography instrument be only applicable to fixed syringe, syringe size change
Afterwards, then need to change different chromatography instruments, i.e., existing chromatography instrument compatibility is told somebody what one's real intentions are, and in turn results in purifying cost high.
In order to overcome above-mentioned technological deficiency, a kind of fast purifying frame is also proposed in the prior art, in use, when
During portable plate declines, four frictions between through hole and guide pillar of portable plate are direct friction, when some or two are logical
Hole, which is sent, to be tilted, the pressure increase of direct friction between inclined through hole and guide pillar, between relative other through hole and guide pillar
Friction pressure reduce, portable plate is in non-standard state, and portable plate does Image processing under non-standard state, then cause to treat layer
Analyse material compression uneven, substantially reduce chromatographic effect, and because of the presence of frictional force so that material pressure to be chromatographed is less than
Press the gravity of thing in itself, reduces the accuracy rate of experiment, in addition after the completion of Image processing, user must also protect portable plate
Water holding level state can easily remove portable plate, otherwise easily partial through holes friction occur because portable plate is under non-standard state
Power strengthens, and increases and takes plate difficulty.
Utility model content
The technical problems to be solved in the utility model is to provide a kind of pressure reduced between portable plate and guide pillar, improves layer
Analyse effect, improve the albumen sample fast purifying frame of experiment accuracy rate and use.
The concrete technical scheme that it is used is as follows：
A kind of albumen sample fast purifying frame, wherein, including：
Bottom plate；
Guide pillar, is arranged at the predetermined position of the bottom plate and on the bottom plate；
First laminate, along guide pillar activity and is fixedly installed on the first pre-position of the bottom plate upper end；
Second laminate, is active between the guide pillar top and first precalculated position along the guide pillar；
Wherein, the guide pillar includes the first shell of column, the 3rd shell of column and is arranged at first shell of column and the 3rd post
The second shell of column between section, first shell of column, the sectional view of the 3rd shell of column are taper.
Preferably, above-mentioned a kind of albumen sample fast purifying frame, wherein, second shell of column is cylinder, described the
One shell of column, the 3rd shell of column are symmetricly set in the second shell of column both sides.
Preferably, above-mentioned a kind of albumen sample fast purifying frame, wherein, described in the diameter matches of second shell of column
First round diameter of one shell of column or the 3rd shell of column.
Preferably, above-mentioned a kind of albumen sample fast purifying frame, wherein, in addition to the 4th shell of column, the 4th shell of column
It is arranged at the 3rd shell of column bottom.
Preferably, above-mentioned a kind of albumen sample fast purifying frame, wherein, described in the diameter matches of the 4th shell of column
Second round diameter of one shell of column or the 3rd shell of column
Preferably, above-mentioned a kind of albumen sample fast purifying frame, wherein, in the second precalculated position of second laminate
It is provided with counterweight guide pillar.
Preferably, above-mentioned a kind of albumen sample fast purifying frame, wherein, first laminate is provided with cell body, described
Cell body is included in the rectangular or square cell body of a semi-circular through hole and the connection semi-circular through hole, the semi-circular through hole
Side is arranged at adjusting means.
Preferably, above-mentioned a kind of albumen sample fast purifying frame, wherein, the adjusting means include the first adjuster,
Second adjuster, first adjuster sets the side for being movably disposed in the semi-circular through hole, second regulation
Device is movably disposed in the opposite side of the semi-circular through hole, and first adjuster is with reference to second adjuster formation one
Accommodate the through hole of carrier to be compressed.
Preferably, above-mentioned a kind of albumen sample fast purifying frame, wherein, set respectively at the top of first adjuster
The first junction button is equipped with, the top of second adjuster is provided with the second junction button, first junction button and institute
State and be provided with an elastic device between the second junction button, pass through the elastic device and connect first junction button and described second
Junction button.
Compared in prior art, the utility model has the advantages that.
In the utility model, when the second laminate is constantly pushed close to first precalculated position, inside the syringe
Push rod does downward motion, now does Image processing to the material in syringe.Because frictional force is smaller so that the second laminate completely by
Gravity declines, it is ensured that the second laminate is in horizontality, while the gravity of weight thing is carried on push rod, then syringe is pushed away
Uniform-compression at the top of bar, improves chromatographic effect.The gravity of weight thing is almost carried completely by material to be chromatographed simultaneously, improves examination
The accuracy rate tested.Complete after Image processing, first unload dish-type counterweight, the second laminate is dismantled from the 3rd shell of column bottom plate along guide pillar, because
3rd shell of column is tapered cylinders, and the second laminate is not directly contacted with the 3rd shell of column, and its frictional force is smaller, is kept without the second laminate
Horizontality is detachable second layer plate, is user-friendly.
Brief description of the drawings
The utility model is described in further detail with embodiment below in conjunction with the accompanying drawings：
Fig. 1 is a kind of dimensional structure diagram of albumen sample fast purifying frame in the utility model embodiment；
Fig. 2 is a kind of guide pillar schematic diagram of albumen sample fast purifying frame in the utility model embodiment.
Embodiment
The present invention is described in further detail with reference to the accompanying drawings and examples.It is understood that this place is retouched
The specific embodiment stated is used only for explaining the present invention, rather than limitation of the invention.It also should be noted that, in order to just
Part related to the present invention rather than entire infrastructure are illustrate only in description, accompanying drawing.
, it is necessary to by means of a syringe, chromatographic column 7 and weight thing, waste liquid disk to complete in purifying sample processing procedure
Purification process, wherein the syringe, the syringe includes syringe needle 61, syringe 62 and 63, the syringe needle 63 stretches into chromatographic column 7
In, the weight thing uses dish-type counterweight 5, and the waste liquid disk is located at the underface of chromatographic column.
As shown in figure 1, a kind of albumen sample fast purifying frame, wherein, including：
In bottom plate 1, the present embodiment, the bottom plate 1 is rectangular, or other figures, such as circular or ellipse, herein not
It is specifically limited；
Guide pillar 2, is arranged at the predetermined position of the bottom plate 1 and on the bottom plate 1；When the bottom plate 1 is square
When shape or square, the guide pillar 2 is arranged at the cornerwise two ends of the bottom plate 1, when the bottom plate 1 is circular or ellipse
When, the guide pillar 2 is symmetricly set in the edge of the bottom plate 1；Further, as shown in Fig. 2 the guide pillar includes the first shell of column
21st, the 3rd shell of column 23 and the second shell of column 22 being arranged between first shell of column 21 and the 3rd shell of column 23, described
One shell of column 21, the sectional view of the 3rd shell of column 23 are taper.
First laminate 3, along the activity of the guide pillar 2 and is fixedly installed on the first pre-position of the upper end of bottom plate 1；Institute
State the first laminate 3 to be socketed on the guide pillar 2, the syringe 62 is fixed on first laminate 3；Wherein described first makes a reservation for
The height of location matches syringe 62.When injector length is longer, injection is worked as in first precalculated position away from the bottom plate 1
When device length is relatively short, first precalculated position is close to the bottom plate 1.
Further, the first guide pad 30 is also provided with first laminate 3, first guide pad 30 is sheathed on
On guide pillar 2, the guide pad of the first laminate 3 be fixed on the lower surface of first laminate 3；Also include holds out against screw：The top
Tight screw passes through the guide pad of the first laminate 3, and it is pre- that first laminate 3 is arranged at into described first by the holds out against screw
Place is put in positioning.The waste liquid disk is on bottom plate 1.
Second laminate 4, is active between the top of guide pillar 2 and first precalculated position along the guide pillar 2；In described
Second precalculated position of the second laminate 4 is provided with counterweight guide pillar 41.The counterweight guide pillar 41 can be located in second laminate 4
Heart district domain.
The weight thing is pressed in the upper surface of the second laminate, and the lower surface of second laminate is pressed on the push rod 63,
The upper surface of second laminate is provided with counterweight guide pillar 41.
When 4 sets of access guide pillars of the second laminate, enter from the top of the first shell of column 21, because the first shell of column 21 is taper
Cylinder, the second laminate 4 is not directly contacted with the first shell of column 21, and its frictional force is smaller, when the second laminate 4 is steadily positioned on push rod
When, the dish-type counterweight 5 is sheathed on counterweight guide pillar 41.
During Image processing, when the second laminate 4 is constantly pushed close to first precalculated position, in the syringe
The push rod 63 in portion does downward motion, now does Image processing to the material in syringe.Because frictional force is smaller so that the second laminate
Declined completely by gravity, it is ensured that the second laminate is in horizontality, while the gravity of weight thing is carried on push rod 63, then notes
Uniform-compression at the top of the push rod of emitter, improves chromatographic effect.The gravity of weight thing is almost carried completely by material to be chromatographed simultaneously,
Improve the accuracy rate of experiment.
Complete after Image processing, first unload dish-type counterweight 5, the second laminate is dismantled from the bottom plate of the 3rd shell of column 23 along guide pillar, because
3rd shell of column 23 is tapered cylinders, and the second laminate 4 is not directly contacted with the 3rd shell of column 23, and its frictional force is smaller, without the second layer
Plate keeps horizontality to be detachable second layer plate, is user-friendly.
In actual use, its course of work is as follows：
First, equilibrium liquid to be detected, sample and eluent are injected in syringe in order, and by it with having selected
Chromatographic column 7 is connected.Then, the syringe 62 of syringe is caught on the first laminate 3 by staff along cell body, so that on syringe 62
Annular nib blocks syringe 62 positioned at the upper end of the first laminate 3.So that syringe is fixed on the first laminate 3.
Then, holds out against screw is unclamped from guide pillar 2, according to the model of the chromatographic column 7 of selection, adjusts hanging down for the first laminate 3
Straight height, and holds out against screw is screwed, the first laminate 3 is fixed on guide pillar 2.And placement waste liquid disk makes waste liquid disk position on bottom plate 1
In the underface of the output end of chromatographic column 7.
Then, by the second laminate 4 along along 21 sets of access guide pillars 2 of the first shell of column, when the second laminate is smoothly positioned over
(one side that second laminate 4 contacts the push rod 63 is plane, while the outer surface of push rod 63 is also flat during the push rod 63
Face, so the second laminate 4 can be smoothly positioned on the push rod 63), it is put into the dish-type as weight thing along counterweight guide pillar 41
Counterweight 5, the second laminate 4 is in the presence of weight thing, because the frictional force between the second laminate 4 and guide pillar is less, when weight thing is
When second laminate 3 presses, the pressure is passed to push rod, makes push rod 63 move with respect to syringe 62, by the equilibrium liquid in syringe 62,
Syringe needle 61 is persistently pressed into chromatographic column 7 again for sample and eluent.During, efflux of the staff according to observation chromatographic column 7
Flow velocity, weight thing is added and subtracted in the upper surface of the second laminate 4.
As further preferred embodiment, a kind of above-mentioned albumen sample fast purifying frame, wherein, second shell of column
22 be cylinder, and first shell of column 21, the 3rd shell of column 23 are symmetricly set in the both sides of the second shell of column 22.
As further preferred embodiment, a kind of above-mentioned albumen sample fast purifying frame, wherein, second shell of column
First round diameter of the first shell of column 21 or the 3rd shell of column 23 described in 22 diameter matches.
As further preferred embodiment, a kind of above-mentioned albumen sample fast purifying frame, wherein, in addition to the 4th post
Section 24, the 4th shell of column 24 is arranged at the bottom of the 3rd shell of column 23.
As further preferred embodiment, a kind of above-mentioned albumen sample fast purifying frame, wherein, the 4th shell of column
Second round diameter of the first shell of column 21 or the 3rd shell of column 23 described in 24 diameter matches.Second round diameter is tapered pole
The top axis of small circle of body, the first round diameter is the bottom axis of great circle of tapered cylinders.
As further preferred embodiment, a kind of above-mentioned albumen sample fast purifying frame, wherein, first laminate
Cell body is provided with, the cell body includes the rectangular or square cell body of a semi-circular through hole and the connection semi-circular through hole,
Adjusting means is arranged on the inside of the semi-circular through hole.
As further preferred embodiment, a kind of above-mentioned albumen sample fast purifying frame, wherein, the adjusting means
Including the first adjuster, the second adjuster, first adjuster sets and is movably disposed in the one of the semi-circular through hole
Side, second adjuster is movably disposed in the opposite side of the semi-circular through hole, and first adjuster is with reference to described
Second adjuster formation one accommodates the through hole of carrier to be compressed.
As further preferred embodiment, a kind of above-mentioned albumen sample fast purifying frame, wherein, respectively at described
The top of one adjuster is provided with the first junction button, and the top of second adjuster is provided with the second junction button, institute
State and be provided with an elastic device between the first junction button and second junction button, described first is connected by the elastic device
Junction button and second junction button.By elastic device, without opening up multiple notches in the second lamina surface, it is only necessary to adjust
Device is the syringe of compatible multiple sizes.
Note, above are only preferred embodiment of the present utility model and institute's application technology principle.Those skilled in the art's meeting
Understand, the utility model is not limited to specific embodiment described here, can carried out for a person skilled in the art various bright
Aobvious change, readjust and substitute without departing from protection domain of the present utility model.Therefore, although pass through above example
The utility model is described in further detail, but the utility model is not limited only to above example, is not departing from
In the case that the utility model is conceived, other more equivalent embodiments can also be included, and scope of the present utility model is by appended
Right determine.
Claims (9)
1. a kind of albumen sample fast purifying frame, it is characterised in that including：
Bottom plate；
Guide pillar, is arranged at the predetermined position of the bottom plate and on the bottom plate；
First laminate, along guide pillar activity and is fixedly installed on the first pre-position of the bottom plate upper end；
Second laminate, is active between the guide pillar top and first precalculated position along the guide pillar；
Wherein, the guide pillar include the first shell of column, the 3rd shell of column and be arranged at first shell of column and the 3rd shell of column it
Between the second shell of column, first shell of column, the 3rd shell of column sectional view be taper.
2. a kind of albumen sample fast purifying frame according to claim 1, it is characterised in that second shell of column is cylinder
Shape, first shell of column, the 3rd shell of column are symmetricly set in the second shell of column both sides.
3. a kind of albumen sample fast purifying frame according to claim 1, it is characterised in that the diameter of second shell of column
Match the first round diameter of first shell of column or the 3rd shell of column.
4. a kind of albumen sample fast purifying frame according to claim 1, it is characterised in that also including the 4th shell of column, institute
State the 4th shell of column and be arranged at the 3rd shell of column bottom.
5. a kind of albumen sample fast purifying frame according to claim 4, it is characterised in that the diameter of the 4th shell of column
Match the second round diameter of first shell of column or the 3rd shell of column.
6. a kind of albumen sample fast purifying frame according to claim 1, it is characterised in that in the of second laminate
Two precalculated positions are provided with counterweight guide pillar.
7. a kind of albumen sample fast purifying frame according to claim 1, it is characterised in that first laminate is provided with
Cell body, the cell body includes the rectangular or square cell body of a semi-circular through hole and the connection semi-circular through hole, described half
Adjusting means is arranged on the inside of manhole.
8. a kind of albumen sample fast purifying frame according to claim 7, it is characterised in that the adjusting means includes the
One adjuster, the second adjuster, first adjuster set the side for being movably disposed in the semi-circular through hole, described
Second adjuster is movably disposed in the opposite side of the semi-circular through hole, and first adjuster is with reference to the described second regulation
Device formation one accommodates the through hole of carrier to be compressed.
9. a kind of albumen sample fast purifying frame according to claim 8, it is characterised in that respectively at the described first regulation
The top of device is provided with the first junction button, and the top of second adjuster is provided with the second junction button, described first
An elastic device is provided between junction button and second junction button, first junction button is connected by the elastic device
With second junction button.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720235364.7U CN206616169U (en) | 2017-03-10 | 2017-03-10 | A kind of albumen sample fast purifying frame |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720235364.7U CN206616169U (en) | 2017-03-10 | 2017-03-10 | A kind of albumen sample fast purifying frame |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206616169U true CN206616169U (en) | 2017-11-07 |
Family
ID=60232366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720235364.7U Active CN206616169U (en) | 2017-03-10 | 2017-03-10 | A kind of albumen sample fast purifying frame |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206616169U (en) |
-
2017
- 2017-03-10 CN CN201720235364.7U patent/CN206616169U/en active Active
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