CN206538363U - A kind of process system for producing D phenylalanines - Google Patents
A kind of process system for producing D phenylalanines Download PDFInfo
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- CN206538363U CN206538363U CN201720044256.1U CN201720044256U CN206538363U CN 206538363 U CN206538363 U CN 206538363U CN 201720044256 U CN201720044256 U CN 201720044256U CN 206538363 U CN206538363 U CN 206538363U
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- condensing crystallizing
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Abstract
The utility model discloses a kind of process system for producing D phenylalanines, including the first reactor being sequentially connected, first centrifuge, first conveyer, second reactor, second centrifuge, second conveyor and the 3rd reactor, 3rd reactor is connected by feed pipe with the raw water room import of electrodialysis plant, the raw water room outlet of electrodialysis plant is connected by raw water discharge nozzle with the first condensing crystallizing kettle, first condensing crystallizing kettle is connected with the 3rd centrifuge and vacuum drier successively, the outlet of electrodialysis plant anion enriched chamber is connected by concentrated water discharge nozzle with the second condensing crystallizing kettle, second condensing crystallizing kettle is connected with the 4th centrifuge, 4th centrifuge is connected by the 4th conveyer with the second reactor.The utility model carries out isolated D phenylalanines to gained double salt using electrodialysis plant, simple to operate, saves the time, high income, up to 85 90%, and need not use methanol and triethylamine, also advantage of lower cost, environmental protection.
Description
Technical field
The utility model is related to a kind of process system for producing D-phenylalanine.
Background technology
D-phenylalanine is a kind of important chiral amino acid, in medicine, chemical field extensive use.Such as, D- phenylpropyl alcohols ammonia
Acid be anti-diabetic nateglinide how (nateglinide), antineoplastic skin (octreotide) difficult to understand bent, AIDS drugs
The raw material of indinavir (indinavir), it is also possible to make chiral reagent or chiral intermediate.In addition, D-phenylalanine also may be used
To be used directly as medicine, compressive resistance agent, control diabetic agent, anti-inflammatory and analgesic agents are such as may be used as, can also conduct
Chiral reagent or chiral intermediate.
Preparation method on D-phenylalanine has many reports, it is industrial at present mainly use by L-phenylalanine not
Symmetrical conversion prepares D-phenylalanine, and its process system includes the first reactor, the first centrifuge, the first conveying being sequentially connected
Machine, the second reactor, the second centrifuge, second conveyor, the 3rd reactor, Suction filtration device and condensing crystallizing kettle, utilize its work
When process system is produced, first L-phenylalanine, catalyst salicylide and solvent acetic acid are added to the first reactor, by institute
The reactant obtained sends into the second reactor, and D- tartaric acid is added into the second reactor, after reaction terminates, concentrated Crystallization Separation
Obtain DL-phenylalanine and send into the second reactor, D- tartaric acid is added into the second reactor, after reaction terminates, concentrated knot
Brilliant isolated D-phenylalanine D- tartaric acid double salt；D-phenylalanine D- tartaric acid double salt is sent into the 3rd reactor,
Triethylamine being added into the 3rd reactor again and methanol being dissociated, after stirring reaction 1-2h, D- tartaric acid is given birth to triethylamine
Into salt because insoluble in methanol separate out, after being filtered to remove through Suction filtration device, obtained filtrate condensing crystallizing in condensing crystallizing kettle
After obtain D- tartaric acid, the triethylamine used is needed in the technique, its is expensive, cost is high, in addition, also needing using substantial amounts of molten
Agent methanol, not environmentally.
Utility model content
The utility model provides a kind of process system for producing D-phenylalanine, and existing process system is improved, profit
Isolated D-phenylalanine is carried out to gained double salt with electrodialysis plant, it is simple to operate, the time is saved, high income can
Up to 85-90%, and without using triethylamine and solvent methanol, advantage of lower cost, environmental protection.
In order to solve the above problems, the technical solution adopted in the present invention is a kind of such, D-phenylalanine of producing
Process system, it is characterised in that including the first reactor being sequentially connected, the first centrifuge, the first conveyer, the second reaction
Kettle, the second centrifuge, second conveyor and the 3rd reactor, described the 3rd reactor passes through feed pipe and electrodialysis plant
The import of raw water room is connected, and the raw water room outlet of electrodialysis plant is connected by raw water discharge nozzle with the first condensing crystallizing kettle, described
The first condensing crystallizing kettle be connected successively with the 3rd centrifuge and vacuum drier, the outlet of electrodialysis plant anion enriched chamber
It is connected by concentrated water discharge nozzle with the second condensing crystallizing kettle, the second described condensing crystallizing kettle is connected with the 4th centrifuge, the 4th
Centrifuge is connected by the 4th conveyer with the second reactor.
Applicable the utility model of existing electrodialysis plant, it is preferable that described electrodialysis plant includes electrodialysis
Groove, described electrodialysis cell passes through the first cation-exchange membrane, the first anion-exchange membrane, the second cation-exchange membrane, second
Anion-exchange membrane is separated into 5 reative cells, respectively is anode chamber, anion enriched chamber, raw water room, cation enriched chamber
And cathode chamber, it is provided with positive electrode, cathode chamber in described anode chamber and is provided with negative electrode.
For the pH in the reactor of on-line determination the 3rd, pH detection meters are provided with the 3rd described reactor.
Beneficial effect：The utility model is improved to existing process system, using electrodialysis plant to gained D- phenylpropyl alcohols
Propylhomoserin D- tartaric acid double salt is separated, and double salt sends into the 3rd reactor after centrifugation, then to the 3rd reactor
Middle addition water, after adjusting its pH value to the isoelectric point of D-phenylalanine through ammoniacal liquor, then the solution addition in the 3rd reactor is electric
In the raw water room of electrodialysis apparatus, in the presence of electric field, it is dense that the D- tartrate ions in raw water room are attracted to negative electrode by force
Contracting room, ammonium ion is attracted to anode enriched chamber by force, and D-phenylalanine solution is then stayed in diluting compartment, is finally imported into
In condensing crystallizing kettle after concentrated crystallization, then through separating and being dried to obtain D-phenylalanine, the process system is simple to operate,
Saving time, high income, up to 85-90%, and without using methanol and expensive triethylamine, advantage of lower cost, ring
Protect.
Brief description of the drawings
Fig. 1 is the utility model structural representation.
Embodiment
In order to deepen to understand of the present utility model, further is made to the utility model below in conjunction with embodiment and accompanying drawing
It is described in detail, the embodiment is only used for explaining the utility model, does not constitute the restriction to the utility model protection domain.
It is a kind of to produce the process system of D-phenylalanine referring to Fig. 1, including the first reactor 1, first being sequentially connected
Centrifuge 111, the first conveyer 112, the second reactor 2, the second centrifuge 221, the reactor 3 of second conveyor 222 and the 3rd,
The 3rd described reactor 3 is connected by feed pipe with the import of raw water room 13 of electrodialysis plant, the raw water room of electrodialysis plant
13 outlets are connected by raw water discharge nozzle with the first condensing crystallizing kettle 5, and the first described condensing crystallizing kettle 5 is centrifuged with the 3rd successively
Machine 331 is connected with vacuum drier 332, and the outlet of electrodialysis plant anion enriched chamber 12 is dense by concentrated water discharge nozzle and second
Contracting crystallization kettle 6 is connected, and the second described condensing crystallizing kettle 6 is connected with the 4th centrifuge 441, and the 4th centrifuge 441 passes through the 4th
Conveyer 442 is connected with the second reactor 2.
Wherein, described electrodialysis plant includes electrodialysis cell, described electrodialysis cell by the first sun of belt supporting frame from
Proton exchange 7, the first anion-exchange membrane 8, the second cation-exchange membrane 9, the second anion-exchange membrane 10 are separated into 5 reactions
Room, respectively is anode chamber 11, anion enriched chamber 12, raw water room 13, cation enriched chamber 14 and cathode chamber 15, described
It is provided with anode chamber 11 in positive electrode 16, cathode chamber 15 and is provided with negative electrode 17.
For the pH in the reactor of on-line determination the 3rd, pH detection meters are provided with the 3rd described reactor.
The course of work：Acetic acid and salicylide are added into the first dried reactor 1, after stirring, then raw material is thrown
L-phenylalanine, after should terminating, condensing crystallizing liquid obtains DL-phenylalanine after being centrifuged through the first centrifuge 111；By gained
DL-phenylalanine is added in the second reactor 2 through the first conveyer 112, adds propionic acid and D- tartaric acid, is heated up, reaction knot
Shu Yihou, condensing crystallizing liquid obtains D-phenylalanine D- tartaric acid double salt through the centrifugation of the second centrifuge 221；By the D- benzene of gained
Alanine D- tartaric acid double salt is delivered in the 3rd reactor 3 through second conveyor 222, after being dissolved in water, and is added ammoniacal liquor and is adjusted
Its pH is saved to the isoelectric point of D-phenylalanine（5.5）；By the D-phenylalanine D- tartaric acid complex salt solutions in the 3rd reactor 3
It is sent in the raw water room 13 of electrodialysis plant, in the presence of electric field, the D- tartrate ions in raw water room 13 are by by force
Negative electrode enriched chamber 12 is attracted to, ammonium ion is then attracted to anode enriched chamber 14 by force, and D-phenylalanine solution then stays in original
In hydroecium 13, when electrical conductivity is zero or so, illustrate that D- tartrate ions and ammonium ion respectively shift to negative electrode enriched chamber
12 and anode enriched chamber 14, now will in raw water room the aqueous solution of D-phenylalanine import it is concentrated in the first condensing crystallizing kettle 5
Crystallization, after the condensing crystallizing liquid of gained is separated through the 3rd centrifuge 331, vacuum dried machine 332 obtains D-phenylalanine；Negative electrode
The D- tartrate ions of enriched chamber import condensing crystallizing in the second condensing crystallizing kettle 6, the condensing crystallizing liquid of gained through the 3rd from
Scheming 441 is centrifugally separating to obtain D- tartaric acid, and gained D- tartaric acid by the 3rd conveyer 442 through being back in the second reactor
Recycling.
Preferred embodiment of the present utility model is the foregoing is only, it is all at this not to limit the utility model
Within the spirit and principle of utility model, any modification, equivalent substitution and improvements made etc. should be included in the utility model
Protection domain within.
Claims (3)
1. a kind of process system for producing D-phenylalanine, it is characterised in that including be sequentially connected the first reactor, first from
Scheming, the first conveyer, the second reactor, the second centrifuge, second conveyor and the 3rd reactor, the 3rd described reactor
Be connected by feed pipe with the raw water room import of electrodialysis plant, the outlet of the raw water room of electrodialysis plant by raw water discharge nozzle with
First condensing crystallizing kettle is connected, and the first described condensing crystallizing kettle is connected with the 3rd centrifuge and vacuum drier successively, electric osmose
The outlet of analysis apparatus anion enriched chamber is connected by concentrated water discharge nozzle with the second condensing crystallizing kettle, the second described condensing crystallizing
Kettle is connected with the 4th centrifuge, and the 4th centrifuge is connected by the 4th conveyer with the second reactor.
2. a kind of process system for producing D-phenylalanine according to claim 1, it is characterised in that described electrodialysis
Device includes electrodialysis cell, described electrodialysis cell by the first cation-exchange membrane of belt supporting frame, the first anion-exchange membrane,
Second cation-exchange membrane, the second anion-exchange membrane are separated into 5 reative cells, respectively are anode chamber, anion concentration
It is provided with room, raw water room, cation enriched chamber and cathode chamber, described anode chamber in positive electrode, cathode chamber and is provided with negative electricity
Pole.
3. a kind of process system for producing D-phenylalanine according to claim 1, it is characterised in that described the 3rd is anti-
Answer and pH detection meters are provided with kettle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720044256.1U CN206538363U (en) | 2017-01-13 | 2017-01-13 | A kind of process system for producing D phenylalanines |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720044256.1U CN206538363U (en) | 2017-01-13 | 2017-01-13 | A kind of process system for producing D phenylalanines |
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| Publication Number | Publication Date |
|---|---|
| CN206538363U true CN206538363U (en) | 2017-10-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201720044256.1U Active CN206538363U (en) | 2017-01-13 | 2017-01-13 | A kind of process system for producing D phenylalanines |
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| Country | Link |
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| CN (1) | CN206538363U (en) |
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