CN206597475U - A kind of raw material mixing machine special of roxithromycin capsules - Google Patents
A kind of raw material mixing machine special of roxithromycin capsules Download PDFInfo
- Publication number
- CN206597475U CN206597475U CN201720251066.7U CN201720251066U CN206597475U CN 206597475 U CN206597475 U CN 206597475U CN 201720251066 U CN201720251066 U CN 201720251066U CN 206597475 U CN206597475 U CN 206597475U
- Authority
- CN
- China
- Prior art keywords
- mixing
- mixing machine
- raw material
- mixing channel
- fixing axle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000002156 mixing Methods 0.000 title claims abstract description 102
- 239000002775 capsule Substances 0.000 title claims abstract description 24
- RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 title claims abstract description 23
- 229960005224 roxithromycin Drugs 0.000 title claims abstract description 23
- 239000002994 raw material Substances 0.000 title claims abstract description 20
- 238000007599 discharging Methods 0.000 claims abstract description 29
- 238000000034 method Methods 0.000 claims abstract description 26
- 230000008569 process Effects 0.000 claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000000463 material Substances 0.000 claims description 17
- 239000003566 sealing material Substances 0.000 claims description 4
- 230000003068 static effect Effects 0.000 claims description 4
- 238000007789 sealing Methods 0.000 claims description 3
- 230000006872 improvement Effects 0.000 abstract description 7
- 239000000498 cooling water Substances 0.000 description 6
- 238000010276 construction Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000002131 composite material Substances 0.000 description 3
- 239000007884 disintegrant Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000010348 incorporation Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000005550 wet granulation Methods 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011538 cleaning material Substances 0.000 description 1
- 238000005034 decoration Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Accessories For Mixers (AREA)
Abstract
The utility model discloses a kind of raw material mixing machine special of roxithromycin capsules, including mixing machine base and the mixing channel being arranged on base, mixing channel includes charging aperture, fixing axle, discharging opening；Fixing axle is connected on mixing machine base, and fixing axle is provided with agitating paddle；Fixing axle connects motor；Discharging opening is located at mixing channel sidewall bottom, and discharging opening rotates connection discharging closure；The body exterior of mixing channel, which is surrounded, is provided with chuck, and chuck is provided with water inlet, delivery port, and water inlet side is provided with magnetic valve；Temperature sensor is fixed with mixing channel inwall, the side of temperature sensor is fixed with control process device, and temperature sensor and magnetic valve is electrically connected in control process device.The mixer structural improvement, increases chuck, and sets temperature sensor, and mixing temperature is monitored in real time, and mixing temperature is controlled using control process device, by mixing temperature control in optimum temperature；Simultaneously to mixer structural improvement, easy-unloading.
Description
Technical field
The utility model is related to a kind of field of pharmaceutical equipment, specially a kind of special mixing of the raw material of roxithromycin capsules
Machine.
Background technology
Roxithromycin capsules are most general ROX formulation at present, and capsule is typically using wet granulation technology or directly
Fill process prepares roxithromycin capsules.Wherein wet granulation technology is by ROX and other auxiliary materials, such as disintegrant, to fill out
Fill agent etc. and be mixed into powder, add adhesive mixing granulation, then dry, it is encapsulated.Direct fill process is by ROX
With auxiliary material, disintegrant, filler etc. are mixed into powder, encapsulated.
Need to be well mixed ROX and other auxiliary materials in the preparation process of roxithromycin capsules, generally using groove
Type mixer is mixed to ROX and its auxiliary material, and existing setting incorporation time is long, and prolonged mixing is easily caused
Raw material generates heat, and often temperature can reach 60 DEG C of even more highs.Because the fusing point of ROX is 111-118 DEG C, Optimum storage bar
Part is that the heating in 2-8 DEG C, therefore mixing can influence the physicochemical property of medicine.Therefore the structural improvement to mixer is needed, dropped
Influence of the low temperature to material.In the prior art, mixing channel can have mercy on after mixing horizontally rotates discharging, this discharge way simultaneously
Need manpower to rotate mixing channel, with manpower cleaning material material, take time and effort.Therefore existing mixer has larger change
Enter space.
The content of the invention
To solve the above problems, the utility model discloses a kind of raw material mixing machine special of roxithromycin capsules.This reality
With the raw material mixing machine special structural improvement of new disclosed roxithromycin capsules, increase chuck, using cooling water temperature, and set
Temperature sensor is put, mixing temperature is monitored in real time, mixing temperature is controlled using control process device, by mixing temperature control most
Thermophilic degree；Simultaneously to mixer structural improvement, easy-unloading.
In order to reach object above, the utility model provides following technical scheme：
A kind of raw material mixing machine special of roxithromycin capsules, including mixing machine base and the mixing being arranged on base
Groove, the mixing channel includes charging aperture, fixing axle, discharging opening；The charging aperture is located at the top of mixing channel, and the charging aperture is certainly
Upper and pyramidal structure that lower relative aperture gradually increases；The charging aperture rotates connection feeding seal lid；The fixing axle is connected to institute
State on mixing machine base, the fixing axle is provided with agitating paddle；The fixing axle connects motor；The discharging opening is located at mixing channel
Sidewall bottom, the discharging opening rotates connection discharging closure；The body exterior of the mixing channel, which is surrounded, is provided with chuck, the folder
Set is made up of jackets inner wall and jackets outer wall sealing, and the chuck is provided with water inlet, delivery port, and the water inlet side is provided with
Magnetic valve；Temperature sensor is fixed with the mixing channel inwall, the side of the temperature sensor is fixed with control
Device is managed, temperature sensor and magnetic valve is electrically connected in the control process device.
Further, time logging program and thermograph program are provided with the control process device.
Further, the control process device also includes alarm buzzer, automatic ring during overtemperature.
Further, the agitating paddle is helical form belt agitating paddle.
Further, the agitating paddle includes two symmetrically arranged helical form belt agitating paddles.
Further, the section of the mixing channel is U-shaped.
Further, the motor connection variable-frequency motor, the variable-frequency motor is engaged with the motor.
Further, feeding seal lid, discharging closure are made of static sealing materials.
The utility model has the following advantages that：
（1）Charging aperture of the present utility model is using the pyramidal structure that aperture gradually increases from top to bottom, convenient charging, charging
Mouth closes feeding seal lid provided with the feeding seal lid for rotating connection after charging, discharging is provided with discharging opening of the present utility model
Closure, is closed during charging, is opened during discharging, it is not necessary to which manpower is tilted.
（2）The body exterior of mixing channel of the present utility model, which is surrounded, is provided with chuck, and chuck is provided with water inlet and delivery port,
The side of water inlet is provided with magnetic valve, is provided with temperature sensor in mixing channel inwall, the temperature in mixing channel is passed at control
Device, control process device connection magnetic valve are managed, and maximum temperature is set in control process device, when mixed in mixing channel
Close temperature and reach after the maximum temperature of setting that can automatically open up magnetic valve, water inlet enters cooling water, passes through the recycle stream of cooling water
It is dynamic that mixing channel is cooled down.If, can Self-shut electromagnetic valve after temperature is less than the maximum temperature set；Pass through the TEMP
Device, control process system, magnetic valve and chuck realize the Automatic Detection and Control to mixing channel temperature so that the mixing temperature of mixing channel
Degree reaches suitable temperature, the influence that the heat produced during reduction mixing is mixed to material.And whole temperature control device structure letter
It is single, set reasonable, safe operation.
Brief description of the drawings
Fig. 1, structural representation of the present utility model.
Reference numerals list：Base 1, mixing channel 2, charging aperture 3, fixing axle 4, discharging opening 5, feeding seal lid 6, agitating paddle
7th, chuck 8, water inlet 81, delivery port 82, magnetic valve 9, temperature sensor 10, control process device 11, alarm buzzer 12, electricity
Machine 13, variable-frequency motor 14.
Embodiment
With reference to the accompanying drawings and detailed description, the utility model is further elucidated, it should be understood that following specific embodiment parties
Formula is merely to illustrate the utility model rather than limits scope of the present utility model.
As shown in figure 1, a kind of raw material mixing machine special of roxithromycin capsules, including mix machine base 1 and be arranged on bottom
Mixing channel 2 on seat, mixing channel includes charging aperture 3, fixing axle 4, discharging opening 5；Wherein fixing axle is connected on base.Mixer
Chassis interior is hollow-core construction, facilitates motor etc. to set and is placed in base, and simple in construction；The section of mixing channel is U-shaped.U
On the one hand type is set can increase material plot ratio, on the other hand facilitate the agitating paddle in fixing axle to stir.
Charging aperture is located at the top of mixing channel, and charging aperture is the pyramidal structure that bore gradually increases from top to bottom.In charging aperture
On by setting automatic feeder or manually feeding.Charging aperture rotates connection feeding seal lid 6.Feeding seal lid is used
Static sealing materials are made.
Fixing axle is provided with agitating paddle 7；Using two symmetrically arranged spirals in helical form belt agitating paddle, the present embodiment
Shape ribbon blender oar.Agitating paddle realizes mixing to material so that material ceaselessly above and below, left and right, inside and outside all directions
Uniform mixing is reached during motion.Using two symmetrically arranged helical form belt agitating paddles, mixing effect significantly, can have
Effect shortens mixing time, and express delivery reaches mixed effect, and composite rate is high.
Fixing axle connects motor 13；Motor connection variable-frequency motor 14, variable-frequency motor is engaged with motor.Frequency conversion behaviour can be achieved
Make.
Discharging opening is located at mixing channel sidewall bottom, and discharging opening rotates connection discharging closure, adopted in the present embodiment
It is hinged, discharging closure, convenient discharging can be opened during discharging.Original technology tilts mixing channel, Ran Houren using manpower
Material at power cleaning, not only waste of manpower, and also easily be present dead angle in cleaning, take time and effort.It is convenient to be discharged after improvement, during saving
Between and manpower.Discharging closure is made of static sealing materials.
Surrounded in the body exterior of mixing channel and be provided with chuck 8, chuck is made up of jackets inner wall and jackets outer wall sealing, at this
Chuck is arranged on the bottom of mixing channel in embodiment, and the jackets inner wall of chuck is mixing groove bottom wall, provided with water inlet on chuck
Mouth 81, delivery port 82, water inlet side are provided with magnetic valve 9.Wherein water inlet connects water source.Agitating paddle mixing when, mixing
The condition of high temperature is predominantly located at the agitating paddle of mixing channel, because the position of agitating paddle is in the middle and lower part of mixing channel, therefore in this reality
Apply the bottom that chuck in example sets mixing channel.
Temperature sensor 10 is fixed with mixing channel inwall, the side of temperature sensor is fixed with control process device
11, the wherein temperature measuring probe of temperature sensor is located on inwall, for detecting the mixing temperature in mixing channel, and the temperature is passed
Sensor is electrically connected with control process device, and control process device is located in the hollow-core construction of mixer chassis interior, control process
Device is electrically connected with magnetic valve.Maximum temperature is set to limit in control process device, when mixing temperature is higher than the highest set
During temperature, magnetic valve can be opened, water source realizes that cooling water circulation cools down mixing channel into water inlet.
In the present embodiment, time logging program and thermograph program are provided with control process device.It can monitor in real time
The change of mixing temperature.
In the present embodiment, control process device also includes alarm buzzer 12, automatic ring during overtemperature.It can be rung during overtemperature
Flute is warned.
Using the raw material mixing machine special of roxithromycin capsules of the present utility model, to needed for production roxithromycin capsules
ROX and its auxiliary material are mixed.
The operation for preparing roxithromycin capsules using the direct fill process of powder is as follows：
The first step, closes discharging closure, opens feeding seal lid, and ROX raw material, filler, disintegrant etc. is auxiliary
Material is then shut off feeding seal lid from charging aperture input.
Second step, opens motor mixing.In mixed process, chuck is provided with water inlet and delivery port, the one of water inlet
Side is provided with magnetic valve, is provided with temperature sensor in mixing channel inwall, the temperature in mixing channel is passed into control process device, the control
Processing unit processed connects magnetic valve, and sets maximum temperature in control process device, when the mixing temperature in mixing channel reaches
After the maximum temperature of setting, magnetic valve can be automatically opened up, water inlet enters cooling water, pass through circulating to mixing channel for cooling water
Cooled down.If, can Self-shut electromagnetic valve after temperature is less than the maximum temperature set；At the temperature sensor, control
Reason system, magnetic valve and chuck realize the Automatic Detection and Control to mixing channel temperature so that the mixing temperature of mixing channel reaches suitable
Close temperature, the influence that the heat produced during reduction mixing is mixed to material.And entirely temperature control device is simple in construction, sets and close
Reason, safe operation.
3rd step, opens discharging closure, the material mixed is poured out, into subsequent processing after the completion of mixing.
In this embodiment, the ROX weight of addition is 60kg, the mixer announced using the utility model with
Mixer of the prior art handle identical ROX material when mixing when temperature, composite rate, incorporation time, to such as
Under
The raw material mixing machine special for the roxithromycin capsules that the utility model is announced, composite rate is high, and incorporation time is short, mixing
Temperature is substantially reduced.The utility model has significant progressive.
Technological means disclosed in the utility model scheme is not limited only to the technological means disclosed in above-mentioned embodiment, also
Including being combined constituted technical scheme by above technical characteristic.It should be pointed out that for the ordinary skill of the art
For personnel, on the premise of the utility model principle is not departed from, some improvements and modifications can also be made, these improve and moistened
Decorations are also considered as protection domain of the present utility model.
Claims (8)
1. a kind of raw material mixing machine special of roxithromycin capsules, including mixing machine base and the mixing channel being arranged on base,
It is characterized in that：The mixing channel includes charging aperture, fixing axle, discharging opening；The charging aperture be located at mixing channel at the top of, it is described enter
Material mouth is the pyramidal structure that bore gradually increases from top to bottom；The charging aperture rotates connection feeding seal lid；The fixing axle
It is connected on the mixing machine base, the fixing axle is provided with agitating paddle；The fixing axle connects motor；The discharging opening position
In mixing channel sidewall bottom, the discharging opening rotates connection discharging closure；The body exterior of the mixing channel is surrounded provided with folder
Set, the chuck is made up of jackets inner wall and jackets outer wall sealing, and the chuck is provided with water inlet, delivery port, the water inlet
Mouth side is provided with magnetic valve；Temperature sensor is fixed with the mixing channel inwall, the side of the temperature sensor is fixed
Provided with control process device, temperature sensor and magnetic valve is electrically connected in the control process device.
2. a kind of raw material mixing machine special of roxithromycin capsules as claimed in claim 1, it is characterised in that：At the control
Manage and time logging program and thermograph program are provided with device.
3. a kind of raw material mixing machine special of roxithromycin capsules as claimed in claim 1 or 2, it is characterised in that：The control
Processing unit processed also includes alarm buzzer, automatic ring during overtemperature.
4. a kind of raw material mixing machine special of roxithromycin capsules as claimed in claim 1, it is characterised in that：The agitating paddle
For helical form belt agitating paddle.
5. a kind of raw material mixing machine special of roxithromycin capsules as claimed in claim 4, it is characterised in that：The agitating paddle
Including two symmetrically arranged helical form belt agitating paddles.
6. a kind of raw material mixing machine special of roxithromycin capsules as claimed in claim 1, it is characterised in that：The mixing channel
Section to be U-shaped.
7. a kind of raw material mixing machine special of roxithromycin capsules as claimed in claim 1, it is characterised in that：The motor connects
Variable-frequency motor is connect, the variable-frequency motor is engaged with the motor.
8. a kind of raw material mixing machine special of roxithromycin capsules as claimed in claim 1, it is characterised in that：Feeding seal
Lid, discharging closure are made of static sealing materials.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720251066.7U CN206597475U (en) | 2017-03-15 | 2017-03-15 | A kind of raw material mixing machine special of roxithromycin capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720251066.7U CN206597475U (en) | 2017-03-15 | 2017-03-15 | A kind of raw material mixing machine special of roxithromycin capsules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206597475U true CN206597475U (en) | 2017-10-31 |
Family
ID=60144200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720251066.7U Expired - Fee Related CN206597475U (en) | 2017-03-15 | 2017-03-15 | A kind of raw material mixing machine special of roxithromycin capsules |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206597475U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107754648A (en) * | 2017-12-07 | 2018-03-06 | 南京高正农用化工有限公司 | A kind of wettable powder mixer |
-
2017
- 2017-03-15 CN CN201720251066.7U patent/CN206597475U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107754648A (en) * | 2017-12-07 | 2018-03-06 | 南京高正农用化工有限公司 | A kind of wettable powder mixer |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106693797A (en) | Production device capable of fully mixing cosmetics | |
| CN206597475U (en) | A kind of raw material mixing machine special of roxithromycin capsules | |
| CN208100758U (en) | A kind of dry-mixed mortar mixed stirring device | |
| CN205323713U (en) | Reaction kettle | |
| CN205146226U (en) | Agitating unit is smashed in pharmacy | |
| CN206746027U (en) | Frame type stirring Agitation Tank | |
| CN206762718U (en) | A kind of efficient heat transfer mixes agitator tank | |
| CN205466827U (en) | A compounding system for medical PVC material | |
| CN105643824A (en) | Mixing system for medical PVC materials | |
| CN107583520A (en) | A kind of agitator tank | |
| CN205517608U (en) | High -speed wet granulator pelletization mechanism | |
| CN206229285U (en) | A kind of medical ultrasonic agitating device | |
| CN206778202U (en) | A kind of caput femoris necrosis test agents preparation agitating device | |
| CN207805618U (en) | A kind of reaction kettle for preparing building thermal-insulating coating | |
| RU2607148C1 (en) | Device for preparation of dry thermolabile biological materials | |
| CN205700287U (en) | A kind of temperature controllable blender | |
| CN206371432U (en) | A kind of milling apparatus suitable for chocolate making process | |
| CN212653669U (en) | Plastic granules mixing arrangement | |
| CN204865643U (en) | Agitator tank of weaving thick liquids | |
| CN208642357U (en) | A kind of dissolving tank of dissolved solid object | |
| CN206391903U (en) | A kind of silica gel kneader | |
| CN207828161U (en) | titanium dioxide coating system | |
| CN207448843U (en) | A kind of color masterbatch mixing tank | |
| CN207113508U (en) | A kind of setastine hydrochloride grain forming and drying unit | |
| CN206127249U (en) | Soap class is smashed and is given a new lease of life to device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171031 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |