CN206529469U - A kind of biofermentation product in-situ separating device - Google Patents
A kind of biofermentation product in-situ separating device Download PDFInfo
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- CN206529469U CN206529469U CN201720208288.0U CN201720208288U CN206529469U CN 206529469 U CN206529469 U CN 206529469U CN 201720208288 U CN201720208288 U CN 201720208288U CN 206529469 U CN206529469 U CN 206529469U
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Abstract
The utility model discloses a kind of biofermentation product in-situ separating device, including fermentation tank, clean storage tank and surge tank, ceramic film component is connected with fermentation tank by the 3rd reflux line, ceramic film component is connected with cleaning storage tank by the first reflux line, adsorption resin column is connected with surge tank by the 4th reflux line, peristaltic pump is provided with 4th reflux line, surge tank is connected with ceramic film component by pipeline, adsorption resin column is connected with strippant storage tank by pipeline, adsorption resin column is connected with fermentation tank by the second reflux line, the bottom of adsorption resin column is provided with connection downstream purification apparatus pipeline, cleaning storage tank is connected with fermentation tank by purge tank connecting pipe.Tunning is isolated by ceramic membrane original position, and by resin column absorption, the useless extraction raffinate of absorption flows down and is circulated back in fermentation tank, realizes the continuous automatic in-situ separation of tunning.
Description
Technical field
The utility model is related to a kind of separator, more particularly to a kind of biofermentation product in-situ separating device.
Background technology
In fermentation process, Product inhibiton problem occurs in many products, therefore needs during the fermentation pair
Product carries out separation in situ, to reduce accumulation of the product in zymotic fluid, reduces Product inhibiton, could improve fermentation yield.Mesh
Before, the tunning separation method in situ generally used mainly has：The isolation technics method in situ of water-oil phase fermentation, fermentation tank
The isolation technics method in situ and ceramic membrane coupled fermentation tank that middle input polymeric adsorbent carries out fermentation absorption carry out tunning
Original position separation.
The above-mentioned biofermentation product taken at present separation method in situ all certain shortcomings of generally existing：Water-oil phase
Method major defect is that oil mixing with water system viscosity is big, is unfavorable for the mass transfer in fermentation process, fermentation production rate is not high；Resin is put into inhale
Subsidiary formula method major defect is more, and substantial amounts of polymeric adsorbent is added in fermentation system, changes solid content, equally influences fermentation process
Mass transfer, while whipping process resin particle shearing force causes certain damage to thalline, suppress thalline vigor, influence to a certain degree
Fermentation production rate, in addition, the warping resin rinsing in later stage produces a large amount of waste water；The separation method in situ of ceramic membrane coupled fermentation tank,
It is technological means conventional at present, it is to avoid thalline damage and mass transfer problem described in the former two, but to biofermentation product
For the separation of original position, after UF membrane, dialyzate contains substantial amounts of polar reaction substrate, carbon nitrogen source and inorganic while product is dialysed
The Nutrious fermented material such as salt, since it is desired that maintaining fermentation thalli concentration and culture medium content, is generally required while UF membrane
Need constantly to add the raw material such as water, polar reaction substrate, carbon nitrogen source, inorganic mineral and ensure that fermentation is normally carried out, on one side thoroughly
Analysis loss raw material cause fermentation raw material largely to waste while keeping and adding, cost rise, while endlessly dialysing
Liquid causes subsequent product purge process to produce a large amount of waste water.
In view of this, it is necessary to which the in-situ separating device for designing product in a kind of biological fermentation process is improved, life is realized
The continuous and automatic of production process, the recycling of proferment material circulation, it is to avoid fermentation workshop section produces extra waste water, reduces cost.
Utility model content
The technical problems to be solved in the utility model is to overcome the defect of prior art former there is provided a kind of biofermentation product
Position separator.
In order to solve the above-mentioned technical problem, the utility model provides following technical scheme：
A kind of biofermentation product in-situ separating device of the utility model, including fermentation tank, ceramic film component, polymeric adsorbent
Post, peristaltic pump, cleaning storage tank and surge tank, the ceramic film component is connected with fermentation tank by the 3rd reflux line, described
One end of 3rd reflux line is provided with the 3rd valve, and the ceramic film component is connected with cleaning storage tank by the first reflux line
Connect, the 4th valve is provided with first reflux line, the adsorption resin column passes through the 4th reflux line phase with surge tank
Peristaltic pump is provided with connection, the 4th reflux line, the side of the peristaltic pump is provided with material inlet valve, the surge tank
It is connected with ceramic film component by pipeline, the adsorption resin column is connected with strippant storage tank by pipeline, the desorption
The bottom of agent storage tank is provided with the first valve, and the adsorption resin column is connected with fermentation tank by the second reflux line, described
The second valve is provided with second reflux line, the bottom of the adsorption resin column is provided with connection downstream purification apparatus pipeline,
Connection downstream purification apparatus valve is provided with the connection downstream purification apparatus pipeline, the cleaning storage tank passes through with fermentation tank
Purge tank connecting pipe is connected, and purge tank connecting valve is provided with the purge tank connecting pipe.
As a kind of optimal technical scheme of the present utility model, the membrane module material of the ceramic film component is zirconium oxide,
Alundum (Al2O3), and separation aperture is 50-400nm, high temperature high voltage resistant.
As a kind of optimal technical scheme of the present utility model, the ceramic film component passes through influent stream pipeline phase with fermentation tank
Steam connector valve is provided with connection, the influent stream pipeline.
As a kind of optimal technical scheme of the present utility model, the ceramic film component concentrated solution outlet is connected with fermentation tank
The 3rd reflux line on heat exchanger is installed.
As a kind of optimal technical scheme of the present utility model, ceramic film component and adsorption resin column the upper end import it
Between, it is connected by pipeline and is connected to surge tank.
As a kind of optimal technical scheme of the present utility model, the adsorption resin column lower end export the second reflux line and
Second valve is connected to fermentation tank charging aperture so that Matter Transfer is returned in fermentation tank.
As a kind of optimal technical scheme of the present utility model, the separating medium in the adsorption column is that resin is that macropore is inhaled
Attached resin, ion exchange resin.
Compared with prior art, the beneficial effects of the utility model are as follows：
The utility model, by the biological fermentation process product in-situ separating device, is ceramic film component and fermentation tank first
Coupling, fermentation process is separated by ceramic membrane to thalline and product liquid, and concentration liquid circulating reflux to fermentation tank is relayed
Supervention ferment, and product is dialysed by ceramic membrane and flowed out, dialyzate flows through resin absorbing column, and the separated medium adsorption and enrichment of product exists
On post bed, because separating medium does not adsorb the Nutrious fermented thing such as polarity substrate and carbon nitrogen source, inorganic salts, mineral matter in zymotic fluid
Polarity substrate and nutriment in matter, therefore UF membrane dialyzate penetrate post bed stream outflow, and circulating reflux is followed into fermentation tank
Ring is utilized, and proceeds fermentation, and such technical characteristic will not both produce a large amount of waste water, the former material such as polarity substrate and nutriment
Material is fully recycled, it is to avoid waste of raw materials；Whole service system is a closed, continuous automated procedure, and operation is more
It is easy.
Brief description of the drawings
Accompanying drawing is used for providing further understanding to of the present utility model, and constitutes a part for specification, with this practicality
New embodiment is used to explain the utility model together, does not constitute to limitation of the present utility model.In the accompanying drawings：
Fig. 1 is overall structure diagram of the present utility model；
In figure：1st, fermentation tank；2nd, steam connector valve；3rd, purge tank connecting valve；4th, purge tank connecting pipe；5th, it is clear
Cleaning of evaporator；6th, the first reflux line；7th, surge tank；8th, downstream purification apparatus valve is connected；9th, downstream purification apparatus pipeline is connected；
10th, the second valve；11st, adsorption resin column；12nd, the first valve；13rd, strippant storage tank；14th, the second reflux line；15th, the 3rd time
Flow tube road；16th, heat exchanger；17th, the 3rd valve；18th, ceramic film component；19th, the 4th valve；20th, peristaltic pump；21st, material inlet valve；
22nd, the 4th reflux line；23rd, influent stream pipeline.
Embodiment
Preferred embodiment of the present utility model is illustrated below in conjunction with accompanying drawing, it will be appreciated that described herein excellent
Select embodiment to be merely to illustrate and explain the utility model, be not used to limit the utility model.
Embodiment 1
As shown in figure 1, the utility model provides biofermentation product in-situ separating device, including fermentation tank 1, ceramic membrane group
Part 18, adsorption resin column 11, peristaltic pump 20, cleaning storage tank 5 and surge tank 7, ceramic film component 18 pass through the 3rd time with fermentation tank 1
Flow tube road 15 is connected, and one end of the 3rd reflux line 15 is provided with the 3rd valve 17, and ceramic film component 18 leads to cleaning storage tank 5
Cross the first reflux line 6 to be connected, the 4th valve 19 is provided with the first reflux line 6, adsorption resin column 11 leads to surge tank 7
Cross the 4th reflux line 22 to be connected, peristaltic pump 20 is provided with the 4th reflux line 22, the side of peristaltic pump is provided with charging
Valve 21, surge tank 7 is connected with ceramic film component 18 by pipeline, and adsorption resin column 11 passes through pipeline with strippant storage tank 13
It is connected, the bottom of strippant storage tank 13 is provided with the first valve 12, and adsorption resin column 11 passes through the second return duct with fermentation tank 1
Road 14 is connected, and the second valve 10 is provided with the second reflux line 14, and the bottom of adsorption resin column 11 is provided with connection downstream
Purification apparatus pipeline 9, connection downstream purification apparatus pipeline 9 on be provided with connection downstream purification apparatus valve 8, cleaning storage tank 5 with
Fermentation tank 1 is connected by purge tank connecting pipe 4, and purge tank connecting valve 3 is provided with purge tank connecting pipe 4.
Further, the membrane module material of ceramic film component 18 is zirconium oxide, alundum (Al2O3), and separation aperture is 50-
400nm, high temperature high voltage resistant, be easy to fermentation substrate and various nutriment raw materials it is not to be adsorbed and penetrate post bed flow down.
Ceramic film component 18 is connected with fermentation tank 1 by influent stream pipeline 23, and steam connection is provided with influent stream pipeline 23
Head valve door 2, is easy to concentrate down cycles to enter in fermentation tank 1 and continues to ferment.
Between ceramic film component 18 and the upper end import of adsorption resin column 11, surge tank is connected with by the 4th reflux line 22
7, saturating imbibition can be achieved and crosses column flow rate regulation.
Heat exchanger 16 is installed on the 3rd reflux line 15 that the concentrated solution outlet of ceramic film component 18 is connected with fermentation tank 1,
It is easy to the cooling of concentrate.
The outlet of the lower end of adsorption resin column 11 is connected to the charging aperture of fermentation tank 1 by the second reflux line 14 and the second valve 10
So that Matter Transfer is returned in fermentation tank 1, it is easy to tunning to continue to ferment.
The adsorbing medium of adsorption resin column 11 is macroporous absorbent resin, ion exchange resin, and separating medium does not adsorb zymotic fluid
The Nutrious fermented materials such as middle polarity substrate and carbon nitrogen source, inorganic salts, mineral matter.
Reached specifically, fermentation tank 1 ferments to product assay under normal operating conditions after defined level, open fermentation
Tank drain hole valve and the 3rd valve 17, steam connection tube valve 2, purge tank connecting valve 3 and clean cycle pipeline valve 19
Close, start ceramic film component 18, concentrate enters in fermentation tank 1 by the down cycles of heat exchanger 16 and continues to ferment during operation,
Dialyzate flows into surge tank 7 after membrane filtration, after dialyzate is collected into a certain amount of in surge tank 7, opens on adsorption resin column 11
The material inlet valve 21 at end and the circulating line valve 10 of lower end, connection downstream purification apparatus valve 9 are closed, and start peristaltic pump 20,
From the top of adsorption resin column 11, charging carries out product absorption to material, and product is by macroporous resin adsorption, and ceramic film component 18 is dialysed
Fermentation substrate and various nutriment raw materials in liquid are not to be adsorbed and penetrate post bed and flow down, by the second reflux line 14 times
Stream, which enters in fermentation tank 1, to be continued to ferment, and whole device running is closed, continuous, an automatic cycle process, tunning
Fermentation system is continuously separated, shifts and is enriched in resin absorbing column 11, continuously and automatically biological hair is realized
Ferment product original position separation so that production concentration maintains reduced levels in fermentation process zymotic fluid, it is to avoid the production of fermentation thalli
Thing suppresses, and improves tunning total output.
After fermentation ends, product, which is completely transferred, to be adsorbed onto in resin, closes the material inlet valve of the upper end of adsorption resin column 11
21 and second valve 10, open and the first valve 12 and link downstream purification apparatus valve 8, start desorption product and pass through pipeline 9
Into downstream refining stage, finished product is obtained by subsequent treatment.
, it is necessary to be cleaned to ceramic film component 18 after fermentation ends, the bottom discharge valve of fermentation tank 1 door and the 3rd valve are closed
Door 17, opens wash feed valve 3 and clean cycle valve 19, starts ceramic membrane operation cleaning procedure.
The utility model, by the biological fermentation process product in-situ separating device, is ceramic film component 18 and fermentation first
Tank 1 is coupled, and fermentation process is separated by ceramic membrane to thalline and product liquid, concentration liquid circulating reflux to fermentation tank 1
Supervention ferment is relayed, and product is dialysed by ceramic membrane and flowed out, dialyzate flows through resin absorbing column 11, the separated medium absorption of product
It is enriched on post bed, because separating medium does not adsorb the fermentation such as polarity substrate and carbon nitrogen source, inorganic salts, mineral matter battalion in zymotic fluid
Material is supported, therefore polarity substrate and nutriment in UF membrane dialyzate penetrates post bed stream outflow, circulating reflux to fermentation tank 1
In recycle, proceed fermentation, such technical characteristic will not both produce a large amount of waste water, polarity substrate and nutriment etc.
Raw material are fully recycled, it is to avoid waste of raw materials；Whole service system is a closed, continuous automated procedure, behaviour
Make easier.
Finally it should be noted that：Preferred embodiment of the present utility model is the foregoing is only, this is not limited to
Utility model, although the utility model is described in detail with reference to the foregoing embodiments, for those skilled in the art
For, it can still modify to the technical scheme described in foregoing embodiments, or to which part technical characteristic
Carry out equivalent substitution.It is all it is of the present utility model spirit and principle within, any modification, equivalent substitution and improvements made etc.,
It should be included within protection domain of the present utility model.
Claims (7)
1. a kind of biofermentation product in-situ separating device, including fermentation tank (1), ceramic film component (18), adsorption resin column
(11), peristaltic pump (20), cleaning storage tank (5) and surge tank (7), it is characterised in that the ceramic film component (18) and fermentation tank
(1) it is connected by the 3rd reflux line (15), one end of the 3rd reflux line (15) is provided with the 3rd valve (17), institute
State ceramic film component (18) with cleaning storage tank (5) by the first reflux line (6) to be connected, on first reflux line (6)
The 4th valve (19) is provided with, the adsorption resin column (11) is connected with surge tank (7) by the 4th reflux line (22), institute
State and peristaltic pump (20) is provided with the 4th reflux line (22), the side of the peristaltic pump is provided with material inlet valve (21), described
Surge tank (7) is connected with ceramic film component (18) by pipeline, and the adsorption resin column (11) is led to strippant storage tank (13)
Piping is connected, and the bottom of the strippant storage tank (13) is provided with the first valve (12), the adsorption resin column (11) with
Fermentation tank (1) is connected by the second reflux line (14), and the second valve (10) is provided with second reflux line (14),
The bottom of the adsorption resin column (11) is provided with connection downstream purification apparatus pipeline (9), the connection downstream purification apparatus pipe
Connection downstream purification apparatus valve (8) is provided with road (9), the cleaning storage tank (5) is connected with fermentation tank (1) by purge tank
Pipeline (4) is connected, and purge tank connecting valve (3) is provided with the purge tank connecting pipe (4).
2. a kind of biofermentation product in-situ separating device according to claim 1, it is characterised in that described ceramic membrane
The membrane module material of component (18) is zirconium oxide, alundum (Al2O3), and separation aperture is 50-400nm, high temperature high voltage resistant.
3. a kind of biofermentation product in-situ separating device according to claim 2, it is characterised in that the ceramic membrane group
Part (18) is connected with fermentation tank (1) by influent stream pipeline (23), and steam connection head valve is provided with the influent stream pipeline (23)
Door (2).
4. a kind of biofermentation product in-situ separating device according to claim 3, it is characterised in that the ceramic membrane group
Between part (18) and adsorption resin column (11) upper end import, surge tank (7) is connected with by the 4th reflux line (22).
5. a kind of biofermentation product in-situ separating device according to claim 4, it is characterised in that the ceramic membrane group
Heat exchanger (16) is installed on the 3rd reflux line (15) that part (18) concentrated solution outlet is connected with fermentation tank (1).
6. a kind of biofermentation product in-situ separating device according to claim 4, it is characterised in that the polymeric adsorbent
The outlet of post (11) lower end is connected to fermentation tank (1) charging aperture and causes material by the second reflux line (14) and the second valve (10)
It is circulated back in fermentation tank (1).
7. a kind of biofermentation product in-situ separating device according to claim 6, it is characterised in that the polymeric adsorbent
Post (11) adsorbing medium is macroporous absorbent resin, ion exchange resin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201720208288.0U CN206529469U (en) | 2017-03-06 | 2017-03-06 | A kind of biofermentation product in-situ separating device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201720208288.0U CN206529469U (en) | 2017-03-06 | 2017-03-06 | A kind of biofermentation product in-situ separating device |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109294892A (en) * | 2018-10-26 | 2019-02-01 | 驻马店天中生物科技有限公司 | A kind of thallus circulating fermentation system |
| CN110172401A (en) * | 2018-10-30 | 2019-08-27 | 武汉武药制药有限公司 | A kind of circulating biological enzymic catalytic reaction system |
| CN110331091A (en) * | 2019-07-17 | 2019-10-15 | 福建师范大学 | Utilize the system and method for Phellinus fermentation and resin separation coupling production morin |
| CN111440700A (en) * | 2020-04-17 | 2020-07-24 | 北京化工大学 | Fat-soluble fermentation product on-line fermentation in-situ separation coupling device and method |
-
2017
- 2017-03-06 CN CN201720208288.0U patent/CN206529469U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109294892A (en) * | 2018-10-26 | 2019-02-01 | 驻马店天中生物科技有限公司 | A kind of thallus circulating fermentation system |
| CN110172401A (en) * | 2018-10-30 | 2019-08-27 | 武汉武药制药有限公司 | A kind of circulating biological enzymic catalytic reaction system |
| CN110172401B (en) * | 2018-10-30 | 2022-10-04 | 武汉武药制药有限公司 | Circulating biological enzyme catalysis reaction system |
| CN110331091A (en) * | 2019-07-17 | 2019-10-15 | 福建师范大学 | Utilize the system and method for Phellinus fermentation and resin separation coupling production morin |
| CN111440700A (en) * | 2020-04-17 | 2020-07-24 | 北京化工大学 | Fat-soluble fermentation product on-line fermentation in-situ separation coupling device and method |
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Shenzhen xinshengrui Biotechnology Co.,Ltd. Assignor: BOTON (SHANGHAI) BIOTECHNOLOGY Co.,Ltd. Contract record no.: X2022980009383 Denomination of utility model: An in situ separation device for biological fermentation products Granted publication date: 20170929 License type: Common License Record date: 20220705 |
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| EE01 | Entry into force of recordation of patent licensing contract |